JP2012521406A5 - - Google Patents
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- Publication number
- JP2012521406A5 JP2012521406A5 JP2012501412A JP2012501412A JP2012521406A5 JP 2012521406 A5 JP2012521406 A5 JP 2012521406A5 JP 2012501412 A JP2012501412 A JP 2012501412A JP 2012501412 A JP2012501412 A JP 2012501412A JP 2012521406 A5 JP2012521406 A5 JP 2012521406A5
- Authority
- JP
- Japan
- Prior art keywords
- dioxo
- acetamide
- pyrimidin
- tetrahydrofuro
- thiazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN665/MUM/2009 | 2009-03-23 | ||
| IN665MU2009 | 2009-03-23 | ||
| US17135509P | 2009-04-21 | 2009-04-21 | |
| US61/171,355 | 2009-04-21 | ||
| IN2213MU2009 | 2009-09-23 | ||
| IN2213/MUM/2009 | 2009-09-23 | ||
| US25199409P | 2009-10-15 | 2009-10-15 | |
| US61/251,994 | 2009-10-15 | ||
| IN2906MU2009 | 2009-12-16 | ||
| IN2906/MUM/2009 | 2009-12-16 | ||
| US29447010P | 2010-01-12 | 2010-01-12 | |
| US61/294,470 | 2010-01-12 | ||
| PCT/IB2010/000840 WO2010109329A1 (en) | 2009-03-23 | 2010-03-22 | Furopyrimidinedione derivatives as trpa1 modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012521406A JP2012521406A (ja) | 2012-09-13 |
| JP2012521406A5 true JP2012521406A5 (https=) | 2013-05-02 |
Family
ID=42780205
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012501412A Pending JP2012521406A (ja) | 2009-03-23 | 2010-03-22 | Ｔｒｐａ１調節因子としてのフロピリミジンジオン誘導体 |
| JP2012501414A Expired - Fee Related JP5612070B2 (ja) | 2009-03-23 | 2010-03-23 | Ｔｒｐａ１調節因子としてのチエノピリミジンジオン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012501414A Expired - Fee Related JP5612070B2 (ja) | 2009-03-23 | 2010-03-23 | Ｔｒｐａ１調節因子としてのチエノピリミジンジオン誘導体 |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US20120178766A1 (https=) |
| EP (3) | EP2411395B1 (https=) |
| JP (2) | JP2012521406A (https=) |
| KR (2) | KR20110128898A (https=) |
| CN (3) | CN102361874A (https=) |
| AP (1) | AP2948A (https=) |
| AU (2) | AU2010227225A1 (https=) |
| BR (2) | BRPI1013705A2 (https=) |
| CA (2) | CA2756535A1 (https=) |
| DK (3) | DK2411395T3 (https=) |
| EA (2) | EA201190138A1 (https=) |
| ES (3) | ES2424341T3 (https=) |
| HU (1) | HUE024538T2 (https=) |
| IL (2) | IL215177A (https=) |
| MX (1) | MX2011009822A (https=) |
| PE (2) | PE20120834A1 (https=) |
| PL (3) | PL2411395T3 (https=) |
| PT (3) | PT2411395E (https=) |
| SG (4) | SG174398A1 (https=) |
| SI (3) | SI2411395T1 (https=) |
| WO (2) | WO2010109329A1 (https=) |
| ZA (2) | ZA201107649B (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2411393T1 (sl) | 2009-03-23 | 2014-03-31 | Glenmark Pharmaceuticals S.A. | Kondenzirani pirimidin-dionski derivati kot TRPA 1 modulatorji |
| EP2411395B1 (en) | 2009-03-23 | 2013-05-29 | Glenmark Pharmaceuticals S.A. | Furopyrimidinedione derivatives as trpa1 modulators |
| PE20140234A1 (es) * | 2010-12-20 | 2014-03-08 | Glenmark Phamaceuticals S A | Compuestos de 2-amino-4-ariltiazol como antagonistas de trpa1 |
| EP2520566A1 (en) | 2011-05-06 | 2012-11-07 | Orion Corporation | New Pharmaceutical Compounds |
| CA2836856A1 (en) * | 2011-06-13 | 2012-12-20 | Glenmark Pharmaceuticals, S.A. | Treatment of respiratory disorders using trpa1 antagonists |
