JP2012510430A - ペプチド模倣大環状分子 - Google Patents

ペプチド模倣大環状分子 Download PDF

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Publication number
JP2012510430A
JP2012510430A JP2011528082A JP2011528082A JP2012510430A JP 2012510430 A JP2012510430 A JP 2012510430A JP 2011528082 A JP2011528082 A JP 2011528082A JP 2011528082 A JP2011528082 A JP 2011528082A JP 2012510430 A JP2012510430 A JP 2012510430A
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JP
Japan
Prior art keywords
amino acid
peptidomimetic macrocycle
peptidomimetic
macrocycle
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2011528082A
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English (en)
Japanese (ja)
Other versions
JP2012510430A5 (https=
Inventor
ヒュー エム． ナッシュ，
ロザナ カペラー−リバーマン，
ジア−ウェン ハン，
トミ ケー． ソーヤー，
ジャスティン ノーエレ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rein Therapeutics Inc
Original Assignee
Aileron Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aileron Therapeutics Inc filed Critical Aileron Therapeutics Inc
Publication of JP2012510430A publication Critical patent/JP2012510430A/ja
Publication of JP2012510430A5 publication Critical patent/JP2012510430A5/ja
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2011528082A 2008-09-22 2009-09-22 ペプチド模倣大環状分子 Withdrawn JP2012510430A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9916508P 2008-09-22 2008-09-22
US61/099,165 2008-09-22
PCT/US2009/057930 WO2010034031A1 (en) 2008-09-22 2009-09-22 Peptidomimetic macrocycles

Publications (2)

Publication Number Publication Date
JP2012510430A true JP2012510430A (ja) 2012-05-10
JP2012510430A5 JP2012510430A5 (https=) 2012-06-21

Family

ID=41692050

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011528082A Withdrawn JP2012510430A (ja) 2008-09-22 2009-09-22 ペプチド模倣大環状分子

Country Status (8)

Country Link
US (1) US20120178700A1 (https=)
EP (1) EP2334697A1 (https=)
JP (1) JP2012510430A (https=)
CN (1) CN102884074A (https=)
AU (1) AU2009294874A1 (https=)
BR (1) BRPI0920889A2 (https=)
CA (1) CA2737920A1 (https=)
WO (1) WO2010034031A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019516779A (ja) * 2016-03-15 2019-06-20 アイディーピー ディスカバリー ファーマ， エセ．エレ． 抗癌活性を有するペプチド
JP2020529429A (ja) * 2017-08-01 2020-10-08 イーデーペー・ディスカバリー・ファルマ，ソシエダッド・リミターダ 抗がんペプチド

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0720306A2 (pt) 2006-12-14 2014-02-04 Aileron Therapeutics Inc Sistemas de macrociclização da bis-sufidrila
ES2649941T3 (es) 2007-02-23 2018-01-16 Aileron Therapeutics, Inc. Aminoácidos sustituidos para preparar péptidos macrocíclicos unidos a triazol
US8592377B2 (en) 2007-03-28 2013-11-26 President And Fellows Of Harvard College Stitched polypeptides
CA2737922A1 (en) 2008-09-22 2010-03-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
BRPI0920899A2 (pt) 2008-11-24 2016-04-26 Aileron Therapeutics Inc macrociclos peptidomiméticos com propriedades melhoradas
US9175047B2 (en) 2009-01-14 2015-11-03 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CN102712675A (zh) 2009-09-22 2012-10-03 爱勒让治疗公司 拟肽大环化合物
ES2711526T3 (es) 2010-08-13 2019-05-06 Aileron Therapeutics Inc Macrociclos peptidomiméticos
WO2012051405A1 (en) 2010-10-13 2012-04-19 Bristol-Myers Squibb Company Methods for preparing macrocycles and macrocycle stabilized peptides
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
US9376469B2 (en) 2011-12-21 2016-06-28 New York University Proteolytically resistant hydrogen bond surrogate helices
EP2819688A4 (en) 2012-02-15 2015-10-28 Aileron Therapeutics Inc TRIAZOL AND THIOETHER-COUPLED PEPTIDOMIMETIC MACROCYCLES
BR112014020103A2 (pt) 2012-02-15 2018-10-09 Aileron Therapeutics, Inc. macrociclos peptidomiméticos
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
JP6822839B2 (ja) 2013-09-13 2021-01-27 ザ・スクリップス・リサーチ・インスティテュート 修飾された治療剤、及びその組成物
KR102455171B1 (ko) 2013-12-18 2022-10-14 더 스크립스 리서치 인스티튜트 변형된 치료제, 스테이플드 펩티드 지질 접합체, 및 이의 조성물
EP3197478A4 (en) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
AU2015320545C1 (en) 2014-09-24 2020-05-14 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
WO2016154058A1 (en) * 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2017044633A1 (en) 2015-09-10 2017-03-16 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of mcl-1
JP7361689B2 (ja) 2017-07-25 2023-10-16 イーデーペー・ディスカバリー・ファルマ，ソシエダッド・リミターダ 抗がんペプチド
WO2019048679A1 (en) 2017-09-08 2019-03-14 Idp Discovery Pharma, S.L. NEW TREATMENTS OF MULTIPLE MYELOMA
MX2022006861A (es) 2019-12-04 2022-07-11 Scripps Research Inst Agonistas del receptor glp2 y metodos de uso.
KR20240032010A (ko) 2021-06-09 2024-03-08 더 스크립스 리서치 인스티튜트 장기 지속형 이중 gip/glp-1 펩타이드 접합체 및 사용 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0633933A1 (en) * 1992-03-23 1995-01-18 Imperial Cancer Research Technology Limited Leucine zippers
US7192713B1 (en) * 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
US7202332B2 (en) * 2004-05-27 2007-04-10 New York University Methods for preparing internally constrained peptides and peptidomimetics
BRPI0720306A2 (pt) * 2006-12-14 2014-02-04 Aileron Therapeutics Inc Sistemas de macrociclização da bis-sufidrila
ES2649941T3 (es) * 2007-02-23 2018-01-16 Aileron Therapeutics, Inc. Aminoácidos sustituidos para preparar péptidos macrocíclicos unidos a triazol
US8592377B2 (en) * 2007-03-28 2013-11-26 President And Fellows Of Harvard College Stitched polypeptides

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019516779A (ja) * 2016-03-15 2019-06-20 アイディーピー ディスカバリー ファーマ， エセ．エレ． 抗癌活性を有するペプチド
JP7098163B2 (ja) 2016-03-15 2022-07-11 アイディーピー ディスカバリー ファーマ， エセ．エレ． 抗癌活性を有するペプチド
JP2020529429A (ja) * 2017-08-01 2020-10-08 イーデーペー・ディスカバリー・ファルマ，ソシエダッド・リミターダ 抗がんペプチド

Also Published As

Publication number Publication date
WO2010034031A1 (en) 2010-03-25
US20120178700A1 (en) 2012-07-12
AU2009294874A1 (en) 2010-03-25
CN102884074A (zh) 2013-01-16
EP2334697A1 (en) 2011-06-22
BRPI0920889A2 (pt) 2017-10-10
CA2737920A1 (en) 2010-03-25

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