JP2012506257A5 - - Google Patents
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- Publication number
- JP2012506257A5 JP2012506257A5 JP2011533338A JP2011533338A JP2012506257A5 JP 2012506257 A5 JP2012506257 A5 JP 2012506257A5 JP 2011533338 A JP2011533338 A JP 2011533338A JP 2011533338 A JP2011533338 A JP 2011533338A JP 2012506257 A5 JP2012506257 A5 JP 2012506257A5
- Authority
- JP
- Japan
- Prior art keywords
- bioreactor
- cell
- matrix
- cells
- cell culture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 210000004027 cell Anatomy 0.000 claims description 32
- 238000004113 cell culture Methods 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 26
- 230000010412 perfusion Effects 0.000 claims description 24
- 239000011159 matrix material Substances 0.000 claims description 22
- 239000006143 cell culture medium Substances 0.000 claims description 19
- 239000012530 fluid Substances 0.000 claims description 13
- 230000010261 cell growth Effects 0.000 claims description 12
- 238000004891 communication Methods 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 230000012010 growth Effects 0.000 claims description 5
- 239000002609 medium Substances 0.000 claims description 3
- 210000003040 circulating cell Anatomy 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 12
- 239000001569 carbon dioxide Substances 0.000 description 6
- 229910002092 carbon dioxide Inorganic materials 0.000 description 6
- 239000007789 gas Substances 0.000 description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 3
- 229920000139 polyethylene terephthalate Polymers 0.000 description 3
- 239000005020 polyethylene terephthalate Substances 0.000 description 3
- 241000700605 Viruses Species 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000019522 cellular metabolic process Effects 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012092 media component Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- -1 polyethylene terephthalate Polymers 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10764408P | 2008-10-22 | 2008-10-22 | |
| US61/107,644 | 2008-10-22 | ||
| PCT/US2009/061700 WO2010048417A2 (en) | 2008-10-22 | 2009-10-22 | Perfusion bioreactors, cell culture systems, and methods for production of cells and cell-derived products |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012506257A JP2012506257A (ja) | 2012-03-15 |
| JP2012506257A5 true JP2012506257A5 (https=) | 2012-12-06 |
Family
ID=42119984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011533338A Withdrawn JP2012506257A (ja) | 2008-10-22 | 2009-10-22 | 細胞および細胞由来生成物の産生のための、灌流バイオリアクター、細胞培養システム、および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110212493A1 (https=) |
| EP (1) | EP2346984A4 (https=) |
| JP (1) | JP2012506257A (https=) |
| AU (1) | AU2009308354A1 (https=) |
| CA (1) | CA2741481A1 (https=) |
| IL (1) | IL212387A0 (https=) |
| WO (1) | WO2010048417A2 (https=) |
Families Citing this family (70)
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| WO2012171026A2 (en) * | 2011-06-10 | 2012-12-13 | Biovest International, Inc. | Methods for high yield virus production |
| WO2012171030A2 (en) | 2011-06-10 | 2012-12-13 | Biovest International, Inc. | Method and apparatus for antibody production and purification |