| WO2012176105A1 (en) | 2011-06-22 | 2012-12-27 | Glenmark Pharmaceuticals Sa | Pharmaceutical composition comprising a trpa1 antagonist and a leukotriene receptor antagonist |
| BR112013031820A2 (pt) * | 2011-06-22 | 2016-12-13 | Glenmark Pharmaceutical S A | composições farmacêuticas, incluindo para administração oral e por inalação, usos de quantidade sinergicamente eficaz de antagonista trpa1 e métodos para tratar distúrbios respiratórios e para melhorar a função pulmonar |
| US20140148423A1 (en) * | 2011-07-25 | 2014-05-29 | Glenmark Pharmaceuticals S.A. | Pharmaceutical composition comprising a trpa1 antagonist and a steroid |
| EP2787991A1 (en) | 2011-12-05 | 2014-10-15 | Glenmark Pharmaceuticals S.A. | Pharmaceutical composition comprising a trpa1 antagonist and an anticholinergic agent |
| SG11201408093PA (en) * | 2012-06-08 | 2015-01-29 | Glenmark Pharmaceuticals Sa | Amides of 2-amino-4-arylthiazole compounds and their salts |
| PT2903965T (pt) | 2012-10-01 | 2017-06-06 | Orion Corp | Derivados de n-prop-2-inilcarboxamida e sua utilização como antagonistas de trpa1 |
| EP3010489A1 (en) | 2013-06-20 | 2016-04-27 | Glenmark Pharmaceuticals S.A. | Nanoparticulate formulation comprising a trpa1 antagonist |
| EP3057583A2 (en) | 2013-10-15 | 2016-08-24 | Glenmark Pharmaceuticals S.A. | Pharmaceutical composition comprising a trpa1 antagonist and an analgesic agent |
| JP6573968B2 (ja) * | 2014-08-11 | 2019-09-11 | ハイドラ バイオサイエンシズ インコーポレイテッドＨｙｄｒａ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． | ＴＲＰＣ５調節因子としての、精神神経障害の処置のためのチエノおよびフロ［２，３−ｄ］ピリミジン−２，４［１Ｈ，３Ｈ］−ジオン誘導体 |
| WO2016023830A1 (en) * | 2014-08-11 | 2016-02-18 | Hydra Biosciences, Inc. | Pyrido[2,3-d]pyrimidine-2,4(1h,3h)-dione derivatives |
| WO2016023825A1 (en) * | 2014-08-11 | 2016-02-18 | Hydra Biosciences, Inc. | Pyrido[3,4-d]pyrimidine-2,4(1h,3h)-dione derivatives |
| JP6667092B2 (ja) * | 2014-08-11 | 2020-03-18 | ハイドラ・バイオサイエンシーズ・リミテッド・ライアビリティ・カンパニーＨｙｄｒａ Ｂｉｏｓｃｉｅｎｃｅｓ， ＬＬＣ | ピロロ［３，２−ｄ］ピリミジン−２，４（３Ｈ，５Ｈ）−ジオン誘導体 |
| WO2016028325A1 (en) | 2014-08-22 | 2016-02-25 | Duke University | Trpa1 and trpv4 inhibitors and methods of using the same for organ-specific inflammation and itch |
| WO2016042501A1 (en) * | 2014-09-16 | 2016-03-24 | Glenmark Pharmaceuticals S.A. | Trpa1 antagonist for the treatment of pain associated to diabetic neuropathic pain |
| US11229628B2 (en) | 2015-01-09 | 2022-01-25 | Duke University | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch |
| WO2017060488A1 (en) | 2015-10-09 | 2017-04-13 | Almirall, S.A. | New trpa1 antagonists |
| WO2017064068A1 (en) | 2015-10-14 | 2017-04-20 | Almirall, S.A. | New trpa1 antagonists |
| CN109310683A (zh) * | 2016-04-07 | 2019-02-05 | 杜克大学 | 用于消毒和麻醉的trpv4和trpa1的小分子双重抑制剂 |
| WO2018162607A1 (en) * | 2017-03-07 | 2018-09-13 | F. Hoffmann-La Roche Ag | Oxadiazole transient receptor potential channel inhibitors |
| CN109422749B (zh) * | 2017-08-21 | 2023-01-24 | 重庆医药工业研究院有限责任公司 | 一种抑制单羧酸转运蛋白的嘧啶二酮衍生物 |
| JP7612682B2 (ja) | 2019-10-15 | 2025-01-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規なテトラゾール |
