JP2012514647A5 - - Google Patents
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- Publication number
- JP2012514647A5 JP2012514647A5 JP2011545446A JP2011545446A JP2012514647A5 JP 2012514647 A5 JP2012514647 A5 JP 2012514647A5 JP 2011545446 A JP2011545446 A JP 2011545446A JP 2011545446 A JP2011545446 A JP 2011545446A JP 2012514647 A5 JP2012514647 A5 JP 2012514647A5
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- JP
- Japan
- Prior art keywords
- compound
- formula
- group
- reaction mixture
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 24
- 238000000034 method Methods 0.000 claims 19
- 239000011541 reaction mixture Substances 0.000 claims 10
- 239000002904 solvent Substances 0.000 claims 8
- 239000004215 Carbon black (E152) Substances 0.000 claims 7
- 238000006243 chemical reaction Methods 0.000 claims 7
- 229930195733 hydrocarbon Natural products 0.000 claims 7
- 150000002430 hydrocarbons Chemical class 0.000 claims 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 230000000865 phosphorylative effect Effects 0.000 claims 5
- 239000008346 aqueous phase Substances 0.000 claims 4
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical group ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 claims 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical group CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 3
- 239000012074 organic phase Substances 0.000 claims 3
- 239000012071 phase Substances 0.000 claims 3
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 claims 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 claims 2
- -1 benzyloxy, adamantanoyl Chemical group 0.000 claims 2
- 239000006227 byproduct Substances 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229910052751 metal Inorganic materials 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 239000003223 protective agent Substances 0.000 claims 2
- 229910001428 transition metal ion Inorganic materials 0.000 claims 2
- YQTCQNIPQMJNTI-UHFFFAOYSA-N 2,2-dimethylpropan-1-one Chemical group CC(C)(C)[C]=O YQTCQNIPQMJNTI-UHFFFAOYSA-N 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 150000003973 alkyl amines Chemical group 0.000 claims 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims 1
- 238000010511 deprotection reaction Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 claims 1
- 238000007327 hydrogenolysis reaction Methods 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 150000007529 inorganic bases Chemical class 0.000 claims 1
- 229910000000 metal hydroxide Inorganic materials 0.000 claims 1
- 150000004692 metal hydroxides Chemical class 0.000 claims 1
- 229910021645 metal ion Inorganic materials 0.000 claims 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 claims 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 1
- 150000003222 pyridines Chemical class 0.000 claims 1
- 238000000638 solvent extraction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14356609P | 2009-01-09 | 2009-01-09 | |
| US61/143,566 | 2009-01-09 | ||
| PCT/US2010/020456 WO2010080969A1 (en) | 2009-01-09 | 2010-01-08 | Process for the synthesis of beta glycerol phosphate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012514647A JP2012514647A (ja) | 2012-06-28 |
| JP2012514647A5 true JP2012514647A5 (enExample) | 2013-01-24 |
| JP5639599B2 JP5639599B2 (ja) | 2014-12-10 |
Family
ID=42316823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011545446A Active JP5639599B2 (ja) | 2009-01-09 | 2010-01-08 | β−グリセロールリン酸を合成するためのプロセス |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8420848B2 (enExample) |
| EP (1) | EP2389348B1 (enExample) |
| JP (1) | JP5639599B2 (enExample) |
| CN (1) | CN102272080A (enExample) |
| ES (1) | ES2657240T3 (enExample) |
| WO (1) | WO2010080969A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010080969A1 (en) | 2009-01-09 | 2010-07-15 | Sigma-Aldrich Co. | Process for the synthesis of beta glycerol phosphate |
| CN104163827A (zh) * | 2014-05-21 | 2014-11-26 | 江苏德峰药业有限公司 | 一种β-磷酸甘油钠的合成方法 |
| CN105732700B (zh) * | 2016-03-23 | 2018-01-16 | 江苏诚信药业有限公司 | 一种制备β‑甘油磷酸钠的方法 |
| US20220395516A1 (en) * | 2021-05-27 | 2022-12-15 | Baxter International Inc. | Pharmaceutical compositions for clinical nutrition |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3264378A (en) * | 1962-04-09 | 1966-08-02 | Armour Pharma | Serine ester of diacyl glycerol phosphate |
| DE3239817A1 (de) * | 1982-07-06 | 1984-01-12 | Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Neue glycerinderivate zur synthese von phospholipiden |
| US4463095A (en) * | 1982-11-26 | 1984-07-31 | Toyo Boseki Kabushiki Kaisha | Process for producing α-glycerophosphate oxidase |
| US4916249A (en) * | 1985-07-03 | 1990-04-10 | Hans Brachwitz | Glycero-3(2)-phospho-L-serine derivatives and salts thereof |
| CA2361703A1 (en) * | 1999-02-05 | 2000-08-10 | Basf Aktiengesellschaft | Tryptophan synthase as a site of herbicide action |
| IL129179A0 (en) * | 1999-03-25 | 2000-02-17 | Yeda Res & Dev | Cyclic glycerophosphates and analogs thereof |
| IL129178A0 (en) * | 1999-03-25 | 2000-02-17 | Yeda Res & Dev | Induction of nerve generation |
| WO2010080969A1 (en) | 2009-01-09 | 2010-07-15 | Sigma-Aldrich Co. | Process for the synthesis of beta glycerol phosphate |
-
2010
- 2010-01-08 WO PCT/US2010/020456 patent/WO2010080969A1/en not_active Ceased
- 2010-01-08 ES ES10729547.9T patent/ES2657240T3/es active Active
- 2010-01-08 EP EP10729547.9A patent/EP2389348B1/en active Active
- 2010-01-08 CN CN2010800044300A patent/CN102272080A/zh active Pending
- 2010-01-08 US US13/142,552 patent/US8420848B2/en active Active
- 2010-01-08 JP JP2011545446A patent/JP5639599B2/ja active Active
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