JP2012520829A - チロフィバンの経皮用医薬製剤および投与 - Google Patents

チロフィバンの経皮用医薬製剤および投与 Download PDF

Info

Publication number
JP2012520829A
JP2012520829A JP2012500012A JP2012500012A JP2012520829A JP 2012520829 A JP2012520829 A JP 2012520829A JP 2012500012 A JP2012500012 A JP 2012500012A JP 2012500012 A JP2012500012 A JP 2012500012A JP 2012520829 A JP2012520829 A JP 2012520829A
Authority
JP
Japan
Prior art keywords
tirofiban
delivery system
transdermal
drug delivery
dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012500012A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012520829A5 (cg-RX-API-DMAC10.html
Inventor
トマス、ジョージ・ロビー
レイマー、ドーソン・ジェームズ
フリーセン、アルバート・デー．
Original Assignee
メディキュア・インターナショナル・インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by メディキュア・インターナショナル・インコーポレーテッド filed Critical メディキュア・インターナショナル・インコーポレーテッド
Publication of JP2012520829A publication Critical patent/JP2012520829A/ja
Publication of JP2012520829A5 publication Critical patent/JP2012520829A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer
    • A61F13/0253—Adhesive bandages or dressings characterised by the skin-adhering layer characterized by the adhesive material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4515—Non condensed piperidines, e.g. piperocaine having a butyrophenone group in position 1, e.g. haloperidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2012500012A 2009-03-18 2010-03-18 チロフィバンの経皮用医薬製剤および投与 Pending JP2012520829A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US16113209P 2009-03-18 2009-03-18
US61/161,132 2009-03-18
US24002109P 2009-09-04 2009-09-04
US61/240,021 2009-09-04
US25968309P 2009-11-10 2009-11-10
US61/259,683 2009-11-10
PCT/CA2010/000373 WO2010105342A1 (en) 2009-03-18 2010-03-18 Transdermal pharmaceutical preparation and administration of tirofiban

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015095030A Division JP2015187115A (ja) 2009-03-18 2015-05-07 チロフィバンの経皮用医薬製剤および投与

Publications (2)

Publication Number Publication Date
JP2012520829A true JP2012520829A (ja) 2012-09-10
JP2012520829A5 JP2012520829A5 (cg-RX-API-DMAC10.html) 2013-02-07

Family

ID=42739074

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2012500012A Pending JP2012520829A (ja) 2009-03-18 2010-03-18 チロフィバンの経皮用医薬製剤および投与
JP2015095030A Pending JP2015187115A (ja) 2009-03-18 2015-05-07 チロフィバンの経皮用医薬製剤および投与

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015095030A Pending JP2015187115A (ja) 2009-03-18 2015-05-07 チロフィバンの経皮用医薬製剤および投与

Country Status (9)

Country Link
US (2) US20120029447A1 (cg-RX-API-DMAC10.html)
EP (1) EP2408440B1 (cg-RX-API-DMAC10.html)
JP (2) JP2012520829A (cg-RX-API-DMAC10.html)
CN (2) CN102427806B (cg-RX-API-DMAC10.html)
AU (1) AU2010225405B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI1009313A2 (cg-RX-API-DMAC10.html)
CA (1) CA2755569A1 (cg-RX-API-DMAC10.html)
RU (1) RU2539398C2 (cg-RX-API-DMAC10.html)
WO (1) WO2010105342A1 (cg-RX-API-DMAC10.html)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114984330A (zh) * 2022-06-07 2022-09-02 新乡医学院 一种兼具抗凝与抗钙化的脱细胞血管支架及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004502725A (ja) * 2000-07-12 2004-01-29 ヘクサル・アクチェンゲゼルシャフト 高分散シリカを用いた経皮治療システム
JP2005532306A (ja) * 2002-05-06 2005-10-27 メルク　エンド　カムパニー　インコーポレーテッド 血小板凝集を阻害する方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5271940A (en) * 1989-09-14 1993-12-21 Cygnus Therapeutic Systems Transdermal delivery device having delayed onset
NZ239846A (en) * 1990-09-27 1994-11-25 Merck & Co Inc Sulphonamide derivatives and pharmaceutical compositions thereof
US6117842A (en) * 1998-03-09 2000-09-12 Merck & Co., Inc. Fibrinogen receptor antagonists
DE10060852A1 (de) * 2000-12-06 2002-06-20 Hexal Ag Absorptionsmittel und Kanalbildner enthaltende wirkstoffundurchlässige Deckschicht oder abziehbare Schutzschicht eines transdermalen therapeutischen Systems
US20040072750A1 (en) * 2001-05-03 2004-04-15 David Phillips Compounds and methods for the modulation of CD154
US20050019742A1 (en) * 2002-10-15 2005-01-27 Jennings Lisa K. Methods for assessment of platelet aggregation
AR049847A1 (es) * 2004-07-29 2006-09-06 Merck & Co Inc Inhibidores de los canales de potasio

