JP2012505221A5 - - Google Patents

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Publication number
JP2012505221A5
JP2012505221A5 JP2011531120A JP2011531120A JP2012505221A5 JP 2012505221 A5 JP2012505221 A5 JP 2012505221A5 JP 2011531120 A JP2011531120 A JP 2011531120A JP 2011531120 A JP2011531120 A JP 2011531120A JP 2012505221 A5 JP2012505221 A5 JP 2012505221A5
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011531120A
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English (en)
Japanese (ja)
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JP2012505221A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/059730 external-priority patent/WO2010042543A2/en
Publication of JP2012505221A publication Critical patent/JP2012505221A/ja
Publication of JP2012505221A5 publication Critical patent/JP2012505221A5/ja
Pending legal-status Critical Current

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JP2011531120A 2008-10-06 2009-10-06 高コレステロール血症および高脂血症ならびにそれらに関連する疾患の予防および処置におけるトル様受容体の阻害剤の使用 Pending JP2012505221A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10297408P 2008-10-06 2008-10-06
US61/102,974 2008-10-06
PCT/US2009/059730 WO2010042543A2 (en) 2008-10-06 2009-10-06 Use of inhibitors of toll-like receptors in the prevention and treatment of hypercholesterolemia and hyperlipidemia and diseases related thereto

Publications (2)

Publication Number Publication Date
JP2012505221A JP2012505221A (ja) 2012-03-01
JP2012505221A5 true JP2012505221A5 (enExample) 2012-07-05

Family

ID=41472585

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011531120A Pending JP2012505221A (ja) 2008-10-06 2009-10-06 高コレステロール血症および高脂血症ならびにそれらに関連する疾患の予防および処置におけるトル様受容体の阻害剤の使用

Country Status (9)

