JP2012521358A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012521358A5 JP2012521358A5 JP2012500998A JP2012500998A JP2012521358A5 JP 2012521358 A5 JP2012521358 A5 JP 2012521358A5 JP 2012500998 A JP2012500998 A JP 2012500998A JP 2012500998 A JP2012500998 A JP 2012500998A JP 2012521358 A5 JP2012521358 A5 JP 2012521358A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- independently
- formulation
- compound according
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003446 ligand Substances 0.000 claims description 10
- 230000008685 targeting Effects 0.000 claims description 8
- 229910052757 nitrogen Inorganic materials 0.000 claims description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- 229920000642 polymer Polymers 0.000 claims description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 3
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 3
- 229910052760 oxygen Inorganic materials 0.000 claims description 3
- 239000001301 oxygen Substances 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims 11
- 238000009472 formulation Methods 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 108091023037 Aptamer Proteins 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 235000018102 proteins Nutrition 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 150000003384 small molecules Chemical class 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- PYSRRFNXTXNWCD-UHFFFAOYSA-N 3-(2-phenylethenyl)furan-2,5-dione Chemical compound O=C1OC(=O)C(C=CC=2C=CC=CC=2)=C1 PYSRRFNXTXNWCD-UHFFFAOYSA-N 0.000 claims 1
- WHNPOQXWAMXPTA-UHFFFAOYSA-N 3-methylbut-2-enamide Chemical compound CC(C)=CC(N)=O WHNPOQXWAMXPTA-UHFFFAOYSA-N 0.000 claims 1
- 102000053642 Catalytic RNA Human genes 0.000 claims 1
- 108090000994 Catalytic RNA Proteins 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 108091027967 Small hairpin RNA Proteins 0.000 claims 1
- 229920000147 Styrene maleic anhydride Polymers 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 239000002981 blocking agent Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 claims 1
- 210000001163 endosome Anatomy 0.000 claims 1
- 230000000799 fusogenic effect Effects 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 230000002934 lysing effect Effects 0.000 claims 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 108091070501 miRNA Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000008191 permeabilizing agent Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 229920001562 poly(N-(2-hydroxypropyl)methacrylamide) Polymers 0.000 claims 1
- 229920002401 polyacrylamide Polymers 0.000 claims 1
- 229920002643 polyglutamic acid Polymers 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108020004418 ribosomal RNA Proteins 0.000 claims 1
- 108091092562 ribozyme Proteins 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16182809P | 2009-03-20 | 2009-03-20 | |
| US61/161,828 | 2009-03-20 | ||
| PCT/US2010/028000 WO2010108108A2 (en) | 2009-03-20 | 2010-03-19 | Polyamine derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015018143A Division JP6190401B2 (ja) | 2009-03-20 | 2015-02-02 | ポリアミン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012521358A JP2012521358A (ja) | 2012-09-13 |
| JP2012521358A5 true JP2012521358A5 (enExample) | 2014-10-16 |
| JP5782602B2 JP5782602B2 (ja) | 2015-09-24 |
Family
ID=42359538
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012500998A Active JP5782602B2 (ja) | 2009-03-20 | 2010-03-19 | ポリアミン誘導体 |
| JP2015018143A Active JP6190401B2 (ja) | 2009-03-20 | 2015-02-02 | ポリアミン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015018143A Active JP6190401B2 (ja) | 2009-03-20 | 2015-02-02 | ポリアミン誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US8460696B2 (enExample) |
| EP (1) | EP2414322B1 (enExample) |
