AU2010217605B2 - Ceramide-analogous metabolites - Google Patents

Ceramide-analogous metabolites Download PDF

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Publication number
AU2010217605B2
AU2010217605B2 AU2010217605A AU2010217605A AU2010217605B2 AU 2010217605 B2 AU2010217605 B2 AU 2010217605B2 AU 2010217605 A AU2010217605 A AU 2010217605A AU 2010217605 A AU2010217605 A AU 2010217605A AU 2010217605 B2 AU2010217605 B2 AU 2010217605B2
Authority
AU
Australia
Prior art keywords
compound
iii
compounds
fty720
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010217605A
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English (en)
Other versions
AU2010217605A1 (en
Inventor
Volker Brinkmann
Guido Jordine
Claudia Sayer
Markus Zollinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of AU2010217605A1 publication Critical patent/AU2010217605A1/en
Application granted granted Critical
Publication of AU2010217605B2 publication Critical patent/AU2010217605B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2010217605A 2009-02-24 2010-02-23 Ceramide-analogous metabolites Ceased AU2010217605B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09153550 2009-02-24
EP09153550.0 2009-02-24
PCT/EP2010/052231 WO2010097371A1 (en) 2009-02-24 2010-02-23 Ceramide-analogous metabolites

Publications (2)

Publication Number Publication Date
AU2010217605A1 AU2010217605A1 (en) 2011-08-18
AU2010217605B2 true AU2010217605B2 (en) 2012-07-26

Family

ID=40447014

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010217605A Ceased AU2010217605B2 (en) 2009-02-24 2010-02-23 Ceramide-analogous metabolites

Country Status (14)

Country Link
US (1) US8673982B2 (enExample)
EP (1) EP2400960B1 (enExample)
JP (1) JP2012518671A (enExample)
KR (1) KR20110126631A (enExample)
CN (1) CN102333530A (enExample)
AU (1) AU2010217605B2 (enExample)
BR (1) BRPI1007994A2 (enExample)
CA (1) CA2752003A1 (enExample)
ES (1) ES2411138T3 (enExample)
MX (1) MX2011008876A (enExample)
PL (1) PL2400960T3 (enExample)
PT (1) PT2400960E (enExample)
RU (1) RU2011138963A (enExample)
WO (1) WO2010097371A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2888634C (en) * 2012-10-19 2019-10-08 Ruth Perez Compositions and methods for the treatment of parkinson's disease
WO2014084676A1 (ko) * 2012-11-30 2014-06-05 (주)아모레퍼시픽 신규한 유사 세라마이드 화합물 및 그 제조방법
EP2964210B1 (en) * 2013-03-05 2023-10-04 Biocon Limited A process for the preparation of 2-amino-1,3-propane diol compounds and salts thereof
KR101510683B1 (ko) 2013-09-03 2015-04-10 (주)네오팜 카나비노이드 수용체에 길항작용을 가지는 신규한 유사 세라마이드 유도체 및 이를 포함하는 약학 또는 화장품 조성물
EP3118621A1 (en) 2015-07-14 2017-01-18 Fundació Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) Methods and compositions for the diagnosis and for the treatment of adrenoleukodystrophy

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0627406A1 (en) * 1992-10-21 1994-12-07 Yoshitomi Pharmaceutical Industries, Ltd. 2-amino-1,3-propanediol compound and immunosuppressant
EP0778263A1 (en) * 1994-08-22 1997-06-11 Yoshitomi Pharmaceutical Industries, Ltd. Benzene compound and medicinal use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5948820A (en) * 1994-08-22 1999-09-07 Yoshitomi Pharmaceutical Industries, Ltd. Benzene compound and pharmaceutical use thereof
RU2402324C2 (ru) * 2004-07-30 2010-10-27 Новартис Аг Композиции на основе соединений 2-амино-1,3-пропандиола
GT200600350A (es) * 2005-08-09 2007-03-28 Formulaciones líquidas
CN101346346B (zh) * 2005-12-15 2012-08-22 田边三菱制药株式会社 胺化合物及其医药用途
CN101240002B (zh) * 2007-02-07 2011-01-26 首都医科大学 脂肪酰氨基酰阿糖胞苷缀合物、其制备方法和应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0627406A1 (en) * 1992-10-21 1994-12-07 Yoshitomi Pharmaceutical Industries, Ltd. 2-amino-1,3-propanediol compound and immunosuppressant
EP0778263A1 (en) * 1994-08-22 1997-06-11 Yoshitomi Pharmaceutical Industries, Ltd. Benzene compound and medicinal use thereof

Also Published As

Publication number Publication date
PT2400960E (pt) 2013-06-28
EP2400960B1 (en) 2013-04-17
AU2010217605A1 (en) 2011-08-18
CN102333530A (zh) 2012-01-25
US20110306672A1 (en) 2011-12-15
BRPI1007994A2 (pt) 2018-03-13
CA2752003A1 (en) 2010-09-02
EP2400960A1 (en) 2012-01-04
RU2011138963A (ru) 2013-04-10
WO2010097371A1 (en) 2010-09-02
KR20110126631A (ko) 2011-11-23
US8673982B2 (en) 2014-03-18
ES2411138T3 (es) 2013-07-04
MX2011008876A (es) 2011-09-21
PL2400960T3 (pl) 2013-08-30
JP2012518671A (ja) 2012-08-16

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired