JP2012521428A5 - - Google Patents
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- Publication number
- JP2012521428A5 JP2012521428A5 JP2012502097A JP2012502097A JP2012521428A5 JP 2012521428 A5 JP2012521428 A5 JP 2012521428A5 JP 2012502097 A JP2012502097 A JP 2012502097A JP 2012502097 A JP2012502097 A JP 2012502097A JP 2012521428 A5 JP2012521428 A5 JP 2012521428A5
- Authority
- JP
- Japan
- Prior art keywords
- chr
- alkyl
- heterocyclyl
- cycloalkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C*1c(c(S)cc(C(N)OC)c2)[n]2c(*)n1 Chemical compound C*1c(c(S)cc(C(N)OC)c2)[n]2c(*)n1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21084509P | 2009-03-23 | 2009-03-23 | |
| US61/210,845 | 2009-03-23 | ||
| PCT/US2010/027286 WO2010111058A1 (en) | 2009-03-23 | 2010-03-15 | P2x3, receptor antagonists for treatment of pain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012521428A JP2012521428A (ja) | 2012-09-13 |
| JP2012521428A5 true JP2012521428A5 (cg-RX-API-DMAC10.html) | 2013-05-02 |
Family
ID=42781385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012502097A Pending JP2012521428A (ja) | 2009-03-23 | 2010-03-15 | 疼痛治療用のｐ２ｘ３受容体アンタゴニスト |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9238647B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2410857B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2012521428A (cg-RX-API-DMAC10.html) |
| AU (1) | AU2010229142A1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2755680A1 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2010111058A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009110985A2 (en) | 2008-02-29 | 2009-09-11 | Renovis, Inc. | Amide compounds, compositions and uses thereof |
| EP2346825A2 (en) | 2008-09-18 | 2011-07-27 | Evotec AG | Modulators of p2x3 receptor activity |
| US20100273805A1 (en) * | 2009-04-23 | 2010-10-28 | Astrazeneca Ab | Sulphide bridged derivatives as modulators of mglur5 733 |
| ES2457543T3 (es) * | 2009-06-22 | 2014-04-28 | F. Hoffmann-La Roche Ag | Nuevas arilamidas de indazol como antagonistas de P2X3 y/o P2X2/3 |
| CA2814998C (en) * | 2010-11-08 | 2019-10-29 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| US9271967B2 (en) * | 2010-11-08 | 2016-03-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| CN103492377B (zh) * | 2011-02-25 | 2016-04-20 | 阵列生物制药公司 | 作为pim激酶抑制剂的三唑并吡啶化合物 |
| DK3381917T3 (da) * | 2013-01-31 | 2021-10-18 | Bellus Health Cough Inc | Imidazopyridinforbindelser og anvendelser deraf |
| KR20220112867A (ko) * | 2013-12-16 | 2022-08-11 | 에이비에스 디벨롭먼트 원 인코포레이티드 | P2x3 및/또는 p2x2/3 화합물 및 방법 |
| EP2905282A1 (en) * | 2014-02-05 | 2015-08-12 | AXXAM S.p.A. | Substituted thiazole or oxazole as P2X7 receptor antagonists |
| WO2016036633A1 (en) | 2014-09-05 | 2016-03-10 | Merck Sharp & Dohme Corp. | Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2 |
| WO2016036638A1 (en) | 2014-09-05 | 2016-03-10 | Merck Sharp & Dohme Corp. | Isoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2 |
| WO2016036636A1 (en) | 2014-09-05 | 2016-03-10 | Merck Sharp & Dohme Corp. | Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2 |
| WO2016088838A1 (ja) * | 2014-12-04 | 2016-06-09 | 塩野義製薬株式会社 | プリン誘導体およびその医薬組成物 |
| JO3637B1 (ar) | 2015-04-28 | 2020-08-27 | Janssen Sciences Ireland Uc | مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv |
| WO2017209267A1 (ja) * | 2016-06-03 | 2017-12-07 | 塩野義製薬株式会社 | プリン誘導体 |
| CA3043206A1 (en) | 2016-11-18 | 2018-05-24 | Merck Sharp & Dohme Corp. | Indole derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2 |
| MA46856A (fr) | 2016-11-18 | 2019-09-25 | Merck Sharp & Dohme | Dérivés d'indazole utiles en tant qu'inhibiteurs de la diacylglycéride o-acyltransférase 2 |
| CA3055509A1 (en) * | 2017-03-15 | 2018-09-20 | Sumitomo Dainippon Pharma Co., Ltd. | Novel benzimidazolone compound and pharmaceutical use thereof |
| TW201932470A (zh) | 2017-11-29 | 2019-08-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | 具有抗ｒｓｖ活性之吡唑并嘧啶 |
| WO2019149734A1 (en) | 2018-01-31 | 2019-08-08 | Janssen Sciences Ireland Unlimited Company | Cycloalkyl substituted pyrazolopyrimidines having activity against rsv |
| US11708369B2 (en) | 2018-04-23 | 2023-07-25 | Janssen Sciences Ireland Unlimited Company | Heteroaromatic compounds having activity against RSV |
