JP2012531208A - 代替軽鎖の発現 - Google Patents

代替軽鎖の発現 Download PDF

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Publication number
JP2012531208A
JP2012531208A JP2012517785A JP2012517785A JP2012531208A JP 2012531208 A JP2012531208 A JP 2012531208A JP 2012517785 A JP2012517785 A JP 2012517785A JP 2012517785 A JP2012517785 A JP 2012517785A JP 2012531208 A JP2012531208 A JP 2012531208A
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sequence
polypeptide
slc
nucleic acid
vpreb
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Japanese (ja)
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JP2012531208A5 (enExample
Inventor
ローレンス ホロヴィッツ，
ラメッシュ バット，
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シー レーン バイオテクノロジーズ， エルエルシー
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Publication of JP2012531208A publication Critical patent/JP2012531208A/ja
Publication of JP2012531208A5 publication Critical patent/JP2012531208A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Holo Graphy (AREA)
JP2012517785A 2009-06-26 2010-06-25 代替軽鎖の発現 Withdrawn JP2012531208A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22087809P 2009-06-26 2009-06-26
US61/220,878 2009-06-26
PCT/US2010/040052 WO2010151808A1 (en) 2009-06-26 2010-06-25 Expression of surrogate light chains

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015256676A Division JP2016105714A (ja) 2009-06-26 2015-12-28 代替軽鎖の発現

Publications (2)

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JP2012531208A true JP2012531208A (ja) 2012-12-10
JP2012531208A5 JP2012531208A5 (enExample) 2013-08-08

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JP2012517785A Withdrawn JP2012531208A (ja) 2009-06-26 2010-06-25 代替軽鎖の発現
JP2015256676A Pending JP2016105714A (ja) 2009-06-26 2015-12-28 代替軽鎖の発現

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JP2015256676A Pending JP2016105714A (ja) 2009-06-26 2015-12-28 代替軽鎖の発現

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US (1) US8969082B2 (enExample)
EP (2) EP3205723A1 (enExample)
JP (2) JP2012531208A (enExample)
KR (2) KR101829073B1 (enExample)
CN (1) CN102498210B (enExample)
AU (1) AU2010265949B2 (enExample)
BR (1) BRPI1015916A2 (enExample)
CA (1) CA2764729C (enExample)
IL (1) IL216796A (enExample)
MX (1) MX2012000129A (enExample)
TW (1) TWI560271B (enExample)
WO (1) WO2010151808A1 (enExample)

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WO2013003647A2 (en) 2011-06-28 2013-01-03 Sea Lane Biotechnologies, Llc Multispecific stacked variable domain binding proteins
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US12466897B2 (en) 2011-10-10 2025-11-11 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
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US9605084B2 (en) 2013-03-15 2017-03-28 Xencor, Inc. Heterodimeric proteins
US11053316B2 (en) 2013-01-14 2021-07-06 Xencor, Inc. Optimized antibody variable regions
CA2898100C (en) 2013-01-14 2023-10-10 Xencor, Inc. Novel heterodimeric proteins
US10131710B2 (en) 2013-01-14 2018-11-20 Xencor, Inc. Optimized antibody variable regions
US9701759B2 (en) 2013-01-14 2017-07-11 Xencor, Inc. Heterodimeric proteins
US10487155B2 (en) 2013-01-14 2019-11-26 Xencor, Inc. Heterodimeric proteins
US10968276B2 (en) 2013-03-12 2021-04-06 Xencor, Inc. Optimized anti-CD3 variable regions
CA2897987A1 (en) 2013-01-15 2014-07-24 Xencor, Inc. Rapid clearance of antigen complexes using novel antibodies
US10106624B2 (en) 2013-03-15 2018-10-23 Xencor, Inc. Heterodimeric proteins
EP2970486B1 (en) 2013-03-15 2018-05-16 Xencor, Inc. Modulation of t cells with bispecific antibodies and fc fusions
US10858417B2 (en) 2013-03-15 2020-12-08 Xencor, Inc. Heterodimeric proteins
US10519242B2 (en) 2013-03-15 2019-12-31 Xencor, Inc. Targeting regulatory T cells with heterodimeric proteins
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
US9783618B2 (en) 2013-05-01 2017-10-10 Kymab Limited Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
US20150033372A1 (en) * 2013-05-01 2015-01-29 Kymab Limited Human VpreB & Chimaeric Surrogate Light Chains in Transgenic Non-Human Vertebrates
US11707056B2 (en) 2013-05-02 2023-07-25 Kymab Limited Animals, repertoires and methods
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
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JP6775422B2 (ja) 2014-03-28 2020-10-28 ゼンコー・インコーポレイテッドＸｅｎｃｏｒ、 Ｉｎｃ． Ｃｄ３８及びｃｄ３に結合する二重特異性抗体
SG11201704283PA (en) 2014-11-26 2017-06-29 Xencor Inc Heterodimeric antibodies that bind cd3 and tumor antigens
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Also Published As

Publication number Publication date
IL216796A (en) 2015-09-24
KR20120095343A (ko) 2012-08-28
TWI560271B (en) 2016-12-01
WO2010151808A1 (en) 2010-12-29
AU2010265949B2 (en) 2016-05-05
EP2446032A1 (en) 2012-05-02
MX2012000129A (es) 2012-02-01
JP2016105714A (ja) 2016-06-16
AU2010265949A1 (en) 2011-12-22
EP2446032B1 (en) 2016-12-21
CA2764729A1 (en) 2010-12-29
CN102498210B (zh) 2015-07-29
IL216796A0 (en) 2012-02-29
CA2764729C (en) 2019-04-02
US8969082B2 (en) 2015-03-03
US20100330676A1 (en) 2010-12-30
TW201107468A (en) 2011-03-01
EP3205723A1 (en) 2017-08-16
BRPI1015916A2 (pt) 2015-09-01
KR101829073B1 (ko) 2018-02-13
CN102498210A (zh) 2012-06-13
EP2446032B8 (en) 2017-03-15
KR20180017231A (ko) 2018-02-20

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