JP2012512815A5 - - Google Patents
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- Publication number
- JP2012512815A5 JP2012512815A5 JP2011541030A JP2011541030A JP2012512815A5 JP 2012512815 A5 JP2012512815 A5 JP 2012512815A5 JP 2011541030 A JP2011541030 A JP 2011541030A JP 2011541030 A JP2011541030 A JP 2011541030A JP 2012512815 A5 JP2012512815 A5 JP 2012512815A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- antagonist
- composition according
- subject
- csf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 230000003042 antagnostic Effects 0.000 claims 3
- 239000005557 antagonist Substances 0.000 claims 3
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
- 102000004965 antibodies Human genes 0.000 claims 2
- 108090001123 antibodies Proteins 0.000 claims 2
- 102000016355 Granulocyte-Macrophage Colony-Stimulating Factor Receptors Human genes 0.000 claims 1
- 108010092372 Granulocyte-Macrophage Colony-Stimulating Factor Receptors Proteins 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
Claims (5)
- 対象における変形性関節症の治療用の、有効量のＧＭ−ＣＳＦの拮抗薬を含むことを特徴とする医薬組成物。
- 請求項１に記載の医薬組成物において、前記対象がヒトであることを特徴とする医薬組成物。
- 請求項１に記載の医薬組成物において、前記対象がマウスであることを特徴とする医薬組成物。
- 請求項１に記載の医薬組成物において、前記拮抗薬がＧＭ−ＣＳＦに特異的な抗体であることを特徴とする医薬組成物。
- 請求項１に記載の医薬組成物において、前記拮抗薬がＧＭ−ＣＳＦ受容体に特異的な抗体であることを特徴とする医薬組成物。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13967908P | 2008-12-22 | 2008-12-22 | |
| US61/139,679 | 2008-12-22 | ||
| US16448609P | 2009-03-30 | 2009-03-30 | |
| US61/164,486 | 2009-03-30 | ||
| PCT/AU2009/001672 WO2010071924A1 (en) | 2008-12-22 | 2009-12-21 | Osteoarthritis treatment |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015031198A Division JP2015143233A (ja) | 2008-12-22 | 2015-02-20 | 変形性関節症の治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012512815A JP2012512815A (ja) | 2012-06-07 |
| JP2012512815A5 true JP2012512815A5 (ja) | 2013-02-14 |
| JP5727379B2 JP5727379B2 (ja) | 2015-06-03 |
Family
ID=42286786
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011541030A Active JP5727379B2 (ja) | 2008-12-22 | 2009-12-21 | 変形性関節症の治療 |
| JP2015031198A Pending JP2015143233A (ja) | 2008-12-22 | 2015-02-20 | 変形性関節症の治療 |
| JP2017114806A Active JP6458086B2 (ja) | 2008-12-22 | 2017-06-12 | 変形性関節症の治療 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015031198A Pending JP2015143233A (ja) | 2008-12-22 | 2015-02-20 | 変形性関節症の治療 |
| JP2017114806A Active JP6458086B2 (ja) | 2008-12-22 | 2017-06-12 | 変形性関節症の治療 |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US9243061B2 (ja) |
| EP (2) | EP3056217B1 (ja) |
| JP (3) | JP5727379B2 (ja) |
| KR (2) | KR101898982B1 (ja) |
| CN (2) | CN102271705A (ja) |
| AU (1) | AU2009329814B2 (ja) |
| BR (1) | BRPI0918356B1 (ja) |
| CA (1) | CA2746827C (ja) |
| CY (1) | CY1117698T1 (ja) |
| DK (1) | DK2376121T4 (ja) |
| ES (2) | ES2572368T5 (ja) |
| HK (1) | HK1226938A1 (ja) |
| HR (1) | HRP20160577T4 (ja) |
| HU (1) | HUE028615T2 (ja) |
| PL (1) | PL2376121T5 (ja) |
| RU (2) | RU2011127334A (ja) |
| SI (2) | SI2376121T2 (ja) |
| SM (1) | SMT201600156B (ja) |
| WO (1) | WO2010071924A1 (ja) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101898982B1 (ko) | 2008-12-22 | 2018-09-14 | 더 유니버시티 오브 멜버른 | 골관절염 치료 |
| CN102256621B (zh) | 2008-12-22 | 2017-12-12 | 墨尔本大学 | 疼痛治疗 |
| SG11201501595YA (en) | 2012-09-20 | 2015-05-28 | Morphosys Ag | Treatment for rheumatoid arthritis |
| DE102013222200A1 (de) * | 2013-10-31 | 2015-08-27 | Osram Opto Semiconductors Gmbh | Elektronisches Bauelement und Verfahren zum Herstellen eines elektronischen Bauelements |
