JP2012510430A5 - - Google Patents
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- Publication number
- JP2012510430A5 JP2012510430A5 JP2011528082A JP2011528082A JP2012510430A5 JP 2012510430 A5 JP2012510430 A5 JP 2012510430A5 JP 2011528082 A JP2011528082 A JP 2011528082A JP 2011528082 A JP2011528082 A JP 2011528082A JP 2012510430 A5 JP2012510430 A5 JP 2012510430A5
- Authority
- JP
- Japan
- Prior art keywords
- peptidomimetic macrocycle
- amino acid
- independently
- alkyl
- cycloalkylalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000002678 macrocyclic compounds Chemical class 0.000 claims description 59
- 239000000816 peptidomimetic Substances 0.000 claims description 58
- 150000001413 amino acids Chemical class 0.000 claims description 24
- 125000000217 alkyl group Chemical group 0.000 claims description 22
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 22
- 125000003342 alkenyl group Chemical group 0.000 claims description 18
- 125000000304 alkynyl group Chemical group 0.000 claims description 18
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 18
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 18
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 18
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 15
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 11
- 125000003118 aryl group Chemical group 0.000 claims description 10
- 125000004450 alkenylene group Chemical group 0.000 claims description 8
- 125000002947 alkylene group Chemical group 0.000 claims description 8
- 125000004419 alkynylene group Chemical group 0.000 claims description 8
- 125000002993 cycloalkylene group Chemical group 0.000 claims description 8
- 125000004474 heteroalkylene group Chemical group 0.000 claims description 8
- 125000006588 heterocycloalkylene group Chemical group 0.000 claims description 8
- 229940124597 therapeutic agent Drugs 0.000 claims description 8
- 125000004122 cyclic group Chemical group 0.000 claims description 6
- 230000003993 interaction Effects 0.000 claims description 5
- 108010000591 Myc associated factor X Proteins 0.000 claims description 4
- 101710150912 Myc protein Proteins 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 230000003042 antagnostic effect Effects 0.000 claims description 4
- 125000000732 arylene group Chemical group 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 125000001475 halogen functional group Chemical group 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- 125000005549 heteroarylene group Chemical group 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 150000002431 hydrogen Chemical class 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 239000003431 cross linking reagent Substances 0.000 claims description 3
- 125000003277 amino group Chemical group 0.000 claims description 2
- 125000005647 linker group Chemical group 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000004971 Cross linker Substances 0.000 claims 1
- 108010091748 peptide A Proteins 0.000 claims 1
- 238000000034 method Methods 0.000 description 7
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9916508P | 2008-09-22 | 2008-09-22 | |
| US61/099,165 | 2008-09-22 | ||
| PCT/US2009/057930 WO2010034031A1 (en) | 2008-09-22 | 2009-09-22 | Peptidomimetic macrocycles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012510430A JP2012510430A (ja) | 2012-05-10 |
| JP2012510430A5 true JP2012510430A5 (https=) | 2012-06-21 |
Family
ID=41692050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011528082A Withdrawn JP2012510430A (ja) | 2008-09-22 | 2009-09-22 | ペプチド模倣大環状分子 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20120178700A1 (https=) |
| EP (1) | EP2334697A1 (https=) |
| JP (1) | JP2012510430A (https=) |
| CN (1) | CN102884074A (https=) |
| AU (1) | AU2009294874A1 (https=) |
| BR (1) | BRPI0920889A2 (https=) |
| CA (1) | CA2737920A1 (https=) |
| WO (1) | WO2010034031A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105061577A (zh) | 2006-12-14 | 2015-11-18 | 爱勒让治疗公司 | 双巯基大环化系统 |
| ES2398310T3 (es) | 2007-02-23 | 2013-03-15 | Aileron Therapeutics, Inc. | Péptidos macrocíclicos unidos a triazol |
