JP2012510430A5 - - Google Patents
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- Publication number
- JP2012510430A5 JP2012510430A5 JP2011528082A JP2011528082A JP2012510430A5 JP 2012510430 A5 JP2012510430 A5 JP 2012510430A5 JP 2011528082 A JP2011528082 A JP 2011528082A JP 2011528082 A JP2011528082 A JP 2011528082A JP 2012510430 A5 JP2012510430 A5 JP 2012510430A5
- Authority
- JP
- Japan
- Prior art keywords
- peptidomimetic macrocycle
- amino acid
- independently
- alkyl
- cycloalkylalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000002678 macrocyclic compounds Chemical class 0.000 claims description 59
- 239000000816 peptidomimetic Substances 0.000 claims description 58
- 150000001413 amino acids Chemical class 0.000 claims description 24
- 125000000217 alkyl group Chemical group 0.000 claims description 22
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 22
- 125000003342 alkenyl group Chemical group 0.000 claims description 18
- 125000000304 alkynyl group Chemical group 0.000 claims description 18
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 18
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 18
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 18
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 15
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 11
- 125000003118 aryl group Chemical group 0.000 claims description 10
- 125000004450 alkenylene group Chemical group 0.000 claims description 8
- 125000002947 alkylene group Chemical group 0.000 claims description 8
- 125000004419 alkynylene group Chemical group 0.000 claims description 8
- 125000002993 cycloalkylene group Chemical group 0.000 claims description 8
- 125000004474 heteroalkylene group Chemical group 0.000 claims description 8
- 125000006588 heterocycloalkylene group Chemical group 0.000 claims description 8
- 229940124597 therapeutic agent Drugs 0.000 claims description 8
- 125000004122 cyclic group Chemical group 0.000 claims description 6
- 230000003993 interaction Effects 0.000 claims description 5
- 108010000591 Myc associated factor X Proteins 0.000 claims description 4
- 101710150912 Myc protein Proteins 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 230000003042 antagnostic effect Effects 0.000 claims description 4
- 125000000732 arylene group Chemical group 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 125000001475 halogen functional group Chemical group 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- 125000005549 heteroarylene group Chemical group 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 150000002431 hydrogen Chemical class 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 239000003431 cross linking reagent Substances 0.000 claims description 3
- 125000003277 amino group Chemical group 0.000 claims description 2
- 125000005647 linker group Chemical group 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000004971 Cross linker Substances 0.000 claims 1
- 108010091748 peptide A Proteins 0.000 claims 1
- 238000000034 method Methods 0.000 description 7
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9916508P | 2008-09-22 | 2008-09-22 | |
| US61/099,165 | 2008-09-22 | ||
| PCT/US2009/057930 WO2010034031A1 (en) | 2008-09-22 | 2009-09-22 | Peptidomimetic macrocycles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012510430A JP2012510430A (ja) | 2012-05-10 |
| JP2012510430A5 true JP2012510430A5 (https=) | 2012-06-21 |
Family
ID=41692050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011528082A Withdrawn JP2012510430A (ja) | 2008-09-22 | 2009-09-22 | ペプチド模倣大環状分子 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20120178700A1 (https=) |
| EP (1) | EP2334697A1 (https=) |
| JP (1) | JP2012510430A (https=) |
| CN (1) | CN102884074A (https=) |
| AU (1) | AU2009294874A1 (https=) |
| BR (1) | BRPI0920889A2 (https=) |
| CA (1) | CA2737920A1 (https=) |
| WO (1) | WO2010034031A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0720306A2 (pt) | 2006-12-14 | 2014-02-04 | Aileron Therapeutics Inc | Sistemas de macrociclização da bis-sufidrila |
