JP2012519159A - Ｐｄｅ４阻害剤及びｎｓａｉｄを含有する複合薬 - Google Patents
Ｐｄｅ４阻害剤及びｎｓａｉｄを含有する複合薬 Download PDFInfo
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- JP2012519159A JP2012519159A JP2011551464A JP2011551464A JP2012519159A JP 2012519159 A JP2012519159 A JP 2012519159A JP 2011551464 A JP2011551464 A JP 2011551464A JP 2011551464 A JP2011551464 A JP 2011551464A JP 2012519159 A JP2012519159 A JP 2012519159A
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- JP
- Japan
- Prior art keywords
- oxo
- pyrimidin
- dihydro
- thieno
- piperazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| EP09153853.8 | 2009-02-27 | ||
| EP09166127.2 | 2009-07-22 | ||
| EP09166127 | 2009-07-22 | ||
| PCT/EP2010/052077 WO2010097332A1 (de) | 2009-02-27 | 2010-02-18 | Arzneimittelkombinationen enthaltend pde4-inhibitoren und nsaids |
Publications (2)
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| JP2012519159A true JP2012519159A (ja) | 2012-08-23 |
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| EP (1) | EP2400961B1 (enExample) |
| JP (1) | JP2012519159A (enExample) |
| CA (1) | CA2753597A1 (enExample) |
| WO (1) | WO2010097332A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012519160A (ja) * | 2009-02-27 | 2012-08-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｐｄｅ４阻害剤及びｎｓａｉｄを含有する組み合わせ薬 |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1847543A1 (de) | 2006-04-19 | 2007-10-24 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen |
| ATE537175T1 (de) | 2007-10-19 | 2011-12-15 | Boehringer Ingelheim Int | Neue piperazino-dihydrothienopyrimidin-derivate |
| PT2215092E (pt) * | 2007-10-19 | 2012-04-10 | Boehringer Ingelheim Int | Piperidino-di-hidrotienopirimidinas substituídas |
| WO2009050242A2 (de) | 2007-10-19 | 2009-04-23 | Boehringer Ingelheim International Gmbh | Heterocyclus-substituierte piperazino-dihydrothienopyrimidine |
| US7964608B2 (en) | 2008-01-25 | 2011-06-21 | High Point Pharmaceuticals, Llc | Tricyclic compounds as modulators of TNF-α synthesis |
| EP2400961B1 (de) * | 2009-02-27 | 2017-11-22 | Boehringer Ingelheim International GmbH | Arzneimittelkombinationen enthaltend pde4-inhibitoren und nsaids |
| GB2477590A (en) * | 2010-02-05 | 2011-08-10 | Biocopea Ltd | A non-steroidal anti-inflammatory drug (NSAID) formulation comprising a lipid carrier |
| US10695431B2 (en) | 2010-10-29 | 2020-06-30 | Infirst Healthcare Limited | Solid solution compositions and use in cardiovascular disease |
| US11730709B2 (en) | 2010-10-29 | 2023-08-22 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
| US9744132B2 (en) | 2010-10-29 | 2017-08-29 | Infirst Healthcare Limited | Solid solution compositions and use in chronic inflammation |
| US9271950B2 (en) | 2010-10-29 | 2016-03-01 | Infirst Healthcare Limited | Compositions for treating chronic inflammation and inflammatory diseases |
| US8895536B2 (en) | 2010-10-29 | 2014-11-25 | Infirst Healthcare Ltd. | Compositions and methods for treating chronic inflammation and inflammatory diseases |
| US11202831B2 (en) | 2010-10-29 | 2021-12-21 | Infirst Healthcare Limited | Solid solution compositions and use in cardiovascular disease |
| US11224659B2 (en) | 2010-10-29 | 2022-01-18 | Infirst Healthcare Limited | Solid solution compositions and use in severe pain |
| US9737500B2 (en) | 2010-10-29 | 2017-08-22 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
| US9308213B2 (en) | 2010-10-29 | 2016-04-12 | Infirst Healthcare Limited | Solid solution compositions and use in chronic inflammation |
| US9504664B2 (en) | 2010-10-29 | 2016-11-29 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
| US10695432B2 (en) | 2010-10-29 | 2020-06-30 | Infirst Healthcare Limited | Solid solution compositions and use in severe pain |
| US9802954B2 (en) | 2011-08-24 | 2017-10-31 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
