JP2012519159A5 - - Google Patents
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- Publication number
- JP2012519159A5 JP2012519159A5 JP2011551464A JP2011551464A JP2012519159A5 JP 2012519159 A5 JP2012519159 A5 JP 2012519159A5 JP 2011551464 A JP2011551464 A JP 2011551464A JP 2011551464 A JP2011551464 A JP 2011551464A JP 2012519159 A5 JP2012519159 A5 JP 2012519159A5
- Authority
- JP
- Japan
- Prior art keywords
- oxo
- pyrimidin
- dihydro
- thieno
- piperazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09153853 | 2009-02-27 | ||
| EP09153853.8 | 2009-02-27 | ||
| EP09166127 | 2009-07-22 | ||
| EP09166127.2 | 2009-07-22 | ||
| PCT/EP2010/052077 WO2010097332A1 (de) | 2009-02-27 | 2010-02-18 | Arzneimittelkombinationen enthaltend pde4-inhibitoren und nsaids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012519159A JP2012519159A (ja) | 2012-08-23 |
| JP2012519159A5 true JP2012519159A5 (enExample) | 2013-04-04 |
Family
ID=41820143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011551464A Pending JP2012519159A (ja) | 2009-02-27 | 2010-02-18 | Ｐｄｅ４阻害剤及びｎｓａｉｄを含有する複合薬 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8592400B2 (enExample) |
| EP (1) | EP2400961B1 (enExample) |
| JP (1) | JP2012519159A (enExample) |
| CA (1) | CA2753597A1 (enExample) |
| WO (1) | WO2010097332A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1847543A1 (de) | 2006-04-19 | 2007-10-24 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen |
| RU2500681C2 (ru) | 2007-10-19 | 2013-12-10 | Берингер Ингельхайм Интернациональ Гмбх | Замещенные гетероциклом пиперазинодигидротиенопиримидины |
| SI2610258T1 (sl) * | 2007-10-19 | 2014-12-31 | Boehringer Ingelheim International Gmbh | Substituirani piperidino-dihidrotienopirimidini |
| EP2215093B1 (de) | 2007-10-19 | 2011-12-14 | Boehringer Ingelheim International GmbH | Neue piperazino-dihydrothienopyrimidin-derivate |
| ES2523169T3 (es) | 2008-01-25 | 2014-11-21 | High Point Pharmaceuticals, Llc | Compuestos tricíclicos como moduladores de la síntesis de TNF y como inhibidores de PDE4 |
| JP2012519160A (ja) * | 2009-02-27 | 2012-08-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｐｄｅ４阻害剤及びｎｓａｉｄを含有する組み合わせ薬 |
| WO2010097332A1 (de) * | 2009-02-27 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Arzneimittelkombinationen enthaltend pde4-inhibitoren und nsaids |
| GB2477590A (en) * | 2010-02-05 | 2011-08-10 | Biocopea Ltd | A non-steroidal anti-inflammatory drug (NSAID) formulation comprising a lipid carrier |
| US9308213B2 (en) | 2010-10-29 | 2016-04-12 | Infirst Healthcare Limited | Solid solution compositions and use in chronic inflammation |
| US9504664B2 (en) | 2010-10-29 | 2016-11-29 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
| US9271950B2 (en) | 2010-10-29 | 2016-03-01 | Infirst Healthcare Limited | Compositions for treating chronic inflammation and inflammatory diseases |
| US11730709B2 (en) | 2010-10-29 | 2023-08-22 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
| US8895537B2 (en) | 2010-10-29 | 2014-11-25 | Infirst Healthcare Ltd. | Compositions and methods for treating cardiovascular diseases |
| US11224659B2 (en) | 2010-10-29 | 2022-01-18 | Infirst Healthcare Limited | Solid solution compositions and use in severe pain |
| US9744132B2 (en) | 2010-10-29 | 2017-08-29 | Infirst Healthcare Limited | Solid solution compositions and use in chronic inflammation |
| US10695432B2 (en) | 2010-10-29 | 2020-06-30 | Infirst Healthcare Limited | Solid solution compositions and use in severe pain |