| ES2649941T3 (es) | 2007-02-23 | 2018-01-16 | Aileron Therapeutics, Inc. | Aminoácidos sustituidos para preparar péptidos macrocíclicos unidos a triazol |
| US8592377B2 (en) | 2007-03-28 | 2013-11-26 | President And Fellows Of Harvard College | Stitched polypeptides |
| CA2737922A1 (en) | 2008-09-22 | 2010-03-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| BRPI0920899A2 (pt) | 2008-11-24 | 2016-04-26 | Aileron Therapeutics Inc | macrociclos peptidomiméticos com propriedades melhoradas |
| US9175047B2 (en) | 2009-01-14 | 2015-11-03 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| CN102712675A (zh) | 2009-09-22 | 2012-10-03 | 爱勒让治疗公司 | 拟肽大环化合物 |
| ES2711526T3 (es) | 2010-08-13 | 2019-05-06 | Aileron Therapeutics Inc | Macrociclos peptidomiméticos |
| WO2012051405A1 (en) | 2010-10-13 | 2012-04-19 | Bristol-Myers Squibb Company | Methods for preparing macrocycles and macrocycle stabilized peptides |
| TW201806968A (zh) | 2011-10-18 | 2018-03-01 | 艾利倫治療公司 | 擬肽巨環化合物 |
| US9376469B2 (en) | 2011-12-21 | 2016-06-28 | New York University | Proteolytically resistant hydrogen bond surrogate helices |
| EP2819688A4 (en) | 2012-02-15 | 2015-10-28 | Aileron Therapeutics Inc | TRIAZOL AND THIOETHER-COUPLED PEPTIDOMIMETIC MACROCYCLES |
| BR112014020103A2 (pt) | 2012-02-15 | 2018-10-09 | Aileron Therapeutics, Inc. | macrociclos peptidomiméticos |
| WO2014071241A1 (en) | 2012-11-01 | 2014-05-08 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
| JP6822839B2 (ja) | 2013-09-13 | 2021-01-27 | ザ・スクリップス・リサーチ・インスティテュート | 修飾された治療剤、及びその組成物 |
| KR102455171B1 (ko) | 2013-12-18 | 2022-10-14 | 더 스크립스 리서치 인스티튜트 | 변형된 치료제, 스테이플드 펩티드 지질 접합체, 및 이의 조성물 |
| EP3197478A4 (en) | 2014-09-24 | 2018-05-30 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| AU2015320545C1 (en) | 2014-09-24 | 2020-05-14 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and formulations thereof |
| WO2016154058A1 (en) * | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| US10059741B2 (en) | 2015-07-01 | 2018-08-28 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| WO2017044633A1 (en) | 2015-09-10 | 2017-03-16 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles as modulators of mcl-1 |
| DK3430031T3 (da) * | 2016-03-15 | 2022-01-17 | Idp Discovery Pharma S L | Peptider med anti-kræftaktivitet |
| JP7361689B2 (ja) | 2017-07-25 | 2023-10-16 | イーデーペー・ディスカバリー・ファルマ，ソシエダッド・リミターダ | 抗がんペプチド |
| KR20200032730A (ko) * | 2017-08-01 | 2020-03-26 | 아이디피 디스커버리 파마, 에스.엘. | 항암 펩타이드 |
| WO2019048679A1 (en) | 2017-09-08 | 2019-03-14 | Idp Discovery Pharma, S.L. | NEW TREATMENTS OF MULTIPLE MYELOMA |
| MX2022006861A (es) | 2019-12-04 | 2022-07-11 | Scripps Research Inst | Agonistas del receptor glp2 y metodos de uso. |
| KR20240032010A (ko) | 2021-06-09 | 2024-03-08 | 더 스크립스 리서치 인스티튜트 | 장기 지속형 이중 gip/glp-1 펩타이드 접합체 및 사용 방법 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0633933A1 (en) * | 1992-03-23 | 1995-01-18 | Imperial Cancer Research Technology Limited | Leucine zippers |
| US7192713B1 (en) * | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| US7202332B2 (en) * | 2004-05-27 | 2007-04-10 | New York University | Methods for preparing internally constrained peptides and peptidomimetics |
| BRPI0720306A2 (pt) * | 2006-12-14 | 2014-02-04 | Aileron Therapeutics Inc | Sistemas de macrociclização da bis-sufidrila |
| ES2649941T3 (es) * | 2007-02-23 | 2018-01-16 | Aileron Therapeutics, Inc. | Aminoácidos sustituidos para preparar péptidos macrocíclicos unidos a triazol |
| US8592377B2 (en) * | 2007-03-28 | 2013-11-26 | President And Fellows Of Harvard College | Stitched polypeptides |
-
2009
- 2009-09-22 BR BRPI0920889A patent/BRPI0920889A2/pt not_active IP Right Cessation
- 2009-09-22 EP EP09740563A patent/EP2334697A1/en not_active Withdrawn
- 2009-09-22 JP JP2011528082A patent/JP2012510430A/ja not_active Withdrawn
- 2009-09-22 CA CA2737920A patent/CA2737920A1/en not_active Abandoned
- 2009-09-22 WO PCT/US2009/057930 patent/WO2010034031A1/en not_active Ceased
- 2009-09-22 US US13/120,360 patent/US20120178700A1/en not_active Abandoned
- 2009-09-22 CN CN2009801429897A patent/CN102884074A/zh active Pending
- 2009-09-22 AU AU2009294874A patent/AU2009294874A1/en not_active Abandoned