| JP (2) | JP5782602B2 (enExample) |
| KR (2) | KR101906392B1 (enExample) |
| CN (2) | CN102438978B (enExample) |
| AU (1) | AU2010226434A1 (enExample) |
| CA (1) | CA2755963C (enExample) |
| ES (1) | ES2931174T3 (enExample) |
| PT (1) | PT2414322T (enExample) |
| WO (1) | WO2010108108A2 (enExample) |
Families Citing this family (99)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2941152B1 (fr) * | 2009-01-20 | 2013-10-18 | Centre Nat Rech Scient | Vecteurs comprenant une macromolecule anionique et un lipide cationique pour l'administration de petits acides nucleiques. |
| CN102438978B (zh) | 2009-03-20 | 2017-02-22 | Clsn实验室股份有限公司 | 聚胺衍生物 |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP3431485B2 (en) | 2010-10-01 | 2024-09-04 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| BR122022001262B1 (pt) | 2010-11-15 | 2022-09-27 | Life Technologies Corporation | Compostos de transfecção contendo amina e complexo de transfecção |
| US20120202890A1 (en) * | 2011-02-08 | 2012-08-09 | Nian Wu | Polymer-carbohydrate-lipid conjugates |
| WO2012135805A2 (en) | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
| WO2012142622A1 (en) * | 2011-04-15 | 2012-10-18 | Molecular Transfer, Inc. | Agents for improved delivery of nucleic acids to eukaryotic cells |
| US8883177B2 (en) * | 2011-06-28 | 2014-11-11 | Nian Wu | Pharmaceutical compositions for parenteral administration |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2763701B1 (en) | 2011-10-03 | 2018-12-19 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| AU2013243949A1 (en) | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of biologics and proteins associated with human disease |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| DE18200782T1 (de) | 2012-04-02 | 2021-10-21 | Modernatx, Inc. | Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen |
| CA2892529C (en) | 2012-11-26 | 2023-04-25 | Moderna Therapeutics, Inc. | Terminally modified rna |
| HK1217215A1 (zh) | 2013-01-17 | 2016-12-30 | Modernatx, Inc. | 用於改变细胞表型的信号传感器多核苷酸 |
| US20160024181A1 (en) | 2013-03-13 | 2016-01-28 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| WO2014152211A1 (en) | 2013-03-14 | 2014-09-25 | Moderna Therapeutics, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| JP6358661B2 (ja) * | 2013-03-19 | 2018-07-18 | 公立大学法人首都大学東京 | 界面活性剤様化合物 |
| US10030243B2 (en) | 2013-07-05 | 2018-07-24 | Bioneer Corporation | Nanoparticle type oligonucleotide structure having high efficiency and method for preparing same |
| US9695421B2 (en) | 2013-07-05 | 2017-07-04 | Bioneer Corporation | Dengue virus-specific siRNA, double helix oligo-RNA structure comprising siRNA, and composition for suppressing proliferation of dengue virus comprising RNA structure |
| KR101867414B1 (ko) * | 2013-07-05 | 2018-06-14 | (주)바이오니아 | 호흡기 질환 연관 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체 및 이를 포함하는 호흡기 질환 예방 또는 치료용 조성물 |
| DK3019619T3 (da) | 2013-07-11 | 2021-10-11 | Modernatx Inc | Sammensætninger, der omfatter syntetiske polynukleotider, som koder for crispr-beslægtede proteiner, og syntetiske sgrna'er, og anvendelsesfremgangsmåder |
| EP3041934A1 (en) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| US20160194368A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EA201690675A1 (ru) | 2013-10-03 | 2016-08-31 | Модерна Терапьютикс, Инк. | Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности |
| KR101647178B1 (ko) * | 2013-11-28 | 2016-08-23 | 충남대학교산학협력단 | 효소 절단성 링커 또는 올리고 라이신을 포함하는 폴리에틸렌글리콜-리피드를 이용한 안정화된 플라스미드-지질 입자 |
| JP2017500865A (ja) | 2013-12-19 | 2017-01-12 | ノバルティス アーゲー | レプチンｍＲＮＡの組成物および製剤 |
| EP3128008B1 (en) | 2014-04-04 | 2024-05-29 | Bioneer Corporation | Double-stranded oligo rna and pharmaceutical composition comprising same for preventing or treating fibrosis or respiratory diseases |
| DK4023249T3 (da) | 2014-04-23 | 2025-01-13 | Modernatx Inc | Nukleinsyrevacciner |
| UA121863C2 (uk) * | 2014-06-24 | 2020-08-10 | Транслейт Байо, Інк. | Стереохімічно збагачені композиції для доставки нуклеїнових кислот |
| WO2016011226A1 (en) | 2014-07-16 | 2016-01-21 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| US20170210788A1 (en) | 2014-07-23 | 2017-07-27 | Modernatx, Inc. | Modified polynucleotides for the production of intrabodies |
| EP3250279B1 (en) * | 2015-01-30 | 2020-08-19 | The Regents of the University of California | Spinal subpial gene delivery system |
| DK3350157T3 (da) | 2015-09-17 | 2022-02-14 | Modernatx Inc | Forbindelser og sammensætninger til intracellulær afgivelse af terapeutiske midler |
| MD3386484T2 (ro) | 2015-12-10 | 2022-11-30 | Modernatx Inc | Compoziții și metode de livrare a unor agenți terapeutici |
| AU2016377681B2 (en) | 2015-12-22 | 2021-05-13 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of agents |
| US11583504B2 (en) | 2016-11-08 | 2023-02-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| AU2018234692B2 (en) | 2017-03-15 | 2022-06-02 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| ES2911186T3 (es) | 2017-03-15 | 2022-05-18 | Modernatx Inc | Formas cristalinas de aminolípidos |
| CA3055653A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Lipid nanoparticle formulation |
| EP3625345B1 (en) | 2017-05-18 | 2023-05-24 | ModernaTX, Inc. | Modified messenger rna comprising functional rna elements |
| WO2018213731A1 (en) | 2017-05-18 | 2018-11-22 | Modernatx, Inc. | Polynucleotides encoding tethered interleukin-12 (il12) polypeptides and uses thereof |
| WO2018232120A1 (en) | 2017-06-14 | 2018-12-20 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of agents |
| EP3638292A1 (en) | 2017-06-14 | 2020-04-22 | ModernaTX, Inc. | Polynucleotides encoding coagulation factor viii |
| US11786607B2 (en) | 2017-06-15 | 2023-10-17 | Modernatx, Inc. | RNA formulations |
| MX2020002348A (es) | 2017-08-31 | 2020-10-08 | Modernatx Inc | Métodos de elaboración de nanopartículas lipídicas. |
| EP3679140B1 (en) | 2017-09-08 | 2022-11-16 | MiNA Therapeutics Limited | Stabilized cebpa sarna compositions and methods of use |
| EP3714045A1 (en) | 2017-11-22 | 2020-09-30 | Modernatx, Inc. | Polynucleotides encoding propionyl-coa carboxylase alpha and beta subunits for the treatment of propionic acidemia |
| WO2019104152A1 (en) | 2017-11-22 | 2019-05-31 | Modernatx, Inc. | Polynucleotides encoding ornithine transcarbamylase for the treatment of urea cycle disorders |
| US11939601B2 (en) | 2017-11-22 | 2024-03-26 | Modernatx, Inc. | Polynucleotides encoding phenylalanine hydroxylase for the treatment of phenylketonuria |
| US11802146B2 (en) | 2018-01-05 | 2023-10-31 | Modernatx, Inc. | Polynucleotides encoding anti-chikungunya virus antibodies |
| KR102056144B1 (ko) | 2018-03-08 | 2019-12-16 | 주식회사 파마리서치프로덕트 | Dna 단편 혼합물이 고농도로 함유된 유동성을 갖는 액제 조성물 및 이의 제조방법 |
| US11566246B2 (en) | 2018-04-12 | 2023-01-31 | Mina Therapeutics Limited | SIRT1-saRNA compositions and methods of use |
| EP3796893A1 (en) | 2018-05-23 | 2021-03-31 | Modernatx, Inc. | Delivery of dna |
| US20220184185A1 (en) | 2018-07-25 | 2022-06-16 | Modernatx, Inc. | Mrna based enzyme replacement therapy combined with a pharmacological chaperone for the treatment of lysosomal storage disorders |
| EP3833762A4 (en) | 2018-08-09 | 2022-09-28 | Verseau Therapeutics, Inc. | Oligonucleotide compositions for targeting ccr2 and csf1r and uses thereof |
| US20220110966A1 (en) | 2018-09-02 | 2022-04-14 | Modernatx, Inc. | Polynucleotides encoding very long-chain acyl-coa dehydrogenase for the treatment of very long-chain acyl-coa dehydrogenase deficiency |
