JP2012511305A5 - - Google Patents
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- Publication number
- JP2012511305A5 JP2012511305A5 JP2011525307A JP2011525307A JP2012511305A5 JP 2012511305 A5 JP2012511305 A5 JP 2012511305A5 JP 2011525307 A JP2011525307 A JP 2011525307A JP 2011525307 A JP2011525307 A JP 2011525307A JP 2012511305 A5 JP2012511305 A5 JP 2012511305A5
- Authority
- JP
- Japan
- Prior art keywords
- nectin
- cancer
- level
- detecting
- double
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 101710043865 Nectin-4 Proteins 0.000 claims description 73
- 238000000034 method Methods 0.000 claims description 67
- 102100035486 Nectin-4 Human genes 0.000 claims description 61
- 206010028980 Neoplasm Diseases 0.000 claims description 49
- 201000011510 cancer Diseases 0.000 claims description 49
- 150000001875 compounds Chemical class 0.000 claims description 38
- 210000004369 blood Anatomy 0.000 claims description 20
- 239000008280 blood Substances 0.000 claims description 20
- 239000000523 sample Substances 0.000 claims description 20
- 230000014509 gene expression Effects 0.000 claims description 18
- 238000003018 immunoassay Methods 0.000 claims description 18
- 230000002018 overexpression Effects 0.000 claims description 17
- 239000003153 chemical reaction reagent Substances 0.000 claims description 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 15
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 14
- 201000005202 lung cancer Diseases 0.000 claims description 14
- 208000020816 lung neoplasm Diseases 0.000 claims description 14
- 229920001184 polypeptide Polymers 0.000 claims description 14
- 238000012360 testing method Methods 0.000 claims description 13
- 108091081021 Sense strand Proteins 0.000 claims description 12
- 238000004393 prognosis Methods 0.000 claims description 11
- 206010005003 Bladder cancer Diseases 0.000 claims description 10
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 10
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 10
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 10
- 239000012472 biological sample Substances 0.000 claims description 10
- 201000010881 cervical cancer Diseases 0.000 claims description 10
- 239000002773 nucleotide Substances 0.000 claims description 10
- 125000003729 nucleotide group Chemical group 0.000 claims description 10
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 10
- 230000004071 biological effect Effects 0.000 claims description 8
- 108091033319 polynucleotide Proteins 0.000 claims description 8
- 239000002157 polynucleotide Substances 0.000 claims description 8
- 102000040430 polynucleotide Human genes 0.000 claims description 8
- 238000012216 screening Methods 0.000 claims description 8
- 210000002966 serum Anatomy 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- 108700008625 Reporter Genes Proteins 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 238000002965 ELISA Methods 0.000 claims description 4
- 230000000692 anti-sense effect Effects 0.000 claims description 4
- 230000000295 complement effect Effects 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 210000002381 plasma Anatomy 0.000 claims description 4
- 230000001105 regulatory effect Effects 0.000 claims description 4
- 230000002103 transcriptional effect Effects 0.000 claims description 4
- 108091034117 Oligonucleotide Proteins 0.000 claims description 2
- 208000009956 adenocarcinoma Diseases 0.000 claims description 2
- 230000027455 binding Effects 0.000 claims description 2
- 230000004663 cell proliferation Effects 0.000 claims description 2
- 239000013068 control sample Substances 0.000 claims description 2
- 108020004999 messenger RNA Proteins 0.000 claims description 2
- 238000010837 poor prognosis Methods 0.000 claims description 2
- 239000013641 positive control Substances 0.000 claims description 2
- 206010041823 squamous cell carcinoma Diseases 0.000 claims description 2
- 238000011156 evaluation Methods 0.000 claims 2
- 239000000439 tumor marker Substances 0.000 claims 2
