JP2009502732A5 - - Google Patents
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- Publication number
- JP2009502732A5 JP2009502732A5 JP2008502763A JP2008502763A JP2009502732A5 JP 2009502732 A5 JP2009502732 A5 JP 2009502732A5 JP 2008502763 A JP2008502763 A JP 2008502763A JP 2008502763 A JP2008502763 A JP 2008502763A JP 2009502732 A5 JP2009502732 A5 JP 2009502732A5
- Authority
- JP
- Japan
- Prior art keywords
- tom34
- polypeptide
- seq
- amino acid
- colon cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 23
- 101000801539 Homo sapiens Mitochondrial import receptor subunit TOM34 Proteins 0.000 claims 17
- 102100033583 Mitochondrial import receptor subunit TOM34 Human genes 0.000 claims 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 15
- 229920001184 polypeptide Polymers 0.000 claims 15
- 238000000034 method Methods 0.000 claims 14
- 150000001413 amino acids Chemical group 0.000 claims 13
- 206010009944 Colon cancer Diseases 0.000 claims 12
- 208000029742 colonic neoplasm Diseases 0.000 claims 12
- 108091033319 polynucleotide Proteins 0.000 claims 8
- 239000002157 polynucleotide Substances 0.000 claims 8
- 102000040430 polynucleotide Human genes 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 230000004071 biological effect Effects 0.000 claims 4
- 239000012472 biological sample Substances 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 238000012216 screening Methods 0.000 claims 4
- 108700008625 Reporter Genes Proteins 0.000 claims 3
- 108091028664 Ribonucleotide Proteins 0.000 claims 3
- 108020004459 Small interfering RNA Proteins 0.000 claims 3
- 229940024606 amino acid Drugs 0.000 claims 3
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 3
- 239000002336 ribonucleotide Substances 0.000 claims 3
- 125000002652 ribonucleotide group Chemical group 0.000 claims 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 2
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 2
- 210000001072 colon Anatomy 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 210000002919 epithelial cell Anatomy 0.000 claims 2
- 229930182817 methionine Natural products 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 230000002103 transcriptional effect Effects 0.000 claims 2
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091081021 Sense strand Proteins 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 230000005809 anti-tumor immunity Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70326505P | 2005-07-27 | 2005-07-27 | |
| US60/703,265 | 2005-07-27 | ||
| PCT/JP2006/314947 WO2007013576A1 (en) | 2005-07-27 | 2006-07-21 | Colon cancer related gene tom34 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012015094A Division JP2012125248A (ja) | 2005-07-27 | 2012-01-27 | 結腸癌関連遺伝子ｔｏｍ３４ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009502732A JP2009502732A (ja) | 2009-01-29 |
| JP2009502732A5 true JP2009502732A5 (https=) | 2009-04-23 |
| JP5095603B2 JP5095603B2 (ja) | 2012-12-12 |
Family
ID=37499354
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008502763A Active JP5095603B2 (ja) | 2005-07-27 | 2006-07-21 | 結腸癌関連遺伝子ｔｏｍ３４ |
| JP2012015094A Pending JP2012125248A (ja) | 2005-07-27 | 2012-01-27 | 結腸癌関連遺伝子ｔｏｍ３４ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012015094A Pending JP2012125248A (ja) | 2005-07-27 | 2012-01-27 | 結腸癌関連遺伝子ｔｏｍ３４ |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8674059B2 (https=) |
| EP (1) | EP1910839B1 (https=) |
| JP (2) | JP5095603B2 (https=) |
| KR (2) | KR101325194B1 (https=) |
| CN (1) | CN101278196B (https=) |
| AU (1) | AU2006273192B2 (https=) |
| BR (1) | BRPI0613970B8 (https=) |
| CA (1) | CA2616497C (https=) |
| CY (1) | CY1117839T1 (https=) |
| DK (1) | DK1910839T3 (https=) |
| ES (1) | ES2584247T3 (https=) |
| HU (1) | HUE027330T2 (https=) |
| PL (1) | PL1910839T3 (https=) |
| PT (1) | PT1910839T (https=) |
| RU (2) | RU2449020C2 (https=) |
| SG (1) | SG163614A1 (https=) |
| SI (1) | SI1910839T1 (https=) |
| WO (1) | WO2007013576A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI1012312A2 (pt) * | 2009-03-04 | 2017-03-21 | Oncotherapy Science Inc | peptídeos vangl1 e vacinas incluindo os mesmos |
| TWI485245B (zh) * | 2010-01-25 | 2015-05-21 | Oncotherapy Science Inc | 經修飾之ｍｅｌｋ胜肽及含此胜肽之疫苗 |
| TW201211250A (en) * | 2010-09-07 | 2012-03-16 | Oncotherapy Science Inc | VANGL1 peptides and vaccines including the same |
