CN102427806B - 替罗非班的透皮药物制剂和给药 - Google Patents

替罗非班的透皮药物制剂和给药 Download PDF

Info

Publication number
CN102427806B
CN102427806B CN201080021932.4A CN201080021932A CN102427806B CN 102427806 B CN102427806 B CN 102427806B CN 201080021932 A CN201080021932 A CN 201080021932A CN 102427806 B CN102427806 B CN 102427806B
Authority
CN
China
Prior art keywords
tirofiban
transdermal
patch
patient
platelet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201080021932.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN102427806A (zh
Inventor
乔治·罗比·托马斯
道森·詹姆斯·赖梅
阿尔伯特·D·弗里森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medicure International Inc
Original Assignee
Medicure International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medicure International Inc filed Critical Medicure International Inc
Priority to CN201510756414.1A priority Critical patent/CN105311003A/zh
Publication of CN102427806A publication Critical patent/CN102427806A/zh
Application granted granted Critical
Publication of CN102427806B publication Critical patent/CN102427806B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer
    • A61F13/0253—Adhesive bandages or dressings characterised by the skin-adhering layer characterized by the adhesive material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4515—Non condensed piperidines, e.g. piperocaine having a butyrophenone group in position 1, e.g. haloperidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201080021932.4A 2009-03-18 2010-03-18 替罗非班的透皮药物制剂和给药 Expired - Fee Related CN102427806B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510756414.1A CN105311003A (zh) 2009-03-18 2010-03-18 替罗非班的透皮药物制剂和给药

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US16113209P 2009-03-18 2009-03-18
US61/161,132 2009-03-18
US24002109P 2009-09-04 2009-09-04
US61/240,021 2009-09-04
US25968309P 2009-11-10 2009-11-10
US61/259,683 2009-11-10
PCT/CA2010/000373 WO2010105342A1 (en) 2009-03-18 2010-03-18 Transdermal pharmaceutical preparation and administration of tirofiban

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201510756414.1A Division CN105311003A (zh) 2009-03-18 2010-03-18 替罗非班的透皮药物制剂和给药

Publications (2)

Publication Number Publication Date
CN102427806A CN102427806A (zh) 2012-04-25
CN102427806B true CN102427806B (zh) 2015-11-25

Family

ID=42739074

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201080021932.4A Expired - Fee Related CN102427806B (zh) 2009-03-18 2010-03-18 替罗非班的透皮药物制剂和给药
CN201510756414.1A Pending CN105311003A (zh) 2009-03-18 2010-03-18 替罗非班的透皮药物制剂和给药

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201510756414.1A Pending CN105311003A (zh) 2009-03-18 2010-03-18 替罗非班的透皮药物制剂和给药

Country Status (9)

Country Link
US (2) US20120029447A1 (cg-RX-API-DMAC10.html)
EP (1) EP2408440B1 (cg-RX-API-DMAC10.html)
JP (2) JP2012520829A (cg-RX-API-DMAC10.html)
CN (2) CN102427806B (cg-RX-API-DMAC10.html)
AU (1) AU2010225405B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI1009313A2 (cg-RX-API-DMAC10.html)
CA (1) CA2755569A1 (cg-RX-API-DMAC10.html)
RU (1) RU2539398C2 (cg-RX-API-DMAC10.html)
WO (1) WO2010105342A1 (cg-RX-API-DMAC10.html)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114984330A (zh) * 2022-06-07 2022-09-02 新乡医学院 一种兼具抗凝与抗钙化的脱细胞血管支架及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5271940A (en) * 1989-09-14 1993-12-21 Cygnus Therapeutic Systems Transdermal delivery device having delayed onset
NZ239846A (en) * 1990-09-27 1994-11-25 Merck & Co Inc Sulphonamide derivatives and pharmaceutical compositions thereof
US6117842A (en) * 1998-03-09 2000-09-12 Merck & Co., Inc. Fibrinogen receptor antagonists
DE10033853A1 (de) * 2000-07-12 2002-01-31 Hexal Ag Transdermales therapeutisches System mit hochdispersem Siliziumdioxid
DE10060852A1 (de) * 2000-12-06 2002-06-20 Hexal Ag Absorptionsmittel und Kanalbildner enthaltende wirkstoffundurchlässige Deckschicht oder abziehbare Schutzschicht eines transdermalen therapeutischen Systems
US20040072750A1 (en) * 2001-05-03 2004-04-15 David Phillips Compounds and methods for the modulation of CD154
US6770660B2 (en) * 2002-05-06 2004-08-03 Artery Llc Method for inhibiting platelet aggregation
US20050019742A1 (en) * 2002-10-15 2005-01-27 Jennings Lisa K. Methods for assessment of platelet aggregation
AR049847A1 (es) * 2004-07-29 2006-09-06 Merck & Co Inc Inhibidores de los canales de potasio

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Tirofiban (Aggrastatt)";Jacquelynn J. Cook et. al.;《Cardiovascular Drug Reviews》;19990930;第17卷(第3期);199-224 *

Also Published As

Publication number Publication date
CN102427806A (zh) 2012-04-25
AU2010225405B2 (en) 2014-10-23
BRPI1009313A2 (pt) 2018-01-30
US20140100537A1 (en) 2014-04-10
WO2010105342A1 (en) 2010-09-23
CN105311003A (zh) 2016-02-10
JP2012520829A (ja) 2012-09-10
EP2408440B1 (en) 2016-05-11
AU2010225405A1 (en) 2011-11-10
RU2539398C2 (ru) 2015-01-20
US20120029447A1 (en) 2012-02-02
RU2011138305A (ru) 2013-03-27
EP2408440A1 (en) 2012-01-25
EP2408440A4 (en) 2013-10-09
JP2015187115A (ja) 2015-10-29
CA2755569A1 (en) 2010-09-23

Similar Documents

Publication Publication Date Title
US5500222A (en) Transdermal administration of oxybutynin
JP6446035B2 (ja) 経皮的デリバリーシステム
EP1814531B1 (en) Transdermal delivery systems
PT1589956E (pt) Granisetron transdérmico
JP4624978B2 (ja) 血小板血症治療用製剤および治療方法
PT1524971E (pt) Sistema melhorado de administração transdérmica
EP1244431A1 (en) Transdermal administration of reboxetine
Mahdiyyah et al. Transdermal Patches: A review of a new drug delivery system approach
Jose et al. Recent progress of transdermal drug delivery systems for biomedical applications
AU2010225405B2 (en) Transdermal pharmaceutical preparation and administration of tirofiban
JP2010514789A (ja) 副腎皮質ステロイド投与のための経皮的方法及びパッチ
Kumar et al. A review on transdermal drug delivery patches
Nikitha et al. Advancements in Transdermal Drug Delivery System
Manogna et al. Development of Medicated Topical Patches in Transdermal drug delivery system
CN117064866B (zh) 一种布瑞哌唑长效透皮贴剂及其制备方法
JPH03157332A (ja) （＋）―（２ｓ，３ｓ）―３―アセトキシ―８―クロロ―５―（２―ジメチルアミノエチル）―２，３―ジヒドロ―２―（４―メトキシフェニル）―１，５―ベンゾチアゼピン―４―（５ｈ）―オンの経皮分配
KR20060052931A (ko) 경피용 와파린-포함 전달 시스템
CN120732863A (zh) 一种特应性皮炎治疗药物及其制备方法和应用
US20220175717A1 (en) Phenprocoumon tts
BChir et al. Transdermal drug delivery in pain management
TARTARATE Advanced Pharmaceutics

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20151125

Termination date: 20170318

CF01 Termination of patent right due to non-payment of annual fee