JP2012525441A5 - - Google Patents

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Publication number
JP2012525441A5
JP2012525441A5 JP2012508795A JP2012508795A JP2012525441A5 JP 2012525441 A5 JP2012525441 A5 JP 2012525441A5 JP 2012508795 A JP2012508795 A JP 2012508795A JP 2012508795 A JP2012508795 A JP 2012508795A JP 2012525441 A5 JP2012525441 A5 JP 2012525441A5
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JP
Japan
Prior art keywords
seq
disease
binding protein
syndrome
cdr1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2012508795A
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English (en)
Japanese (ja)
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JP2012525441A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2010/033246 external-priority patent/WO2010127294A2/en
Publication of JP2012525441A publication Critical patent/JP2012525441A/ja
Publication of JP2012525441A5 publication Critical patent/JP2012525441A5/ja
Withdrawn legal-status Critical Current

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JP2012508795A 2009-05-01 2010-04-30 二重可変ドメイン免疫グロブリンおよびこの使用 Withdrawn JP2012525441A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17480009P 2009-05-01 2009-05-01
US61/174,800 2009-05-01
PCT/US2010/033246 WO2010127294A2 (en) 2009-05-01 2010-04-30 Dual variable domain immunoglobulins and uses thereof

Publications (2)

Publication Number Publication Date
JP2012525441A JP2012525441A (ja) 2012-10-22
JP2012525441A5 true JP2012525441A5 (enExample) 2013-07-11

Family

ID=43032808

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012508795A Withdrawn JP2012525441A (ja) 2009-05-01 2010-04-30 二重可変ドメイン免疫グロブリンおよびこの使用

Country Status (14)

