RU2011138963A - Метаболиты, являющиеся церамидными аналогами - Google Patents
Метаболиты, являющиеся церамидными аналогами Download PDFInfo
- Publication number
- RU2011138963A RU2011138963A RU2011138963/15A RU2011138963A RU2011138963A RU 2011138963 A RU2011138963 A RU 2011138963A RU 2011138963/15 A RU2011138963/15 A RU 2011138963/15A RU 2011138963 A RU2011138963 A RU 2011138963A RU 2011138963 A RU2011138963 A RU 2011138963A
- Authority
- RU
- Russia
- Prior art keywords
- compound
- iii
- alkyl chain
- pharmaceutical composition
- formula
- Prior art date
Links
- OTGQIQQTPXJQRG-UHFFFAOYSA-N N-(octadecanoyl)ethanolamine Chemical class CCCCCCCCCCCCCCCCCC(=O)NCCO OTGQIQQTPXJQRG-UHFFFAOYSA-N 0.000 title 1
- 239000002207 metabolite Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 17
- 125000000217 alkyl group Chemical group 0.000 claims abstract 15
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 13
- 239000000203 mixture Substances 0.000 claims abstract 8
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 claims abstract 6
- 208000023275 Autoimmune disease Diseases 0.000 claims abstract 5
- 230000004968 inflammatory condition Effects 0.000 claims abstract 5
- 201000006417 multiple sclerosis Diseases 0.000 claims abstract 5
- 210000000056 organ Anatomy 0.000 claims abstract 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 4
- 238000000034 method Methods 0.000 claims abstract 4
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 4
- 239000001301 oxygen Substances 0.000 claims abstract 4
- 230000002265 prevention Effects 0.000 claims abstract 4
- 206010052779 Transplant rejections Diseases 0.000 claims abstract 3
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 claims abstract 2
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000002671 adjuvant Substances 0.000 claims abstract 2
- 239000003085 diluting agent Substances 0.000 claims abstract 2
- KKGQTZUTZRNORY-UHFFFAOYSA-N fingolimod Chemical compound CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1 KKGQTZUTZRNORY-UHFFFAOYSA-N 0.000 claims 2
- 229960000556 fingolimod Drugs 0.000 claims 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09153550 | 2009-02-24 | ||
| EP09153550.0 | 2009-02-24 | ||
| PCT/EP2010/052231 WO2010097371A1 (en) | 2009-02-24 | 2010-02-23 | Ceramide-analogous metabolites |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2011138963A true RU2011138963A (ru) | 2013-04-10 |
Family
ID=40447014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2011138963/15A RU2011138963A (ru) | 2009-02-24 | 2010-02-23 | Метаболиты, являющиеся церамидными аналогами |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8673982B2 (enExample) |
| EP (1) | EP2400960B1 (enExample) |
| JP (1) | JP2012518671A (enExample) |
| KR (1) | KR20110126631A (enExample) |
| CN (1) | CN102333530A (enExample) |
| AU (1) | AU2010217605B2 (enExample) |
| BR (1) | BRPI1007994A2 (enExample) |
| CA (1) | CA2752003A1 (enExample) |
| ES (1) | ES2411138T3 (enExample) |
| MX (1) | MX2011008876A (enExample) |
| PL (1) | PL2400960T3 (enExample) |
| PT (1) | PT2400960E (enExample) |
| RU (1) | RU2011138963A (enExample) |
| WO (1) | WO2010097371A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2663833C2 (ru) * | 2013-03-05 | 2018-08-10 | Биокон Лимитед | Способ получения соединений 2-амино-1,3-пропандиола и их солей |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10391066B2 (en) * | 2012-10-19 | 2019-08-27 | Texas Tech University System | Compositions and methods for the treatment of Parkinson's disease |