| MA53608A (fr) | 2018-09-13 | 2021-07-21 | Modernatx Inc | Polynucléotides codant pour les sous-unités e1-alpha, e1-beta et e2 du complexe alpha-cétoacide déshydrogénase à chaîne ramifiée pour le traitement de la leucinose |
| WO2020056147A2 (en) | 2018-09-13 | 2020-03-19 | Modernatx, Inc. | Polynucleotides encoding glucose-6-phosphatase for the treatment of glycogen storage disease |
| CA3112398A1 (en) | 2018-09-14 | 2020-03-19 | Modernatx, Inc. | Polynucleotides encoding uridine diphosphate glycosyltransferase 1 family, polypeptide a1 for the treatment of crigler-najjar syndrome |
| EP4509118A3 (en) | 2018-09-19 | 2025-05-14 | ModernaTX, Inc. | High-purity peg lipids and uses thereof |
| US12263248B2 (en) | 2018-09-19 | 2025-04-01 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| CA3113025A1 (en) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Peg lipids and uses thereof |
| US12090235B2 (en) | 2018-09-20 | 2024-09-17 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| US20220152225A1 (en) | 2018-09-27 | 2022-05-19 | Modernatx, Inc. | Polynucleotides encoding arginase 1 for the treatment of arginase deficiency |
| WO2020208361A1 (en) | 2019-04-12 | 2020-10-15 | Mina Therapeutics Limited | Sirt1-sarna compositions and methods of use |
| EP3965797A1 (en) | 2019-05-08 | 2022-03-16 | AstraZeneca AB | Compositions for skin and wounds and methods of use thereof |
| CA3154618A1 (en) | 2019-09-19 | 2021-03-25 | Modernatx, Inc. | Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents |
| US20230235298A1 (en) | 2020-06-01 | 2023-07-27 | Modernatx, Inc. | Phenylalanine hydroxylase variants and uses thereof |
| JPWO2022075460A1 (enExample) * | 2020-10-09 | 2022-04-14 | ||
| AU2021377895A1 (en) | 2020-11-13 | 2023-06-15 | Modernatx, Inc. | Polynucleotides encoding cystic fibrosis transmembrane conductance regulator for the treatment of cystic fibrosis |
| US11524023B2 (en) | 2021-02-19 | 2022-12-13 | Modernatx, Inc. | Lipid nanoparticle compositions and methods of formulating the same |
| US20240207374A1 (en) | 2021-03-24 | 2024-06-27 | Modernatx, Inc. | Lipid nanoparticles containing polynucleotides encoding glucose-6-phosphatase and uses thereof |
| JP2024512026A (ja) | 2021-03-24 | 2024-03-18 | モデルナティエックス インコーポレイテッド | オルニチントランスカルバミラーゼ欠損症の治療を目的とした脂質ナノ粒子及びオルニチントランスカルバミラーゼをコードするポリヌクレオチド |
| WO2022204380A1 (en) | 2021-03-24 | 2022-09-29 | Modernatx, Inc. | Lipid nanoparticles containing polynucleotides encoding propionyl-coa carboxylase alpha and beta subunits and uses thereof |
| WO2022204369A1 (en) | 2021-03-24 | 2022-09-29 | Modernatx, Inc. | Polynucleotides encoding methylmalonyl-coa mutase for the treatment of methylmalonic acidemia |
| WO2022204390A1 (en) | 2021-03-24 | 2022-09-29 | Modernatx, Inc. | Lipid nanoparticles containing polynucleotides encoding phenylalanine hydroxylase and uses thereof |
| EP4314292A1 (en) | 2021-03-26 | 2024-02-07 | MiNA Therapeutics Limited | Tmem173 sarna compositions and methods of use |
| EP4355882A2 (en) | 2021-06-15 | 2024-04-24 | Modernatx, Inc. | Engineered polynucleotides for cell-type or microenvironment-specific expression |
| US20240376445A1 (en) | 2021-06-22 | 2024-11-14 | Modernatx, Inc. | Polynucleotides encoding uridine diphosphate glycosyltransferase 1 family, polypeptide a1 for the treatment of crigler-najjar syndrome |
| US20250017867A1 (en) | 2021-10-01 | 2025-01-16 | Modernatx, Inc. | Polynucleotides encoding relaxin for the treatment of fibrosis and/or cardiovascular disease |
| WO2023099884A1 (en) | 2021-12-01 | 2023-06-08 | Mina Therapeutics Limited | Pax6 sarna compositions and methods of use |
| KR20230096311A (ko) * | 2021-12-23 | 2023-06-30 | 주식회사 삼양홀딩스 | 약물의 폐 전달용 나노입자 조성물 |
| KR102852074B1 (ko) * | 2021-12-23 | 2025-08-28 | 주식회사 삼양홀딩스 | 약물 전달용 지질 및 이를 포함하는 나노입자, 및 이 나노입자를 포함하는 약물 전달용 조성물 |
