JP2012523243A5 - - Google Patents
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- JP2012523243A5 JP2012523243A5 JP2012505149A JP2012505149A JP2012523243A5 JP 2012523243 A5 JP2012523243 A5 JP 2012523243A5 JP 2012505149 A JP2012505149 A JP 2012505149A JP 2012505149 A JP2012505149 A JP 2012505149A JP 2012523243 A5 JP2012523243 A5 JP 2012523243A5
- Authority
- JP
- Japan
- Prior art keywords
- promoter
- tumor
- stem cell
- cytotoxic protein
- coding region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16878709P | 2009-04-13 | 2009-04-13 | |
| US61/168,787 | 2009-04-13 | ||
| PCT/EP2010/054844 WO2010119039A1 (en) | 2009-04-13 | 2010-04-13 | Engineered mesenchymal stem cells and method of using same to treat tumors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012523243A JP2012523243A (ja) | 2012-10-04 |
| JP2012523243A5 true JP2012523243A5 (enExample) | 2013-05-23 |
| JP5727458B2 JP5727458B2 (ja) | 2015-06-03 |
Family
ID=42270435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012505149A Active JP5727458B2 (ja) | 2009-04-13 | 2010-04-13 | 改変間葉系幹細胞及びそれを使用した腫瘍の治療方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9434925B2 (enExample) |
| EP (1) | EP2419113B1 (enExample) |
| JP (1) | JP5727458B2 (enExample) |
| KR (1) | KR20120088542A (enExample) |
| CN (1) | CN102695517B (enExample) |
| AU (1) | AU2010237130B2 (enExample) |
| BR (1) | BRPI1013771A2 (enExample) |
| CA (1) | CA2758120C (enExample) |
| IL (1) | IL215581A0 (enExample) |
| RU (1) | RU2539099C2 (enExample) |
| SG (1) | SG175127A1 (enExample) |
| WO (1) | WO2010119039A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100183558A1 (en) | 2008-10-17 | 2010-07-22 | Zhennan Lai | Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules |
| US20130171115A1 (en) * | 2011-12-30 | 2013-07-04 | Gang Li | Cell-mediated gene therapy for cancer using mesenchymal stem cells expressing a suicide gene |
| CN104160027B (zh) * | 2012-02-01 | 2016-06-22 | 浦项工科大学校产学协力团 | 同时表达十二聚体trail及hsv-tk自杀基因的载体及利用其的抗癌干细胞治疗剂 |
| US20130203166A1 (en) * | 2012-02-06 | 2013-08-08 | Protobios Llc | Stimulation of multipotency of mesenchymal stem cells by chemokine ccl5 |
| GB201202319D0 (en) | 2012-02-10 | 2012-03-28 | Orbsen Therapeutics Ltd | Stromal stem cells |
| US20140065110A1 (en) | 2012-08-31 | 2014-03-06 | The Regents Of The University Of California | Genetically modified msc and therapeutic methods |
| ES2884598T3 (es) * | 2012-11-05 | 2021-12-10 | Regeneron Pharma | Animales no humanos modificados genéticamente y métodos de uso de los mismos |
| US10472647B2 (en) | 2012-12-21 | 2019-11-12 | The Administrators Of The Tulane Educational Fund | Primary mesenchymal stem cells as a vaccine platform |
| WO2015100268A1 (en) * | 2013-12-23 | 2015-07-02 | The Regents Of The University Of California | Mesenchymal stem cells for targeted cancer therapy |
| WO2015108856A2 (en) * | 2014-01-17 | 2015-07-23 | Wake Forest University Health Sciences | Methods for enhancing the delivery of active agents |
| WO2016026854A2 (en) * | 2014-08-18 | 2016-02-25 | Apceth Gmbh & Co. Kg | Genetically modified mesenchymal stem cells expressing an immune response-stimulating cytokine to attract and/or activate immune cells |
| WO2016065330A1 (en) * | 2014-10-24 | 2016-04-28 | Aladar Szalay | Combination immunotherapy approach for treatment of cancer |
| CN104622903B (zh) * | 2015-01-20 | 2018-10-09 | 奥思达干细胞有限公司 | 抗恶性黑色素瘤的干细胞制剂及其制备方法 |