| US11202831B2 (en) | 2010-10-29 | 2021-12-21 | Infirst Healthcare Limited | Solid solution compositions and use in cardiovascular disease |
| US9737500B2 (en) | 2010-10-29 | 2017-08-22 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
| US10695431B2 (en) | 2010-10-29 | 2020-06-30 | Infirst Healthcare Limited | Solid solution compositions and use in cardiovascular disease |
| US20130059866A1 (en) | 2011-08-24 | 2013-03-07 | Boehringer Ingelheim International Gmbh | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma |
| US9802954B2 (en) | 2011-08-24 | 2017-10-31 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
| IN2015CH01318A (enExample) | 2015-03-18 | 2015-04-10 | Wipro Ltd | |
| WO2019147824A1 (en) | 2018-01-26 | 2019-08-01 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a pde4 inhibitor |
| CN113348011B (zh) | 2018-11-19 | 2023-04-18 | 比奥拉治疗股份有限公司 | 用生物治疗剂治疗疾病的方法和装置 |
| CN121197633A (zh) | 2019-12-13 | 2025-12-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| CN113861189A (zh) | 2020-06-29 | 2021-12-31 | Vtv治疗有限责任公司 | 喹啉衍生物，其药学上可接受的盐及其使用方法 |
| US12545676B2 (en) | 2020-07-28 | 2026-02-10 | Vtv Therapeutics Llc | Crystalline form of hydrochloride salt of quinoline derivative |
| JP2025528779A (ja) * | 2022-08-09 | 2025-09-02 | シーザン ハイスーク ファーマシューティカル カンパニー リミテッド | Ｐｄｅ４ｂ阻害剤及びその用途 |
| WO2025067168A1 (zh) * | 2023-09-25 | 2025-04-03 | 苏州爱科百发生物医药技术有限公司 | 氮杂稠环类化合物及其制备方法和用途 |
| WO2025162289A2 (zh) * | 2024-02-04 | 2025-08-07 | 西藏海思科制药有限公司 | 一种pde4b抑制剂的晶型及其在医药上的用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3032994A1 (de) | 1980-09-02 | 1982-04-22 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue pyrazino-azepine, deren herstellung und diese sie enthaltende arzneimittel |
| DE4439479A1 (de) | 1994-11-08 | 1996-05-09 | Bocklenberg & Motte Bomoro | Kraftfahrzeug-Türverschluß mit Zentralverriegelungsantrieb |
| IL150963A0 (en) * | 2000-02-08 | 2003-02-12 | Smithkline Beecham Corp | Method and compositions for treating an inflammatory disease |
| IL160271A0 (en) | 2001-09-19 | 2004-07-25 | Altana Pharma Ag | Pharmaceutical compositions containing pde4-inhibitors and nsaid |
| US20080171746A1 (en) * | 2005-03-14 | 2008-07-17 | Thomas Klein | Method for Preventing Cardiovascular Diseases |
| EP1847543A1 (de) | 2006-04-19 | 2007-10-24 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen |
| HRP20090395T1 (hr) | 2006-04-19 | 2009-08-31 | Boehringer Ingelheim International Gmbh | Dihidrotienpirimidini za liječenje upalnih bolesti |
| RU2500681C2 (ru) * | 2007-10-19 | 2013-12-10 | Берингер Ингельхайм Интернациональ Гмбх | Замещенные гетероциклом пиперазинодигидротиенопиримидины |
| CA2702447A1 (en) | 2007-10-19 | 2009-04-30 | Boehringer Ingelheim International Gmbh | New phenyl-substituted piperazino-dihydrothienopyrimidines |
| JP2012519160A (ja) * | 2009-02-27 | 2012-08-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｐｄｅ４阻害剤及びｎｓａｉｄを含有する組み合わせ薬 |
| WO2010097332A1 (de) * | 2009-02-27 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Arzneimittelkombinationen enthaltend pde4-inhibitoren und nsaids |
-
2010
- 2010-02-18 WO PCT/EP2010/052077 patent/WO2010097332A1/de not_active Ceased
- 2010-02-18 CA CA2753597A patent/CA2753597A1/en not_active Abandoned
- 2010-02-18 US US13/201,262 patent/US8592400B2/en active Active
- 2010-02-18 EP EP10704367.1A patent/EP2400961B1/de active Active
- 2010-02-18 JP JP2011551464A patent/JP2012519159A/ja active Pending
-
2013
- 2013-08-15 US US13/967,448 patent/US8759326B2/en active Active
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