| US20130059866A1 (en) | 2011-08-24 | 2013-03-07 | Boehringer Ingelheim International Gmbh | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma |
| IN2015CH01318A (enExample) | 2015-03-18 | 2015-04-10 | Wipro Ltd | |
| WO2019147824A1 (en) | 2018-01-26 | 2019-08-01 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a pde4 inhibitor |
| JP7482866B2 (ja) | 2018-11-19 | 2024-05-14 | ビオラ・セラピューティクス・インコーポレイテッド | 生物学的治療薬による疾患処置方法およびデバイス |
| CN121197633A (zh) | 2019-12-13 | 2025-12-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| IL318673A (en) * | 2022-08-09 | 2025-03-01 | Xizang Haisco Pharmaceutical Co Ltd | PDE4B inhibitor and its use |
| WO2025067168A1 (zh) * | 2023-09-25 | 2025-04-03 | 苏州爱科百发生物医药技术有限公司 | 氮杂稠环类化合物及其制备方法和用途 |
| TW202535412A (zh) * | 2024-02-04 | 2025-09-16 | 大陸商西藏海思科製藥有限公司 | Pde4b抑制劑的晶型及其在醫藥上的用途 |
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| JP2003522142A (ja) * | 2000-02-08 | 2003-07-22 | スミスクライン・ビーチャム・コーポレイション | 炎症性疾患の治療法および治療用組成物 |
| JP2005504077A (ja) * | 2001-09-19 | 2005-02-10 | アルタナ ファルマ アクチエンゲゼルシャフト | 併用剤 |
| JP2008533090A (ja) * | 2005-03-14 | 2008-08-21 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 心血管疾患の防止方法 |
| JP2008536890A (ja) * | 2006-04-19 | 2008-09-11 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 炎症性疾患の治療用新規化合物 |
| JP2012519160A (ja) * | 2009-02-27 | 2012-08-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｐｄｅ４阻害剤及びｎｓａｉｄを含有する組み合わせ薬 |
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| DE3032994A1 (de) | 1980-09-02 | 1982-04-22 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue pyrazino-azepine, deren herstellung und diese sie enthaltende arzneimittel |
| DE4439479A1 (de) | 1994-11-08 | 1996-05-09 | Bocklenberg & Motte Bomoro | Kraftfahrzeug-Türverschluß mit Zentralverriegelungsantrieb |
| EP1847543A1 (de) | 2006-04-19 | 2007-10-24 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen |
| EP2214673B1 (de) | 2007-10-19 | 2012-05-30 | Boehringer Ingelheim International GmbH | Phenyl-substituierte piperazino-dihydrothienopyrimidine |
| WO2009050242A2 (de) | 2007-10-19 | 2009-04-23 | Boehringer Ingelheim International Gmbh | Heterocyclus-substituierte piperazino-dihydrothienopyrimidine |
| EP2400961B1 (de) * | 2009-02-27 | 2017-11-22 | Boehringer Ingelheim International GmbH | Arzneimittelkombinationen enthaltend pde4-inhibitoren und nsaids |
-
2010
- 2010-02-18 EP EP10704367.1A patent/EP2400961B1/de active Active
- 2010-02-18 US US13/201,262 patent/US8592400B2/en active Active
- 2010-02-18 WO PCT/EP2010/052077 patent/WO2010097332A1/de not_active Ceased
- 2010-02-18 CA CA2753597A patent/CA2753597A1/en not_active Abandoned
- 2010-02-18 JP JP2011551464A patent/JP2012519159A/ja active Pending
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2013
- 2013-08-15 US US13/967,448 patent/US8759326B2/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003522142A (ja) * | 2000-02-08 | 2003-07-22 | スミスクライン・ビーチャム・コーポレイション | 炎症性疾患の治療法および治療用組成物 |
| JP2005504077A (ja) * | 2001-09-19 | 2005-02-10 | アルタナ ファルマ アクチエンゲゼルシャフト | 併用剤 |
| JP2008533090A (ja) * | 2005-03-14 | 2008-08-21 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 心血管疾患の防止方法 |
| JP2008536890A (ja) * | 2006-04-19 | 2008-09-11 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 炎症性疾患の治療用新規化合物 |
| JP2012519160A (ja) * | 2009-02-27 | 2012-08-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｐｄｅ４阻害剤及びｎｓａｉｄを含有する組み合わせ薬 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012519160A (ja) * | 2009-02-27 | 2012-08-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｐｄｅ４阻害剤及びｎｓａｉｄを含有する組み合わせ薬 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20120028932A1 (en) | 2012-02-02 |
| CA2753597A1 (en) | 2010-09-02 |
| US8592400B2 (en) | 2013-11-26 |
| WO2010097332A1 (de) | 2010-09-02 |
| US8759326B2 (en) | 2014-06-24 |
| EP2400961B1 (de) | 2017-11-22 |
| US20140031343A1 (en) | 2014-01-30 |
| EP2400961A1 (de) | 2012-01-04 |
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