| WO2023170435A1 (en) | 2022-03-07 | 2023-09-14 | Mina Therapeutics Limited | Il10 sarna compositions and methods of use |
| WO2023183909A2 (en) | 2022-03-25 | 2023-09-28 | Modernatx, Inc. | Polynucleotides encoding fanconi anemia, complementation group proteins for the treatment of fanconi anemia |
| TW202412818A (zh) | 2022-07-26 | 2024-04-01 | 美商現代公司 | 用於暫時控制表現之經工程化多核苷酸 |
| CA3264851A1 (en) * | 2022-08-26 | 2024-02-29 | Renagade Therapeutics Man Inc | PEGYLATED LIPID COMPOUNDS AND THEIR METHODS OF USE |
| EP4634388A1 (en) | 2022-12-14 | 2025-10-22 | Providence Therapeutics Holdings Inc. | Compositions and methods for infectious diseases |
| WO2024134199A1 (en) | 2022-12-22 | 2024-06-27 | Mina Therapeutics Limited | Chemically modified sarna compositions and methods of use |
| WO2024197033A1 (en) | 2023-03-21 | 2024-09-26 | Modernatx, Inc. | Polynucleotides encoding relaxin for the treatment of heart failure |
| WO2024229321A1 (en) | 2023-05-03 | 2024-11-07 | Modernatx, Inc. | Polynucleotides encoding cystic fibrosis transmembrane conductance regulator for the treatment of cystic fibrosis |
| WO2025072482A1 (en) | 2023-09-27 | 2025-04-03 | Modernatx, Inc. | Immunoglobulin a protease polypeptides, polynucleotides, and uses thereof |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2580880A (en) | 1942-03-27 | 1952-01-01 | Nat Aluminate Corp | Prevention of foaming in steam generation |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| WO1989008098A2 (en) | 1988-02-19 | 1989-09-08 | The Upjohn Company | Lipophilic polyamines useful for treating hypercholesterolemia |
| JP2610752B2 (ja) * | 1992-07-02 | 1997-05-14 | 花王株式会社 | 新規ジアミドアミン及びその製造法 |
| JPH06345704A (ja) | 1993-06-04 | 1994-12-20 | Lion Corp | 新規なジアミドアミン化合物、その中間体及びその製造方法と柔軟剤 |
| JP3626187B2 (ja) | 1993-06-07 | 2005-03-02 | バイカル インコーポレイテッド | 遺伝子治療に適するプラスミド |
| JPH0718569A (ja) * | 1993-06-29 | 1995-01-20 | Lion Corp | 柔軟剤組成物 |
| JPH0718571A (ja) * | 1993-06-29 | 1995-01-20 | Lion Corp | 柔軟剤組成物 |
| DE4425857A1 (de) * | 1994-07-07 | 1996-01-11 | Schering Ag | Kaskaden-Polymer-Komplexe, Verfahren zur ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
| US5962428A (en) | 1995-03-30 | 1999-10-05 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| JPH101869A (ja) | 1996-06-12 | 1998-01-06 | Lion Corp | 液体柔軟剤組成物 |
| ATE318143T1 (de) * | 1996-10-25 | 2006-03-15 | Gilead Sciences Inc | Gefaesszellen wachstumsfaktor (vegf) nukleinsaureligand-komplexe |
| KR20010015856A (ko) * | 1997-12-12 | 2001-02-26 | 마크로메드 인코퍼레이션 | 단백질 변성용으로 헤테로 작용기를 가진 별 모양의폴리(에틸렌글리콜) |
| AUPP249298A0 (en) | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
| US6656498B1 (en) * | 1998-11-25 | 2003-12-02 | Vanderbilt University | Cationic liposomes for gene transfer |
| US20030235916A1 (en) * | 2002-06-14 | 2003-12-25 | Monahan Sean D. | Novel methods for the delivery of polynucleotides to cells |
| SG190613A1 (en) * | 2003-07-16 | 2013-06-28 | Protiva Biotherapeutics Inc | Lipid encapsulated interfering rna |
| EP1664316B1 (en) * | 2003-09-15 | 2012-08-29 | Protiva Biotherapeutics Inc. | Polyethyleneglycol-modified lipid compounds and uses thereof |
| US20050095280A1 (en) * | 2003-10-15 | 2005-05-05 | Michalakis Savva | Single-component pH-sensitive liposomes of reduced solid-to-liquid phase transition temperatures |
| US7846972B2 (en) * | 2004-11-02 | 2010-12-07 | The New Industrial Research Organization | Multimeric oleamide derivative having connexin-26 inhibiting potency and use thereof in cancer therapy, etc |
| CA2602128C (en) * | 2005-04-15 | 2012-08-07 | The Procter & Gamble Company | Cleaning compositions with alkoxylated polyalkylenimines |
| EP1776943B1 (en) * | 2005-10-20 | 2011-12-14 | Dentsply DeTrey GmbH | Dental adhesive |
