JP2012511034A5 - - Google Patents

Info

Publication number

JP2012511034A5

JP2012511034A5 JP2011539796A JP2011539796A JP2012511034A5 JP 2012511034 A5 JP2012511034 A5 JP 2012511034A5 JP 2011539796 A JP2011539796 A JP 2011539796A JP 2011539796 A JP2011539796 A JP 2011539796A JP 2012511034 A5 JP2012511034 A5 JP 2012511034A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

composition according

effective amount

active corticosteroid

corticosteroid

Prior art date

2009-12-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 21
• 239000003246 corticosteroid Substances 0.000 claims 14
• 239000002207 metabolite Substances 0.000 claims 6
• 238000002512 chemotherapy Methods 0.000 claims 4
• 230000005855 radiation Effects 0.000 claims 4
• KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 claims 3
• 102000003972 Fibroblast growth factor 7 Human genes 0.000 claims 3
• 108090000385 Fibroblast growth factor 7 Proteins 0.000 claims 3
• OHYGPBKGZGRQKT-XGQKBEPLSA-N [(8s,9r,10s,11s,13s,14s,16s,17r)-9-chloro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate Chemical group C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(OC(=O)CC)[C@@]1(C)C[C@@H]2O OHYGPBKGZGRQKT-XGQKBEPLSA-N 0.000 claims 3
• 229950000210 beclometasone dipropionate Drugs 0.000 claims 3
• 229940006003 beclomethasone 17-monopropionate Drugs 0.000 claims 3
• 239000006186 oral dosage form Substances 0.000 claims 3
• 238000001959 radiotherapy Methods 0.000 claims 3
• 230000000451 tissue damage Effects 0.000 claims 3
• 231100000827 tissue damage Toxicity 0.000 claims 3
• GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
• 230000006378 damage Effects 0.000 claims 2
• 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
• DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 claims 1
• WRGQSWVCFNIUNZ-GDCKJWNLSA-N 1-oleoyl-sn-glycerol 3-phosphate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)COP(O)(O)=O WRGQSWVCFNIUNZ-GDCKJWNLSA-N 0.000 claims 1
• 102000010907 Cyclooxygenase 2 Human genes 0.000 claims 1
• 108010037462 Cyclooxygenase 2 Proteins 0.000 claims 1
• 102400000921 Gastrin Human genes 0.000 claims 1
• 108010052343 Gastrins Proteins 0.000 claims 1
• 101800001586 Ghrelin Proteins 0.000 claims 1
• 102400000442 Ghrelin-28 Human genes 0.000 claims 1
• 101000825954 Homo sapiens R-spondin-1 Proteins 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 102000004137 Lysophosphatidic Acid Receptors Human genes 0.000 claims 1
• 108090000642 Lysophosphatidic Acid Receptors Proteins 0.000 claims 1
• 108010016076 Octreotide Proteins 0.000 claims 1
• 102100022762 R-spondin-1 Human genes 0.000 claims 1
• 102000005157 Somatostatin Human genes 0.000 claims 1
• 108010056088 Somatostatin Proteins 0.000 claims 1
• 229930003427 Vitamin E Natural products 0.000 claims 1
• 239000000556 agonist Substances 0.000 claims 1
• AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 1
• 239000005557 antagonist Substances 0.000 claims 1
• 230000003110 anti-inflammatory effect Effects 0.000 claims 1
• 239000002246 antineoplastic agent Substances 0.000 claims 1
• 239000003963 antioxidant agent Substances 0.000 claims 1
• 235000006708 antioxidants Nutrition 0.000 claims 1
• 210000004027 cell Anatomy 0.000 claims 1
• 230000005779 cell damage Effects 0.000 claims 1
• 230000001413 cellular effect Effects 0.000 claims 1
• AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 229960001334 corticosteroids Drugs 0.000 claims 1
• 229940127089 cytotoxic agent Drugs 0.000 claims 1
• 230000003013 cytotoxicity Effects 0.000 claims 1
• 231100000135 cytotoxicity Toxicity 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 210000002919 epithelial cell Anatomy 0.000 claims 1
• 210000000981 epithelium Anatomy 0.000 claims 1
• WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 1
• GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 claims 1
• 239000003102 growth factor Substances 0.000 claims 1
• 229940088597 hormone Drugs 0.000 claims 1
• 239000005556 hormone Substances 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 239000003112 inhibitor Substances 0.000 claims 1
• XGZVUEUWXADBQD-UHFFFAOYSA-L lithium carbonate Chemical compound [Li+].[Li+].[O-]C([O-])=O XGZVUEUWXADBQD-UHFFFAOYSA-L 0.000 claims 1
• 229910052808 lithium carbonate Inorganic materials 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 210000000214 mouth Anatomy 0.000 claims 1
• 229960002700 octreotide Drugs 0.000 claims 1
• 230000003537 radioprotector Effects 0.000 claims 1
• 230000001105 regulatory effect Effects 0.000 claims 1
• 210000000813 small intestine Anatomy 0.000 claims 1
• NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 claims 1
• 229960000553 somatostatin Drugs 0.000 claims 1
• MNQYNQBOVCBZIQ-JQOFMKNESA-A sucralfate Chemical compound O[Al](O)OS(=O)(=O)O[C@@H]1[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](COS(=O)(=O)O[Al](O)O)O[C@H]1O[C@@]1(COS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)O1 MNQYNQBOVCBZIQ-JQOFMKNESA-A 0.000 claims 1
• 229960004291 sucralfate Drugs 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• 230000000699 topical effect Effects 0.000 claims 1
• 235000019165 vitamin E Nutrition 0.000 claims 1
• 229940046009 vitamin E Drugs 0.000 claims 1
• 239000011709 vitamin E Substances 0.000 claims 1