| KR20200054171A (ko) * | 2017-08-14 | 2020-05-19 | 지네르바 파마슈티컬스, 인코포레이티드 | 경피 칸나비디올 겔을 이용한 골관절염의 치료 방법 |
| WO2020104833A1 (en) * | 2018-11-19 | 2020-05-28 | 4P-Pharma | Composition and methods for regulating chondrocyte proliferation and increasing of cartilage matrix production |
| CN110075304B (zh) * | 2019-05-29 | 2020-02-11 | 四川大学华西医院 | 一种治疗骨关节炎的药物组合物及其用途 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5225539A (en) * | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| MY105946A (en) | 1989-07-14 | 1995-02-28 | Schering Corp | Antagonists of gm-csf derived from the carboxyl terminus. |
| JP3267966B2 (ja) | 1989-08-11 | 2002-03-25 | アムラド・コーポレイション・リミテッド | 顆粒球―マクロファージコロニー刺激因子受容体およびその誘導体における改良 |
| US5747032A (en) | 1990-08-10 | 1998-05-05 | Amrad Corporation Limited | Monoclonal antibody to human granulocyte macrophage colony stimulating factor |
| WO1994011404A1 (en) | 1992-11-19 | 1994-05-26 | Dana-Farber Cancer Institute | Antibodies for gm-csf receptor and uses thereof |
| ATE219517T1 (de) | 1995-08-18 | 2002-07-15 | Morphosys Ag | Protein-/(poly)peptidbibliotheken |
| AUPP525198A0 (en) | 1998-08-13 | 1998-09-03 | Medvet Science Pty. Ltd. | Monoclonal antibody inhibitor of GM-CSF, IL-3 and IL-5 and other cytokines and uses thereof |
| US7108852B2 (en) | 2000-03-20 | 2006-09-19 | Warner-Lambert Company Llc | Methods of treating inflammation using antibodies to M-CSF |
| US7455836B2 (en) * | 2000-05-08 | 2008-11-25 | The University Of Melbourne | Method of treatment and agents useful for same |
| AU2002346882A1 (en) * | 2001-10-26 | 2003-05-06 | Novartis Ag | Methods for the treatment of osteoarthritis and compositions thereof |
| JP2006500905A (ja) | 2002-02-13 | 2006-01-12 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | ヒト化ｇｍ−ｃｓｆ抗体 |
| US20040241755A1 (en) * | 2003-06-02 | 2004-12-02 | Pfizer Inc. | Human cell assay to determine effect of sample compounds on Col2 enhancer expression |
| ATE464908T1 (de) | 2004-02-11 | 2010-05-15 | Warner Lambert Co | Verfahren zur behandlung von osteoarthritis mit anti-il-6 antikörpern |
| US7642243B2 (en) * | 2004-03-31 | 2010-01-05 | Kazuwa Nakao | Method of treating arthritis and promoting growth of articular chondrocytes |
| DK1593690T3 (da) | 2004-05-05 | 2009-11-09 | Micromet Ag | Fremstilling af ScFv-antistoffragmenter |
| WO2006023412A2 (en) * | 2004-08-18 | 2006-03-02 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Biomarkers for osteoarthritis |
| US20060040258A1 (en) | 2004-08-23 | 2006-02-23 | Huiyan Guo | Water-soluble conjugates and methods of preparation |
| UA94403C2 (ru) | 2005-04-18 | 2011-05-10 | Микромет Аг | Человеческое моноклональное антитело, которое нейтрализует gm-csf |
| EP3150221A1 (en) * | 2005-05-18 | 2017-04-05 | MorphoSys AG | Anti-gm-csf antibodies and uses therefor |
| JP4736037B2 (ja) | 2005-10-26 | 2011-07-27 | 株式会社イーベック | ヒトｇｍ−ｃｓｆに結合するヒトのモノクローナル抗体並びにその抗原結合部分 |
| CA2629850A1 (en) * | 2005-12-01 | 2007-06-07 | Domantis Limited | Competitive domain antibody formats that bind interleukin 1 receptor type 1 |
| HUE032584T2 (en) * | 2006-02-08 | 2017-09-28 | Morphotek Inc | Antigen GM-CSF peptides and GM-CSF antibodies |
| CN103641916A (zh) | 2006-03-27 | 2014-03-19 | 医学免疫有限公司 | Gm-csf受体结合元件 |
| US7741273B2 (en) * | 2006-04-13 | 2010-06-22 | Warsaw Orthopedic, Inc. | Drug depot implant designs |
