JP2012526850A5 - - Google Patents
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- JP2012526850A5 JP2012526850A5 JP2012511031A JP2012511031A JP2012526850A5 JP 2012526850 A5 JP2012526850 A5 JP 2012526850A5 JP 2012511031 A JP2012511031 A JP 2012511031A JP 2012511031 A JP2012511031 A JP 2012511031A JP 2012526850 A5 JP2012526850 A5 JP 2012526850A5
- Authority
- JP
- Japan
- Prior art keywords
- patient
- dependent kinase
- cdk4
- use according
- cyclin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 claims 20
- 102000013698 Cyclin-Dependent Kinase 6 Human genes 0.000 claims 20
- 108010025468 Cyclin-Dependent Kinase 6 Proteins 0.000 claims 20
- 102100036252 Cyclin-dependent kinase 4 Human genes 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 9
- 239000012623 DNA damaging agent Substances 0.000 claims 8
- 239000003638 chemical reducing agent Substances 0.000 claims 7
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 6
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 6
- 231100000419 toxicity Toxicity 0.000 claims 6
- 230000001988 toxicity Effects 0.000 claims 6
- 239000003102 growth factor Substances 0.000 claims 5
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 4
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 4
- 102000015696 Interleukins Human genes 0.000 claims 4
- 108010063738 Interleukins Proteins 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 102000003951 Erythropoietin Human genes 0.000 claims 3
- 108090000394 Erythropoietin Proteins 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 229940105423 erythropoietin Drugs 0.000 claims 3
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 3
- 108010024986 Cyclin-Dependent Kinase 2 Proteins 0.000 claims 2
- 102100036239 Cyclin-dependent kinase 2 Human genes 0.000 claims 2
- 229940083347 Cyclin-dependent kinase 4 inhibitor Drugs 0.000 claims 2
- 102000003972 Fibroblast growth factor 7 Human genes 0.000 claims 2
- 108090000385 Fibroblast growth factor 7 Proteins 0.000 claims 2
- 102000015215 Stem Cell Factor Human genes 0.000 claims 2
- 108010039445 Stem Cell Factor Proteins 0.000 claims 2
- 102000036693 Thrombopoietin Human genes 0.000 claims 2
- 108010041111 Thrombopoietin Proteins 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000009437 off-target effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000011084 recovery Methods 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 210000000601 blood cell Anatomy 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 231100001157 chemotherapeutic toxicity Toxicity 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 230000012010 growth Effects 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 230000011132 hemopoiesis Effects 0.000 claims 1
- 230000005865 ionizing radiation Effects 0.000 claims 1
- 108010048732 pegylated erythropoietin Proteins 0.000 claims 1
- 230000006320 pegylation Effects 0.000 claims 1
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17772409P | 2009-05-13 | 2009-05-13 | |
| US61/177,724 | 2009-05-13 | ||
| PCT/US2010/034816 WO2010132725A2 (en) | 2009-05-13 | 2010-05-13 | Cyclin dependent kinase inhibitors and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012526850A JP2012526850A (ja) | 2012-11-01 |
| JP2012526850A5 true JP2012526850A5 (enExample) | 2013-06-27 |
Family
ID=43085590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012511031A Pending JP2012526850A (ja) | 2009-05-13 | 2010-05-13 | サイクリン依存性キナーゼ阻害剤及びその用法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20120100100A1 (enExample) |
| EP (4) | EP3025724B1 (enExample) |
| JP (1) | JP2012526850A (enExample) |
| CN (1) | CN102458443A (enExample) |
| AU (1) | AU2010248886A1 (enExample) |
| CA (1) | CA2761896A1 (enExample) |
| ES (1) | ES2561216T3 (enExample) |
| IL (1) | IL216315A0 (enExample) |
| WO (1) | WO2010132725A2 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010039997A2 (en) * | 2008-10-01 | 2010-04-08 | The University Of North Carolina At Chapel Hill | Hematopoietic protection against chemotherapeutic compounds using selective cyclin-dependent kinase 4/6 inhibitors |
| AU2009310352A1 (en) * | 2008-10-01 | 2010-05-06 | The University Of North Carolina At Chapel Hill | Hematopoietic protection against ionizing radiation using selective cyclin-dependent kinase 4/6 inhibitors |
