JP2012515170A5 - - Google Patents
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- JP2012515170A5 JP2012515170A5 JP2011545542A JP2011545542A JP2012515170A5 JP 2012515170 A5 JP2012515170 A5 JP 2012515170A5 JP 2011545542 A JP2011545542 A JP 2011545542A JP 2011545542 A JP2011545542 A JP 2011545542A JP 2012515170 A5 JP2012515170 A5 JP 2012515170A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- prg4
- androgen
- vaginal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 101001123332 Homo sapiens Proteoglycan 4 Proteins 0.000 claims 10
- 102100028965 Proteoglycan 4 Human genes 0.000 claims 10
- 239000003098 androgen Substances 0.000 claims 6
- 238000005461 lubrication Methods 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 229920002674 hyaluronan Polymers 0.000 claims 3
- 229960003160 hyaluronic acid Drugs 0.000 claims 3
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 2
- 229920002385 Sodium hyaluronate Polymers 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 230000003110 anti-inflammatory effect Effects 0.000 claims 2
- 239000000430 cytokine receptor antagonist Substances 0.000 claims 2
- 230000003247 decreasing effect Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 230000009245 menopause Effects 0.000 claims 2
- 239000000849 selective androgen receptor modulator Substances 0.000 claims 2
- 230000001568 sexual effect Effects 0.000 claims 2
- 229940010747 sodium hyaluronate Drugs 0.000 claims 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims 2
- 238000013268 sustained release Methods 0.000 claims 2
- 239000012730 sustained-release form Substances 0.000 claims 2
- 238000011282 treatment Methods 0.000 claims 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 1
- 150000000319 19-nortestosterones Chemical class 0.000 claims 1
- QUKZBUCPOSYYFO-KYQPOWKGSA-N 5alpha-Androstan-17beta-ol Chemical class C1CCC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 QUKZBUCPOSYYFO-KYQPOWKGSA-N 0.000 claims 1
- 206010002261 Androgen deficiency Diseases 0.000 claims 1
- 206010059313 Anogenital warts Diseases 0.000 claims 1
- 206010003694 Atrophy Diseases 0.000 claims 1
- 208000004926 Bacterial Vaginosis Diseases 0.000 claims 1
- 241000222122 Candida albicans Species 0.000 claims 1
- 206010007134 Candida infections Diseases 0.000 claims 1
- 229930105110 Cyclosporin A Natural products 0.000 claims 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- 206010012442 Dermatitis contact Diseases 0.000 claims 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 claims 1
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 claims 1
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims 1
- 102100026018 Interleukin-1 receptor antagonist protein Human genes 0.000 claims 1
- 101710144554 Interleukin-1 receptor antagonist protein Proteins 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims 1
- 206010030247 Oestrogen deficiency Diseases 0.000 claims 1
- QSLJIVKCVHQPLV-PEMPUTJUSA-N Oxandrin Chemical class C([C@@H]1CC2)C(=O)OC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@](C)(O)[C@@]2(C)CC1 QSLJIVKCVHQPLV-PEMPUTJUSA-N 0.000 claims 1
- 208000002500 Primary Ovarian Insufficiency Diseases 0.000 claims 1
- 229940079156 Proteasome inhibitor Drugs 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 229940083324 Selective androgen receptor modulator Drugs 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 208000037009 Vaginitis bacterial Diseases 0.000 claims 1
- 208000003728 Vulvodynia Diseases 0.000 claims 1
- 206010069055 Vulvovaginal pain Diseases 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 230000001548 androgenic effect Effects 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940124599 anti-inflammatory drug Drugs 0.000 claims 1
- 239000003886 aromatase inhibitor Substances 0.000 claims 1
- 229940046844 aromatase inhibitors Drugs 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- 230000037444 atrophy Effects 0.000 claims 1
- 239000003855 balanced salt solution Substances 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- -1 bicyclic hydantoin analog Chemical class 0.000 claims 1
- 201000003984 candidiasis Diseases 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 230000006020 chronic inflammation Effects 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 235000013477 citrulline Nutrition 0.000 claims 1
- 229960002173 citrulline Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 208000010247 contact dermatitis Diseases 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 229960005309 estradiol Drugs 0.000 claims 1