| CN116348471B (zh) * | 2020-10-14 | 2025-10-31 | 勃林格殷格翰国际有限公司 | 作为trpa1抑制剂的四唑衍生物 |
| AU2021363101A1 (en) * | 2020-10-14 | 2023-03-23 | Boehringer Ingelheim International Gmbh | Tetrazole derivatives as TRPA1 inhibitors |
| CN116940575A (zh) * | 2021-02-23 | 2023-10-24 | 深圳市康哲药业有限公司 | 噻吩并嘧啶二酮类化合物及其应用 |
| AU2022257269A1 (en) | 2021-04-14 | 2023-08-17 | Boehringer Ingelheim International Gmbh | 3H,4H-THIENO[2,3-d]PYRIMIDIN-4-ONE DERIVATIVES AS TRPA1 INHIBITORS |
| CN114671875A (zh) * | 2022-04-27 | 2022-06-28 | 成都施贝康生物医药科技有限公司 | 新型二氢嘧啶类化合物、异构体或盐及其制备方法和用途 |
| CN114656480B (zh) * | 2022-04-27 | 2024-01-26 | 成都施贝康生物医药科技有限公司 | 噻吩并嘧啶类化合物、异构体或盐及其制备方法和用途 |
| WO2025264860A2 (en) | 2024-06-18 | 2025-12-26 | Yale University | Methods of treating post-covid airway disease |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2248231A1 (de) | 1972-10-02 | 1974-04-11 | Basf Ag | 3-aminoisothiazolo eckige klammer auf 3,4-d eckige klammer zu pyrimidine |
| SE9701398D0 (sv) | 1997-04-15 | 1997-04-15 | Astra Pharma Prod | Novel compounds |
| SE9702001D0 (sv) * | 1997-05-28 | 1997-05-28 | Astra Pharma Prod | Novel compounds |
| DE69912618T2 (de) * | 1998-08-28 | 2004-10-28 | Astrazeneca Ab | NEUE THIENO[2,3-d]PYRIMIDINDIONE, VERFAHREN FÜR IHRE HERSTELLUNG UND IHRE VERWENDUNG IN DER THERAPIE |
| ES2193839B1 (es) * | 2001-06-22 | 2005-02-16 | Almirall Prodesfarma, S.A. | Nuevos derivados de 6-fenildihidropirrolpirimidindiona. |
| GB0118479D0 (en) * | 2001-07-28 | 2001-09-19 | Astrazeneca Ab | Novel compounds |
| AU2003253165A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Pyrimidine fused bicyclic metalloproteinase inhibitors |
| AR043057A1 (es) * | 2002-10-30 | 2005-07-13 | Vertex Pharma | Compuestos derivados de piridintiazoles como inhibidores de la quinasa rock y otras proteinas quinasa |
| US6890923B2 (en) * | 2002-12-16 | 2005-05-10 | Astrazeneca Ab | Compounds |
| WO2004055054A1 (en) | 2002-12-18 | 2004-07-01 | Novartis Ag | Anktm1, a cold-activated trp-like channel expressed in nociceptive neurons |
| SE0300119D0 (sv) * | 2003-01-17 | 2003-01-17 | Astrazeneca Ab | Novel compounds |
| EP1657238A4 (en) | 2003-08-22 | 2008-12-03 | Takeda Pharmaceutical | CONDENSATE PYRIMIDINE DERIVATIVE AND ITS USE |
| WO2005077959A1 (en) * | 2004-02-11 | 2005-08-25 | Smithkline Beecham Corporation | Pth agonists |
| WO2005089206A2 (en) | 2004-03-13 | 2005-09-29 | Irm Llc | Modulators of ion channel trpa1 |
| EP1847541A4 (en) * | 2005-02-03 | 2009-12-30 | Takeda Pharmaceutical | CONDENSED PYRIMIDINE DERIVATIVE AND USE THEREOF |
| US20070032531A1 (en) * | 2005-08-04 | 2007-02-08 | Apogee Biotechnology Corporation | Sphingosine kinase inhibitors and methods of their use |
| CN101351463A (zh) * | 2005-11-08 | 2009-01-21 | 欧加农股份有限公司 | 用于治疗trpv1相关病症的2-(苯并咪唑-1-基)-n-(4-苯基噻唑-2-基)乙酰胺衍生物 |
| WO2007054480A1 (en) * | 2005-11-08 | 2007-05-18 | N.V. Organon | 2-(benzimidazol-1-yl)-acetamide biaryl derivatives and their use as inhibitors of the trpv1 receptor |
| US20070105920A1 (en) * | 2005-11-08 | 2007-05-10 | Akzo Nobel N.V. | 2-(Benzimidazol-1-Yl)-N-(4-phenylthiazol-2-yl) acetamide derivatives |