| WO2020256430A1 (ko) * | 2019-06-19 | 2020-12-24 | 주식회사 엘지화학 | 인돌 또는 인다졸 화합물의 제조방법 |
| EP4103572A4 (en) | 2020-02-14 | 2024-03-06 | Bellus Health Cough Inc. | MAKING A P2X3 ANTAGONIST |
| WO2022063205A1 (zh) * | 2020-09-24 | 2022-03-31 | 中国医药研究开发中心有限公司 | 芳基甲酰胺类化合物及其制备方法和医药用途 |
| CN115322143B (zh) * | 2022-07-21 | 2023-07-14 | 安徽德诺医药股份有限公司 | 一种4-哌啶甲酸叔丁酯盐酸盐的制备方法 |
| WO2024137671A1 (en) * | 2022-12-20 | 2024-06-27 | Exelixis, Inc. | Compounds that inhibit pkmyt1 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0934307B1 (en) * | 1996-06-19 | 2011-04-27 | Aventis Pharma Limited | Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase |
| IL141724A0 (en) * | 1998-08-28 | 2002-03-10 | Scios Inc | INHIBITORS OF P38-α KINASE |
| KR100875222B1 (ko) | 1999-08-19 | 2008-12-19 | 아스트라제네카 아베 | 헤테로폴리사이클릭 화합물 및 간접 글루타메이트 수용체길항제로서의 그들의 용도 |
| CA2450555A1 (en) * | 2001-06-25 | 2003-01-03 | Merck & Co., Inc. | (pyrimidyl)(phenyl)substituted fused heteroaryl p38 inhibiting and pkg kinase inhibiting compounds |
| EP1711498A2 (en) | 2004-01-26 | 2006-10-18 | Altana Pharma AG | 1,2,4-triazolo¬1,5-a|pyridines as gastric acid secretion inhibitors |
| EP1863635A2 (en) | 2005-03-24 | 2007-12-12 | Arrow Coated Products Limited | Combined multi-layered water soluble film and process for producing the same |
| ES2552804T3 (es) | 2005-05-04 | 2015-12-02 | Evotec Ag | Compuestos heterocíclicos condensados, y sus composiciones y usos |
| MY147756A (en) * | 2005-05-25 | 2013-01-15 | Theravance Inc | Benzimidazole-carboxamide compounds as 5-ht4 receptor agonists |
| CN101203220A (zh) | 2005-06-28 | 2008-06-18 | 阿斯利康(瑞典)有限公司 | 新用途 |
| JP4987871B2 (ja) * | 2005-08-15 | 2012-07-25 | エフ．ホフマン−ラ ロシュ アーゲー | Ｐ２ｘ３アンタゴニストとしてのピペリジン及びピペラジン誘導体 |
| PL1924264T3 (pl) | 2005-09-01 | 2014-03-31 | Hoffmann La Roche | Diaminopirymidyny jako modulatory P2X<sub>3</sub> I P2X<sub>2/3</sub> |
| EP1934364A4 (en) | 2005-09-30 | 2009-03-25 | Merck & Co Inc | FOR P2X3, A FUNCTIONAL SÜUGER PURINORE CECTOR, CODING NUCLEIC ACIDS, PROCESS FOR THE PREPARATION AND USE THEREOF |
| AU2006311729A1 (en) * | 2005-11-07 | 2007-05-18 | Vertex Pharmaceuticals Incorporated | Benzimidazole derivatives as gyrase inhibitors |
| WO2007069053A1 (en) * | 2005-12-14 | 2007-06-21 | Pfizer Products Inc. | Benzimidazole antagonists of the h-3 receptor |
| WO2007086080A2 (en) * | 2006-01-30 | 2007-08-02 | Glenmark Pharmaceuticals Limited | NOVEL IMIDAZO[1,2-a]PYRIDINE CANNABINOID RECEPTOR LIGANDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| EP2038264B1 (en) | 2006-06-29 | 2016-10-26 | F.Hoffmann-La Roche Ag | Tetrazole-substituted arylamides |
| FR2903107B1 (fr) | 2006-07-03 | 2008-08-22 | Sanofi Aventis Sa | Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
| WO2008027812A2 (en) * | 2006-08-28 | 2008-03-06 | Forest Laboratories Holdings Limited | Imidazopyridine and imidazopyrimidine derivatives |
| CN101631786A (zh) * | 2006-12-20 | 2010-01-20 | 先灵公司 | 新颖的jnk抑制剂 |
| WO2008085302A1 (en) * | 2006-12-20 | 2008-07-17 | Merck & Co., Inc. | Imidazopyridine analogs as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases |
| ES2553412T3 (es) | 2007-10-31 | 2015-12-09 | Merck Sharp & Dohme Corp. | Antagonistas del receptor P2X3 para el tratamiento del dolor |
| US8247401B2 (en) | 2007-10-31 | 2012-08-21 | Merck Sharp & Dohme Corp. | P2X3 receptor antagonists for treatment of pain |
| ES2534199T3 (es) | 2008-10-31 | 2015-04-20 | Merck Sharp & Dohme Corp. | Antagonistas del receptor P2X3 para el tratamiento del dolor |
| WO2010059836A1 (en) * | 2008-11-20 | 2010-05-27 | Decode Genetics Ehf | Substituted aza-bridged bicyclics for cardiovascular and cns disease |
| ES2457543T3 (es) * | 2009-06-22 | 2014-04-28 | F. Hoffmann-La Roche Ag | Nuevas arilamidas de indazol como antagonistas de P2X3 y/o P2X2/3 |
-
2010
- 2010-03-15 AU AU2010229142A patent/AU2010229142A1/en not_active Abandoned
- 2010-03-15 JP JP2012502097A patent/JP2012521428A/ja active Pending
- 2010-03-15 US US13/259,040 patent/US9238647B2/en active Active
- 2010-03-15 EP EP10756586.3A patent/EP2410857B1/en not_active Not-in-force
- 2010-03-15 CA CA2755680A patent/CA2755680A1/en not_active Abandoned
- 2010-03-15 WO PCT/US2010/027286 patent/WO2010111058A1/en not_active Ceased
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