| EA200900709A1 (ru) * | 2006-11-21 | 2009-12-30 | Калобиос Фармасьютикалс, Инк. | Способы лечения хронических воспалительных заболеваний с использованием антагониста gm-csf |
| US7879856B2 (en) * | 2006-12-22 | 2011-02-01 | Rigel Pharmaceuticals, Inc. | Diaminothiazoles useful as Axl inhibitors |
| JP2010527939A (ja) * | 2007-05-23 | 2010-08-19 | シーアールシー・フォー・アズマ・アンド・エアウェイズ・リミテッド | 中和抗体 |
| TW200918553A (en) * | 2007-09-18 | 2009-05-01 | Amgen Inc | Human GM-CSF antigen binding proteins |
| US20090163440A1 (en) * | 2007-09-26 | 2009-06-25 | Waddell David D | Ion-Channel Regulator Compositions and Methods of Using Same |
| US20100297135A1 (en) | 2007-11-12 | 2010-11-25 | Crc For Asthma And Airways Ltd. | Epitope for neutralizing antibodies |
| ES2401536T3 (es) * | 2007-11-13 | 2013-04-22 | Evec Inc. | Anticuerpos monoclonales que se unen a HGM-CSF y composiciones medicinales que los comprenden |
| EP2271671A2 (en) | 2008-03-24 | 2011-01-12 | Abbott Biotechnology Ltd. | Tnf-alpha inhibitors for treating bone loss |
| KR101852915B1 (ko) * | 2008-04-28 | 2018-04-27 | 휴머니건, 아이엔씨. | 과립구-대식세포 콜로니 자극 인자에 대한 항체 |
| CN102256621B (zh) | 2008-12-22 | 2017-12-12 | 墨尔本大学 | 疼痛治疗 |
| KR101898982B1 (ko) | 2008-12-22 | 2018-09-14 | 더 유니버시티 오브 멜버른 | 골관절염 치료 |
| SG175305A1 (en) | 2009-04-23 | 2011-11-28 | Theraclone Sciences Inc | Granulocyte-macrophage colony-stimulating factor (gm-csf) neutralizing antibodies |
-
2009
- 2009-12-21 KR KR1020177032850A patent/KR101898982B1/ko active IP Right Grant
- 2009-12-21 CN CN2009801516359A patent/CN102271705A/zh active Pending
- 2009-12-21 ES ES09833924T patent/ES2572368T5/es active Active
- 2009-12-21 EP EP15194091.3A patent/EP3056217B1/en active Active
- 2009-12-21 ES ES15194091T patent/ES2886063T3/es active Active
- 2009-12-21 SI SI200931446T patent/SI2376121T2/sl unknown
- 2009-12-21 SI SI200931446A patent/SI2376121T1/sl unknown
- 2009-12-21 US US13/140,467 patent/US9243061B2/en active Active
- 2009-12-21 HU HUE09833924A patent/HUE028615T2/en unknown
- 2009-12-21 KR KR1020117017015A patent/KR101799264B1/ko active IP Right Grant
- 2009-12-21 RU RU2011127334/15A patent/RU2011127334A/ru unknown
- 2009-12-21 WO PCT/AU2009/001672 patent/WO2010071924A1/en active Application Filing
- 2009-12-21 BR BRPI0918356-6A patent/BRPI0918356B1/pt active IP Right Grant
- 2009-12-21 DK DK09833924.5T patent/DK2376121T4/da active
- 2009-12-21 CN CN201610822096.9A patent/CN106397591A/zh active Pending
- 2009-12-21 JP JP2011541030A patent/JP5727379B2/ja active Active
- 2009-12-21 CA CA2746827A patent/CA2746827C/en active Active
- 2009-12-21 EP EP09833924.5A patent/EP2376121B2/en active Active
- 2009-12-21 AU AU2009329814A patent/AU2009329814B2/en active Active
- 2009-12-21 RU RU2016102339A patent/RU2712273C2/ru active
- 2009-12-21 PL PL09833924T patent/PL2376121T5/pl unknown
-
2015
- 2015-02-20 JP JP2015031198A patent/JP2015143233A/ja active Pending
- 2015-12-18 US US14/975,024 patent/US20160185868A1/en not_active Abandoned
-
2016
- 2016-05-18 CY CY20161100433T patent/CY1117698T1/el unknown
- 2016-05-30 HR HRP20160577TT patent/HRP20160577T4/hr unknown
- 2016-06-01 SM SM201600156T patent/SMT201600156B/it unknown
- 2016-12-06 HK HK16113893A patent/HK1226938A1/zh unknown
-
2017
- 2017-06-12 JP JP2017114806A patent/JP6458086B2/ja active Active
- 2017-11-13 US US15/811,279 patent/US20180066062A1/en not_active Abandoned
-
2020
- 2020-03-31 US US16/836,464 patent/US20200247895A1/en not_active Abandoned
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