JP2011529084A5 - - Google Patents
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- JP2011529084A5 JP2011529084A5 JP2011520233A JP2011520233A JP2011529084A5 JP 2011529084 A5 JP2011529084 A5 JP 2011529084A5 JP 2011520233 A JP2011520233 A JP 2011520233A JP 2011520233 A JP2011520233 A JP 2011520233A JP 2011529084 A5 JP2011529084 A5 JP 2011529084A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- sequence
- acid residue
- covalently linked
- amyloid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000539 amino acid group Chemical group 0.000 claims 104
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 30
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 30
- 229930182817 methionine Chemical group 0.000 claims 30
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical group CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 28
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 26
- 239000004474 valine Substances 0.000 claims 26
- 235000004279 alanine Nutrition 0.000 claims 24
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Chemical group CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 23
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Chemical group CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 23
- 229960000310 isoleucine Drugs 0.000 claims 23
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical group C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 21
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical group CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 19
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical group CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 19
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Chemical group OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 19
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical group OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 18
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical group NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 17
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical group CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 17
- 150000001413 amino acids Chemical group 0.000 claims 15
- 239000004471 Glycine Chemical group 0.000 claims 13
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical group OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 12
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Chemical group OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 12
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 9
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical group OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 8
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Chemical group OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 8
- 206010002022 amyloidosis Diseases 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 4
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 4
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 claims 4
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 4
- 239000000816 peptidomimetic Substances 0.000 claims 4
- 239000004475 Arginine Chemical group 0.000 claims 3
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Chemical group OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical group NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 3
- 239000004472 Lysine Substances 0.000 claims 3
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Chemical group OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 3
- 235000009582 asparagine Nutrition 0.000 claims 3
- 229960001230 asparagine Drugs 0.000 claims 3
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 3
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 201000010374 Down Syndrome Diseases 0.000 claims 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical group OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 2
- 229940024606 amino acid Drugs 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical group OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical group OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical group C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Chemical group CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
- 239000004473 Threonine Chemical group 0.000 claims 1
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Chemical group OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8358908P | 2008-07-25 | 2008-07-25 | |
| US61/083,589 | 2008-07-25 | ||
| PCT/US2009/051721 WO2010011947A2 (en) | 2008-07-25 | 2009-07-24 | AMYLOID ß PEPTIDE ANALOGUES, OLIGOMERS THEREOF, PROCESSES FOR PREPARING AND COMPOSITIONS COMPRISING SAID ANALOGUES OR OLIGOMERS, AND THEIR USES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011529084A JP2011529084A (ja) | 2011-12-01 |
| JP2011529084A5 true JP2011529084A5 (https=) | 2012-05-31 |
Family
ID=41570887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011520233A Pending JP2011529084A (ja) | 2008-07-25 | 2009-07-24 | アミロイドβペプチド類似体、これらのオリゴマー、前記類似体またはオリゴマーを調製するためのプロセスおよび前記類似体またはオリゴマーを含む組成物ならびにこれらの使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110092445A1 (https=) |
| EP (1) | EP2303920A4 (https=) |
| JP (1) | JP2011529084A (https=) |
| CN (1) | CN102203124A (https=) |
| CA (1) | CA2730804A1 (https=) |
| MX (1) | MX2011000975A (https=) |
| WO (1) | WO2010011947A2 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| US8691224B2 (en) | 2005-11-30 | 2014-04-08 | Abbvie Inc. | Anti-Aβ globulomer 5F7 antibodies |
| HRP20140240T4 (hr) | 2005-11-30 | 2017-02-24 | Abbvie Inc. | Monoklonalna antitijela protiv amiloidnih beta proteina i njihova upotreba |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
