JP2012510515A5 - - Google Patents

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Publication number
JP2012510515A5
JP2012510515A5 JP2011539569A JP2011539569A JP2012510515A5 JP 2012510515 A5 JP2012510515 A5 JP 2012510515A5 JP 2011539569 A JP2011539569 A JP 2011539569A JP 2011539569 A JP2011539569 A JP 2011539569A JP 2012510515 A5 JP2012510515 A5 JP 2012510515A5
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JP
Japan
Prior art keywords
acid
carbonyl
oxo
carboxylic acid
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2011539569A
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English (en)
Japanese (ja)
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JP2012510515A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/064971 external-priority patent/WO2010065310A1/en
Publication of JP2012510515A publication Critical patent/JP2012510515A/ja
Publication of JP2012510515A5 publication Critical patent/JP2012510515A5/ja
Withdrawn legal-status Critical Current

Links

JP2011539569A 2008-12-03 2009-11-18 ジアシルグリセロールアシルトランスフェラーゼの阻害剤 Withdrawn JP2012510515A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11946708P 2008-12-03 2008-12-03
US61/119,467 2008-12-03
PCT/US2009/064971 WO2010065310A1 (en) 2008-12-03 2009-11-18 Inhibitors of diacylglycerol acyltransferase

Publications (2)

Publication Number Publication Date
JP2012510515A JP2012510515A (ja) 2012-05-10
JP2012510515A5 true JP2012510515A5 (enExample) 2013-01-10

Family

ID=42231833

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011539569A Withdrawn JP2012510515A (ja) 2008-12-03 2009-11-18 ジアシルグリセロールアシルトランスフェラーゼの阻害剤

Country Status (8)

Country Link
US (1) US8124766B2 (enExample)
EP (1) EP2367817A4 (enExample)
JP (1) JP2012510515A (enExample)
CN (1) CN102239165A (enExample)
AU (1) AU2009322774A1 (enExample)
CA (1) CA2744152A1 (enExample)
IL (1) IL212916A0 (enExample)
WO (1) WO2010065310A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8153644B2 (en) * 2007-05-22 2012-04-10 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
US8115011B2 (en) 2007-05-22 2012-02-14 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
US8211884B2 (en) 2008-08-06 2012-07-03 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
JP4900361B2 (ja) * 2008-10-21 2012-03-21 ソニー株式会社 画像処理装置、画像処理方法およびプログラム
US8324385B2 (en) 2008-10-30 2012-12-04 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
JP2012512252A (ja) 2008-12-17 2012-05-31 ブイアイエイ・ファーマシューティカルズ・インコーポレーテッド ジアシルグリセロールアシルトランスフェラーゼの阻害剤
PA8854101A1 (es) 2008-12-18 2010-07-27 Ortho Mcneil Janssen Pharm Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa
CN102325765B (zh) 2009-02-06 2014-12-24 杨森制药公司 作为γ-分泌酶调节剂的取代的双环杂环化合物
TWI461425B (zh) 2009-02-19 2014-11-21 Janssen Pharmaceuticals Inc 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類
EA019702B1 (ru) 2009-05-07 2014-05-30 Янссен Фармасьютикалз, Инк. Замещенные производные индазола и азаиндазола в качестве модуляторов гамма-секретазы
WO2011006903A1 (en) 2009-07-15 2011-01-20 Ortho-Mcneil-Janssen Pharmaceuticals, Inc Substituted triazole and imidazole derivatives as gamma secretase modulators
EP2477498A4 (en) * 2009-09-14 2013-02-27 Merck Sharp & Dohme INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE
PH12012501381A1 (en) 2010-01-15 2012-10-22 Janssen Pharmaceuticals Inc Novel substituted bicyclic triazole derivatives as gamma secretase modulators
ES2536442T3 (es) 2011-03-24 2015-05-25 Janssen Pharmaceuticals, Inc. Derivados novedosos de triazolil piperazina y triazolil piperidina como moduladores de la gamma secretasa
CN103874702B (zh) 2011-07-15 2015-12-09 杨森制药公司 作为γ分泌酶调节剂的经取代的吲哚衍生物
CN104583208B (zh) 2012-05-16 2016-09-28 杨森制药公司 可用于治疗(尤其是)阿尔茨海默病的取代的3,4-二氢-2H-吡啶并[1,2-a]吡嗪-1,6-二酮衍生物
WO2014096212A1 (en) 2012-12-20 2014-06-26 Janssen Pharmaceutica Nv NOVEL TRICYCLIC 3,4-DIHYDRO-2H-PYRIDO[1,2-α]PYRAZINE-1,6-DIONE DERIVATIVES AS GAMMA SECRETASE MODULATORS
KR102171710B1 (ko) 2013-01-17 2020-10-30 얀센 파마슈티카 엔.브이. 감마 세크레타제 조절 인자로서의 신규 치환 피리도-피페라지논 유도체
US10562897B2 (en) 2014-01-16 2020-02-18 Janssen Pharmaceutica Nv Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
CA3183081A1 (en) 2020-06-24 2021-12-30 Arnold Levine Combination therapy for treatment of cancer
KR102993831B1 (ko) * 2020-10-08 2026-07-23 머크 샤프 앤드 돔 엘엘씨 신규 디아실글리세리드 o-아실트랜스퍼라제 2 억제제로서의 옥스인돌 유도체의 제조
WO2024199387A1 (zh) * 2023-03-30 2024-10-03 微境生物医药科技(上海)有限公司 作为DGKζ抑制剂的化合物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3250771A (en) * 1962-12-17 1966-05-10 Geigy Chem Corp 5-monocarbocyclic aryl-n-lower alkyl-2-pyrrolidine carboxylic acid, esters, amides and derivatives thereof
DE2337461A1 (de) * 1973-07-24 1975-02-06 Boehringer Mannheim Gmbh Neue indolderivate und verfahren zu deren herstellung
US4066654A (en) * 1975-04-16 1978-01-03 G. D. Searle & Co. 1-triarylalkyl-4-phenyl-4-piperidine carboxylic acids and derivatives
US6495558B1 (en) * 1999-01-22 2002-12-17 Amgen Inc. Kinase inhibitors
US6756374B2 (en) * 2001-01-22 2004-06-29 Hoffmann-La Roche Inc. Diaminothiazoles having antiproliferative activity
BR0212158A (pt) 2001-08-31 2004-07-13 Aventis Pharma Gmbh Derivados de diarilcicloalquila, processos para a sua preparação e sua aplicação como ativadores de ppar
US7553867B2 (en) 2002-09-06 2009-06-30 Takeda Pharmaceutical Company Limited Furan or thiophene derivative and medicinal use thereof
EP1562956A4 (en) * 2002-11-22 2007-10-10 Japan Tobacco Inc HETEROCYCLES CONTAINING FUSED BICYCLIC NITROGEN
CA2610188A1 (en) 2005-06-11 2006-12-21 Astrazeneca Ab Oxadiazole derivatives as dgat inhibitors
BRPI0619052A2 (pt) 2005-11-28 2011-09-20 Hoffmann La Roche compostos, processo para a sua preparação, composições farmacêuticas que os compreendem, método para o tratamento terapêutico e/ou profilático de enfermidades que são moduladas por inibidores de diacilglicerol aciltransferase, e seu uso
US20100093733A1 (en) * 2007-02-15 2010-04-15 Prosidion Limited Amide and urea derivatives for the treatment of metabolic diseases
EP2155687A1 (en) 2007-05-22 2010-02-24 Via Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors

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