JP2012511917A - 1型の血液細胞成分の同定のためのエピジェネティックマーカー - Google Patents

1型の血液細胞成分の同定のためのエピジェネティックマーカー Download PDF

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JP2012511917A
JP2012511917A JP2011541165A JP2011541165A JP2012511917A JP 2012511917 A JP2012511917 A JP 2012511917A JP 2011541165 A JP2011541165 A JP 2011541165A JP 2011541165 A JP2011541165 A JP 2011541165A JP 2012511917 A JP2012511917 A JP 2012511917A
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lymphocytes
seq
amplification product
methylation
cpg
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JP2012511917A5 (enExample
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オレク,スフェン
テュルバコファ,イファナ
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エピオンティス ゲーエムベーハー
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Wood Science & Technology (AREA)
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JP2011541165A 2008-12-16 2009-12-08 1型の血液細胞成分の同定のためのエピジェネティックマーカー Pending JP2012511917A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20080021838 EP2199411B1 (en) 2008-12-16 2008-12-16 Epigenetic markers for the identification of CD3 positive T-lymphocytes
EP08021838.1 2008-12-16
PCT/EP2009/008764 WO2010069499A2 (en) 2008-12-16 2009-12-08 Epigenetic markers for the identification of blood sub-cells of type 1

Publications (2)

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JP2012511917A true JP2012511917A (ja) 2012-05-31
JP2012511917A5 JP2012511917A5 (enExample) 2012-12-20

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JP2011541165A Pending JP2012511917A (ja) 2008-12-16 2009-12-08 1型の血液細胞成分の同定のためのエピジェネティックマーカー

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US (1) US20120107810A1 (enExample)
EP (2) EP2199411B1 (enExample)
JP (1) JP2012511917A (enExample)
CA (1) CA2747312C (enExample)
DK (2) DK2199411T3 (enExample)
ES (1) ES2606350T3 (enExample)
PL (1) PL2376648T3 (enExample)
WO (1) WO2010069499A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016515397A (ja) * 2013-04-19 2016-05-30 エピオンティス ゲーエムベーハー 生体サンプルにおける定量的細胞組成を特定する方法
JP2020505938A (ja) * 2017-02-09 2020-02-27 エピオンティス ゲーエムベーハー エピジェネティックな免疫細胞計数のための改善された方法
JP2021502061A (ja) * 2017-10-25 2021-01-28 エピオンティス ゲーエムベーハー 免疫細胞、特にpd1+ 細胞の同定のためのエピジェネティックマーカーとしてのpdcd1

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170233807A1 (en) 2008-12-16 2017-08-17 Epiontis Gmbh Epigenetic Markers for the Identification of Blood Sub-cells of Type 1
WO2012021867A2 (en) * 2010-08-13 2012-02-16 The Johns Hopkins University A comprehensive methylome map of myeloid and lymphoid commitment from hematopoietic progenitors
WO2012045888A1 (en) 2010-10-08 2012-04-12 Epiontis Gmbh Method for determining cancer patient survival based on analyzing tumor-infiltrating overall t-lymphocytes
US20130296328A1 (en) * 2011-01-20 2013-11-07 Université Libre de Bruxelles Epigenetic portraits of human breast cancers
US20140178348A1 (en) 2011-05-25 2014-06-26 The Regents Of The University Of California Methods using DNA methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies
EP2714933A4 (en) * 2011-05-25 2014-12-31 Univ Brown METHODIZED METHOD FOR IDENTIFYING A CELL OR MIXING CELLS FOR THE PROGNOSIS AND DIAGNOSIS OF ILLNESSES AND FOR CELL HEALING THERAPIES
EP2788510B1 (en) 2012-03-12 2016-12-14 Epiontis GmbH Epigenetic marker for the identification of cd3cd4 positive t lymphocytes
GB201221133D0 (en) 2012-11-23 2013-01-09 Epiontis Gmbh Epigenetic method for the identification of subpopulations of CD8 and T lympocytes, in particular CD8 alpha and beta T lymphocytes
EP3382033B1 (en) * 2017-03-30 2020-08-05 Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen Method for determining blood counts based on dna methylation
DE102018116353B4 (de) 2018-07-05 2020-06-10 Epiontis Gmbh Verfahren zum Nachweis und zur Zählung epigenetischer Immunzellen in humanen Blutproben für Immundiagnostik und Neugeborenen-Screening
CN116949156B (zh) * 2023-09-19 2023-12-08 美迪西普亚医药科技(上海)有限公司 一种基于核酸变体的通用型检测人t细胞的分析方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002171973A (ja) 2000-12-07 2002-06-18 Univ Tokyo Dnaメチル化パターンによる細胞の同定法
AU2003285586A1 (en) 2002-12-03 2004-06-23 Medical Research Council Regulatory t-cells
ATE508207T1 (de) 2006-02-28 2011-05-15 Charite Universitaetsmedizin Nachweis und qualitätskontrolle von regulator-t- zellen mittels dna-methylierungsanalyse des foxp3-gens

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JPN5012005213; FLANAGAN B F et al: 'DNASE HYPERSENSITIVITY AND METHYLATION OF THE HUMAN CD3G AND D GENES DURING T-CELL DEVELOPMENT' IMMUNOGENETICS Vol. 31, 1990, p. 13-20, SPRINGER VERLAG *
JPN5012005214; CLEVERS H et al: EMBO JOURNAL Vol. 8, No. 9, 1989, p. 2527-2535 *
JPN5012005215; TUTT LANDOLFI M M et al: 'SPECIFIC DEMETHYLATION OF THE CD4 GENE DURING CD4 T LYMPHOCYTE DIFFERENTIATION' MOLECULAR IMMUNOLOGY Vol. 34, No. 1, 199701, p. 53-61 *
JPN5012005216; LUSSO P et al: NATURE Vol. 349, 19910207, p. 533-535 *
JPN5012005217; GEORGOPOULOS K et al: THE EMBO JOURNAL Vol. 7, No. 8, 1988, p. 2401-2407 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016515397A (ja) * 2013-04-19 2016-05-30 エピオンティス ゲーエムベーハー 生体サンプルにおける定量的細胞組成を特定する方法
JP2020505938A (ja) * 2017-02-09 2020-02-27 エピオンティス ゲーエムベーハー エピジェネティックな免疫細胞計数のための改善された方法
JP2021502061A (ja) * 2017-10-25 2021-01-28 エピオンティス ゲーエムベーハー 免疫細胞、特にpd1+ 細胞の同定のためのエピジェネティックマーカーとしてのpdcd1

Also Published As

Publication number Publication date
EP2199411B1 (en) 2015-05-06
DK2199411T3 (en) 2015-08-03
CA2747312C (en) 2018-11-06
EP2376648B1 (en) 2016-09-14
WO2010069499A3 (en) 2010-08-26
EP2199411A1 (en) 2010-06-23
ES2606350T3 (es) 2017-03-23
WO2010069499A2 (en) 2010-06-24
HK1163189A1 (zh) 2012-09-07
CA2747312A1 (en) 2010-06-24
DK2376648T3 (da) 2017-01-02
PL2376648T3 (pl) 2017-05-31
EP2376648A2 (en) 2011-10-19
US20120107810A1 (en) 2012-05-03

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