Country Link
US (1) US20110008766A1 (enExample)
EP (1) EP2424566A4 (enExample)
JP (1) JP2012525441A (enExample)
KR (1) KR20140014382A (enExample)
CN (1) CN102458459A (enExample)
AU (1) AU2010242840B2 (enExample)
BR (1) BRPI1012195A2 (enExample)
CA (1) CA2760332A1 (enExample)
IL (1) IL216048A0 (enExample)
MX (1) MX2011011670A (enExample)
RU (1) RU2011148918A (enExample)
SG (1) SG175426A1 (enExample)
TW (1) TW201116624A (enExample)
WO (1) WO2010127294A2 (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2163256B1 (en) 2001-05-11 2015-09-02 Ludwig Institute for Cancer Research Ltd. Specific binding proteins and uses thereof
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
CN104043123B (zh) * 2007-01-25 2019-08-13 达娜-法勃肿瘤研究所公司 抗egfr抗体在治疗egfr突变体介导的疾病中的用途
CN101688229B (zh) * 2007-03-15 2013-06-12 路德维格癌症研究所 包含egfr抗体和src抑制剂的组合物及其在制备用于治疗哺乳动物癌症的药物中的用途
CN108424454B (zh) 2007-08-14 2022-05-31 路德维格癌症研究所有限公司 靶向egf受体的单克隆抗体175及其衍生物和用途
NZ588554A (en) 2008-04-29 2013-03-28 Abbott Lab Dual variable domain immunoglobulins and uses thereof
US20100260668A1 (en) * 2008-04-29 2010-10-14 Abbott Laboratories Dual Variable Domain Immunoglobulins and Uses Thereof
SG191625A1 (en) * 2008-06-03 2013-07-31 Abbott Lab Dual variable domain immunoglobulins and uses thereof
AU2009256250B2 (en) * 2008-06-03 2013-05-30 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
SG192489A1 (en) 2008-07-08 2013-08-30 Abbott Lab Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
RU2011127198A (ru) * 2008-12-04 2013-01-10 Эбботт Лэборетриз Иммуноглобулины с двойными вариабельными доменами и их применение
UY32808A (es) * 2009-07-29 2011-02-28 Abbott Lab Inmunoglobulinas como dominio variable dual y usos de las mismas
EP2470568A2 (en) 2009-08-29 2012-07-04 Abbott Laboratories Therapeutic dll4 binding proteins
CN102612524A (zh) 2009-09-01 2012-07-25 雅培制药有限公司 双重可变结构域免疫球蛋白及其用途
US20110076232A1 (en) * 2009-09-29 2011-03-31 Ludwig Institute For Cancer Research Specific binding proteins and uses thereof
PH12012500691A1 (en) 2009-10-15 2012-11-12 Abbott Lab Dual variable domain immunoglobulins and uses thereof
UY32979A (es) * 2009-10-28 2011-02-28 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
NZ602734A (en) 2010-03-02 2014-10-31 Abbvie Inc Therapeutic dll4 binding proteins
MX341579B (es) 2010-08-03 2016-08-25 Abbvie Inc * Inmunoglobulinas de dominio variable doble y usos de las mismas.
TW201211252A (en) 2010-08-26 2012-03-16 Abbott Lab Dual variable domain immunoglobulins and uses thereof
CA2826564C (en) 2011-02-08 2018-05-15 Abbvie Inc. Treatment of osteoarthritis and pain
AU2012223358A1 (en) 2011-03-01 2013-09-05 Amgen Inc. Sclerostin and DKK-1 bispecific binding agents
AU2011382454B2 (en) 2011-11-30 2017-02-23 Abbvie Biotechnology Ltd Vectors and host cells comprising a modified SV40 promoter for protein expression
BR112014015851A2 (pt) 2011-12-30 2019-09-24 Abbvie Inc proteínas de ligação específicas duplas direcionadas contra il-13 e/ou il-17
JOP20200308A1 (ar) 2012-09-07 2017-06-16 Novartis Ag جزيئات إرتباط il-18
HK1212448A1 (en) 2012-09-07 2016-06-10 The Governors Of The University Of Alberta Methods and compositions for diagnosis of inflammatory liver disease
PE20151179A1 (es) 2012-11-01 2015-09-12 Abbvie Inc Inmunoglobulinas de dominio variable dual anti-vegf/dll4 y usos de las mismas
JP2016522793A (ja) 2013-03-15 2016-08-04 アッヴィ・インコーポレイテッド IL−1βおよび/またはIL−17に対して指向された二重特異的結合タンパク質
GB201308271D0 (en) * 2013-05-08 2013-06-12 Nat Univ Ireland Semi-automated whole blood immuno potency assay
WO2015048312A1 (en) 2013-09-26 2015-04-02 Costim Pharmaceuticals Inc. Methods for treating hematologic cancers
EA201690731A1 (ru) 2013-11-06 2016-10-31 Астьют Медикал, Инк. Анализ igfbp7, имеющий улучшенную характеристику в биологических образцах
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
JOP20200096A1 (ar) 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
ES2770684T3 (es) 2014-03-14 2020-07-02 Novartis Ag Moléculas de anticuerpos contra LAG-3 y usos de los mismos
RU2718914C2 (ru) 2014-09-13 2020-04-15 Новартис Аг Сочетанные способы лечения с использованием ингибиторов alk
ES2981450T3 (es) * 2014-11-19 2024-10-08 P & M Venge Ab Métodos de diagnóstico que emplean HNL
ES2571441B1 (es) * 2014-11-24 2017-03-07 Instituto De Investigación Sanitaria - Fundación Jiménez Díaz Uso de moléculas que reducen los niveles de lipocalina-2 para la fabricación de un medicamento para el tratamiento de aneurisma aórtico abdominal (AAA)
WO2016094881A2 (en) 2014-12-11 2016-06-16 Abbvie Inc. Lrp-8 binding proteins
TW201710286A (zh) 2015-06-15 2017-03-16 艾伯維有限公司 抗vegf、pdgf及/或其受體之結合蛋白
BR112020005737A2 (pt) * 2017-09-22 2020-11-17 F. Hoffmann-La Roche Ag anticorpo recombinante multivalente e uso do mesmo, kit e método para detectar um antígeno
CN109678958B (zh) * 2019-01-31 2022-03-18 重庆探生科技有限公司 一种人NT-proBNP特异性重组羊单克隆抗体及其制备方法和应用
WO2022020680A1 (en) 2020-07-23 2022-01-27 Othair Prothena Limited Anti-abeta antibodies
AU2022303155A1 (en) * 2021-06-30 2024-01-25 Board Of Regents, The University Of Texas System Polypeptides targeting cd70-positive cancers
CN114366853B (zh) * 2022-01-20 2023-04-14 华东理工大学 一种高诱骨活性牙种植体涂层及其制备方法