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004502725A (ja) * 2000-07-12 2004-01-29 ヘクサル・アクチェンゲゼルシャフト 高分散シリカを用いた経皮治療システム
JP2005532306A (ja) * 2002-05-06 2005-10-27 メルク　エンド　カムパニー　インコーポレーテッド 血小板凝集を阻害する方法

Also Published As

Publication number Publication date
CN102427806A (zh) 2012-04-25
CN102427806B (zh) 2015-11-25
AU2010225405B2 (en) 2014-10-23
BRPI1009313A2 (pt) 2018-01-30
US20140100537A1 (en) 2014-04-10
WO2010105342A1 (en) 2010-09-23
CN105311003A (zh) 2016-02-10
EP2408440B1 (en) 2016-05-11
AU2010225405A1 (en) 2011-11-10
RU2539398C2 (ru) 2015-01-20
US20120029447A1 (en) 2012-02-02
RU2011138305A (ru) 2013-03-27
EP2408440A1 (en) 2012-01-25
EP2408440A4 (en) 2013-10-09
JP2015187115A (ja) 2015-10-29
CA2755569A1 (en) 2010-09-23

Similar Documents

Publication Publication Date Title
CN105431175B (zh) 透皮递送系统
JP2020500882A (ja) トレプロスチニルおよびその塩の皮膚投与および経皮投与方法
CN101146523B (zh) 透皮给药系统
US20150126481A1 (en) Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same
Kumar et al. Transdermal drug delivery systems
JP4624978B2 (ja) 血小板血症治療用製剤および治療方法
Jose et al. Recent progress of transdermal drug delivery systems for biomedical applications
JP2015187115A (ja) チロフィバンの経皮用医薬製剤および投与
Chavan et al. A simple glance at the transdermal drug delivery system
JP2010514789A (ja) 副腎皮質ステロイド投与のための経皮的方法及びパッチ
US7323191B2 (en) Transdermal warfarin system
Macit et al. Steam bath, vibration, and thermal ablation administrations augment the release of tramadol HCl from transdermal patch and enhance the plasma concentration in rats
Nikitha et al. Advancements in Transdermal Drug Delivery System
Kailash et al. Transdermal delivery: A recent trend in treatment of chronic diseases
CN115666537B (zh) 缓释医用硬膏剂
US20230390215A1 (en) Systems, devices, and formulations for time-phased histamine delivery
JP2012520829A5 (cg-RX-API-DMAC10.html)
Huang et al. An Overview of the Transdermal Drug Delivery System
WO2007121949A1 (en) Transdermal delivery system comprising sufentanil and its analogues
Magar et al. A Review Article on Drug Selection Criteria for TDDS
Karthikeyan et al. TRANSDERMAL DRUG DELIVERY SYSTEM-A NON INVASIVE WAY OF DRUG ADMINISTRATION
JP2019034905A (ja) デヒドロ酢酸含有経皮吸収製剤

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121211

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20130313

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140415

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140715

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140723

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20141015

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20150106