JP2012516147A5 - - Google Patents
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- JP2012516147A5 JP2012516147A5 JP2011546955A JP2011546955A JP2012516147A5 JP 2012516147 A5 JP2012516147 A5 JP 2012516147A5 JP 2011546955 A JP2011546955 A JP 2011546955A JP 2011546955 A JP2011546955 A JP 2011546955A JP 2012516147 A5 JP2012516147 A5 JP 2012516147A5
- Authority
- JP
- Japan
- Prior art keywords
- dna
- protelomerase
- template
- sequence
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 19
- 108020004414 DNA Proteins 0.000 claims 18
- 102000053602 DNA Human genes 0.000 claims 18
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 5
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 5
- 108091026890 Coding region Proteins 0.000 claims 4
- 230000003321 amplification Effects 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 238000003199 nucleic acid amplification method Methods 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108020004638 Circular DNA Proteins 0.000 claims 2
- 238000006073 displacement reaction Methods 0.000 claims 2
- 108700028149 Bacteriophage N15 protelomerase Proteins 0.000 claims 1
- 108020004682 Single-Stranded DNA Proteins 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 230000003362 replicative effect Effects 0.000 claims 1
- 238000005096 rolling process Methods 0.000 claims 1
- 230000005030 transcription termination Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0901593.4 | 2009-01-30 | ||
| GBGB0901593.4A GB0901593D0 (en) | 2009-01-30 | 2009-01-30 | Production of closed linear DNA |
| PCT/GB2010/000165 WO2010086626A1 (en) | 2009-01-30 | 2010-02-01 | Production of closed linear dna |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015175262A Division JP6454243B2 (ja) | 2009-01-30 | 2015-09-07 | 閉鎖型直鎖状ｄｎａの製造 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012516147A JP2012516147A (ja) | 2012-07-19 |
| JP2012516147A5 true JP2012516147A5 (https=) | 2013-03-21 |
Family
ID=40469378
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011546955A Pending JP2012516147A (ja) | 2009-01-30 | 2010-02-01 | 閉鎖型直鎖状ｄｎａの製造 |
| JP2015175262A Active JP6454243B2 (ja) | 2009-01-30 | 2015-09-07 | 閉鎖型直鎖状ｄｎａの製造 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015175262A Active JP6454243B2 (ja) | 2009-01-30 | 2015-09-07 | 閉鎖型直鎖状ｄｎａの製造 |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US9109250B2 (https=) |
| EP (3) | EP2391731B1 (https=) |
| JP (2) | JP2012516147A (https=) |
| KR (1) | KR101926662B1 (https=) |
| CN (2) | CN102301010B (https=) |
| AU (1) | AU2010209532B2 (https=) |
| BR (1) | BRPI1005683B1 (https=) |
| CA (1) | CA2751130C (https=) |
| DK (2) | DK3150722T3 (https=) |
| EA (1) | EA021069B1 (https=) |
| ES (2) | ES2400890T3 (https=) |
| GB (1) | GB0901593D0 (https=) |
| IL (1) | IL213930A (https=) |
| LT (1) | LT3150722T (https=) |
| MX (1) | MX2011007937A (https=) |
| NZ (1) | NZ594004A (https=) |
| SG (1) | SG173102A1 (https=) |
| WO (1) | WO2010086626A1 (https=) |
| ZA (1) | ZA201105013B (https=) |
Families Citing this family (74)
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| ES2351294B8 (es) * | 2009-07-02 | 2012-06-06 | Consejo Superior De Investigaciones Científicas (Csic) | Metodo para la replicación, amplificación, o secuenciación de un adn molde. |
| GB201013153D0 (en) | 2010-08-04 | 2010-09-22 | Touchlight Genetics Ltd | Primer for production of closed linear DNA |
| US9290800B2 (en) | 2013-03-15 | 2016-03-22 | Pacific Biosciences Of California, Inc. | Targeted rolling circle amplification |
| GB201502645D0 (en) * | 2015-02-17 | 2015-04-01 | Touchlight Genetics Ltd | Method |
| FR3042121A1 (fr) * | 2015-10-08 | 2017-04-14 | Jean-Marc Limacher | Composition anti-tumorale |
