JP2012505883A5 - - Google Patents
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- Publication number
- JP2012505883A5 JP2012505883A5 JP2011532085A JP2011532085A JP2012505883A5 JP 2012505883 A5 JP2012505883 A5 JP 2012505883A5 JP 2011532085 A JP2011532085 A JP 2011532085A JP 2011532085 A JP2011532085 A JP 2011532085A JP 2012505883 A5 JP2012505883 A5 JP 2012505883A5
- Authority
- JP
- Japan
- Prior art keywords
- acceptable salt
- pharmaceutically acceptable
- sv2a inhibitor
- composition
- patent application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims description 100
- 101710084141 Synaptic vesicle glycoprotein 2A Proteins 0.000 claims description 76
- 239000003112 inhibitor Substances 0.000 claims description 73
- 208000010877 cognitive disease Diseases 0.000 claims description 40
- 239000000203 mixture Substances 0.000 claims description 34
- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 claims description 28
- 229940102566 valproate Drugs 0.000 claims description 28
- 229960002161 brivaracetam Drugs 0.000 claims description 23
- MSYKRHVOOPPJKU-BDAKNGLRSA-N brivaracetam Chemical compound CCC[C@H]1CN([C@@H](CC)C(N)=O)C(=O)C1 MSYKRHVOOPPJKU-BDAKNGLRSA-N 0.000 claims description 23
- 229960004002 levetiracetam Drugs 0.000 claims description 23
- HPHUVLMMVZITSG-ZCFIWIBFSA-N levetiracetam Chemical group CC[C@H](C(N)=O)N1CCCC1=O HPHUVLMMVZITSG-ZCFIWIBFSA-N 0.000 claims description 23
- 208000028698 Cognitive impairment Diseases 0.000 claims description 17
- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- ANWPENAPCIFDSZ-BQBZGAKWSA-N seletracetam Chemical compound CC[C@@H](C(N)=O)N1C[C@@H](C=C(F)F)CC1=O ANWPENAPCIFDSZ-BQBZGAKWSA-N 0.000 claims description 10
- 229950000852 seletracetam Drugs 0.000 claims description 10
- 230000003920 cognitive function Effects 0.000 claims description 8
- 239000008280 blood Substances 0.000 claims description 6
- 210000004369 blood Anatomy 0.000 claims description 6
- 238000009472 formulation Methods 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims 15
- 238000004519 manufacturing process Methods 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 45
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10584708P | 2008-10-16 | 2008-10-16 | |
| US61/105,847 | 2008-10-16 | ||
| US15263109P | 2009-02-13 | 2009-02-13 | |
| US61/152,631 | 2009-02-13 | ||
| US17553609P | 2009-05-05 | 2009-05-05 | |
| US61/175,536 | 2009-05-05 | ||
| PCT/US2009/005647 WO2010044878A1 (en) | 2008-10-16 | 2009-10-16 | Methods and compositions for improving cognitive function |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014129145A Division JP2014169339A (ja) | 2008-10-16 | 2014-06-24 | 認知機能を改善するための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012505883A JP2012505883A (ja) | 2012-03-08 |
| JP2012505883A5 true JP2012505883A5 (OSRAM) | 2012-11-29 |
| JP5917148B2 JP5917148B2 (ja) | 2016-05-11 |
Family
ID=41403972
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011532085A Active JP5917148B2 (ja) | 2008-10-16 | 2009-10-16 | 認知機能を改善するための方法および組成物 |
| JP2014129145A Withdrawn JP2014169339A (ja) | 2008-10-16 | 2014-06-24 | 認知機能を改善するための方法および組成物 |
| JP2016103917A Active JP6271641B2 (ja) | 2008-10-16 | 2016-05-25 | 認知機能を改善するための方法および組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014129145A Withdrawn JP2014169339A (ja) | 2008-10-16 | 2014-06-24 | 認知機能を改善するための方法および組成物 |
| JP2016103917A Active JP6271641B2 (ja) | 2008-10-16 | 2016-05-25 | 認知機能を改善するための方法および組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US20100099735A1 (OSRAM) |
| EP (2) | EP3260118B1 (OSRAM) |
| JP (3) | JP5917148B2 (OSRAM) |
| CN (2) | CN102227217A (OSRAM) |
| AU (1) | AU2009303834B2 (OSRAM) |
| BR (1) | BRPI0920342A2 (OSRAM) |
| CA (1) | CA2740610C (OSRAM) |
| DK (2) | DK2346500T3 (OSRAM) |
| EA (1) | EA033130B1 (OSRAM) |
| ES (2) | ES2865504T3 (OSRAM) |
| HK (1) | HK1245099A1 (OSRAM) |
| WO (1) | WO2010044878A1 (OSRAM) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2865504T3 (es) | 2008-10-16 | 2021-10-15 | Univ Johns Hopkins | Procedimientos y composiciones para la mejora de la función cognitiva |