| AU2009236699B2 (en) * | 2008-04-14 | 2013-09-05 | Alzinova Ab | Stable amyloid beta monomers and oligomers |
| CN102112488A (zh) * | 2008-07-01 | 2011-06-29 | 由卫生福利和体育大臣代表的荷兰王国 | 抗淀粉样折叠中间体的疫苗 |
| JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
| JP6190113B2 (ja) * | 2010-03-03 | 2017-08-30 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | オリゴマー特異アミロイドベータエピトープおよび抗体 |
| AU2013205000B2 (en) * | 2010-03-03 | 2015-05-28 | The University Of British Columbia | Oligomer-specific amyloid beta epitope and antibodies |
| US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| WO2011156003A2 (en) | 2010-06-09 | 2011-12-15 | New York University | Peptoid and synthetic oligomers, pharmaceutical compositions and methods of using same |
| EP3533803B1 (en) | 2010-08-14 | 2021-10-27 | AbbVie Inc. | Anti-amyloid-beta antibodies |
| US20120089291A1 (en) * | 2010-10-12 | 2012-04-12 | Halder Bibhrajit | Autonomous machine control system |
| WO2012072611A1 (de) * | 2010-11-29 | 2012-06-07 | Philipps-Universität Marburg | SYNTHETISCHE LIGANDEN FÜR HUMANE ANTI-Aβ-ANTIKÖRPER |
| PL2646462T3 (pl) | 2010-11-29 | 2017-10-31 | Akershus Univ | Sposoby i kompozycje do monitorowania aktywności fagocytarnej |
| CA2857539C (en) * | 2011-11-29 | 2021-08-03 | Neurophage Pharmaceuticals, Inc. | Bacteriophage gene 3 protein compositions and use as amyloid binding agents |
| US20130164217A1 (en) * | 2011-12-21 | 2013-06-27 | Meso Scale Technologies, Llc | Method of diagnosing, preventing and/or treating dementia & related disorders |
| DE102012021222B4 (de) * | 2012-10-27 | 2015-02-05 | Forschungszentrum Jülich GmbH | Verfahren zur Herstellung einer nanoporösen Schicht auf einem Substrat |
| EP2746402A1 (en) * | 2013-03-12 | 2014-06-25 | Academisch Medisch Centrum | Method of prognosis of Alzheimers disease and substrates for use therein |
| EP2787349A1 (en) | 2013-04-03 | 2014-10-08 | Affiris AG | Method for detecting proteinopathy-specific antibodies in a biological sample |
| EP2787347A1 (en) * | 2013-04-03 | 2014-10-08 | Affiris AG | Method for detecting Aß-specific antibodies in a biological sample |
| RU2692258C2 (ru) | 2014-01-31 | 2019-06-24 | Когнишн Терапьютикс, Инк. | Композиции изоиндолина и способы лечения нейродегенеративного заболевания |
| SG11201700071WA (en) * | 2014-07-07 | 2017-02-27 | Abbvie Deutschland | IMMUNOGENIC PRODUCTS BASED ON MUTEIN AMYLOID ß (Aß) AMINO ACID SEQUENCES AND USES THEREOF |
| JP6675403B2 (ja) * | 2014-09-05 | 2020-04-01 | システム オブ システムズ アナリティクス インコーポレイテッド | アミロイドベータオリゴマーを検出する方法 |
| ES2571055B1 (es) * | 2016-02-15 | 2016-12-28 | Araclon Biotech, S.L. | Conjugado amiloide y usos y procedimientos del mismo |
| WO2018005980A1 (en) * | 2016-07-01 | 2018-01-04 | The Scripps Research Institute | Compositions and diagnostic methods related to transthyretin amyloid diseases |
| DK3634394T3 (da) | 2017-05-15 | 2026-03-02 | Cognition Therapeutics Inc | Sammensætninger til behandling af neurogenerative sygdomme |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| CN108148115A (zh) * | 2018-01-30 | 2018-06-12 | 中国药科大学 | 一种环肽合成新方法及其在药物开发中的应用 |
| WO2019246140A1 (en) * | 2018-06-18 | 2019-12-26 | Emory University | Parallel enzyme digestion for protein biomarker detection |
| CN109851660A (zh) * | 2019-03-20 | 2019-06-07 | 横琴欣健生物科技研究院有限公司 | 一种治疗老年痴呆症的多肽及其疫苗 |
| CN109912687A (zh) * | 2019-03-20 | 2019-06-21 | 横琴欣健生物科技研究院有限公司 | 一种治疗老年痴呆症的多肽药物 |
| JP7357354B2 (ja) * | 2020-02-04 | 2023-10-06 | 国立大学法人京都大学 | アミロイドβ４２架橋アナログペプチド |
| KR102767892B1 (ko) * | 2021-12-30 | 2025-02-14 | 고려대학교 산학협력단 | 신규한 단백질 변이체 및 이를 이용한 신경퇴행성 질환 치료용 조성물 |
| US12037375B2 (en) * | 2021-12-30 | 2024-07-16 | Korea University Research And Business Foundation | Protein variant and composition for treating neurodegenerative disease using the same |
| WO2026030341A1 (en) | 2024-07-29 | 2026-02-05 | Cognition Therapeutics, Inc. | Zervimesine for treating neurodegenerative disease |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE239797T1 (de) * | 1993-01-25 | 2003-05-15 | Takeda Chemical Industries Ltd | Antikörper gegen beta-amyloid oder derivative davon und seine verwendung |
| DE10101430B4 (de) * | 2001-01-13 | 2008-10-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Lösliche cyclische Analoga zur Modulation der Amyloidogenese |
| US20020132758A1 (en) * | 2001-01-18 | 2002-09-19 | Shell John W. | Method for identifying compounds to treat medical pathologies associated with molecular crystallization |
| US20070213512A1 (en) * | 2002-10-01 | 2007-09-13 | Krafft Grant A | Amyloid beta peptide analogs and assemblies thereof |
| DE10303974A1 (de) * | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| EP1676859A1 (en) * | 2004-12-30 | 2006-07-05 | Pevion Biotech Ltd. | Immunogenic compositions of cyclic peptides derived from the beta-amyloid peptide |
| WO2006094724A2 (en) * | 2005-03-05 | 2006-09-14 | Abbott Gmbh & Co. Kg | Screening method, process for purifying of non-diffusible a-beta oligomers, selective antibodies against said non-diffusible a-beta oligomers and a process for manufacturing of said antibodies |
| JP2009518010A (ja) * | 2005-11-30 | 2009-05-07 | アボット・ラボラトリーズ | ヒトβアミロイドタンパク質の組み換え形態の調製方法及びこれらのタンパク質の使用 |
| ATE554085T1 (de) * | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
-
2009
- 2009-07-24 CN CN200980137576XA patent/CN102203124A/zh active Pending
- 2009-07-24 JP JP2011520233A patent/JP2011529084A/ja active Pending
- 2009-07-24 CA CA2730804A patent/CA2730804A1/en not_active Abandoned
- 2009-07-24 US US12/509,325 patent/US20110092445A1/en not_active Abandoned
- 2009-07-24 WO PCT/US2009/051721 patent/WO2010011947A2/en not_active Ceased
- 2009-07-24 MX MX2011000975A patent/MX2011000975A/es not_active Application Discontinuation
- 2009-07-24 EP EP09801088A patent/EP2303920A4/en not_active Withdrawn
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