- 239000000463 material Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000556 agonist Substances 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002823 phage display Methods 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20181108P | 2008-12-12 | 2008-12-12 | |
| US61/201,811 | 2008-12-12 | ||
| PCT/JP2009/004026 WO2010067487A1 (en) | 2008-12-12 | 2009-08-21 | Nectin-4 for target genes of cancer therapy and diagnosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012511305A JP2012511305A (ja) | 2012-05-24 |
| JP2012511305A5 true JP2012511305A5 (https=) | 2012-10-11 |
Family
ID=42242486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011525307A Withdrawn JP2012511305A (ja) | 2008-12-12 | 2009-08-21 | 癌の治療および診断の標的遺伝子としてのネクチン−４ |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20110301056A1 (https=) |
| EP (1) | EP2373794A4 (https=) |
| JP (1) | JP2012511305A (https=) |
| WO (1) | WO2010067487A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2517555A4 (en) | 2009-12-25 | 2014-09-24 | Chugai Pharmaceutical Co Ltd | SEARCHING AND SCREENING METHOD FOR A TARGET MOLECULE OF A CANCER WITH A NON-MENTAL ANIMAL MODEL WITH A NO-CANCER LINE OF TRANSPLANTED LINE |
| JP6230789B2 (ja) | 2010-10-06 | 2017-11-15 | 中外製薬株式会社 | 癌幹細胞集団及びその作製方法 |
| CA2825094C (en) * | 2011-01-18 | 2020-01-07 | Dalhousie University | Pvrl4 (nectin 4) is a receptor for measles virus. |
| EP2772268B8 (en) | 2011-10-28 | 2020-01-08 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell-specific molecule |
| EP3347048B1 (en) * | 2015-09-09 | 2020-04-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antibodies having specificity to nectin-4 and uses thereof |
| CN110392697A (zh) * | 2017-03-02 | 2019-10-29 | 国家医疗保健研究所 | 对nectin-4具有特异性的抗体及其用途 |
| WO2018226578A1 (en) | 2017-06-05 | 2018-12-13 | Agensys, Inc. | Nectin-4-binding proteins and methods of use thereof |
| SG11202001930QA (en) * | 2017-09-07 | 2020-04-29 | Dragonfly Therapeutics Inc | Proteins binding nkg2d, cd16 and a tumor-associated antigen |
| US12123881B2 (en) * | 2018-04-20 | 2024-10-22 | Unm Rainforest Innovations | Rap1-Gtp, Rac1-GTP and FMS-like tyrosine kinase 3 ligand (FLT3-L) as biomarkers for early detection of sepsis |
| KR102280672B1 (ko) * | 2019-12-20 | 2021-07-23 | 주식회사 베르티스 | 암의 진단용 조성물 |
| EP4096717B1 (en) | 2020-01-31 | 2024-12-11 | Innate Pharma | Treatment of cancer |
| JP7735291B2 (ja) * | 2020-02-21 | 2025-09-08 | エーアールエス ファーマシューティカルズ、インコーポレイテッド | ネクチン－４抗体コンジュゲートおよびその使用 |
| CN115768798A (zh) * | 2020-06-18 | 2023-03-07 | 生物蛋白有限公司 | 条件活性抗粘附分子-4(nectin-4)抗体 |
| MX2023005873A (es) * | 2020-11-25 | 2023-06-05 | Innate Pharma | Tratamiento del cancer. |
| WO2022253051A1 (zh) * | 2021-06-01 | 2022-12-08 | 南京明德新药研发有限公司 | 多肽偶联药物及其应用 |
| AU2023273063A1 (en) * | 2022-05-16 | 2024-11-14 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Pharmaceutical composition containing anti-nectin-4 antibody drug conjugate and use thereof |
| CA3262070A1 (en) * | 2022-07-14 | 2025-06-13 | Bio-Thera Solutions, Ltd. | ANTI-NECTIN-4 ANTIBODIES AND THEIR USES |
| CN115877008A (zh) * | 2022-12-05 | 2023-03-31 | 中国科学院自动化研究所 | 用于膀胱癌检测的光学分子成像探针及其制备方法和应用 |
| WO2024251260A1 (zh) * | 2023-06-08 | 2024-12-12 | 江苏迈威康新药研发有限公司 | 结合Nectin-4的抗体及其用途 |
| CN120271712A (zh) * | 2025-04-18 | 2025-07-08 | 哈尔滨医科大学 | 靶向Nectin-4的纳米抗体及其应用 |
| CN120330199B (zh) * | 2025-06-23 | 2025-08-29 | 上海交通大学医学院附属仁济医院 | 一种Nectin-4靶向核酸适体核素诊疗一体化探针 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200413725A (en) * | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
| US20080268476A1 (en) * | 2004-05-12 | 2008-10-30 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Nectin 4 (N4) as a Marker for Cancer Prognosis |
| US20090214517A1 (en) * | 2004-07-27 | 2009-08-27 | Justin Wong | Compositions and methods of use for modulators of nectin 4, semaphorin 4b, igsf9, and kiaa0152 in treating disease |
| CN101175862A (zh) * | 2005-02-10 | 2008-05-07 | 肿瘤疗法科学股份有限公司 | 诊断膀胱癌的方法 |
-
2009
- 2009-08-21 US US13/133,935 patent/US20110301056A1/en not_active Abandoned
- 2009-08-21 JP JP2011525307A patent/JP2012511305A/ja not_active Withdrawn
- 2009-08-21 EP EP09831596A patent/EP2373794A4/en not_active Withdrawn
- 2009-08-21 WO PCT/JP2009/004026 patent/WO2010067487A1/en not_active Ceased
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