JP2012525407A5 - - Google Patents

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Publication number
JP2012525407A5
JP2012525407A5 JP2012508634A JP2012508634A JP2012525407A5 JP 2012525407 A5 JP2012525407 A5 JP 2012525407A5 JP 2012508634 A JP2012508634 A JP 2012508634A JP 2012508634 A JP2012508634 A JP 2012508634A JP 2012525407 A5 JP2012525407 A5 JP 2012525407A5
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JP
Japan
Prior art keywords
agent
microns
support
hydroxyapatite
mixture
Prior art date
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Granted
Application number
JP2012508634A
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English (en)
Japanese (ja)
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JP5863640B2 (ja
JP2012525407A (ja
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Priority claimed from PCT/US2010/032724 external-priority patent/WO2010126979A1/en
Publication of JP2012525407A publication Critical patent/JP2012525407A/ja
Publication of JP2012525407A5 publication Critical patent/JP2012525407A5/ja
Application granted granted Critical
Publication of JP5863640B2 publication Critical patent/JP5863640B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2012508634A 2009-04-29 2010-04-28 免疫複合体の精製 Expired - Fee Related JP5863640B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17389609P 2009-04-29 2009-04-29
US61/173,896 2009-04-29
PCT/US2010/032724 WO2010126979A1 (en) 2009-04-29 2010-04-28 Purification of immunoconjugates

Publications (3)

Publication Number Publication Date
JP2012525407A JP2012525407A (ja) 2012-10-22
JP2012525407A5 true JP2012525407A5 (https=) 2013-06-06
JP5863640B2 JP5863640B2 (ja) 2016-02-16

Family

ID=43030882

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012508634A Expired - Fee Related JP5863640B2 (ja) 2009-04-29 2010-04-28 免疫複合体の精製

Country Status (5)

Country Link
US (1) US8481694B2 (https=)
EP (1) EP2424875B1 (https=)
JP (1) JP5863640B2 (https=)
CA (1) CA2759502C (https=)
WO (1) WO2010126979A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2670704B1 (en) * 2011-02-02 2018-12-12 Bio-Rad Laboratories, Inc. Apatite surface neutralization with alkali solutions
WO2013122834A1 (en) * 2012-02-14 2013-08-22 Bio-Rad Laboratories, Inc. REDUCING pH EXCURSIONS IN ION EXCHANGE CHROMATOGRAPHY
GB201310028D0 (en) * 2013-06-05 2013-07-17 Algeta Asa Pharmaceutical preparation
WO2017044530A1 (en) 2015-09-08 2017-03-16 Waters Technologies Corporation Multidimensional chromatoggraphy method for analysis of antibody-drug conjugates
US11661438B2 (en) * 2015-12-21 2023-05-30 Pfizer, Inc. Purification of antibody drug conjugates using a sodium phosphate gradient
WO2017165745A1 (en) * 2016-03-24 2017-09-28 The Trustees Of Columbia University In The City Of New York Selectively and fully cleavable fluorescent probes for sequential, itrative immunostaining
US10934366B2 (en) 2016-09-29 2021-03-02 Bio-Rad Laboratories, Inc. Protein-nanoparticle conjugate purification methods
JP2020531557A (ja) * 2017-08-30 2020-11-05 アレス トレーディング ソシエテ アノニム タンパク質の精製方法

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Publication number Priority date Publication date Assignee Title
US4307016A (en) 1978-03-24 1981-12-22 Takeda Chemical Industries, Ltd. Demethyl maytansinoids
US4256746A (en) 1978-11-14 1981-03-17 Takeda Chemical Industries Dechloromaytansinoids, their pharmaceutical compositions and method of use
JPS55102583A (en) 1979-01-31 1980-08-05 Takeda Chem Ind Ltd 20-acyloxy-20-demethylmaytansinoid compound
JPS55162791A (en) 1979-06-05 1980-12-18 Takeda Chem Ind Ltd Antibiotic c-15003pnd and its preparation
JPS5645483A (en) 1979-09-19 1981-04-25 Takeda Chem Ind Ltd C-15003phm and its preparation
EP0028683A1 (en) 1979-09-21 1981-05-20 Takeda Chemical Industries, Ltd. Antibiotic C-15003 PHO and production thereof
JPS5645485A (en) 1979-09-21 1981-04-25 Takeda Chem Ind Ltd Production of c-15003pnd
WO1982001188A1 (en) 1980-10-08 1982-04-15 Takeda Chemical Industries Ltd 4,5-deoxymaytansinoide compounds and process for preparing same
US4450254A (en) 1980-11-03 1984-05-22 Standard Oil Company Impact improvement of high nitrile resins
US4315929A (en) 1981-01-27 1982-02-16 The United States Of America As Represented By The Secretary Of Agriculture Method of controlling the European corn borer with trewiasine
US4313946A (en) 1981-01-27 1982-02-02 The United States Of America As Represented By The Secretary Of Agriculture Chemotherapeutically active maytansinoids from Trewia nudiflora
US4563304A (en) 1981-02-27 1986-01-07 Pharmacia Fine Chemicals Ab Pyridine compounds modifying proteins, polypeptides or polysaccharides
JPS57192389A (en) 1981-05-20 1982-11-26 Takeda Chem Ind Ltd Novel maytansinoid
US4737456A (en) 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
EP0563475B1 (en) 1992-03-25 2000-05-31 Immunogen Inc Cell binding agent conjugates of derivatives of CC-1065
NZ507557A (en) * 1998-05-06 2003-10-31 Genentech Inc Protein purification by ion exchange chromatography
US6333410B1 (en) 2000-08-18 2001-12-25 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
AU2003201824A1 (en) * 2002-01-03 2003-07-24 Smithkline Beecham Corporation Methods for preparing immunoconjugates
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
KR101221862B1 (ko) 2003-10-27 2013-01-14 와이어쓰 엘엘씨 하이드록시아파타이트 크로마토그래피를 사용한 고분자량응집체의 제거
US20060160998A1 (en) * 2005-01-19 2006-07-20 Suk Roelf J Methods for isolation and purification of fluorochrome-antibody conjugates
CA3000520C (en) * 2005-08-24 2023-04-04 Immunogen, Inc. Process for preparing antibody maytansinoid conjugates
CN101365948B (zh) * 2006-01-06 2012-11-07 Emd密理博公司 亲和层析基质及其制备和使用方法
JP2010510963A (ja) 2006-06-14 2010-04-08 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー セラミックヒドロキシアパタイトを使用する抗体の精製方法
US7999085B2 (en) * 2007-01-09 2011-08-16 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of protein by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
US7691980B2 (en) * 2007-01-09 2010-04-06 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers

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