Country Link
US (1) US8853177B2 (enExample)
EP (2) EP3087988A3 (enExample)
JP (1) JP2012505221A (enExample)
KR (1) KR20110071108A (enExample)
CN (1) CN102281880A (enExample)
AU (1) AU2009302468A1 (enExample)
CA (1) CA2738816A1 (enExample)
MX (1) MX2011003625A (enExample)
WO (1) WO2010042543A2 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3002443A1 (en) 2006-11-20 2008-05-29 President And Fellows Of Harvard College Methods, compositions, and kits for treating pain and pruritis
WO2010054288A2 (en) * 2008-11-07 2010-05-14 National Jewish Health Diagnosis and treatment of autoimmune diseases by targeting autoimmune-related b cells ("abcs")
WO2011005942A2 (en) * 2009-07-08 2011-01-13 Idera Pharmaceuticals, Inc. Oligonucleotide-based compounds as inhibitors of toll-like receptors
CN102725401A (zh) 2009-07-10 2012-10-10 哈佛大学校长及研究员协会 作为抗炎药的永久带电荷的钠和钙通道阻断剂
WO2012068470A2 (en) 2010-11-19 2012-05-24 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
WO2014085154A1 (en) 2012-11-27 2014-06-05 Beth Israel Deaconess Medical Center, Inc. Methods for treating renal disease
JP6385957B2 (ja) 2013-01-08 2018-09-05 イデラ ファーマシューティカルズ インコーポレイテッドIdera Pharmaceuticals, Inc. トール様受容体に基づく免疫応答を調節するための免疫調節オリゴヌクレオチド(iro)化合物
CN108434138A (zh) 2013-03-15 2018-08-24 小利兰·斯坦福大学托管委员会 用于治疗与炎症相关的疾病的去乙基羟氯喹
JP6286065B2 (ja) 2014-12-14 2018-02-28 ヴィア アライアンス セミコンダクター カンパニー リミテッド アウトオブオーダープロセッサの書き込み結合メモリ領域アクセスに依存するロードリプレイを除外する装置及び方法
KR101745524B1 (ko) 2015-05-29 2017-06-12 아주대학교산학협력단 신규한 tlr2 길항제
WO2016195194A2 (ko) * 2015-05-29 2016-12-08 아주대학교산학협력단 신규한 tlr2 길항제
CN108348774A (zh) 2015-08-03 2018-07-31 哈佛大学校长及研究员协会 带电离子通道阻断剂及其应用
CN105506119A (zh) * 2016-01-08 2016-04-20 张君 大鼠网膜脂肪组织炎症通路关键因子表达水平的测定方法
CN105695625B (zh) * 2016-04-29 2021-12-17 宁波大学 一种用于辅助诊断原发性高血压的检测试剂盒及其应用
AU2017277647B2 (en) 2016-06-08 2023-07-27 President And Fellows Of Harvard College Engineered viral vector reduces induction of inflammatory and immune responses
KR20200085812A (ko) 2017-11-08 2020-07-15 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 바이러스 벡터-유도된 염증 반응을 억제하기 위한 조성물 및 방법
US12440536B2 (en) 2018-05-18 2025-10-14 The University Of Hong Kong Compositions of toll-like receptor 5 (TLR5) agonist and methods of use thereof
WO2020011869A2 (en) 2018-07-11 2020-01-16 Roche Innovation Center Copenhagen A/S Antisense oligonucleotides targeting tlr2
CN109251956A (zh) * 2018-09-18 2019-01-22 青岛大学 糖尿病大鼠胰岛内MyD88 mRNA表达及黄芪的调节作用
KR20210143791A (ko) 2019-03-11 2021-11-29 녹시온 테라퓨틱스 인코포레이티드 하전된 이온 채널 차단제 및 사용 방법
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
JP7630439B2 (ja) 2019-03-11 2025-02-17 ノシオン セラピューティクス,インコーポレイテッド エステル置換イオンチャンネル遮断薬および使用方法
WO2020185928A1 (en) 2019-03-11 2020-09-17 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US10828287B2 (en) 2019-03-11 2020-11-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US10842798B1 (en) 2019-11-06 2020-11-24 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
JP7513713B2 (ja) 2019-11-06 2024-07-09 ノシオン セラピューティクス,インコーポレイテッド 荷電したイオンチャンネル遮断薬および使用方法
CN119118953A (zh) 2020-03-11 2024-12-13 诺西恩医疗公司 带电的离子通道阻滞剂及其使用方法
US12162851B2 (en) 2020-03-11 2024-12-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO203996A0 (en) * 1996-08-30 1996-09-26 Novogen Research Pty Ltd Therapeutic uses
US6426334B1 (en) * 1997-04-30 2002-07-30 Hybridon, Inc. Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal
ES2233426T3 (es) * 1999-08-13 2005-06-16 Hybridon, Inc. Modulacion de la estimulacion inmunitaria medida por cpg de oligonucleotido por modificacion de la posicion de los nucleosidos.
US6899891B2 (en) * 1999-12-16 2005-05-31 Harry J. Siskind Nutritional composition, methods of producing said composition and methods of using said composition
CA2398432C (en) * 2000-01-26 2012-06-19 Hybridon, Inc. Modulation of oligonucleotide cpg-mediated immune stimulation by positional modification of nucleosides
AU2001257366B2 (en) 2000-05-01 2006-03-16 Idera Pharmaceuticals, Inc. Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
