JP2012521207A5 - - Google Patents
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- Publication number
- JP2012521207A5 JP2012521207A5 JP2012501286A JP2012501286A JP2012521207A5 JP 2012521207 A5 JP2012521207 A5 JP 2012521207A5 JP 2012501286 A JP2012501286 A JP 2012501286A JP 2012501286 A JP2012501286 A JP 2012501286A JP 2012521207 A5 JP2012521207 A5 JP 2012521207A5
- Authority
- JP
- Japan
- Prior art keywords
- bordetella
- polypeptide
- seq
- sequence
- cyaa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 32
- 108090000765 processed proteins & peptides Proteins 0.000 claims 32
- 102000004196 processed proteins & peptides Human genes 0.000 claims 32
- 241000588780 Bordetella parapertussis Species 0.000 claims 12
- 241000588779 Bordetella bronchiseptica Species 0.000 claims 9
- 241001477981 Bordetella hinzii Species 0.000 claims 9
- 241000588832 Bordetella pertussis Species 0.000 claims 9
- 238000006467 substitution reaction Methods 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 102000030621 adenylate cyclase Human genes 0.000 claims 7
- 108060000200 adenylate cyclase Proteins 0.000 claims 7
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 7
- 239000012634 fragment Substances 0.000 claims 7
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 7
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 claims 7
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 7
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 230000028993 immune response Effects 0.000 claims 6
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 5
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 claims 5
- 102100022338 Integrin alpha-M Human genes 0.000 claims 5
- 102100025390 Integrin beta-2 Human genes 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 241000588807 Bordetella Species 0.000 claims 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 238000003780 insertion Methods 0.000 claims 3
- 230000037431 insertion Effects 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- 208000035473 Communicable disease Diseases 0.000 claims 2
- 208000031888 Mycoses Diseases 0.000 claims 2
- 208000030852 Parasitic disease Diseases 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000003071 parasitic effect Effects 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 235000018102 proteins Nutrition 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000001177 retroviral effect Effects 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 108010016626 Dipeptides Proteins 0.000 claims 1
- 241000991587 Enterovirus C Species 0.000 claims 1
- 241000725303 Human immunodeficiency virus Species 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 210000003161 choroid Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09155929.4A EP2233569B1 (en) | 2009-03-23 | 2009-03-23 | Mutant CyaA polypeptides and polypeptide derivatives suitable for the delivery of immunogenic molecules into a cell |
| EP09155929.4 | 2009-03-23 | ||
| US12/409,324 | 2009-03-23 | ||
| US12/409,324 US8017132B2 (en) | 2009-03-23 | 2009-03-23 | Mutant CyaA polypeptides and polypeptide derivatives suitable for the delivery of immunogenic molecules into a cell |
| PCT/EP2010/053795 WO2010136231A1 (en) | 2009-03-23 | 2010-03-23 | MUTANT CyaA POLYPEPTIDES AND POLYPEPTIDE DERIVATIVES SUITABLE FOR THE DELIVERY OF IMMUNOGENIC MOLECULES INTO A CELL |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012521207A JP2012521207A (ja) | 2012-09-13 |
| JP2012521207A5 true JP2012521207A5 (OSRAM) | 2013-05-09 |
| JP5770711B2 JP5770711B2 (ja) | 2015-08-26 |
Family
ID=42224889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012501286A Expired - Fee Related JP5770711B2 (ja) | 2009-03-23 | 2010-03-23 | 細胞中への免疫原性分子のデリバリーに適したＣｙａＡポリペプチド突然変異体及びポリペプチド誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP2411513B1 (OSRAM) |
| JP (1) | JP5770711B2 (OSRAM) |
| CN (2) | CN102439146A (OSRAM) |
| CA (1) | CA2755694A1 (OSRAM) |
| ES (1) | ES2612945T3 (OSRAM) |
| RU (1) | RU2585216C2 (OSRAM) |
| WO (1) | WO2010136231A1 (OSRAM) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2690172A1 (en) * | 2012-07-23 | 2014-01-29 | Genticel | CYAA-based chimeric proteins comprising a heterologous polypeptide and their uses in the induction of immune responses |
| EP2975120A1 (en) | 2014-07-17 | 2016-01-20 | Institut Pasteur | Monomeric and functional adenylate cyclase CyaA toxin |
| WO2018091613A1 (en) * | 2016-11-17 | 2018-05-24 | Ecole Nationale Vétérinaire de Toulouse | Immunogenic and vaccine compositions for use against bordetella bronchiseptica infection |
| EP3323426A1 (en) * | 2016-11-17 | 2018-05-23 | Ecole Nationale Vétérinaire de Toulouse | Immunogenic and vaccine compositions for use against bordetella bronchiseptica infection |
| EP3381931A1 (en) * | 2017-03-29 | 2018-10-03 | Mikrobiologicky ustav AV CR, v.v.i. | Adenylate cyclase toxoid with reduced cytolytic activity |
| DE102018215551A1 (de) | 2018-09-12 | 2020-03-12 | Virolutions Biotech Gmbh | Verfahren zur Herstellung eines antitumoralen Arenavirus sowie Arenavirusmutanten |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL86583A0 (en) * | 1987-06-04 | 1988-11-15 | Molecular Eng Ass | Vaccine containing a derivative of a microbe and method for the production thereof |
| FR2638169B1 (fr) * | 1988-10-25 | 1991-01-11 | Pasteur Institut | Derives d'adenyl cyclase et leurs utilisations biologiques |
| PT637335E (pt) | 1992-04-21 | 2007-10-31 | Pasteur Institut | Mutantes recombinantes para induzir respostas imunitárias específicas |
| FR2805544B1 (fr) * | 2000-02-28 | 2004-07-16 | Pasteur Institut | Adenylcyclase recombinante et procede de tri de molecules a activite proteolytique utilisant cette adenylcyclase |
| ATE438409T1 (de) * | 2000-09-15 | 2009-08-15 | Pasteur Institut | Proteinhaltigen vektoren zur einführung von moleküle in cd11b exprimirende zellen |
| EP1489092A1 (en) * | 2003-06-18 | 2004-12-22 | Institut Pasteur | Modified Bordetella adenylate cyclase comprising or lacking CD11b/CD18 interaction domain and uses thereof |
| WO2005035557A2 (en) * | 2003-10-14 | 2005-04-21 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin | Adenylate cyclase in the treatment and/or prophylaxis of immune-medicated disease |
| ES2293178T3 (es) * | 2004-03-18 | 2008-03-16 | Institut Pasteur | Proteina recombinante que contiene epitopos del papilomavirus humano insertados en un proteina adenilato ciclasa o un fragmento de la misma y usos terapeuticos de la misma. |
-
2010
- 2010-03-23 CN CN2010800225471A patent/CN102439146A/zh active Pending
- 2010-03-23 RU RU2011138706/10A patent/RU2585216C2/ru not_active IP Right Cessation
- 2010-03-23 CA CA2755694A patent/CA2755694A1/en not_active Abandoned
- 2010-03-23 JP JP2012501286A patent/JP5770711B2/ja not_active Expired - Fee Related
- 2010-03-23 WO PCT/EP2010/053795 patent/WO2010136231A1/en not_active Ceased
- 2010-03-23 ES ES10713874.5T patent/ES2612945T3/es active Active
- 2010-03-23 EP EP10713874.5A patent/EP2411513B1/en active Active
- 2010-03-23 CN CN201510983155.6A patent/CN105602924A/zh active Pending
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