| AU2008232709C1 (en) | 2007-03-28 | 2015-01-15 | President And Fellows Of Harvard College | Stitched polypeptides |
| ES2666458T3 (es) | 2008-09-22 | 2018-05-04 | Aileron Therapeutics, Inc. | Macrociclos peptidomiméticos |
| EP2352507A4 (en) | 2008-11-24 | 2012-04-25 | Aileron Therapeutics Inc | PEPTIDOMIMETIC MACROCYCLES WITH IMPROVED PROPERTIES |
| WO2010083347A2 (en) | 2009-01-14 | 2010-07-22 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| US20130072439A1 (en) | 2009-09-22 | 2013-03-21 | Huw M. Nash | Peptidomimetic macrocycles |
| KR20170058446A (ko) | 2010-08-13 | 2017-05-26 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| US9169295B2 (en) | 2010-10-13 | 2015-10-27 | Bristol-Myers Squibb Company | Macrocycles and macrocycle stabilized peptides |
| AR088392A1 (es) | 2011-10-18 | 2014-05-28 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos |
| CN104066435A (zh) * | 2011-12-21 | 2014-09-24 | 纽约大学 | 蛋白水解抗性的氢键替代螺旋 |
| HK1205454A1 (en) | 2012-02-15 | 2015-12-18 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| CA2862038C (en) | 2012-02-15 | 2021-05-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| BR112015009470A2 (pt) | 2012-11-01 | 2019-12-17 | Aileron Therapeutics Inc | aminoácidos dissubstituídos e seus métodos de preparação e uso |
| CN105792851B (zh) | 2013-09-13 | 2023-10-10 | 斯克利普斯研究所 | 修饰的治疗剂及其组合物 |
| AU2014364589B2 (en) | 2013-12-18 | 2020-02-27 | The California Institute For Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
| SG11201702175YA (en) | 2014-09-24 | 2017-04-27 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and formulations thereof |
| WO2016049359A1 (en) | 2014-09-24 | 2016-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| US10253067B2 (en) * | 2015-03-20 | 2019-04-09 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| US10059741B2 (en) | 2015-07-01 | 2018-08-28 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| JP2018528217A (ja) | 2015-09-10 | 2018-09-27 | エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | Ｍｃｌ−１のモジュレーターとしてのペプチド模倣大環状分子 |
| DK3430031T3 (da) * | 2016-03-15 | 2022-01-17 | Idp Discovery Pharma S L | Peptider med anti-kræftaktivitet |
| KR20200032183A (ko) | 2017-07-25 | 2020-03-25 | 아이디피 디스커버리 파마, 에스.엘. | 항암 펩타이드 |
| AU2018311129B2 (en) * | 2017-08-01 | 2022-09-29 | Idp Discovery Pharma, S.L. | Anticancer peptides |
| US20200261534A1 (en) | 2017-09-08 | 2020-08-20 | Idp Discovery Pharma, S.L. | New treatments of multiple myeloma |
| AU2020397917A1 (en) | 2019-12-04 | 2022-06-23 | The Scripps Research Institute | GLP2 receptor agonists and methods of use |
| MX2023014771A (es) | 2021-06-09 | 2024-03-19 | Scripps Research Inst | Conjugados peptidicos duales gip/glp-1 de accion prolongada y metodos de uso. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0633933A1 (en) * | 1992-03-23 | 1995-01-18 | Imperial Cancer Research Technology Limited | Leucine zippers |
| US7192713B1 (en) * | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| WO2005118620A2 (en) * | 2004-05-27 | 2005-12-15 | New York University | Methods for preparing internally constraied peptides and peptidomimetics |
| CN105061577A (zh) * | 2006-12-14 | 2015-11-18 | 爱勒让治疗公司 | 双巯基大环化系统 |
| ES2398310T3 (es) * | 2007-02-23 | 2013-03-15 | Aileron Therapeutics, Inc. | Péptidos macrocíclicos unidos a triazol |
| AU2008232709C1 (en) * | 2007-03-28 | 2015-01-15 | President And Fellows Of Harvard College | Stitched polypeptides |
-
2009
- 2009-09-22 CN CN2009801429897A patent/CN102884074A/zh active Pending
- 2009-09-22 BR BRPI0920889A patent/BRPI0920889A2/pt not_active IP Right Cessation
- 2009-09-22 WO PCT/US2009/057930 patent/WO2010034031A1/en not_active Ceased
- 2009-09-22 AU AU2009294874A patent/AU2009294874A1/en not_active Abandoned
- 2009-09-22 EP EP09740563A patent/EP2334697A1/en not_active Withdrawn
- 2009-09-22 US US13/120,360 patent/US20120178700A1/en not_active Abandoned
- 2009-09-22 JP JP2011528082A patent/JP2012510430A/ja not_active Withdrawn
- 2009-09-22 CA CA2737920A patent/CA2737920A1/en not_active Abandoned