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2134212T3 (es) * 1991-04-25 1999-10-01 Chugai Pharmaceutical Co Ltd Anticuerpo humano reconstituido contra el receptor de la interleuquina 6 humano.
WO1994011026A2 (en) * 1992-11-13 1994-05-26 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human b lymphocyte restricted differentiation antigen for treatment of b cell lymphoma
US6491916B1 (en) * 1994-06-01 2002-12-10 Tolerance Therapeutics, Inc. Methods and materials for modulation of the immunosuppresive activity and toxicity of monoclonal antibodies
US6090382A (en) * 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
US7179892B2 (en) * 2000-12-06 2007-02-20 Neuralab Limited Humanized antibodies that recognize beta amyloid peptide
EP2364997A3 (en) * 1999-01-15 2012-07-04 Genentech, Inc. Polypeptide variants with altered effector function
US6818392B2 (en) * 2000-12-06 2004-11-16 Abbott Laboratories Monoclonal antibodies to human immunodeficiency virus and uses thereof
AU2002308722B2 (en) * 2001-05-30 2007-05-17 Genentech, Inc. Anti-NGF antibodies for the treatment of various disorders
PL369446A1 (en) * 2001-09-25 2005-04-18 Immuno-Biological Laboratories Co, Ltd. Recombinant anti-osteopontin antibody and use thereof
AU2004265595B2 (en) * 2003-07-18 2011-12-08 Amgen Fremont Inc. Specific binding agents to hepatocyte growth factor
CA2536408A1 (en) * 2003-08-22 2005-03-03 Biogen Idec Ma Inc. Improved antibodies having altered effector function and methods for making the same
EA012162B1 (ru) * 2004-10-22 2009-08-28 Эмджен Инк. Способ рефолдинга рекомбинантных антител
US8048992B2 (en) * 2005-02-28 2011-11-01 Institute For Antibodies Co., Ltd. Anti-IgSF4 antibody and utilization of the same
ZA200707258B (en) * 2005-03-24 2008-06-25 Thromb X N V Novel anti-PLGF antibody
US7592429B2 (en) * 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
KR20140053410A (ko) * 2005-08-19 2014-05-07 아보트 러보러터리즈 이원 가변 도메인 면역글로불린 및 이의 용도
US20070041905A1 (en) * 2005-08-19 2007-02-22 Hoffman Rebecca S Method of treating depression using a TNF-alpha antibody
US7612181B2 (en) * 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
JP2009539384A (ja) * 2006-06-06 2009-11-19 ジェネンテック・インコーポレーテッド 抗dll4抗体および抗dll4抗体使用の方法
ATE537450T1 (de) * 2006-06-30 2011-12-15 Schering Corp Igfbp2-biomarker
SI3339445T1 (sl) * 2006-09-08 2020-12-31 Abbvie Bahamas Ltd. Beljakovine za vezavo interlevkin-13
GB0708002D0 (en) * 2007-04-25 2007-06-06 Univ Sheffield Antibodies
EP1997832A1 (en) * 2007-05-29 2008-12-03 Ganymed Pharmaceuticals AG Monoclonal antibodies against Claudin-18 for treatment of cancer
WO2009003142A1 (en) * 2007-06-27 2008-12-31 The Board Of Trustees Of The Leland, Stanford Junior University Beta2-microglobulin and c reactive protein (crp) as biomarkers for peripheral artery disease
JP2010535771A (ja) * 2007-08-08 2010-11-25 アボット・ラボラトリーズ 抗体を結晶化させるための組成物及び方法
US9624309B2 (en) * 2007-08-15 2017-04-18 Bayer Intellectual Property Gmbh Monospecific and multispecific antibodies and method of use
WO2009052400A1 (en) * 2007-10-19 2009-04-23 Abbott Laboratories Antibodies that bind to mammalian ngal and uses thereof
US9273136B2 (en) * 2008-08-04 2016-03-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Fully human anti-human NKG2D monoclonal antibodies
EP2342562B1 (en) * 2008-09-30 2013-09-18 AbbVie Inc. Improved method of rna display
JP2014500712A (ja) * 2010-11-02 2014-01-16 アッヴィ・インコーポレイテッド 二重可変ドメイン免疫グロブリンおよびその使用
AR083705A1 (es) * 2010-11-04 2013-03-13 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
BR112014015851A2 (pt) * 2011-12-30 2019-09-24 Abbvie Inc proteínas de ligação específicas duplas direcionadas contra il-13 e/ou il-17
AR089528A1 (es) * 2011-12-30 2014-08-27 Abbvie Inc Dominio variable dual de inmunoglobulinas y sus usos
AR090047A1 (es) * 2011-12-30 2014-10-15 Abbvie Inc Dominio variable dual de inmunoglobulinas y sus usos

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