| EP3025724B1 (en) | 2009-05-13 | 2018-07-11 | The University of North Carolina At Chapel Hill | Cyclin dependent kinase inhibitors and methods of use |
| US8691830B2 (en) | 2010-10-25 | 2014-04-08 | G1 Therapeutics, Inc. | CDK inhibitors |
| KR102186969B1 (ko) | 2010-10-25 | 2020-12-04 | 쥐원 쎄라퓨틱스, 인크. | Cdk 억제제 |
| WO2012068381A2 (en) | 2010-11-17 | 2012-05-24 | The University Of North Carolina At Chapel Hill | Protection of renal tissues from schema through inhibition of the proliferative kisses cdk4 and cdk6 |
| HUE041576T2 (hu) | 2011-09-14 | 2019-05-28 | Samumed Llc | Indazol-3-karboxamid-származékok és alkalmazásuk Wnt/b-katenin szignalizáló útvonal inhibitorokként |
| EP3216792B1 (en) | 2012-03-29 | 2020-05-27 | G1 Therapeutics, Inc. | Lactam kinase inhibitors |
| PH12017500997A1 (en) | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
| SG11201407148XA (en) | 2012-05-04 | 2014-11-27 | Samumed Llc | 1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof |
| CA2906157C (en) | 2013-03-15 | 2022-05-17 | G1 Therapeutics, Inc. | Highly active anti-neoplastic and anti-proliferative agents |
| JP6430483B2 (ja) | 2013-03-15 | 2018-11-28 | ジー１、セラピューティクス、インコーポレイテッドＧ１ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 化学療法の間の正常細胞の一時的な保護 |
| JP2016512831A (ja) | 2013-03-15 | 2016-05-09 | コンサート ファーマシューティカルズ インコーポレイテッド | 重水素化されたパルボシクリブ |
| WO2014144596A2 (en) * | 2013-03-15 | 2014-09-18 | G1 Therapeutics, Inc. | Transient protection of hematopoietic stem and progenitor cells against ionizing radiation |
| EP4772247A2 (en) | 2013-08-14 | 2026-07-08 | Novartis AG | Combination therapy comprising ribociclib and fulvestrant for the treatment of cancer |
| US20160361314A1 (en) * | 2013-08-28 | 2016-12-15 | Novartis Ag | Combination of an alk inhibitor and a cdk inhibitor for the treatment of cell proliferative diseases |
| US9943677B2 (en) | 2013-10-15 | 2018-04-17 | Radux Devices, LLC | Securing a medical device to a valve instrument |
| US11767507B2 (en) | 2013-11-08 | 2023-09-26 | The Mclean Hospital Corporation | Methods for efficient generation of GABAergic interneurons from pluripotent stem cells |
| WO2015161283A1 (en) | 2014-04-17 | 2015-10-22 | G1 Therapeutics, Inc. | Tricyclic lactams for use in hspc-sparing treatments for rb-positive abnormal cellular proliferation |
| WO2016015597A1 (en) * | 2014-07-26 | 2016-02-04 | Sunshine Lake Pharma Co., Ltd. | Compounds as cdk small-molecule inhibitors and uses thereof |
| WO2016040184A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040185A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof |
| WO2016040190A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof |
| WO2016040181A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040848A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors |
| EP3191098A4 (en) | 2014-09-12 | 2018-04-25 | G1 Therapeutics, Inc. | Combinations and dosing regimes to treat rb-positive tumors |
| CN104610254B (zh) * | 2015-01-26 | 2017-02-01 | 新发药业有限公司 | 一种帕博赛布的低成本制备方法 |
| US10383861B2 (en) | 2015-08-03 | 2019-08-20 | Sammumed, LLC | 3-(1H-pyrrolo[2,3-C]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof |
| US10350199B2 (en) | 2015-08-03 | 2019-07-16 | Samumed, Llc | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof |
| US10463651B2 (en) | 2015-08-03 | 2019-11-05 | Samumed, Llc | 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-indazoles and therapeutic uses thereof |
| US10329309B2 (en) | 2015-08-03 | 2019-06-25 | Samumed, Llc | 3-(3H-imidazo[4,5-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| US10604512B2 (en) | 2015-08-03 | 2020-03-31 | Samumed, Llc | 3-(1H-indol-2-yl)-1H-indazoles and therapeutic uses thereof |
| US10285983B2 (en) | 2015-08-03 | 2019-05-14 | Samumed, Llc | 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-B] pyridines and therapeutic uses thereof |
| WO2017023980A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof |
| WO2017023989A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| WO2017024025A1 (en) | 2015-08-03 | 2017-02-09 | Sunil Kumar Kc | 3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| CN106565611A (zh) * | 2015-10-13 | 2017-04-19 | 华东师范大学 | 一种1-（4-环戊胺基-2-甲硫基嘧啶-5-）基乙酮的制备方法 |
| WO2017079759A1 (en) | 2015-11-06 | 2017-05-11 | Samumed, Llc | 2-(1h-indazol-3-yl)-3h-imidazo[4,5-c]pyridines and their anti-inflammatory uses thereof |