- 229930182833 estradiol Natural products 0.000 claims 1
- 239000003687 estradiol congener Substances 0.000 claims 1
- 229940011871 estrogen Drugs 0.000 claims 1
- 239000000262 estrogen Substances 0.000 claims 1
- 239000000328 estrogen antagonist Substances 0.000 claims 1
- 238000009164 estrogen replacement therapy Methods 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 229940028334 follicle stimulating hormone Drugs 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 210000004392 genitalia Anatomy 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 230000006651 lactation Effects 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 1
- 229940012843 omega-3 fatty acid Drugs 0.000 claims 1
- 239000006014 omega-3 oil Substances 0.000 claims 1
- 235000020665 omega-6 fatty acid Nutrition 0.000 claims 1
- 229940033080 omega-6 fatty acid Drugs 0.000 claims 1
- 230000003204 osmotic effect Effects 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 206010036601 premature menopause Diseases 0.000 claims 1
- 239000000186 progesterone Substances 0.000 claims 1
- 229960003387 progesterone Drugs 0.000 claims 1
- 229940080818 propionamide Drugs 0.000 claims 1
- 239000003207 proteasome inhibitor Substances 0.000 claims 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 238000002271 resection Methods 0.000 claims 1
- 229940095743 selective estrogen receptor modulator Drugs 0.000 claims 1
- 239000000333 selective estrogen receptor modulator Substances 0.000 claims 1
- 150000003515 testosterones Chemical class 0.000 claims 1
- 125000000147 tetrahydroquinolinyl group Chemical class N1(CCCC2=CC=CC=C12)* 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 239000012049 topical pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14434409P | 2009-01-13 | 2009-01-13 | |
| US61/144,344 | 2009-01-13 | ||
| US26040209P | 2009-11-12 | 2009-11-12 | |
| US61/260,402 | 2009-11-12 | ||
| PCT/US2010/020929 WO2010083239A2 (en) | 2009-01-13 | 2010-01-13 | Therapeutic modulation of vaginal epithelium boundary lubrication |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015062261A Division JP6039723B2 (ja) | 2009-01-13 | 2015-03-25 | 膣上皮境界潤滑の治療的調節 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012515170A JP2012515170A (ja) | 2012-07-05 |
| JP2012515170A5 true JP2012515170A5 (enExample) | 2012-09-13 |
Family
ID=42340279
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011545542A Pending JP2012515170A (ja) | 2009-01-13 | 2010-01-13 | 膣上皮境界潤滑の治療的調節 |
| JP2015062261A Expired - Fee Related JP6039723B2 (ja) | 2009-01-13 | 2015-03-25 | 膣上皮境界潤滑の治療的調節 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015062261A Expired - Fee Related JP6039723B2 (ja) | 2009-01-13 | 2015-03-25 | 膣上皮境界潤滑の治療的調節 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8980840B2 (enExample) |
| EP (1) | EP2381957B1 (enExample) |
| JP (2) | JP2012515170A (enExample) |
| CN (1) | CN102438645A (enExample) |
| CA (1) | CA2749480C (enExample) |
| ES (1) | ES2534082T3 (enExample) |
| WO (1) | WO2010083239A2 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090215731A1 (en) | 2005-10-19 | 2009-08-27 | Chavah Pty Ltd. | Reduction of Side Effects From Aromatase Inhibitors Used for Treating Breast Cancer |
| CN102438645A (zh) * | 2009-01-13 | 2012-05-02 | 卢布里斯有限责任公司 | 阴道上皮界面润滑的治疗调节 |
| CA3110817C (en) * | 2009-05-22 | 2023-08-15 | Lubris, Llc | Application and uses of prg4 and therapeutic modulation thereof |
| CA2771110C (en) * | 2009-08-13 | 2019-02-26 | Singularis, Inc. | Prg4 treatment for interstitial cystitis |
| CN102552996A (zh) * | 2010-12-07 | 2012-07-11 | 宁小静 | 人体润滑剂 |
| ES2395801B1 (es) * | 2011-06-23 | 2014-06-06 | María Carmen PARDINA PALLEJÀ | "pentoxifilina por vía transvaginal para el tratamiento de la infertilidad" |
| RS62297B1 (sr) | 2011-11-23 | 2021-09-30 | Therapeuticsmd Inc | Prirodne kombinovane hormonske supstitucione formulacije i terapije |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9982027B2 (en) | 2013-10-22 | 2018-05-29 | Lubris Llc | Control of rheological properties of mixed hyaluronate/lubricin solutions |
| JP6571101B2 (ja) | 2013-11-26 | 2019-09-04 | ルブリス，エルエルシー． | 細胞間相互作用を阻害するための組成物及び方法 |
| JP2017516768A (ja) | 2014-05-22 | 2017-06-22 | セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． | 天然の併用ホルモン補充療法剤及び療法 |
| US10098894B2 (en) | 2014-07-29 | 2018-10-16 | Therapeuticsmd, Inc. | Transdermal cream |
| CN107405353B (zh) | 2014-10-22 | 2021-07-30 | 哈瓦赫治疗有限公司 | 降低乳房摄影乳腺密度和/或乳腺癌风险的方法 |