| CA2927045A1 (en) * | 2006-10-03 | 2008-04-10 | Muthiah Manoharan | Lipid containing formulations |
| EP1955712A1 (en) * | 2007-02-09 | 2008-08-13 | Scil proteins GmbH | Multimeric conjugate |
| CN102438978B (zh) | 2009-03-20 | 2017-02-22 | Clsn实验室股份有限公司 | 聚胺衍生物 |
-
2010
- 2010-03-19 CN CN201080022046.3A patent/CN102438978B/zh active Active
- 2010-03-19 US US12/727,987 patent/US8460696B2/en active Active
- 2010-03-19 CA CA2755963A patent/CA2755963C/en active Active
- 2010-03-19 ES ES10709947T patent/ES2931174T3/es active Active
- 2010-03-19 CN CN201510146197.4A patent/CN104922676B/zh active Active
- 2010-03-19 KR KR1020177033391A patent/KR101906392B1/ko active Active
- 2010-03-19 AU AU2010226434A patent/AU2010226434A1/en not_active Abandoned
- 2010-03-19 EP EP10709947.5A patent/EP2414322B1/en active Active
- 2010-03-19 WO PCT/US2010/028000 patent/WO2010108108A2/en not_active Ceased
- 2010-03-19 KR KR1020117024770A patent/KR101800833B1/ko not_active Expired - Fee Related
- 2010-03-19 JP JP2012500998A patent/JP5782602B2/ja active Active
- 2010-03-19 PT PT107099475T patent/PT2414322T/pt unknown
-
2013
- 2013-03-08 US US13/790,980 patent/US8900621B2/en active Active
- 2013-03-08 US US13/791,102 patent/US8932638B2/en active Active
-
2014
- 2014-12-18 US US14/575,555 patent/US9254334B2/en active Active
-
2015
- 2015-02-02 JP JP2015018143A patent/JP6190401B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012521358A5 (enExample) | ||
| Haussecker | Current issues of RNAi therapeutics delivery and development | |
| US20190038557A1 (en) | Means for lung specific delivery | |
| Merkel et al. | Nonviral siRNA delivery to the lung: Investigation of PEG− PEI polyplexes and their in vivo performance | |
| Hasan et al. | Delivery of multiple siRNAs using lipid-coated PLGA nanoparticles for treatment of prostate cancer | |
| Vicentini et al. | Delivery systems and local administration routes for therapeutic siRNA | |
| Carmona et al. | Controlling HBV replication in vivo by intravenous administration of triggered PEGylated siRNA-nanoparticles | |
| US20070218122A1 (en) | siRNA silencing of influenza virus gene expression | |
| US10030243B2 (en) | Nanoparticle type oligonucleotide structure having high efficiency and method for preparing same | |
| WO2008118013A3 (en) | Targeted intracellular delivery of antiviral agents | |
| JP2021525508A (ja) | 核酸治療薬のための調節可能な共カップリングポリペプチドナノ粒子送達系の組成物および方法 | |
| Li et al. | Co-delivery of dexamethasone and a microRNA-155 inhibitor using dendrimer-entrapped gold nanoparticles for acute lung injury therapy | |
| Miller | Delivery of RNAi therapeutics: work in progress | |
| CN116744979A (zh) | 包含甘露糖的脂质纳米颗粒或其应用 | |
| US20160168573A1 (en) | LIVER CANCER RELATED GENES-SPECIFIC siRNA, DOUBLE-STRANDED OLIGO RNA MOLECULES COMPRISING THE siRNA, AND COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING THE SAME | |
| Dong et al. | Inhalable siRNA targeting IL-11 nanoparticles significantly inhibit bleomycin-induced pulmonary fibrosis | |
| JPWO2020023655A5 (enExample) | ||
| US12016930B2 (en) | Skin-permeating carrier containing nucleic acid complex and use thereof | |
| Li et al. | Combinatorial synthesis and high-throughput screening of alkyl amines for nonviral gene delivery | |
| JP2018512858A (ja) | 癌治療のためのヒト抗原Ｒ発現のｓｉＲＮＡ阻害 | |
| Paul et al. | The promising therapeutic potential of oligonucleotides for pulmonary fibrotic diseases | |
| JP2019523302A5 (enExample) | ||
| Wang et al. | A self-assembled peptide nucleic acid–microRNA nanocomplex for dual modulation of cancer-related microRNAs | |
| CN115176006A (zh) | 用于肝癌治疗的rna纳米颗粒 | |
| Mansouri et al. | The Fomivirsen, Patisiran, and Givosiran Odyssey: How the Success Stories May Pave the Way for Future Clinical Translation of Nucleic Acid Drugs |