JP2012523434A5 - - Google Patents
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- JP2012523434A5 JP2012523434A5 JP2012504907A JP2012504907A JP2012523434A5 JP 2012523434 A5 JP2012523434 A5 JP 2012523434A5 JP 2012504907 A JP2012504907 A JP 2012504907A JP 2012504907 A JP2012504907 A JP 2012504907A JP 2012523434 A5 JP2012523434 A5 JP 2012523434A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- amylin agonist
- agonist compound
- composition according
- month
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 102000036770 Islet Amyloid Polypeptide Human genes 0.000 claims 13
- 108010041872 Islet Amyloid Polypeptide Proteins 0.000 claims 13
- 239000000556 agonist Substances 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 13
- 241000124008 Mammalia Species 0.000 claims 4
- 230000009245 menopause Effects 0.000 claims 4
- 208000008589 Obesity Diseases 0.000 claims 3
- 206010033307 Overweight Diseases 0.000 claims 3
- 235000020824 obesity Nutrition 0.000 claims 3
- 101150035467 BDNF gene Proteins 0.000 claims 2
- 229940089838 Glucagon-like peptide 1 receptor agonist Drugs 0.000 claims 2
- 210000000577 adipose tissue Anatomy 0.000 claims 2
- 150000001413 amino acids Chemical group 0.000 claims 2
- 230000002950 deficient Effects 0.000 claims 2
- 229940011871 estrogen Drugs 0.000 claims 2
- 239000000262 estrogen Substances 0.000 claims 2
- 239000003877 glucagon like peptide 1 receptor agonist Substances 0.000 claims 2
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims 2
- 238000009806 oophorectomy Methods 0.000 claims 2
- 230000004584 weight gain Effects 0.000 claims 2
- 235000019786 weight gain Nutrition 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 108010011459 Exenatide Proteins 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 101800004266 Glucagon-like peptide 1(7-37) Proteins 0.000 claims 1
- 108010092277 Leptin Proteins 0.000 claims 1
- 102000016267 Leptin Human genes 0.000 claims 1
- 206010030247 Oestrogen deficiency Diseases 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 108091005466 amylin receptors Proteins 0.000 claims 1
- 235000019789 appetite Nutrition 0.000 claims 1
- 230000036528 appetite Effects 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- JUFFVKRROAPVBI-PVOYSMBESA-N chembl1210015 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N[C@H]1[C@@H]([C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@]3(O[C@@H](C[C@H](O)[C@H](O)CO)[C@H](NC(C)=O)[C@@H](O)C3)C(O)=O)O2)O)[C@@H](CO)O1)NC(C)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 JUFFVKRROAPVBI-PVOYSMBESA-N 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 229960001519 exenatide Drugs 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 230000030136 gastric emptying Effects 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 229940039781 leptin Drugs 0.000 claims 1
- 108700008455 metreleptin Proteins 0.000 claims 1
- 229960000668 metreleptin Drugs 0.000 claims 1
- OKPYIWASQZGASP-UHFFFAOYSA-N n-(2-hydroxypropyl)-2-methylprop-2-enamide Chemical compound CC(O)CNC(=O)C(C)=C OKPYIWASQZGASP-UHFFFAOYSA-N 0.000 claims 1
- 230000036470 plasma concentration Effects 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical group C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 238000001525 receptor binding assay Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000036186 satiety Effects 0.000 claims 1
- 235000019627 satiety Nutrition 0.000 claims 1
- 210000002027 skeletal muscle Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16831709P | 2009-04-10 | 2009-04-10 | |
| US61/168,317 | 2009-04-10 | ||
| PCT/US2010/030625 WO2010118384A2 (en) | 2009-04-10 | 2010-04-09 | Amylin agonist compounds for estrogen-deficient mammals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012523434A JP2012523434A (ja) | 2012-10-04 |
| JP2012523434A5 true JP2012523434A5 (https=) | 2013-05-30 |
Family
ID=42936899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012504907A Pending JP2012523434A (ja) | 2009-04-10 | 2010-04-09 | エストロゲン欠乏哺乳類のためのアミリンアゴニスト化合物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20120071401A1 (https=) |
| EP (1) | EP2416797A4 (https=) |
| JP (1) | JP2012523434A (https=) |
| WO (1) | WO2010118384A2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2504021A4 (en) * | 2009-11-23 | 2013-05-15 | Amylin Pharmaceuticals Llc | Polypeptide conjugate |
| CA2868688A1 (en) | 2012-04-03 | 2013-10-10 | Trustees Of Boston University | Compositions, methods and assays comprising amylin or amlyin analogs for abeta-peptide mediated disorders |
| WO2020180534A1 (en) | 2019-03-01 | 2020-09-10 | President And Fellows Of Harvard College | Methods and compositions for protein delivery |
| TWI850611B (zh) | 2020-12-18 | 2024-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | Glp-1及澱粉素受體之共促效劑 |
| AU2022386166A1 (en) | 2021-11-10 | 2024-06-20 | I2O Therapeutics, Inc. | Ionic liquid compositions |
Family Cites Families (77)
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| US6071695A (en) * | 1992-02-21 | 2000-06-06 | Creative Biomolecules, Inc. | Methods and products for identification of modulators of osteogenic protein-1 gene expression |
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| JP5252435B2 (ja) * | 2006-03-15 | 2013-07-31 | ノボ・ノルデイスク・エー／エス | アミリン誘導体 |
| US20070287684A1 (en) * | 2006-05-22 | 2007-12-13 | Irshad Chaudry | Methods and compositions for treating trauma-hemorrhage using estrogen and derivatives thereof |
| CN101125207B (zh) | 2006-11-14 | 2012-09-05 | 上海华谊生物技术有限公司 | 带有聚乙二醇基团的艾塞丁或其类似物及其制剂和用途 |
| JP2008169195A (ja) | 2007-01-05 | 2008-07-24 | Hanmi Pharmaceutical Co Ltd | キャリア物質を用いたインスリン分泌ペプチド薬物結合体 |
| EA026578B1 (ru) * | 2007-01-22 | 2017-04-28 | ДЖиТиЭкс, ИНК. | Вещества, связывающие ядерные рецепторы |
| US8268806B2 (en) * | 2007-08-10 | 2012-09-18 | Endorecherche, Inc. | Pharmaceutical compositions |
-
2010
- 2010-04-09 EP EP20100762535 patent/EP2416797A4/en not_active Withdrawn
- 2010-04-09 US US13/263,070 patent/US20120071401A1/en not_active Abandoned
- 2010-04-09 JP JP2012504907A patent/JP2012523434A/ja active Pending
- 2010-04-09 WO PCT/US2010/030625 patent/WO2010118384A2/en not_active Ceased
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