| CN104854081A (zh) * | 2012-11-30 | 2015-08-19 | 株式会社爱茉莉太平洋 | 新型的类神经酰胺化合物其及其制备方法 |
| KR101510683B1 (ko) | 2013-09-03 | 2015-04-10 | (주)네오팜 | 카나비노이드 수용체에 길항작용을 가지는 신규한 유사 세라마이드 유도체 및 이를 포함하는 약학 또는 화장품 조성물 |
| EP3118621A1 (en) | 2015-07-14 | 2017-01-18 | Fundació Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Methods and compositions for the diagnosis and for the treatment of adrenoleukodystrophy |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5604229A (en) * | 1992-10-21 | 1997-02-18 | Yoshitomi Pharmaceutical Industries, Ltd. | 2-amino-1,3-propanediol compound and immunosuppressant |
| EP0778263B1 (en) * | 1994-08-22 | 2002-01-09 | Welfide Corporation | Benzene compound and medicinal use thereof |
| US5948820A (en) * | 1994-08-22 | 1999-09-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzene compound and pharmaceutical use thereof |
| CN1993115B (zh) * | 2004-07-30 | 2011-12-28 | 诺瓦提斯公司 | 2-氨基-1,3-丙二醇化合物的制剂 |
| GT200600350A (es) * | 2005-08-09 | 2007-03-28 | Formulaciones líquidas | |
| PT1961734E (pt) * | 2005-12-15 | 2011-10-06 | Mitsubishi Tanabe Pharma Corp | Composto de amina e sua utilização para fins médicos |
| CN101240002B (zh) * | 2007-02-07 | 2011-01-26 | 首都医科大学 | 脂肪酰氨基酰阿糖胞苷缀合物、其制备方法和应用 |
-
2010
- 2010-02-23 PL PL10705160T patent/PL2400960T3/pl unknown
- 2010-02-23 BR BRPI1007994A patent/BRPI1007994A2/pt not_active IP Right Cessation
- 2010-02-23 CN CN2010800089918A patent/CN102333530A/zh active Pending
- 2010-02-23 US US13/202,939 patent/US8673982B2/en not_active Expired - Fee Related
- 2010-02-23 MX MX2011008876A patent/MX2011008876A/es not_active Application Discontinuation
- 2010-02-23 KR KR1020117019540A patent/KR20110126631A/ko not_active Withdrawn
- 2010-02-23 WO PCT/EP2010/052231 patent/WO2010097371A1/en not_active Ceased
- 2010-02-23 ES ES10705160T patent/ES2411138T3/es active Active
- 2010-02-23 CA CA2752003A patent/CA2752003A1/en not_active Abandoned
- 2010-02-23 AU AU2010217605A patent/AU2010217605B2/en not_active Ceased
- 2010-02-23 RU RU2011138963/15A patent/RU2011138963A/ru not_active Application Discontinuation
- 2010-02-23 PT PT107051609T patent/PT2400960E/pt unknown
- 2010-02-23 EP EP10705160.9A patent/EP2400960B1/en not_active Not-in-force
- 2010-02-23 JP JP2011551479A patent/JP2012518671A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2663833C2 (ru) * | 2013-03-05 | 2018-08-10 | Биокон Лимитед | Способ получения соединений 2-амино-1,3-пропандиола и их солей |
Also Published As
| Publication number | Publication date |
|---|---|
| PL2400960T3 (pl) | 2013-08-30 |
| EP2400960B1 (en) | 2013-04-17 |
| ES2411138T3 (es) | 2013-07-04 |
| CN102333530A (zh) | 2012-01-25 |
| EP2400960A1 (en) | 2012-01-04 |
| PT2400960E (pt) | 2013-06-28 |
| AU2010217605B2 (en) | 2012-07-26 |
| US20110306672A1 (en) | 2011-12-15 |
| US8673982B2 (en) | 2014-03-18 |
| BRPI1007994A2 (pt) | 2018-03-13 |
| KR20110126631A (ko) | 2011-11-23 |
| WO2010097371A1 (en) | 2010-09-02 |
| JP2012518671A (ja) | 2012-08-16 |
| MX2011008876A (es) | 2011-09-21 |
| AU2010217605A1 (en) | 2011-08-18 |
| CA2752003A1 (en) | 2010-09-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20140718 |