JP2012524113A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012524113A5 JP2012524113A5 JP2012506308A JP2012506308A JP2012524113A5 JP 2012524113 A5 JP2012524113 A5 JP 2012524113A5 JP 2012506308 A JP2012506308 A JP 2012506308A JP 2012506308 A JP2012506308 A JP 2012506308A JP 2012524113 A5 JP2012524113 A5 JP 2012524113A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100207167A CN101525361B (zh) | 2009-04-21 | 2009-04-21 | 基于吉西他滨结构的前药及其合成方法及应用 |
| CN200910020716.7 | 2009-04-21 | ||
| PCT/CN2010/000372 WO2010121486A1 (zh) | 2009-04-21 | 2010-03-25 | 基于吉西他滨结构的前药及其合成方法及应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012524113A JP2012524113A (ja) | 2012-10-11 |
| JP2012524113A5 true JP2012524113A5 (enExample) | 2013-05-09 |
Family
ID=41093454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012506308A Pending JP2012524113A (ja) | 2009-04-21 | 2010-03-25 | ゲムシタビン構造に基づくプロドラッグおよびその合成方法と応用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8653048B2 (enExample) |
| EP (1) | EP2423215A4 (enExample) |
| JP (1) | JP2012524113A (enExample) |
| CN (2) | CN101525361B (enExample) |
| CA (1) | CA2759474A1 (enExample) |
| IL (1) | IL215792A0 (enExample) |
| WO (1) | WO2010121486A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101525361B (zh) | 2009-04-21 | 2010-11-17 | 济南圣鲁金药物技术开发有限公司 | 基于吉西他滨结构的前药及其合成方法及应用 |
| CN102115485A (zh) * | 2009-12-30 | 2011-07-06 | 济南圣鲁金药物技术开发有限公司 | 基于阿糖胞苷结构的前药及其合成方法及应用 |
| CN102432654A (zh) * | 2011-09-26 | 2012-05-02 | 宋云龙 | 吉西他滨酰胺衍生物及其制备方法和用途 |
| US9447137B2 (en) * | 2012-11-07 | 2016-09-20 | Nucorion Pharmaceuticals, Inc. | Substituted gemcitabine aryl amide analogs |
| JP6420247B2 (ja) | 2012-11-13 | 2018-11-07 | ボーイエン セラピューティクス，インコーポレイティド | ゲムシタビンプロドラッグ及びその使用 |
| WO2014145207A1 (en) * | 2013-03-15 | 2014-09-18 | Ohio State Innovation Foundation | Substituted gemcitabine bicyclic amide analogs and treatment methods using same |
| EP3078671A4 (en) * | 2013-12-04 | 2017-05-31 | Hangzhou Minsheng Institutes for Pharma Research Co., Ltd. | Gemcitabine derivative, composition containing the derivative and pharmaceutical use of the derivative |
| US10463684B2 (en) | 2014-01-29 | 2019-11-05 | Board Of Regents, The Uneversety Of Texas System | Nucleobase analogue derivatives and their applications |
| WO2015134334A1 (en) * | 2014-03-03 | 2015-09-11 | Suo Zucai | Gemcitabine analogs |
| CN105001291B (zh) * | 2014-04-15 | 2018-12-04 | 上海知萌生物医药科技有限公司 | 吉西他滨化学传递前药及其制备方法和应用 |
| CN104910024B (zh) * | 2015-05-12 | 2017-02-22 | 四川理工学院 | 一种驱油用表面活性剂 |
| US10752589B2 (en) | 2016-03-14 | 2020-08-25 | Sphaera Pharma Pvt. Ltd. | Trigonelline based compounds |
| US10435429B2 (en) | 2017-10-03 | 2019-10-08 | Nucorion Pharmaceuticals, Inc. | 5-fluorouridine monophosphate cyclic triester compounds |
| AU2019207626B2 (en) | 2018-01-10 | 2023-10-05 | Nucorion Pharmaceuticals, Inc. | Phosphor(n)amidatacetal and phosph(on)atalcetal compounds |
| US11427550B2 (en) | 2018-01-19 | 2022-08-30 | Nucorion Pharmaceuticals, Inc. | 5-fluorouracil compounds |
| CN108329371B (zh) * | 2018-03-06 | 2021-04-09 | 沈阳药科大学 | 白蛋白结合型吉西他滨前药及其合成和应用 |
| WO2019204869A1 (en) * | 2018-04-26 | 2019-10-31 | NanoMed Holdings Pty Ltd | Gemcitabine amphiphile prodrugs |
| WO2021011692A1 (en) | 2019-07-17 | 2021-01-21 | Nucorion Pharmaceuticals, Inc. | Cyclic deoxyribonucleotide compounds |
| CN110845560B (zh) * | 2019-11-21 | 2021-08-24 | 广东中科药物研究有限公司 | 苯丙氨酸酰胺化的核苷酸衍生物及其制备方法与应用 |
| CN111298132B (zh) * | 2020-02-22 | 2022-06-24 | 新乡医学院 | 一种树状分子吉西他滨自组装纳米前药及其制备方法和应用 |
| WO2021216431A1 (en) | 2020-04-21 | 2021-10-28 | Ligand Pharmaceuticals, Inc. | Benzyloxy phosph(on)ate compounds |
| EP4143199B1 (en) | 2020-04-21 | 2025-11-19 | Ligand Pharmaceuticals, