JP2012528180A5 - - Google Patents
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- Publication number
- JP2012528180A5 JP2012528180A5 JP2012513215A JP2012513215A JP2012528180A5 JP 2012528180 A5 JP2012528180 A5 JP 2012528180A5 JP 2012513215 A JP2012513215 A JP 2012513215A JP 2012513215 A JP2012513215 A JP 2012513215A JP 2012528180 A5 JP2012528180 A5 JP 2012528180A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- pharmaceutically acceptable
- isotope
- acceptable salt
- propan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18173609P | 2009-05-28 | 2009-05-28 | |
| US61/181,736 | 2009-05-28 | ||
| PCT/US2010/036211 WO2010138598A2 (en) | 2009-05-28 | 2010-05-26 | Lxr modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012528180A JP2012528180A (ja) | 2012-11-12 |
| JP2012528180A5 true JP2012528180A5 (https=) | 2013-05-30 |
| JP5625050B2 JP5625050B2 (ja) | 2014-11-12 |
Family
ID=43223342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012513215A Expired - Fee Related JP5625050B2 (ja) | 2009-05-28 | 2010-05-26 | Ｌｘｒの調節因子 |
Country Status (31)
| Country | Link |
|---|---|
| US (4) | US8618154B2 (https=) |
| EP (1) | EP2435410B1 (https=) |
| JP (1) | JP5625050B2 (https=) |
| KR (1) | KR101676704B1 (https=) |
| CN (1) | CN102648184B (https=) |
| AR (1) | AR078049A1 (https=) |
| AU (1) | AU2010254082B2 (https=) |
| BR (1) | BRPI1013259B8 (https=) |
| CA (1) | CA2761934C (https=) |
| CL (1) | CL2011002972A1 (https=) |
| CO (1) | CO6470826A2 (https=) |
| CY (1) | CY1119407T1 (https=) |
| DK (1) | DK2435410T3 (https=) |
| EA (1) | EA019960B1 (https=) |
| ES (1) | ES2620451T3 (https=) |
| HR (1) | HRP20170194T1 (https=) |
| IL (1) | IL216176A (https=) |
| LT (1) | LT2435410T (https=) |
| MX (1) | MX2011012559A (https=) |
| MY (1) | MY153958A (https=) |
| NZ (1) | NZ596330A (https=) |
| PE (1) | PE20120797A1 (https=) |
| PL (1) | PL2435410T3 (https=) |
| PT (1) | PT2435410T (https=) |
| SG (1) | SG176247A1 (https=) |
| SI (1) | SI2435410T1 (https=) |
| SM (1) | SMT201700253T1 (https=) |
| TN (1) | TN2011000585A1 (https=) |
| TW (1) | TWI488844B (https=) |
| WO (1) | WO2010138598A2 (https=) |
| ZA (1) | ZA201108181B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101676704B1 (ko) * | 2009-05-28 | 2016-11-16 | 엑셀리시스 페이턴트 컴퍼니 엘엘씨 | Ｌｘｒ 조절자 |
| AR088728A1 (es) * | 2011-03-25 | 2014-07-02 | Bristol Myers Squibb Co | Moduladores de lxr como prodroga de imidazol |
| SG10201607345YA (en) | 2012-03-02 | 2016-11-29 | Ralexar Therapeutics Inc | Liver x receptor (lxr) modulators for the treatment of dermal diseases, disorders and conditions |
| AU2013302861A1 (en) | 2012-08-13 | 2015-03-05 | The Rockefeller University | Treatment and diagnosis of melanoma |
| JP6456909B2 (ja) | 2013-03-15 | 2019-01-23 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｌｘｒ調節因子 |
| CN105209039B (zh) * | 2013-03-15 | 2018-06-22 | 百时美施贵宝公司 | Lxr调节剂 |
| RS60479B1 (sr) | 2013-09-04 | 2020-08-31 | Ellora Therapeutics Inc | Modulatori receptora x jetre (lxr) |
| JP2016532713A (ja) | 2013-09-04 | 2016-10-20 | アレクサー セラピューティクス， インク． | 肝臓ｘ受容体（ｌｘｒ）調節因子 |
| WO2015106164A1 (en) | 2014-01-10 | 2015-07-16 | Rgenix, Inc. | Lxr agonists and uses thereof |
| KR101815734B1 (ko) | 2015-05-29 | 2018-01-05 | 가톨릭대학교 산학협력단 | ｍｉＲ－７, ｍｉＲ－１８ａ 또는 ｍｉＲ－１８ｂ를 유효성분으로 포함하는 대사성 질환의 예방 또는 치료용 약학적 조성물 |
| EP3402477A4 (en) | 2016-01-11 | 2019-08-21 | The Rockefeller University | METHOD FOR THE TREATMENT OF DISEASES RELATED TO MYELOID-DERIVED SUPPRESSOR CELLS |
| CA3078981A1 (en) | 2017-11-21 | 2019-05-31 | Rgenix, Inc. | Polymorphs and uses thereof |
| EP3999055A1 (en) | 2019-07-15 | 2022-05-25 | Novartis AG | Methods for treating meibomian gland dysfunction with liver x receptor agonists |
| CN110305141B (zh) * | 2019-07-18 | 2022-01-11 | 深圳市三启药物开发有限公司 | 一种螺(3,3’-异丙基吡咯烷氧化吲哚)类肝x受体调节剂及其制备方法和应用 |
| TWI888447B (zh) | 2019-12-13 | 2025-07-01 | 美商因思博納公司 | 金屬鹽及其用途 |
| CN115656401B (zh) * | 2022-11-09 | 2025-03-28 | 武汉海特生物创新医药研究有限公司 | 一种咪唑-4-甲酸乙酯纯度的hplc检测方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4231938A (en) | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| US4444784A (en) | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| DK149080C (da) | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
| HU204253B (en) | 1982-11-22 | 1991-12-30 | Sandoz Ag | Process for producing mevalonolactone analogues and derivatives and pharmaceutical compositions containing them |
| US5354772A (en) | 1982-11-22 | 1994-10-11 | Sandoz Pharm. Corp. | Indole analogs of mevalonolactone and derivatives thereof |
| FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| US5177080A (en) | 1990-12-14 | 1993-01-05 | Bayer Aktiengesellschaft | Substituted pyridyl-dihydroxy-heptenoic acid and its salts |
| CA2115452A1 (en) | 1991-09-17 | 1993-04-01 | Ronald M. Evans | Receptor of the thyroid/steroid hormone receptor superfamily |
| CN1248916A (zh) | 1997-01-24 | 2000-03-29 | 加利福尼亚大学董事会 | FXR、PPARα和LXRα激活剂恢复屏障功能、促进表皮分化和抑制增生的用途 |
| EP1115853A2 (en) | 1998-09-23 | 2001-07-18 | Ludmila Solomin | Analysis of ligand activated nuclear receptors in vivo |
| JP2002532729A (ja) | 1998-12-23 | 2002-10-02 | グラクソ グループ リミテッド | 核内受容体のリガンドのアッセイ |
| EP1165135B1 (en) | 1999-03-26 | 2004-09-01 | City of Hope | Methods of screening for compounds modulating fxr receptors |
| CN100513570C (zh) | 1999-06-18 | 2009-07-15 | Cv治疗公司 | 结合框运输蛋白abc1的调节作用 |
| WO2001082917A2 (en) | 2000-05-03 | 2001-11-08 | Tularik Inc. | Treatment of hypertriglyceridemia and other conditions using lxr modulators |
| US6924311B2 (en) | 2001-10-17 | 2005-08-02 | X-Ceptor Therapeutics, Inc. | Methods for affecting various diseases utilizing LXR compounds |
| US7482366B2 (en) * | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
| WO2004011446A1 (en) * | 2002-07-26 | 2004-02-05 | Bayer Pharmaceuticals Corporation | Indane, dihydrobenzofuran, and tetrahydronaphthalene carboxylic acid derivatives and their use as antidiabetics |
| US7109227B2 (en) * | 2002-08-26 | 2006-09-19 | National Health Research Institutes | Imidazolamino compounds |
| MXPA05012679A (es) * | 2003-05-27 | 2006-02-08 | Sod Conseils Rech Applic | Nuevos derivados de imidazoles, su preparacion y su uso como medicamento. |
| CA2545942C (en) * | 2003-11-14 | 2012-07-10 | Lorus Therapeutics Inc. | Aryl imidazoles and their use as anti-cancer agents |
| AU2005211809B2 (en) * | 2004-02-11 | 2009-02-12 | Irm Llc | Compounds and compositions as LXR modulators |
| BRPI0612287A8 (pt) * | 2005-06-27 | 2019-01-22 | Exelixis Inc | composição para uso farmacêutico no tratamento de doenças através da medicina nuclear e métodos de uso e para modulação de atividade de receptor nuclear |
| SG162803A1 (en) * | 2005-06-27 | 2010-07-29 | Exelixis Inc | Imidazole based lxr modulators |
| KR20090094125A (ko) * | 2006-12-08 | 2009-09-03 | 엑셀리시스, 인코포레이티드 | Ｌｘｒ 및 ｆｘｒ 조절자 |
| KR101676704B1 (ko) * | 2009-05-28 | 2016-11-16 | 엑셀리시스 페이턴트 컴퍼니 엘엘씨 | Ｌｘｒ 조절자 |
-
2010
- 2010-05-26 KR KR1020117031397A patent/KR101676704B1/ko not_active Expired - Fee Related
- 2010-05-26 JP JP2012513215A patent/JP5625050B2/ja not_active Expired - Fee Related
- 2010-05-26 AU AU2010254082A patent/AU2010254082B2/en not_active Ceased
- 2010-05-26 BR BRPI1013259A patent/BRPI1013259B8/pt not_active IP Right Cessation
- 2010-05-26 CN CN201080033601.2A patent/CN102648184B/zh not_active Expired - Fee Related
- 2010-05-26 EA EA201171488A patent/EA019960B1/ru not_active IP Right Cessation
- 2010-05-26 EP EP10721902.4A patent/EP2435410B1/en active Active
- 2010-05-26 DK DK10721902.4T patent/DK2435410T3/da active
- 2010-05-26 PT PT107219024T patent/PT2435410T/pt unknown
- 2010-05-26 PE PE2011002005A patent/PE20120797A1/es active IP Right Grant
- 2010-05-26 WO PCT/US2010/036211 patent/WO2010138598A2/en not_active Ceased
- 2010-05-26 LT LTEP10721902.4T patent/LT2435410T/lt unknown
- 2010-05-26 SI SI201031427A patent/SI2435410T1/sl unknown
- 2010-05-26 NZ NZ596330A patent/NZ596330A/xx unknown
- 2010-05-26 ES ES10721902.4T patent/ES2620451T3/es active Active
- 2010-05-26 CA CA2761934A patent/CA2761934C/en active Active
- 2010-05-26 MX MX2011012559A patent/MX2011012559A/es active IP Right Grant
- 2010-05-26 HR HRP20170194TT patent/HRP20170194T1/hr unknown
- 2010-05-26 SM SM20170253T patent/SMT201700253T1/it unknown
- 2010-05-26 US US13/319,937 patent/US8618154B2/en not_active Expired - Fee Related
- 2010-05-26 SG SG2011087459A patent/SG176247A1/en unknown
- 2010-05-26 MY MYPI2011006278A patent/MY153958A/en unknown
- 2010-05-26 PL PL10721902T patent/PL2435410T3/pl unknown
- 2010-05-28 AR ARP100101870A patent/AR078049A1/es not_active Application Discontinuation
- 2010-05-28 TW TW099117252A patent/TWI488844B/zh not_active IP Right Cessation
-
2011
- 2011-11-07 IL IL216176A patent/IL216176A/en active IP Right Grant
- 2011-11-08 ZA ZA2011/08181A patent/ZA201108181B/en unknown
- 2011-11-16 TN TNP2011000585A patent/TN2011000585A1/en unknown
- 2011-11-24 CL CL2011002972A patent/CL2011002972A1/es unknown
- 2011-11-25 CO CO11161736A patent/CO6470826A2/es active IP Right Grant
-
2013
- 2013-11-21 US US14/085,926 patent/US20140163081A1/en not_active Abandoned
-
2015
- 2015-05-04 US US14/703,247 patent/US20150299136A1/en not_active Abandoned
-
2016
- 2016-06-07 US US15/175,425 patent/US20160280661A1/en not_active Abandoned
-
2017
- 2017-04-05 CY CY20171100403T patent/CY1119407T1/el unknown
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