| EP3701963A1 (en) | 2015-12-22 | 2020-09-02 | CureVac AG | Method for producing rna molecule compositions |
| RU2616279C1 (ru) * | 2015-12-28 | 2017-04-13 | Федеральное государственное бюджетное учреждение науки Институт биохимии и генетики Уфимского научного центра Российской академии наук (ИБГ УНЦ РАН) | Способ получения маркерных лестниц для гель-электрофоретического определения размеров фрагментов нуклеиновых кислот |
| US10077459B2 (en) | 2016-05-04 | 2018-09-18 | General Electric Company | Cell-free protein expression using rolling circle amplification product |
| DK3500682T3 (da) * | 2016-08-16 | 2020-08-24 | Touchlight Ip Ltd | Fremstilling af lukket, lineært dna |
| WO2019118806A1 (en) * | 2017-12-14 | 2019-06-20 | Solid Biosciences Inc. | Non-viral production and delivery of genes |
| GB201721846D0 (en) * | 2017-12-22 | 2018-02-07 | Arecor Ltd | Novel composition |
| CN109971825B (zh) * | 2017-12-28 | 2020-11-10 | 南京金斯瑞生物科技有限公司 | 快速制备桑格测序模板的方法 |
| GB201805683D0 (en) * | 2018-04-05 | 2018-05-23 | Touchlight Ip Ltd | Reprogramming vectors |
| EP3810782A2 (en) * | 2018-06-22 | 2021-04-28 | Asklepios Biopharmaceutical, Inc. | Vectors for gene delivery that persist within cells |
| US12297446B2 (en) | 2018-11-02 | 2025-05-13 | Nikegen Limited | Recombinant parvoviral vectors and method of making and use thereof |
| GB201905651D0 (en) * | 2019-04-24 | 2019-06-05 | Lightbio Ltd | Nucleic acid constructs and methods for their manufacture |
| US12595501B2 (en) | 2019-06-13 | 2026-04-07 | Global Life Sciences Solutions Usa Llc | Expression of products from nucleic acid concatemers |
| WO2020255014A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Recombinant interleukin 12 construct and uses thereof |
| JP2022536850A (ja) | 2019-06-18 | 2022-08-19 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | Ｂ型肝炎ウイルス（ｈｂｖ）ワクチンおよび抗ｐｄ－１または抗ｐｄ－ｌ１抗体の組合せ |
| WO2020255010A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of recombinant interleukin 12 construct and hepatitis b virus (hbv) vaccines |
| MA56533A (fr) | 2019-06-18 | 2022-04-27 | Janssen Sciences Ireland Unlimited Co | Combinaison de vaccins contre le virus de l'hépatite b (vhb) et d'anticorps anti-pd-1 |
| WO2020254876A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Virus-like particle delivery of hepatitis b virus (hbv) vaccines |
| CA3143679A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and hbv-targeting rnai |
| KR20220042116A (ko) | 2019-06-18 | 2022-04-04 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | B형 간염 바이러스(HBV) 백신 및 HBV-타케팅 RNAi의 조합 |
| AU2020297019A1 (en) | 2019-06-20 | 2022-02-17 | Janssen Sciences Ireland Unlimited Company | Carbohydrate nanocarrier delivery of hepatitis B virus (HBV) vaccines |
| WO2020255062A1 (en) | 2019-06-20 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Lipid nanoparticle or liposome delivery of hepatitis b virus (hbv) vaccines |
| EP3792367A1 (en) | 2019-09-11 | 2021-03-17 | Universität Bielefeld | Method for the production of raav and method for the in vitro generation of genetically engineered, linear, single-stranded nucleic acid fragments containing itr sequences flanking a gene of interest |
| GB2700048B (en) | 2019-09-18 | 2026-03-04 | Aldevron Llc | synthetic dna vectors and method of use |
| GB201915163D0 (en) | 2019-10-18 | 2019-12-04 | Univ Southampton | Cancer vaccine |
| JP7766029B2 (ja) | 2019-12-20 | 2025-11-07 | キージーン ナムローゼ フェンノートシャップ | 共有結合で閉端された核酸分子末端を使用したｎｇｓライブラリー調製 |
| WO2021146591A2 (en) * | 2020-01-17 | 2021-07-22 | Asklepios Biopharmaceutical, Inc. | Recombinant aav production |
| CN115023503A (zh) * | 2020-01-31 | 2022-09-06 | 泰瑞斯疗法公司 | 生产闭合线性dna的方法 |