| US10690673B2 (en) | 2016-03-29 | 2020-06-23 | Mayo Foundation For Medical Education And Research | Method of treating cancer metastasis by CDK 4/6 inhibitors |
| MY199242A (en) | 2016-06-01 | 2023-10-22 | Samumed Llc | Process for preparing n-(5-(3-(7-(3-fluorophenyl)-3h-imidazo[4,5-c]pyridin-2-yl)-1h-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide |
| BR112019008061A2 (pt) | 2016-10-21 | 2019-09-17 | Samumed Llc | métodos de uso de indazol-3-carboxamidas e seu uso como inibidores da via de sinalização de wnt/b-catenina |
| MA46696A (fr) | 2016-11-07 | 2019-09-11 | Samumed Llc | Formulations injectables à dose unique prêtes à l'emploi |
| IL317919A (en) | 2016-12-05 | 2025-02-01 | G1 Therapeutics Inc | Preservation of immune response during chemotherapy regimens |
| JP7229162B2 (ja) | 2017-01-06 | 2023-02-27 | ジー１ セラピューティクス， インコーポレイテッド | 癌の治療に対する併用療法 |
| US11395821B2 (en) | 2017-01-30 | 2022-07-26 | G1 Therapeutics, Inc. | Treatment of EGFR-driven cancer with fewer side effects |
| WO2018202866A1 (en) * | 2017-05-05 | 2018-11-08 | Fundación Para La Investigación Hospital Clínico Universitario De Valencia Incliva | Medical uses of p15/p16 agonists |
| EP3645001B1 (en) | 2017-06-29 | 2024-07-03 | G1 Therapeutics, Inc. | Morphic forms of git38 and methods of manufacture thereof |
| WO2019136451A1 (en) | 2018-01-08 | 2019-07-11 | G1 Therapeutics, Inc. | G1t38 superior dosage regimes |
| ES2968899T3 (es) | 2018-05-14 | 2024-05-14 | Pfizer | Formulación de la solución oral |
| KR102962306B1 (ko) | 2018-08-24 | 2026-05-08 | 쥐원 쎄라퓨틱스, 인크. | 1,4-디아자스피로[5.5]운데칸-3-온의 개선된 합성 |
| SMT202500028T1 (it) | 2018-09-10 | 2025-03-12 | Mirati Therapeutics Inc | Terapie combinate |
| US20210340502A1 (en) * | 2018-09-28 | 2021-11-04 | The Mclean Hospital Corporation | Generation of Post-Mitotic Migratory Cortical Interneurons |
| EP3797776B1 (en) | 2019-09-30 | 2025-07-23 | Universitätsmedizin Mainz | Cdk4/6 inhibitors for the treatment of psoriasis |
| US10988479B1 (en) | 2020-06-15 | 2021-04-27 | G1 Therapeutics, Inc. | Morphic forms of trilaciclib and methods of manufacture thereof |
| WO2022113003A1 (en) | 2020-11-27 | 2022-06-02 | Rhizen Pharmaceuticals Ag | Cdk inhibitors |
| WO2022149057A1 (en) | 2021-01-05 | 2022-07-14 | Rhizen Pharmaceuticals Ag | Cdk inhibitors |
| WO2023207875A1 (en) * | 2022-04-25 | 2023-11-02 | Onquality Pharmaceuticals China Ltd. | Cdk inhibitors, pharmaceutical compositions, and therapeutic applications |
| CN115364195B (zh) * | 2022-09-28 | 2026-03-17 | 中南大学湘雅二医院 | Thiostrepton在制备预防和治疗硬皮病的药物中的应用 |
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| WO2025085360A1 (en) | 2023-10-16 | 2025-04-24 | The Board Of Regents Of The University Of Oklahoma | Heteroarotinoids and/or cdk4/6 inhibitors for treating human papillomavirus (hpv)-induced dysplasias, warts, and cancer in hpv-infected subjects |
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| EP3025724B1 (en) | 2009-05-13 | 2018-07-11 | The University of North Carolina At Chapel Hill | Cyclin dependent kinase inhibitors and methods of use |
| KR102186969B1 (ko) | 2010-10-25 | 2020-12-04 | 쥐원 쎄라퓨틱스, 인크. | Cdk 억제제 |
| WO2012068381A2 (en) | 2010-11-17 | 2012-05-24 | The University Of North Carolina At Chapel Hill | Protection of renal tissues from schema through inhibition of the proliferative kisses cdk4 and cdk6 |
-
2010
- 2010-05-13 EP EP15196712.2A patent/EP3025724B1/en active Active
- 2010-05-13 EP EP20176318.2A patent/EP3718560A3/en not_active Withdrawn
- 2010-05-13 CN CN2010800318669A patent/CN102458443A/zh active Pending
- 2010-05-13 CA CA2761896A patent/CA2761896A1/en not_active Abandoned
- 2010-05-13 WO PCT/US2010/034816 patent/WO2010132725A2/en not_active Ceased
- 2010-05-13 JP JP2012511031A patent/JP2012526850A/ja active Pending
- 2010-05-13 EP EP18181639.8A patent/EP3406260B1/en active Active
- 2010-05-13 EP EP10775575.3A patent/EP2429566B1/en active Active
- 2010-05-13 ES ES10775575.3T patent/ES2561216T3/es active Active
- 2010-05-13 US US13/319,828 patent/US20120100100A1/en not_active Abandoned
- 2010-05-13 AU AU2010248886A patent/AU2010248886A1/en not_active Abandoned
-
2011
- 2011-11-10 IL IL216315A patent/IL216315A0/en unknown
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2013
- 2013-12-11 US US14/103,359 patent/US9616062B2/en not_active Expired - Fee Related
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