| JP6095671B2 (ja) * | 2011-10-07 | 2017-03-15 | ポール テクノロジー ユーケイ リミテッドＰａｌｌ Ｔｅｃｈｎｏｌｏｇｙ Ｕｋ Ｌｉｍｉｔｅｄ | 流体処理制御システムおよび対応する方法 |
| US9683207B2 (en) | 2012-05-01 | 2017-06-20 | FiberCell Production Solutions LLC | Method for growing cells in hollow fibers |
| CN104583386A (zh) * | 2012-08-20 | 2015-04-29 | 泰尔茂比司特公司 | 浓缩穿过细胞生长腔室循环的流体的组分 |
| EP2909302A4 (en) * | 2012-08-28 | 2016-07-27 | Biovest Int Inc | BIOFABRICATION FILAMENT AND METHOD FOR LARGE-SCALE PRODUCTION OF CELLS, VIRUSES AND BIOMOLECULES |
| WO2014036488A1 (en) | 2012-08-31 | 2014-03-06 | Biovest International, Inc. | Methods for producing high-fidelity autologous idiotype vaccines |
| EP2706112A1 (en) * | 2012-09-06 | 2014-03-12 | Université Catholique De Louvain | Fluidic device for studying of surface-dwelling multicellular layers and microbial biofilms |
| RU2615179C2 (ru) | 2012-09-06 | 2017-04-04 | Плуристем Лтд. | Устройства и способы культивирования клеток |
| ES2489315B1 (es) * | 2013-01-16 | 2015-09-09 | Fundación Para La Investigación Biomédica Del Hospital Universitario La Paz | Cámara de cultivo celular sobre biomateriales |
| HUE042094T2 (hu) | 2013-02-22 | 2019-06-28 | Genzyme Corp | Mikrokarrier-perfúziós tenyésztési eljárások és alkalmazásuk |
| WO2015027186A1 (en) | 2013-08-22 | 2015-02-26 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | A modular, microfluidic, mechanically active bioreactor for 3d, multi-tissue, tissue culture |
| WO2015048712A2 (en) * | 2013-09-30 | 2015-04-02 | Weyerhaeuser Nr Company | Independent ports in automated bioreactor system |
| WO2015073913A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
| EP3105311A1 (en) | 2014-02-10 | 2016-12-21 | Univercells NV | System, apparatus and method for biomolecules production |
| EP3110428A4 (en) * | 2014-02-28 | 2017-11-22 | Bdbc Sciences Corp. | A system for tissue manipulation |
| US10039244B2 (en) * | 2014-03-04 | 2018-08-07 | Greenonyx Ltd | Systems and methods for cultivating and distributing aquatic organisms |
| WO2015148704A1 (en) | 2014-03-25 | 2015-10-01 | Terumo Bct, Inc. | Passive replacement of media |
| CN106232801A (zh) | 2014-04-28 | 2016-12-14 | 维瓦生物细胞股份公司 | 自动化细胞培养和收获装置 |
| TWI743024B (zh) * | 2014-06-06 | 2021-10-21 | 美商健臻公司 | 灌注培養方法及其用途 |
| EP3198006B1 (en) | 2014-09-26 | 2021-03-24 | Terumo BCT, Inc. | Scheduled feed |
| JP6807749B2 (ja) * | 2014-12-11 | 2021-01-06 | 株式会社アイカムス・ラボ | 細胞培養方法及び細胞培養装置 |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| EP3359642A4 (en) | 2015-10-06 | 2019-05-08 | University of Pittsburgh- Of the Commonwealth System of Higher Education | MICROFLUIDIC TISSUE DEVELOPMENT SYSTEMS |
| CA3002810A1 (en) | 2015-10-20 | 2017-04-27 | Sharmistha MAZUMDER | Apparatus, systems and methods for growing microorganisms |
| WO2017087535A1 (en) * | 2015-11-17 | 2017-05-26 | Oregon State University | Bio-lamina bioreactors and methods of making and using the same |
| KR20240173213A (ko) * | 2016-01-26 | 2024-12-10 | 베링거 인겔하임 인터내셔날 게엠베하 | 연결된 관류 대 연속-유동식 교반-탱크 반응기 세포 배양 시스템 |
| US11965175B2 (en) | 2016-05-25 | 2024-04-23 | Terumo Bct, Inc. | Cell expansion |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| GB2554635A (en) * | 2016-08-03 | 2018-04-11 | Northwick Park Institute For Medical Res Ltd | Bioreactors and methods for processing biological material |