| MY166516A (en) * | 2010-12-02 | 2018-07-05 | Oncotherapy Science Inc | Tomm34 peptides and vaccines including the same |
| CN104066746B (zh) * | 2011-10-28 | 2017-12-05 | 肿瘤疗法科学股份有限公司 | Topk肽及包含它们的疫苗 |
| US20150359864A1 (en) | 2012-03-09 | 2015-12-17 | Oncotherapy Science, Inc. | Pharmaceutical composition containing peptides |
| CN107073117A (zh) * | 2014-08-26 | 2017-08-18 | 埃塔根有限公司 | 用于识别wls蛋白特定基序的抗体和含有其的药物组合物 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4722848A (en) | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
| US5785973A (en) * | 1988-02-01 | 1998-07-28 | Praxis Biologics, Inc. | Synthetic peptides representing a T-cell epitope as a carrier molecule for conjugate vaccines |
| ATE123780T1 (de) * | 1989-02-17 | 1995-06-15 | Chiron Mimotopes Pty Ltd | Verfahren zur verwendung und herstellung von peptiden. |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5804566A (en) | 1993-08-26 | 1998-09-08 | The Regents Of The University Of California | Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides |
| US5679647A (en) | 1993-08-26 | 1997-10-21 | The Regents Of The University Of California | Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
| US5739118A (en) | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| US5736524A (en) | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
| US5922687A (en) | 1995-05-04 | 1999-07-13 | Board Of Trustees Of The Leland Stanford Junior University | Intracellular delivery of nucleic acids using pressure |
| WO1997005900A1 (en) | 1995-08-03 | 1997-02-20 | Rijksuniversiteit Te Leiden | Cell derived antigen presenting vesicles |
| US5840839A (en) * | 1996-02-09 | 1998-11-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein |
| US5853719A (en) | 1996-04-30 | 1998-12-29 | Duke University | Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA |
| JP2000516090A (ja) | 1996-07-26 | 2000-12-05 | スローン―ケッタリング インスティチュート フォー キャンサー リサーチ | 遺伝子的免疫化のための方法と試薬 |
| FR2766205B1 (fr) | 1997-07-16 | 2002-08-30 | Inst Nat Sante Rech Med | Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede |
| US7166573B1 (en) | 1999-05-28 | 2007-01-23 | Ludwig Institute For Cancer Research | Breast, gastric and prostate cancer associated antigens and uses therefor |
| EP1250145A4 (en) | 2000-01-03 | 2003-03-26 | Argonex Pharmaceuticals Inc | PEPTIDES DERIVED FROM ONCOGENE C-SKI FOR THE PREVENTION, TREATMENT AND DIAGNOSIS OF CANCER |
| US7700359B2 (en) | 2000-06-02 | 2010-04-20 | Novartis Vaccines And Diagnostics, Inc. | Gene products differentially expressed in cancerous cells |
| US20040181344A1 (en) | 2002-01-29 | 2004-09-16 | Massachusetts Institute Of Technology | Systems and methods for providing diagnostic services |
| TW200413406A (en) * | 2002-08-26 | 2004-08-01 | Kirin Brewery | Peptides and drugs containing the same |
| DE602004015064D1 (de) * | 2003-01-06 | 2008-08-28 | Wyeth Corp | Zusammensetzungen und verfahren zur diagnose und behandlung von kolonkrebs |
-
2006
- 2006-07-21 HU HUE06781857A patent/HUE027330T2/en unknown
- 2006-07-21 BR BRPI0613970A patent/BRPI0613970B8/pt not_active IP Right Cessation
- 2006-07-21 SI SI200632057A patent/SI1910839T1/sl unknown
- 2006-07-21 KR KR1020087004601A patent/KR101325194B1/ko not_active Expired - Fee Related
- 2006-07-21 AU AU2006273192A patent/AU2006273192B2/en not_active Ceased
- 2006-07-21 EP EP06781857.5A patent/EP1910839B1/en active Active
- 2006-07-21 JP JP2008502763A patent/JP5095603B2/ja active Active
- 2006-07-21 CA CA2616497A patent/CA2616497C/en active Active
- 2006-07-21 KR KR1020137019800A patent/KR20130087639A/ko not_active Withdrawn
- 2006-07-21 ES ES06781857.5T patent/ES2584247T3/es active Active
- 2006-07-21 DK DK06781857.5T patent/DK1910839T3/en active
- 2006-07-21 SG SG201005112-6A patent/SG163614A1/en unknown
- 2006-07-21 WO PCT/JP2006/314947 patent/WO2007013576A1/en not_active Ceased
- 2006-07-21 RU RU2008107318/15A patent/RU2449020C2/ru active
- 2006-07-21 CN CN2006800353844A patent/CN101278196B/zh not_active Expired - Fee Related
- 2006-07-21 PL PL06781857.5T patent/PL1910839T3/pl unknown
- 2006-07-21 RU RU2011127868/15A patent/RU2526196C2/ru active
- 2006-07-21 PT PT67818575T patent/PT1910839T/pt unknown
- 2006-07-21 US US11/913,228 patent/US8674059B2/en active Active
-
2012
- 2012-01-27 JP JP2012015094A patent/JP2012125248A/ja active Pending
-
2016
- 2016-07-21 CY CY20161100717T patent/CY1117839T1/el unknown
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