| BR112013020283A2 (pt) * | 2011-02-09 | 2016-07-19 | Univ Johns Hopkins | "uso de inibidor de proteína de vesícula sináptica 2a (sv2a), valproato, levetiracetam, brivarecetam e seletracetam no tratamento de deficiência cognitiva, bem como composição farmacêutica compreendendo os mesmos" |
| US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| WO2014144546A1 (en) * | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Methods and compositons for improving cognitive function |
| JP6433482B2 (ja) | 2013-03-15 | 2018-12-05 | エージンバイオ, インコーポレイテッド | 認知機能を改善するための方法および組成物 |
| US10806717B2 (en) | 2013-03-15 | 2020-10-20 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| DK3297611T3 (da) * | 2015-05-22 | 2019-09-02 | Agenebio Inc | Farmaceutiske sammensætninger af levetiracetam med langvarig frigivelse |
| AU2016268096B2 (en) * | 2015-05-22 | 2021-04-01 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
| JP6902033B2 (ja) | 2015-12-30 | 2021-07-14 | アダマス ファーマシューティカルズ, インコーポレイテッド | 発作−関連障害の処置のための方法および組成物 |
| EP3458049B1 (en) * | 2016-05-20 | 2025-03-05 | Institut Pasteur | Levetiracetam, brivaracetam or selectracetam for use in treating sepsis induced acute brain dysfunction |
| US10370561B2 (en) | 2016-06-28 | 2019-08-06 | Prc-Desoto International, Inc. | Urethane/urea-containing bis(alkenyl) ethers, prepolymers prepared using urethane/urea-containing bis(alkenyl) ethers, and uses thereof |
| US11098222B2 (en) | 2018-07-03 | 2021-08-24 | Prc-Desoto International, Inc. | Sprayable polythioether coatings and sealants |
| CN109892247B (zh) * | 2019-04-19 | 2023-08-18 | 桂林医学院 | 一种猫参与的检测大鼠认知功能的实验装置 |
| CN112569216B (zh) * | 2019-09-30 | 2022-02-15 | 厦门大学 | 戊酸衍生物在治疗唐氏综合征中的应用 |
| WO2022011318A1 (en) * | 2020-07-10 | 2022-01-13 | Agenebio, Inc. | Combinations of gabaa alpha 5 agonists and sv2a inhibitors and methods of using in the treatment of cognitive impairment |
| JP2024508052A (ja) * | 2021-02-26 | 2024-02-21 | シンデシ セラピューティクス ソシエテ アノニム | 認知障害の治療のための化合物 |
| AU2023324882A1 (en) | 2022-08-19 | 2025-03-20 | Agenebio, Inc. | Benzazepine derivatives, compositions, and methods for treating cognitive impairment |
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| GB1039113A (en) | 1964-08-06 | 1966-08-17 | Ucb Sa | New n-substituted lactams |
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| ES2865504T3 (es) | 2008-10-16 | 2021-10-15 | Univ Johns Hopkins | Procedimientos y composiciones para la mejora de la función cognitiva |
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| EP2461808A2 (en) | 2009-08-07 | 2012-06-13 | UCB Pharma S.A. | Methods for enhancing the cognitive function |
-
2009
- 2009-10-16 ES ES17167125T patent/ES2865504T3/es active Active
- 2009-10-16 AU AU2009303834A patent/AU2009303834B2/en active Active
- 2009-10-16 EA EA201170571A patent/EA033130B1/ru not_active IP Right Cessation
- 2009-10-16 JP JP2011532085A patent/JP5917148B2/ja active Active
- 2009-10-16 US US12/580,464 patent/US20100099735A1/en not_active Abandoned
- 2009-10-16 DK DK09748527.0T patent/DK2346500T3/en active
- 2009-10-16 ES ES09748527.0T patent/ES2637497T3/es active Active
- 2009-10-16 CN CN2009801474233A patent/CN102227217A/zh active Pending
- 2009-10-16 BR BRPI0920342-7A patent/BRPI0920342A2/pt not_active Application Discontinuation
- 2009-10-16 CN CN201710440380.4A patent/CN107243007A/zh active Pending
- 2009-10-16 DK DK17167125.8T patent/DK3260118T3/da active
- 2009-10-16 EP EP17167125.8A patent/EP3260118B1/en active Active
- 2009-10-16 EP EP09748527.0A patent/EP2346500B1/en active Active
- 2009-10-16 CA CA2740610A patent/CA2740610C/en active Active
- 2009-10-16 WO PCT/US2009/005647 patent/WO2010044878A1/en not_active Ceased
-
2011
- 2011-11-02 US US13/287,531 patent/US8604075B2/en active Active
-
2014
- 2014-04-25 US US14/261,962 patent/US20150094352A1/en not_active Abandoned
- 2014-06-24 JP JP2014129145A patent/JP2014169339A/ja not_active Withdrawn
-
2016
- 2016-05-25 JP JP2016103917A patent/JP6271641B2/ja active Active
-
2018
- 2018-04-06 HK HK18104537.2A patent/HK1245099A1/zh unknown
-
2021
- 2021-08-17 US US17/404,124 patent/US20220218665A1/en not_active Abandoned
-
2023
- 2023-10-03 US US18/376,127 patent/US20240293363A1/en active Pending
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