| IL296024A (en) | 2020-03-04 | 2022-10-01 | Flagship Pioneering Innovations Vi Llc | Methods and compositions for modulating a genome |
| GB202007428D0 (en) | 2020-05-19 | 2020-07-01 | Fabricnano Ltd | Polynucleotide synthesis |
| EP4165183A1 (en) | 2020-06-12 | 2023-04-19 | University of Rochester | Encoding and expression of ace-trnas |
| US20230310584A1 (en) | 2020-08-26 | 2023-10-05 | Scancell Limited | Nucleic acids encoding a polypeptide comprising a modified fc region of a human igg1 and at least one heterologous antigen |
| WO2022074058A1 (en) | 2020-10-06 | 2022-04-14 | Keygene N.V. | Targeted sequence addition |
| WO2022209987A1 (ja) | 2021-03-29 | 2022-10-06 | 株式会社カネカ | ベクター、及びそれを用いた直鎖状共有結合閉鎖ｄｎａの作製方法、並びにパルボウイルスベクターの作製方法、及びパルボウイルスベクター産生細胞 |
| GB202108176D0 (en) | 2021-06-08 | 2021-07-21 | Touchlight Ip Ltd | Vector |
| US20250122528A1 (en) | 2021-06-08 | 2025-04-17 | Touchlight IP Limited | Lentiviral vector |
| CA3223292A1 (en) | 2021-06-25 | 2022-12-29 | Laura Van Lieshout | Adeno-associated virus packaging systems |
| CA3226725A1 (en) | 2021-07-13 | 2023-01-19 | Stonehaven Incubate AG | Composition and uses thereof |
| EP4124660A1 (en) * | 2021-07-30 | 2023-02-01 | 4basebio, S.L.U. | Linear dna with enhanced resistance against exonucleases and methods for the production thereof |
| JP2024533311A (ja) | 2021-09-08 | 2024-09-12 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | ゲノムを調節するための方法及び組成物 |
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| US20250027107A1 (en) | 2021-10-18 | 2025-01-23 | Flagship Pioneering Innovations Vii, Llc | Dna compositions and related methods |
| WO2023114901A2 (en) | 2021-12-15 | 2023-06-22 | Oxford Biomedica Solutions Llc | Methods and compositions for the production of adeno-associated virus |
| AU2022422134A1 (en) * | 2021-12-23 | 2024-07-04 | Generation Bio Co. | Scalable and high-purity cell-free synthesis of closed-ended dna vectors |
| CN114561372B (zh) * | 2022-04-27 | 2022-07-26 | 南京巨匠生物科技有限公司 | Bst DNA聚合酶突变体及其应用和产品、基因、重组质粒和基因工程菌 |
| EP4293101A1 (en) | 2022-06-14 | 2023-12-20 | Asklepios Biopharmaceutical, Inc. | Reactor with temperature control and method of using the same |
| EP4570912A1 (en) | 2022-08-10 | 2025-06-18 | Zhenjiang Probio Biotech Co., Ltd. | Method for preparing linear closed dna and plasmid for use in the method |
| WO2024039652A1 (en) | 2022-08-16 | 2024-02-22 | Aldevron, L.L.C. | Cell-free method of producing synthetic circular nucleic acid |
| WO2024058155A1 (ja) | 2022-09-12 | 2024-03-21 | 株式会社カネカ | 二本鎖環状ｄｎａベクター、直鎖状共有結合閉鎖ｄｎａの作製方法、並びにプロテロメラーゼ及びエンドヌクレアーゼを含む融合ポリペプチド |
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2009
- 2009-01-30 GB GBGB0901593.4A patent/GB0901593D0/en not_active Ceased
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2010
- 2010-02-01 EP EP10702726A patent/EP2391731B1/en active Active
- 2010-02-01 CN CN201080006024.8A patent/CN102301010B/zh active Active
- 2010-02-01 CN CN201510314041.2A patent/CN104911177A/zh active Pending
- 2010-02-01 ES ES10702726T patent/ES2400890T3/es active Active
- 2010-02-01 CA CA2751130A patent/CA2751130C/en active Active
- 2010-02-01 DK DK16195596.8T patent/DK3150722T3/da active
- 2010-02-01 JP JP2011546955A patent/JP2012516147A/ja active Pending
- 2010-02-01 EA EA201101141A patent/EA021069B1/ru not_active IP Right Cessation
- 2010-02-01 AU AU2010209532A patent/AU2010209532B2/en active Active
- 2010-02-01 MX MX2011007937A patent/MX2011007937A/es active IP Right Grant
- 2010-02-01 ES ES16195596T patent/ES2749629T3/es active Active
- 2010-02-01 EP EP16195596.8A patent/EP3150722B1/en not_active Revoked
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- 2010-02-01 LT LT16195596T patent/LT3150722T/lt unknown
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