JP2012512633A5 - - Google Patents

Info

Publication number

JP2012512633A5

JP2012512633A5 JP2011541228A JP2011541228A JP2012512633A5 JP 2012512633 A5 JP2012512633 A5 JP 2012512633A5 JP 2011541228 A JP2011541228 A JP 2011541228A JP 2011541228 A JP2011541228 A JP 2011541228A JP 2012512633 A5 JP2012512633 A5 JP 2012512633A5

Authority

JP

Japan

Prior art keywords

amino acid

compound

subunit

polypeptide fragment

seq

Prior art date

2009-12-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 150000001875 compounds Chemical class 0.000 claims 23
• 108090000765 processed proteins & peptides Proteins 0.000 claims 21
• 239000012634 fragment Substances 0.000 claims 20
• 229920001184 polypeptide Polymers 0.000 claims 20
• 102000004196 processed proteins & peptides Human genes 0.000 claims 20
• 238000000034 method Methods 0.000 claims 13
• 125000003275 alpha amino acid group Chemical group 0.000 claims 11
• 150000001413 amino acids Chemical class 0.000 claims 11
• 230000000694 effects Effects 0.000 claims 10
• 102000004533 Endonucleases Human genes 0.000 claims 8
• 108010042407 Endonucleases Proteins 0.000 claims 8
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
• 210000004027 cell Anatomy 0.000 claims 4
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
• 241000700605 Viruses Species 0.000 claims 3
• 102000040430 polynucleotide Human genes 0.000 claims 3
• 108091033319 polynucleotide Proteins 0.000 claims 3
• 239000002157 polynucleotide Substances 0.000 claims 3
• 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 2
• 108090000626 DNA-directed RNA polymerases Proteins 0.000 claims 2
• 102000004163 DNA-directed RNA polymerases Human genes 0.000 claims 2
• 241000712431 Influenza A virus Species 0.000 claims 2
• 241000713196 Influenza B virus Species 0.000 claims 2
• 241000713297 Influenza C virus Species 0.000 claims 2
• 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 2
• 241000712464 Orthomyxoviridae Species 0.000 claims 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
• 108020000999 Viral RNA Proteins 0.000 claims 2
• 150000001768 cations Chemical class 0.000 claims 2
• 238000005094 computer simulation Methods 0.000 claims 2
• 230000001419 dependent effect Effects 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• 150000003384 small molecules Chemical class 0.000 claims 2
• 101100338269 Caenorhabditis elegans his-41 gene Proteins 0.000 claims 1
• PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims 1
• -1 SEQ ID NO: 2 amino acid Chemical class 0.000 claims 1
• 239000007983 Tris buffer Substances 0.000 claims 1
• 208000036142 Viral infection Diseases 0.000 claims 1
• 239000000654 additive Substances 0.000 claims 1
• 210000004899 c-terminal region Anatomy 0.000 claims 1
• 238000004364 calculation method Methods 0.000 claims 1
• 239000013078 crystal Substances 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 239000003446 ligand Substances 0.000 claims 1
• UEGPKNKPLBYCNK-UHFFFAOYSA-L magnesium acetate Chemical compound [Mg+2].CC([O-])=O.CC([O-])=O UEGPKNKPLBYCNK-UHFFFAOYSA-L 0.000 claims 1
• 235000011285 magnesium acetate Nutrition 0.000 claims 1
• 239000011654 magnesium acetate Substances 0.000 claims 1
• 229940069446 magnesium acetate Drugs 0.000 claims 1
• 229910052748 manganese Inorganic materials 0.000 claims 1
• 239000011572 manganese Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
• 239000012460 protein solution Substances 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 238000005215 recombination Methods 0.000 claims 1
• 230000006798 recombination Effects 0.000 claims 1
• 239000011780 sodium chloride Substances 0.000 claims 1
• 239000000243 solution Substances 0.000 claims 1
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 1
• 230000009385 viral infection Effects 0.000 claims 1