| AU2006327181A1 (en) | 2005-12-22 | 2007-06-28 | Hydra Biosciences, Inc. | TRPA1 inhibitors for treating pain |
| TW200800997A (en) | 2006-03-22 | 2008-01-01 | Astrazeneca Ab | Chemical compounds |
| AR065081A1 (es) | 2007-01-29 | 2009-05-13 | Xenon Pharmaceuticals Inc | Compuestos de quinazolinona y pirimidona fusionados y composicion farmaceutica |
| ES2609912T3 (es) | 2007-06-22 | 2017-04-25 | Hydra Biosciences, Inc. | Compuestos de 2,6-dioxo, -2,3-dihidro-1h-purina útiles para el tratamiento de trastornos relacionados con la actividad del canal trpa1 |
| WO2009002983A1 (en) * | 2007-06-25 | 2008-12-31 | Sandisk Corporation | Non-volatile storage with individually controllable shield plates between storage elements |
| US7951814B2 (en) | 2008-06-17 | 2011-05-31 | Glenmark Pharmaceuticals, S.A. | Quinazolinedione derivatives as TRPA1 modulators |
| WO2009158719A2 (en) | 2008-06-27 | 2009-12-30 | Hydra Biosciences, Inc. | Methods and compositions for treating disorders |
| UA103918C2 (en) | 2009-03-02 | 2013-12-10 | Айерем Элелси | N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators |
| US8623880B2 (en) | 2009-03-23 | 2014-01-07 | Glenmark Pharmaceuticals S.A. | Fused pyrimidine-dione derivatives as TRPA1 modulators |
| EP2411395B1 (en) | 2009-03-23 | 2013-05-29 | Glenmark Pharmaceuticals S.A. | Furopyrimidinedione derivatives as trpa1 modulators |
| WO2010109328A1 (en) | 2009-03-23 | 2010-09-30 | Glenmark Pharmaceuticals, S.A. | Isothiazolo-pyrimidinedione derivatives as trpa1 modulators |
| AR076332A1 (es) | 2009-04-21 | 2011-06-01 | Boehringer Ingelheim Int | Derivados heterociclicos de 5-alquinil-piridinas, composiciones farmaceuticas que los comprenden y uso de los mismos para el tratamiento y/o prevencion del cancer, procesos inflamatorios, autoinmunes, y/o infecciones. |
| AR078522A1 (es) | 2009-10-15 | 2011-11-16 | Lilly Co Eli | Compuesto de espiropiperidina, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para tratar diabetes y compuesto intermediario para su sintesis |
| ES2426407T3 (es) | 2009-10-15 | 2013-10-23 | Pfizer Inc. | Compuestos de pirrolo[2,3-d]pirimidina |
| US8440710B2 (en) | 2009-10-15 | 2013-05-14 | Hoffmann-La Roche Inc. | HSL inhibitors useful in the treatment of diabetes |
| US8377980B2 (en) | 2009-12-16 | 2013-02-19 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| ES2539170T3 (es) | 2010-01-12 | 2015-06-26 | Ab Science | Inhibidores de quinasas de oxazol |
| DK2483255T3 (da) | 2010-07-13 | 2014-01-20 | Novartis Ag | Oxazinderivater samt deres anvendelse ved behandling af neurologiske lidelser |
-
2010
- 2010-03-22 EP EP10716050.9A patent/EP2411395B1/en not_active Not-in-force
- 2010-03-22 JP JP2012501412A patent/JP2012521406A/ja active Pending
- 2010-03-22 ES ES10716050T patent/ES2424341T3/es active Active
- 2010-03-22 EA EA201190138A patent/EA201190138A1/ru unknown
- 2010-03-22 KR KR1020117022604A patent/KR20110128898A/ko not_active Withdrawn
- 2010-03-22 WO PCT/IB2010/000840 patent/WO2010109329A1/en not_active Ceased
- 2010-03-22 US US13/257,280 patent/US20120178766A1/en not_active Abandoned