| JP6942448B2 (ja) * | 2016-08-08 | 2021-09-29 | 株式会社カネカ | 細胞培養容器、これを用いた細胞培養システム、および細胞培養方法 |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| CN117247899A (zh) | 2017-03-31 | 2023-12-19 | 泰尔茂比司特公司 | 细胞扩增 |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| TWI675696B (zh) * | 2017-06-01 | 2019-11-01 | 美商Ｅｍｄ密理博公司 | 用於灌注應用之切向流過濾裝置 |
| KR102176500B1 (ko) | 2017-07-21 | 2020-11-09 | 포항공과대학교 산학협력단 | 관류식 바이오 리액터를 사용한 세포밖 소포체 분비량 향상 방법 및 이를 위한 시스템 |
| US11680241B2 (en) | 2018-02-08 | 2023-06-20 | University Of Florida Research Foundation, Inc. | Perfusion enabled bioreactors |
| WO2020013221A1 (ja) * | 2018-07-12 | 2020-01-16 | 日本曹達株式会社 | 培養装置、担体、および培養対象回収方法 |
| JP7133409B2 (ja) * | 2018-09-18 | 2022-09-08 | テルモ株式会社 | バイオリアクタ、細胞培養システム及び細胞培養方法 |
| JP7133410B2 (ja) * | 2018-09-18 | 2022-09-08 | テルモ株式会社 | バイオリアクタ、細胞培養システム及び細胞培養方法 |
| IL263127B (en) * | 2018-11-19 | 2022-07-01 | The Interdisciplinary Center Herzliya Cc | A liquid-based biological system |
| KR20210108406A (ko) * | 2018-12-21 | 2021-09-02 | 론자 워커스빌 아이엔씨. | 바이러스 벡터의 자동화된 생산 |
| WO2020163329A1 (en) | 2019-02-05 | 2020-08-13 | Corning Incorporated | Woven cell culture substrates |
| IL288338B2 (en) | 2019-05-28 | 2023-02-01 | Upside Foods Inc | Apparatuses and methods for preparing a comestible meat product |
| WO2021038997A1 (ja) * | 2019-08-29 | 2021-03-04 | ファナック株式会社 | 細胞製造装置 |
| US11118151B2 (en) | 2019-11-05 | 2021-09-14 | Corning Incorporated | Fixed bed bioreactor and methods of using the same |
| AU2020386085B2 (en) | 2019-11-20 | 2022-08-11 | Upside Foods, Inc. | Apparatuses and systems for preparing a meat product |
| WO2021108089A1 (en) * | 2019-11-27 | 2021-06-03 | Corning Incorporated | Radial flow fixed bed bioreactor and methods of using the same |
| KR102417445B1 (ko) * | 2019-11-29 | 2022-07-06 | 주식회사 아모그린텍 | 세포배양장치 |
| USD961115S1 (en) * | 2020-01-20 | 2022-08-16 | Adva Biotechnology Ltd. | Bioreactor cabinet |
| KR20220166825A (ko) * | 2020-04-10 | 2022-12-19 | 사우스웨스트 리서치 인스티튜트 | 바이러스 벡터 생산을 위한 3차원 생물 반응기 |
| CN116194569A (zh) * | 2020-08-17 | 2023-05-30 | 东北大学 | 用于金属纳米颗粒生产的微生物辅助灌流系统 |
| EP4314244B1 (en) | 2021-03-23 | 2025-07-23 | Terumo BCT, Inc. | Cell capture and expansion |
| US11752509B2 (en) | 2021-06-17 | 2023-09-12 | Upside Foods, Inc. | Fluid dispenser for recovering material from a surface |
| US20230066039A1 (en) * | 2021-09-01 | 2023-03-02 | Global Life Sciences Solutions Usa Llc | Perfusion filter membrane and method of use |
| US12606788B2 (en) | 2021-09-01 | 2026-04-21 | Global Life Sciences Solutions Usa Llc | Perfusion filter membrane assembly |
| US12241050B2 (en) | 2021-09-01 | 2025-03-04 | Global Life Sciences Solutions Usa, Llc | Perfusion filter assembly for increased cross flow |
| WO2023121655A1 (en) * | 2021-12-21 | 2023-06-29 | Bayer Aktiengesellschaft | Improved cell culture method |
| US12209689B2 (en) | 2022-02-28 | 2025-01-28 | Terumo Kabushiki Kaisha | Multiple-tube pinch valve assembly |
| WO2023164273A1 (en) * | 2022-02-28 | 2023-08-31 | University Of Georgia Research Foundation, Inc. | Bioreactor for cell expansion and cultivation |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
