JP2012518671A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012518671A5 JP2012518671A5 JP2011551479A JP2011551479A JP2012518671A5 JP 2012518671 A5 JP2012518671 A5 JP 2012518671A5 JP 2011551479 A JP2011551479 A JP 2011551479A JP 2011551479 A JP2011551479 A JP 2011551479A JP 2012518671 A5 JP2012518671 A5 JP 2012518671A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- iii
- pharmaceutical composition
- alkyl chain
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims description 21
- 125000000217 alkyl group Chemical group 0.000 claims description 16
- 239000008194 pharmaceutical composition Substances 0.000 claims description 16
- 208000023275 Autoimmune disease Diseases 0.000 claims description 8
- 206010052779 Transplant rejections Diseases 0.000 claims description 8
- 230000004968 inflammatory condition Effects 0.000 claims description 8
- 201000006417 multiple sclerosis Diseases 0.000 claims description 8
- 210000000056 organ Anatomy 0.000 claims description 8
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 claims description 6
- 230000002265 prevention Effects 0.000 claims description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims description 4
- KKGQTZUTZRNORY-UHFFFAOYSA-N fingolimod Chemical compound CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1 KKGQTZUTZRNORY-UHFFFAOYSA-N 0.000 claims description 4
- 229960000556 fingolimod Drugs 0.000 claims description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 239000001301 oxygen Substances 0.000 claims description 4
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 claims description 2
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 208000024891 symptom Diseases 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 239000012074 organic phase Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000012071 phase Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09153550 | 2009-02-24 | ||
| EP09153550.0 | 2009-02-24 | ||
| PCT/EP2010/052231 WO2010097371A1 (en) | 2009-02-24 | 2010-02-23 | Ceramide-analogous metabolites |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012518671A JP2012518671A (ja) | 2012-08-16 |
| JP2012518671A5 true JP2012518671A5 (enExample) | 2013-03-28 |
Family
ID=40447014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011551479A Pending JP2012518671A (ja) | 2009-02-24 | 2010-02-23 | セラミド類似体代謝物 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8673982B2 (enExample) |
| EP (1) | EP2400960B1 (enExample) |
| JP (1) | JP2012518671A (enExample) |
| KR (1) | KR20110126631A (enExample) |
| CN (1) | CN102333530A (enExample) |
| AU (1) | AU2010217605B2 (enExample) |
| BR (1) | BRPI1007994A2 (enExample) |
| CA (1) | CA2752003A1 (enExample) |
| ES (1) | ES2411138T3 (enExample) |
| MX (1) | MX2011008876A (enExample) |
| PL (1) | PL2400960T3 (enExample) |
| PT (1) | PT2400960E (enExample) |
| RU (1) | RU2011138963A (enExample) |
| WO (1) | WO2010097371A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2888634C (en) * | 2012-10-19 | 2019-10-08 | Ruth Perez | Compositions and methods for the treatment of parkinson's disease |
| WO2014084676A1 (ko) * | 2012-11-30 | 2014-06-05 | (주)아모레퍼시픽 | 신규한 유사 세라마이드 화합물 및 그 제조방법 |
| EP2964210B1 (en) * | 2013-03-05 | 2023-10-04 | Biocon Limited | A process for the preparation of 2-amino-1,3-propane diol compounds and salts thereof |
| KR101510683B1 (ko) | 2013-09-03 | 2015-04-10 | (주)네오팜 | 카나비노이드 수용체에 길항작용을 가지는 신규한 유사 세라마이드 유도체 및 이를 포함하는 약학 또는 화장품 조성물 |