US7105495B2 (en) * 2001-04-30 2006-09-12 Idera Pharmaceuticals, Inc. Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
WO2003035836A2 (en) * 2001-10-24 2003-05-01 Hybridon Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends
US7276489B2 (en) * 2002-10-24 2007-10-02 Idera Pharmaceuticals, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
WO2003084527A1 (en) * 2002-04-08 2003-10-16 Takeda Chemical Industries, Ltd. Severe sepsis preventive therapeutic agent
US20040009949A1 (en) * 2002-06-05 2004-01-15 Coley Pharmaceutical Group, Inc. Method for treating autoimmune or inflammatory diseases with combinations of inhibitory oligonucleotides and small molecule antagonists of immunostimulatory CpG nucleic acids
SE0201701D0 (sv) 2002-06-05 2002-06-05 Gotovax Ab Treatment of epithelial tumors and infections
EP1393745A1 (en) 2002-07-29 2004-03-03 Hybridon, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5'ends
WO2004094671A2 (en) 2003-04-22 2004-11-04 Coley Pharmaceutical Gmbh Methods and products for identification and assessment of tlr ligands
EA200600069A1 (ru) 2003-06-20 2006-08-25 Коли Фармасьютикал Гмбх Низкомолекулярные антагонисты toll-подобных рецепторов (tlr)
EP1648913A4 (en) * 2003-07-15 2008-09-10 Idera Pharmaceuticals Inc SYNERGISTIC STIMULATION OF THE IMMUNE SYSTEM WITH IMMUNOSTIMULATING OLIGONUCLEOTIDES AND / OR IMMUNOMER COMPOUNDS RELATED TO CYTOKINES AND / OR CHEMOTHERAPEAN MEDICAMENTS OR RADIATION THERAPY
EP1697389A4 (en) * 2003-10-24 2008-12-24 Eisai R&D Man Co Ltd COMPOUNDS AND METHODS FOR TREATING ILLNESS AND SUFFERING TOLL-LIKE RECEPTOR 2 RELATED DISORDERS
US20050239733A1 (en) * 2003-10-31 2005-10-27 Coley Pharmaceutical Gmbh Sequence requirements for inhibitory oligonucleotides
GB0329146D0 (en) 2003-12-16 2004-01-21 Glaxosmithkline Biolog Sa Vaccine
JP2007534775A (ja) * 2004-05-28 2007-11-29 セダーズ−シナイ メディカル センター 脈管の疾患を処置するための方法
NZ553581A (en) * 2004-09-01 2011-04-29 Dynavax Tech Corp Methods and compositions for inhibition of innate immune responses and autoimmunity using immunoregulatory polynucleotides with a TGC sequence
WO2006063072A2 (en) 2004-12-08 2006-06-15 3M Innovative Properties Company Immunomodulatory compositions, combinations and methods
WO2006066003A2 (en) * 2004-12-17 2006-06-22 Dynavax Technologies Corporation Methods and compositions for induction or promotion of immune tolerance
US20060257411A1 (en) * 2005-05-06 2006-11-16 Bruce Beutler Compositions and methods for modulating cells via CD14 and toll-like receptor 4 signaling pathway
EP1928500A2 (en) 2005-09-27 2008-06-11 Coley Pharmaceutical GmbH Modulation of tlr-mediated immune responses using adaptor oligonucleotides
US8399423B2 (en) * 2005-10-12 2013-03-19 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
US8383598B2 (en) * 2005-10-12 2013-02-26 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
US8426375B2 (en) * 2005-10-12 2013-04-23 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
WO2007047396A2 (en) * 2005-10-12 2007-04-26 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
US8377898B2 (en) * 2006-10-12 2013-02-19 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
CA2694973A1 (en) * 2007-08-15 2009-02-19 Idera Pharmaceuticals, Inc. Toll like receptor modulators
AU2008317261B2 (en) * 2007-10-26 2015-04-09 Dynavax Technologies Corporation Methods and compositions for inhibition of immune responses and autoimmunity
US20090131512A1 (en) * 2007-10-31 2009-05-21 Dynavax Technologies Corp. Inhibition of type I in IFN production
WO2009154609A1 (en) * 2008-06-17 2009-12-23 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
US11114308B2 (en) 2018-09-25 2021-09-07 International Business Machines Corporation Controlling of height of high-density interconnection structure on substrate
US11116008B2 (en) 2018-11-02 2021-09-07 Samsung Electronics Co., Ltd. Method and device for radio resource allocation in wireless communication system
TWI711225B (zh) 2019-07-01 2020-11-21 唐虞企業股份有限公司 連接器總成

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