| WO2024073071A1 (en) * | 2022-09-29 | 2024-04-04 | The University Of Akron | Chamber assembly for ex-vivo electroretinogram with filleted perfusion inlet and outlet |
| US11981884B2 (en) | 2022-10-17 | 2024-05-14 | Upside Foods, Inc. | Pipe-based bioreactors for producing comestible meat products and methods of using the same |
| WO2026046948A1 (en) * | 2024-08-26 | 2026-03-05 | Qorium B.V. | Perfusion bioreactor, scaffold cassette, and method for culturing cells |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4804628A (en) * | 1984-10-09 | 1989-02-14 | Endotronics, Inc. | Hollow fiber cell culture device and method of operation |
| US5266476A (en) * | 1985-06-18 | 1993-11-30 | Yeda Research & Development Co., Ltd. | Fibrous matrix for in vitro cell cultivation |
| US5786215A (en) * | 1987-05-20 | 1998-07-28 | Baxter International Inc. | Method for culturing animal cells |
| DE3923279A1 (de) * | 1989-07-14 | 1990-01-18 | Will W Prof Dr Minuth | Minusheets ist ein neues produkt, um zellen in beliebigen behaeltnissen in hochdifferenzierter form auf einer moeglichst natuerlichen unterlage zu kultivieren |
| US5126269A (en) * | 1990-09-13 | 1992-06-30 | Life Techologies, Inc. | Spin filter perfusion bioreactor (sfpb) cell culture apparatus |
| BE1009306A5 (fr) * | 1995-04-28 | 1997-02-04 | Baxter Int | Bioreacteur. |
| CA2279996A1 (en) * | 1997-01-16 | 1998-07-16 | Yissum Research Development Company Of The Hebrew University In Jerusale M | A device and method for performing a biological modification of a fluid |
| WO1998050522A1 (en) * | 1997-05-07 | 1998-11-12 | Baxter International Inc. | Method and apparatus for high volume production of viral particles |
| US6875605B1 (en) * | 2002-08-21 | 2005-04-05 | Florida State University Research Foundation, Inc. | Modular cell culture bioreactor and associated methods |
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| US7534601B2 (en) * | 2002-08-27 | 2009-05-19 | Vanderbilt University | Capillary perfused bioreactors with multiple chambers |
| CN101120083B (zh) * | 2003-10-08 | 2013-03-27 | 威尔森沃尔夫制造公司 | 利用透气性材料进行细胞培养的方法及装置 |
| US7767446B2 (en) * | 2004-09-16 | 2010-08-03 | Becton, Dickinson And Company | Perfusion bioreactors for culturing cells |
| JP4639799B2 (ja) * | 2004-12-27 | 2011-02-23 | カシオ計算機株式会社 | カメラ装置、レンズ駆動方法 |
| WO2007071072A1 (en) * | 2005-12-22 | 2007-06-28 | Corporation De L'ecole Polytechnique De Montreal | High-rate perfusion bioreactor |
| EP2029722B1 (en) * | 2006-05-22 | 2019-10-16 | Biovest International, Inc. | Method and system for the production of cells |
-
2009
- 2009-10-22 EP EP09822715.0A patent/EP2346984A4/en not_active Withdrawn
- 2009-10-22 JP JP2011533338A patent/JP2012506257A/ja not_active Withdrawn
- 2009-10-22 CA CA2741481A patent/CA2741481A1/en not_active Abandoned
- 2009-10-22 WO PCT/US2009/061700 patent/WO2010048417A2/en not_active Ceased
- 2009-10-22 AU AU2009308354A patent/AU2009308354A1/en not_active Abandoned
-
2011
- 2011-04-14 IL IL212387A patent/IL212387A0/en unknown
- 2011-04-22 US US13/092,836 patent/US20110212493A1/en not_active Abandoned
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