| EP3118621A1 (en) | 2015-07-14 | 2017-01-18 | Fundació Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Methods and compositions for the diagnosis and for the treatment of adrenoleukodystrophy |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2579602B2 (ja) * | 1992-10-21 | 1997-02-05 | 吉富製薬株式会社 | ２−アミノ−１，３−プロパンジオール化合物および免疫抑制剤 |
| DE69524962D1 (de) * | 1994-08-22 | 2002-02-14 | Welfide Corp | Benzolderivate und deren medizinische verwendung |
| US5948820A (en) * | 1994-08-22 | 1999-09-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzene compound and pharmaceutical use thereof |
| RU2402324C2 (ru) * | 2004-07-30 | 2010-10-27 | Новартис Аг | Композиции на основе соединений 2-амино-1,3-пропандиола |
| GT200600350A (es) * | 2005-08-09 | 2007-03-28 | Formulaciones líquidas | |
| CN101346346B (zh) * | 2005-12-15 | 2012-08-22 | 田边三菱制药株式会社 | 胺化合物及其医药用途 |
| CN101240002B (zh) * | 2007-02-07 | 2011-01-26 | 首都医科大学 | 脂肪酰氨基酰阿糖胞苷缀合物、其制备方法和应用 |
-
2010
- 2010-02-23 PL PL10705160T patent/PL2400960T3/pl unknown
- 2010-02-23 EP EP10705160.9A patent/EP2400960B1/en not_active Not-in-force
- 2010-02-23 ES ES10705160T patent/ES2411138T3/es active Active
- 2010-02-23 PT PT107051609T patent/PT2400960E/pt unknown
- 2010-02-23 BR BRPI1007994A patent/BRPI1007994A2/pt not_active IP Right Cessation
- 2010-02-23 CA CA2752003A patent/CA2752003A1/en not_active Abandoned
- 2010-02-23 RU RU2011138963/15A patent/RU2011138963A/ru not_active Application Discontinuation
- 2010-02-23 WO PCT/EP2010/052231 patent/WO2010097371A1/en not_active Ceased
- 2010-02-23 US US13/202,939 patent/US8673982B2/en not_active Expired - Fee Related
- 2010-02-23 KR KR1020117019540A patent/KR20110126631A/ko not_active Withdrawn
- 2010-02-23 JP JP2011551479A patent/JP2012518671A/ja active Pending
- 2010-02-23 AU AU2010217605A patent/AU2010217605B2/en not_active Ceased
- 2010-02-23 MX MX2011008876A patent/MX2011008876A/es not_active Application Discontinuation
- 2010-02-23 CN CN2010800089918A patent/CN102333530A/zh active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7236215B2 (ja) | ニコチンアミドリボシドの結晶形 | |
| JP6462045B2 (ja) | スルフォラファンの単離及び精製 | |
| AU2009308511B2 (en) | Transition metal complexes of a bis[thiohydrazide amide] compound | |
| JP6401317B2 (ja) | がんを治療するためのシステム、方法、および製剤 | |
| EP3563873B1 (en) | Application of combination of polyethylene glycol and local anesthetic in non-narcotic analgesia | |
| JPH11506793A (ja) | エンドトキセミアの治療及び防止に有用な置換されたリポ糖類 | |
| TW200817371A (en) | Compounds for treating proliferative disorders | |
| JP2013536825A (ja) | ドパミン作動性安定化剤として有用なプリドピジンの重水素化類似体 | |
| JP2009533457A (ja) | Ｃ−ニトロソから誘導されるニトロキシル供与体 | |
| JP2012518671A5 (enExample) | ||
| CN102256937A (zh) | 双[硫代酰肼酰胺]化合物的过渡金属络合物 | |
| WO2023165094A1 (zh) | 一种羟戊苯甲酸双酯化合物及其制备方法和应用 | |
| JP2012523432A5 (enExample) | ||
| EP2763673B1 (en) | Use of indolyl hydroxamates for treating heart failure or neuronal injury | |
| TWI721697B (zh) | 用於治療骨關節炎的化合物 | |
| WO2019245590A1 (en) | Chemical compounds | |
| KR20090121832A (ko) | 2-(2-히드록시벤조일)히드라진카르복시아미드 유도체 또는이의 약학적으로 허용가능한 염, 이의 제조방법, 및 이를유효 성분으로 함유하는 선택적 면역 억제용 약학적 조성물 | |
| JP4541879B2 (ja) | ケイ皮酸二量体、その製造方法及び退行性脳疾患治療のためのその用途 | |
| US10905673B2 (en) | Lipidic furan, pyrrole, and thiophene compounds for use in the treatment of atrophic vaginitis | |
| KR20130097121A (ko) | 암 전이를 치료하기 위한 방법 및 조성물 | |
| EP3641756A1 (en) | Tricyclic compounds as cyp1 inhibitors | |
| US20240109934A1 (en) | Antibiotics with improved drug resistance profile | |
| CN107056819B (zh) | 一种预防和治疗心肌缺血的药物及其制备方法 | |
| CN103193642B (zh) | 香芹酚衍生物及其合成方法和应用 | |
| JP7426756B2 (ja) | チオベンゾピラン系化合物及び関節リウマチの治療薬の調製におけるその使用 |