JP2012525407A5 - - Google Patents

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Publication number
JP2012525407A5
JP2012525407A5 JP2012508634A JP2012508634A JP2012525407A5 JP 2012525407 A5 JP2012525407 A5 JP 2012525407A5 JP 2012508634 A JP2012508634 A JP 2012508634A JP 2012508634 A JP2012508634 A JP 2012508634A JP 2012525407 A5 JP2012525407 A5 JP 2012525407A5
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JP
Japan
Prior art keywords
agent
microns
support
hydroxyapatite
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012508634A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012525407A (ja
JP5863640B2 (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2010/032724 external-priority patent/WO2010126979A1/en
Publication of JP2012525407A publication Critical patent/JP2012525407A/ja
Publication of JP2012525407A5 publication Critical patent/JP2012525407A5/ja
Application granted granted Critical
Publication of JP5863640B2 publication Critical patent/JP5863640B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2012508634A 2009-04-29 2010-04-28 免疫複合体の精製 Expired - Fee Related JP5863640B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17389609P 2009-04-29 2009-04-29
US61/173,896 2009-04-29
PCT/US2010/032724 WO2010126979A1 (en) 2009-04-29 2010-04-28 Purification of immunoconjugates

Publications (3)

Publication Number Publication Date
JP2012525407A JP2012525407A (ja) 2012-10-22
JP2012525407A5 true JP2012525407A5 (https=) 2013-06-06
JP5863640B2 JP5863640B2 (ja) 2016-02-16

Family

ID=43030882

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012508634A Expired - Fee Related JP5863640B2 (ja) 2009-04-29 2010-04-28 免疫複合体の精製

Country Status (5)

Country Link
US (1) US8481694B2 (https=)
EP (1) EP2424875B1 (https=)
JP (1) JP5863640B2 (https=)
CA (1) CA2759502C (https=)
WO (1) WO2010126979A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5881744B2 (ja) * 2011-02-02 2016-03-09 バイオ−ラッド ラボラトリーズ インコーポレーティッド アルカリ溶液でのアパタイトの表面中和方法
US9442050B2 (en) 2012-02-14 2016-09-13 Bio-Rad Laboratories, Inc. Reducing pH excursions in ion exchange chromatography using displacing counter ions
GB201310028D0 (en) * 2013-06-05 2013-07-17 Algeta Asa Pharmaceutical preparation
CN108348604B (zh) * 2015-09-08 2022-04-29 沃特世科技公司 用于分析抗体-药物缀合物的多维色谱方法
US11661438B2 (en) * 2015-12-21 2023-05-30 Pfizer, Inc. Purification of antibody drug conjugates using a sodium phosphate gradient
WO2017165745A1 (en) * 2016-03-24 2017-09-28 The Trustees Of Columbia University In The City Of New York Selectively and fully cleavable fluorescent probes for sequential, itrative immunostaining
US10934366B2 (en) 2016-09-29 2021-03-02 Bio-Rad Laboratories, Inc. Protein-nanoparticle conjugate purification methods
US20210130396A1 (en) * 2017-08-30 2021-05-06 Ares Trading S.A. Method for purifying proteins

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4307016A (en) 1978-03-24 1981-12-22 Takeda Chemical Industries, Ltd. Demethyl maytansinoids
US4256746A (en) 1978-11-14 1981-03-17 Takeda Chemical Industries Dechloromaytansinoids, their pharmaceutical compositions and method of use
JPS55102583A (en) 1979-01-31 1980-08-05 Takeda Chem Ind Ltd 20-acyloxy-20-demethylmaytansinoid compound
JPS55162791A (en) 1979-06-05 1980-12-18 Takeda Chem Ind Ltd Antibiotic c-15003pnd and its preparation
JPS5645483A (en) 1979-09-19 1981-04-25 Takeda Chem Ind Ltd C-15003phm and its preparation
EP0028683A1 (en) 1979-09-21 1981-05-20 Takeda Chemical Industries, Ltd. Antibiotic C-15003 PHO and production thereof
JPS5645485A (en) 1979-09-21 1981-04-25 Takeda Chem Ind Ltd Production of c-15003pnd
WO1982001188A1 (en) 1980-10-08 1982-04-15 Takeda Chemical Industries Ltd 4,5-deoxymaytansinoide compounds and process for preparing same
US4450254A (en) 1980-11-03 1984-05-22 Standard Oil Company Impact improvement of high nitrile resins
US4315929A (en) 1981-01-27 1982-02-16 The United States Of America As Represented By The Secretary Of Agriculture Method of controlling the European corn borer with trewiasine
US4313946A (en) 1981-01-27 1982-02-02 The United States Of America As Represented By The Secretary Of Agriculture Chemotherapeutically active maytansinoids from Trewia nudiflora
US4563304A (en) 1981-02-27 1986-01-07 Pharmacia Fine Chemicals Ab Pyridine compounds modifying proteins, polypeptides or polysaccharides
JPS57192389A (en) 1981-05-20 1982-11-26 Takeda Chem Ind Ltd Novel maytansinoid
US4737456A (en) 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
ES2149768T3 (es) 1992-03-25 2000-11-16 Immunogen Inc Conjugados de agentes enlazantes de celulas derivados de cc-1065.
PT1308456E (pt) * 1998-05-06 2007-12-03 Genentech Inc Purificação de anticorpos por cromatografia de permuta iónica
US6333410B1 (en) 2000-08-18 2001-12-25 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
AU2003201824A1 (en) * 2002-01-03 2003-07-24 Smithkline Beecham Corporation Methods for preparing immunoconjugates
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
EP2336172B1 (en) 2003-10-27 2014-12-10 Wyeth LLC Removal of high molecular weight aggregates using hydroxyapatite chromatography
US20060160998A1 (en) 2005-01-19 2006-07-20 Suk Roelf J Methods for isolation and purification of fluorochrome-antibody conjugates
EP3539572A1 (en) * 2005-08-24 2019-09-18 ImmunoGen, Inc. Process for preparing maytansinoid antibody conjugates
WO2007081851A2 (en) * 2006-01-06 2007-07-19 Millipore Corporation Affinity chromatography matrices and methods of making and using the same
US20100234577A1 (en) * 2006-06-14 2010-09-16 Smithkline Beecham Corporation Methods for purifying antibodies using ceramic hydroxyapatite
US7999085B2 (en) * 2007-01-09 2011-08-16 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of protein by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
US7691980B2 (en) * 2007-01-09 2010-04-06 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers

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