| JP6734283B2 (ja) | 2015-01-21 | 2020-08-05 | フレッド ハッチンソン キャンサー リサーチ センター | 遺伝子治療用ポイントオブケア及び／又はポータブルプラットフォーム |
| WO2016138340A1 (en) * | 2015-02-27 | 2016-09-01 | Saint Louis University | Tumor suppressor sall1 as a therapeutic agent for treating cancer |
| ES2750008T3 (es) | 2015-02-27 | 2020-03-24 | Apceth Gmbh & Co Kg | Células madre mesenquimatosas modificadas genéticamente que expresan klotho |
| WO2016146819A1 (en) * | 2015-03-18 | 2016-09-22 | Apceth Gmbh & Co. Kg | Hypoxia-induced expression of therapeutic proteins in mesenchymal stem cells |
| WO2017007994A1 (en) | 2015-07-08 | 2017-01-12 | American Gene Technologies International Inc. | Hiv pre-immunization and immunotherapy |
| EA201800148A1 (ru) | 2015-08-11 | 2019-01-31 | Калиди Биотерапьютикс, Инк. | Оспенная вакцина для лечения рака |
| WO2017036925A1 (en) * | 2015-08-28 | 2017-03-09 | Apceth Gmbh & Co. Kg | Mesenchymal stem cells for the treatment of metastatic liver disease |
| CN111569090A (zh) | 2016-01-15 | 2020-08-25 | 美国基因技术国际有限公司 | 用于活化γ-δ T细胞的方法和组合物 |
| US10137144B2 (en) | 2016-01-15 | 2018-11-27 | American Gene Technologies International Inc. | Methods and compositions for the activation of gamma-delta T-cells |
| JP7153332B2 (ja) | 2016-02-08 | 2022-10-14 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | Ｈｉｖワクチン接種および免疫療法 |
| ES2911448T3 (es) | 2016-03-09 | 2022-05-19 | American Gene Tech Int Inc | Vectores combinados y métodos para el tratamiento del cáncer |
| EP3462883B1 (en) * | 2016-06-07 | 2023-08-16 | The Pacific Heart, Lung,&Blood Institute | Compositions and their use in treating cancer |
| US11976292B2 (en) | 2016-06-08 | 2024-05-07 | American Gene Technologies International Inc. | Non-integrating viral delivery system and methods related thereto |
| EP3481418A4 (en) | 2016-07-08 | 2020-03-11 | American Gene Technologies International Inc. | PRE-IMMUNIZATION AND IMMUNOTHERAPY OF HIV |
| US11583562B2 (en) | 2016-07-21 | 2023-02-21 | American Gene Technologies International Inc. | Viral vectors for treating Parkinson's disease |
| CA3042360A1 (en) | 2016-11-03 | 2018-05-11 | Exostem Biotec Ltd. | Mesenchymal stem cells populations, their products, and use thereof |
| TW201839136A (zh) | 2017-02-06 | 2018-11-01 | 瑞士商諾華公司 | 治療血色素異常症之組合物及方法 |
| JP2020512815A (ja) | 2017-04-03 | 2020-04-30 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | フェニルケトン尿症を処置するための組成物および方法 |
| JP2020516654A (ja) | 2017-04-13 | 2020-06-11 | センティ バイオサイエンシズ インコーポレイテッド | 組み合わせがん免疫療法 |
| WO2018232359A1 (en) | 2017-06-16 | 2018-12-20 | American Gene Technologies International Inc. | Methods and compositions for the activation of tumor cytotoxicity via human gamma-delta t-cells |
| US11246890B2 (en) | 2018-04-03 | 2022-02-15 | The Board Of Trustees Of The Leland Stanford Junior University | Systemic targeting of inflammatory sites and enhanced immunomodulatory function by introducing the chimeric antigen receptor (CAR) into mesenchymal stem cells for inflammatory and autoimmune diseases |
| US11505782B2 (en) | 2018-06-04 | 2022-11-22 | Calidi Biotherapeutics, Inc. | Cell-based vehicles for potentiation of viral therapy |
| JP2021526865A (ja) * | 2018-06-14 | 2021-10-11 | ロマ・リンダ・ユニヴァーシティ | 急性骨髄性白血病の処置のための操作された造血幹細胞 |
| US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| TW202035685A (zh) | 2018-10-17 | 2020-10-01 | 美商聖堤生物科技股份有限公司 | 組合癌症免疫療法 |