| MA53108A (fr) * | 2015-01-26 | 2021-05-12 | Lubris Llc | Utilisation de prg4 comme agent anti-inflammatoire |
| DK3300482T3 (da) | 2015-05-19 | 2021-10-18 | Lubris Llc | Brug af prg4 til at forbedre dynamisk synsstyrke og højere ordens aberrationer |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| SG11201803260PA (en) | 2015-10-22 | 2018-05-30 | Havah Therapeutics Pty Ltd | Methods of reducing mammographic breast density and/or breast cancer risk |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| JP2022535827A (ja) | 2019-06-03 | 2022-08-10 | ハバ セラピューティクス ピーティワイ エルティディ | アンドロゲン剤およびアロマターゼ阻害剤の送達のための医薬製剤およびシステム、ならびに使用のための方法 |
| US20240408128A1 (en) * | 2021-09-15 | 2024-12-12 | Chemex Global | Topical pharmaceutical compositions for treatment of infertility |
| CN118976097B (zh) * | 2024-10-22 | 2025-01-24 | 北京岷德生物科技有限公司 | 一种治疗妇科疾病的组合物及其制备方法和应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7027A (en) * | 1850-01-15 | Circulak | ||
| US3005A (en) * | 1843-03-17 | Power-loom | ||
| US7000A (en) * | 1850-01-08 | Smut-machine | ||
| US6433142B1 (en) | 1989-08-08 | 2002-08-13 | Genetics Institute, Llc | Megakaryocyte stimulating factors |
| US5326558A (en) | 1989-08-08 | 1994-07-05 | Genetics Institute, Inc. | Megakaryocytopoietic factor |
| AU740758B2 (en) * | 1997-10-28 | 2001-11-15 | Vivus, Inc. | Treatment of female sexual dysfunction |
| US6960562B2 (en) | 1999-04-23 | 2005-11-01 | Rhode Island Hospital, A Lifespan Partner | Tribonectin polypeptides and uses thereof |
| US6743774B1 (en) | 1999-04-23 | 2004-06-01 | Rhode Island Hospital | Tribonectins |
| US7452545B2 (en) | 2001-11-13 | 2008-11-18 | Yu Ruey J | Oligosaccharide aldonic acids and their topical use |
| US6335023B1 (en) | 1999-06-30 | 2002-01-01 | Ruey J. Yu | Oligosaccharide aldonic acids and their topical use |
| US20030059489A1 (en) * | 2001-09-24 | 2003-03-27 | Canolio Inc. | Genital lubricating compositions and uses thereof |
| US7005408B2 (en) * | 2002-05-01 | 2006-02-28 | Mcneil-Ppc, Inc. | Warming and nonirritating lubricant compositions and method of comparing irritation |
| WO2005000331A2 (en) * | 2003-06-04 | 2005-01-06 | Mucosal Therapeutics, Inc. | Compositions for the treatment and prevention of degenerative joint disorders |
| KR101078202B1 (ko) * | 2003-08-14 | 2011-11-01 | 와이어쓰 엘엘씨 | 재조합 루브리신 분자 및 이의 용도 |
| JP2007523952A (ja) * | 2004-02-25 | 2007-08-23 | スミスクライン ビーチャム コーポレーション | 選択的エストロゲンレセプターモジュレーターとして使用するための置換キノリン化合物 |
| US20070275032A1 (en) * | 2004-03-05 | 2007-11-29 | Synthes (U.S.A.) | Use Of A Mixture For The Production Of An Agent For Treating Defective Or Degenerated Cartilage In The Production Of Natural Cartilage Replacement In Vitro |
| US8703198B2 (en) * | 2005-03-02 | 2014-04-22 | Aquatrove Biosciences | Water-based personal moisturizers and lubricants, in particular vaginal lubricants, and uses thereof |
| US10016442B2 (en) | 2005-06-16 | 2018-07-10 | Allergan Pharmaceuticals International Limited | Estrogen compositions for vaginal administration |
| WO2007070067A1 (en) * | 2005-12-16 | 2007-06-21 | Lyle Corporate Development, Inc. | Regeneration of vaginal tissue with non-systemic vaginal administration of estrogen |
| US20070264309A1 (en) * | 2006-01-20 | 2007-11-15 | Chollet Janet A | Method Of Treating Atrophic Vaginitis |
| US20080286211A1 (en) * | 2007-04-27 | 2008-11-20 | Barker Nicholas P | Using mucin glycoproteins in combination with therapeutic agents to treat epithelial lesions and disorders of impaired mucin function |
| WO2008143816A1 (en) * | 2007-05-15 | 2008-11-27 | Mucosal Therapeutics | Compositions and methods for reducing friction between the surface of tendons or other soft tissues |
| GB0722507D0 (en) * | 2007-11-19 | 2007-12-27 | Zhao Xiaobin | Hyaluronic acid personal lubricant |
| CN102438645A (zh) * | 2009-01-13 | 2012-05-02 | 卢布里斯有限责任公司 | 阴道上皮界面润滑的治疗调节 |
-
2010
- 2010-01-13 CN CN2010800112543A patent/CN102438645A/zh active Pending
- 2010-01-13 JP JP2011545542A patent/JP2012515170A/ja active Pending
- 2010-01-13 US US13/144,203 patent/US8980840B2/en active Active
- 2010-01-13 EP EP10732051.7A patent/EP2381957B1/en not_active Not-in-force
- 2010-01-13 WO PCT/US2010/020929 patent/WO2010083239A2/en not_active Ceased
- 2010-01-13 ES ES10732051.7T patent/ES2534082T3/es active Active
- 2010-01-13 CA CA2749480A patent/CA2749480C/en active Active
-
2015
- 2015-03-25 JP JP2015062261A patent/JP6039723B2/ja not_active Expired - Fee Related
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