- 2010-03-22 SG SG2011066446A patent/SG174398A1/en unknown
- 2010-03-22 SI SI201030233T patent/SI2411395T1/sl unknown
- 2010-03-22 PL PL10716050T patent/PL2411395T3/pl unknown
- 2010-03-22 CA CA2756535A patent/CA2756535A1/en not_active Abandoned
- 2010-03-22 PE PE2011001704A patent/PE20120834A1/es not_active Application Discontinuation
- 2010-03-22 PT PT107160509T patent/PT2411395E/pt unknown
- 2010-03-22 AU AU2010227225A patent/AU2010227225A1/en not_active Abandoned
- 2010-03-22 CN CN2010800134701A patent/CN102361874A/zh active Pending
- 2010-03-22 DK DK10716050.9T patent/DK2411395T3/da active
- 2010-03-22 SG SG2012069472A patent/SG184767A1/en unknown
- 2010-03-22 BR BRPI1013705A patent/BRPI1013705A2/pt not_active IP Right Cessation
- 2010-03-23 MX MX2011009822A patent/MX2011009822A/es unknown
- 2010-03-23 DK DK10751712.0T patent/DK2411396T3/da active
- 2010-03-23 BR BRPI1009381A patent/BRPI1009381B8/pt active IP Right Grant
- 2010-03-23 DK DK13002731T patent/DK2634191T3/en active
- 2010-03-23 PL PL10751712T patent/PL2411396T3/pl unknown
- 2010-03-23 AU AU2010227230A patent/AU2010227230B2/en not_active Ceased
- 2010-03-23 EA EA201190139A patent/EA022029B1/ru unknown
- 2010-03-23 KR KR1020117022603A patent/KR101524337B1/ko not_active Expired - Fee Related
- 2010-03-23 JP JP2012501414A patent/JP5612070B2/ja not_active Expired - Fee Related
- 2010-03-23 PE PE2011001705A patent/PE20120775A1/es active IP Right Grant
- 2010-03-23 AP AP2011005889A patent/AP2948A/xx active
- 2010-03-23 PT PT13002731T patent/PT2634191E/pt unknown
- 2010-03-23 WO PCT/IB2010/000930 patent/WO2010109334A2/en not_active Ceased
- 2010-03-23 SG SG2012069530A patent/SG184769A1/en unknown
- 2010-03-23 HU HUE13002731A patent/HUE024538T2/hu unknown
- 2010-03-23 EP EP10751712.0A patent/EP2411396B1/en active Active
- 2010-03-23 ES ES13002731.1T patent/ES2532386T3/es active Active
- 2010-03-23 ES ES10751712T patent/ES2424342T3/es active Active
- 2010-03-23 EP EP13002731.1A patent/EP2634191B1/en active Active
- 2010-03-23 US US12/936,451 patent/US8507503B2/en not_active Expired - Fee Related
- 2010-03-23 PT PT107517120T patent/PT2411396E/pt unknown
- 2010-03-23 CA CA2756536A patent/CA2756536C/en active Active
- 2010-03-23 PL PL13002731T patent/PL2634191T3/pl unknown
- 2010-03-23 SG SG2011066503A patent/SG174404A1/en unknown
- 2010-03-23 SI SI201030231T patent/SI2411396T1/sl unknown
- 2010-03-23 CN CN201080013463.1A patent/CN102361877B/zh not_active Expired - Fee Related
- 2010-03-23 CN CN201310628814.5A patent/CN103755720B/zh not_active Expired - Fee Related
- 2010-03-23 SI SI201030891T patent/SI2634191T1/sl unknown
-
2011
- 2011-09-15 IL IL215177A patent/IL215177A/en not_active IP Right Cessation
- 2011-09-15 IL IL215175A patent/IL215175A/en active IP Right Grant
- 2011-10-19 ZA ZA2011/07649A patent/ZA201107649B/en unknown
- 2011-10-19 ZA ZA2011/07650A patent/ZA201107650B/en unknown
-
2013
- 2013-06-25 US US13/925,975 patent/US8987278B2/en active Active
-
2015
- 2015-02-12 US US14/620,721 patent/US9474758B2/en not_active Expired - Fee Related
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