| US11352646B2 (en) | 2018-11-05 | 2022-06-07 | American Gene Technologies International Inc. | Vector system for expressing regulatory RNA |
| CN113271955A (zh) | 2018-11-06 | 2021-08-17 | 卡利迪生物治疗有限公司 | 用于细胞介导的溶瘤病毒疗法的增强的系统 |
| US20220241337A1 (en) * | 2019-02-22 | 2022-08-04 | The Trustees Of Columbia University In The City Of Newyork | Preparing tissues for delivery of therapeutic and diagnostic agents and delivering the agents |
| SG10201902002SA (en) * | 2019-03-06 | 2020-10-29 | Nat Univ Singapore | Non-viral modification of mesenchymal stem cells |
| US20220288129A1 (en) * | 2019-08-23 | 2022-09-15 | Orbsen Therapeutics Limited | Compositions for monocyte and macrophage polarization and methods of use |
| EP4240323A1 (en) | 2020-11-06 | 2023-09-13 | AATEC Medical GmbH | A composition comprising extra-cellular vesicles from mesenchymal stem cells and alpha-1 antitrypsin for the treatment of viral infections |
| EP3995130A1 (en) | 2020-11-06 | 2022-05-11 | JunctuCell Biomed Manufacturing GmbH | A composition comprising extra-cellular vesicles from mesenchymal stem cells and alpha-1 antitrypsin for the treatment of viral infections |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6265564B1 (en) * | 1996-08-02 | 2001-07-24 | Regeneron Pharmaceuticals, Inc. | Expressed ligand-vascular intercellular signalling molecule |
| US7098185B2 (en) * | 1998-05-18 | 2006-08-29 | University College London | Polypeptide hormone phosphatonin |
| AU2001265187A1 (en) * | 2000-05-30 | 2001-12-11 | Baylor College Of Medicine | Chimeric viral vectors for gene therapy |
| WO2002069953A1 (en) * | 2001-03-01 | 2002-09-12 | The Board Of Regents Of The University Of Texas System | Methods of treating lung inflammation |
| US20030165579A1 (en) * | 2002-02-27 | 2003-09-04 | Chih-Hui Lin | Euphorbia antiquorum extract, a pharmaceutical composition containing the same and methods for treatment of cancers |
| DE60319240D1 (de) * | 2003-12-19 | 2008-04-03 | Charite Universitaetsmedizin | Verwendung von Liganden von CD52 Antigen zur Behandlung von soliden Tumoren und von Knochenkrebserkrankungen |
| JP2006194752A (ja) * | 2005-01-14 | 2006-07-27 | Sumitomo Metal Mining Co Ltd | Ｘ線回折測定における試料固定方法および試料固定具 |
| KR101022401B1 (ko) * | 2005-09-29 | 2011-03-15 | 아주대학교산학협력단 | 자살유전자를 발현하는 중간엽 줄기세포를 포함하는 암치료용 조성물 |
| AU2008260651B2 (en) | 2007-05-24 | 2014-06-12 | Apceth Gmbh & Co. Kg | CD34 stem cell-related methods and compositions |
-
2010
- 2010-04-13 KR KR1020117026918A patent/KR20120088542A/ko not_active Ceased
- 2010-04-13 BR BRPI1013771A patent/BRPI1013771A2/pt not_active IP Right Cessation
- 2010-04-13 US US13/264,084 patent/US9434925B2/en not_active Expired - Fee Related
- 2010-04-13 JP JP2012505149A patent/JP5727458B2/ja active Active
- 2010-04-13 WO PCT/EP2010/054844 patent/WO2010119039A1/en not_active Ceased
- 2010-04-13 CN CN201080026333.1A patent/CN102695517B/zh not_active Expired - Fee Related
- 2010-04-13 SG SG2011073418A patent/SG175127A1/en unknown
- 2010-04-13 CA CA2758120A patent/CA2758120C/en not_active Expired - Fee Related
- 2010-04-13 EP EP10713933.9A patent/EP2419113B1/en not_active Not-in-force
- 2010-04-13 RU RU2011146048/10A patent/RU2539099C2/ru not_active IP Right Cessation
- 2010-04-13 AU AU2010237130A patent/AU2010237130B2/en not_active Ceased
-
2011
- 2011-10-06 IL IL215581A patent/IL215581A0/en unknown
-
2016
- 2016-08-31 US US15/253,353 patent/US20170015976A1/en not_active Abandoned
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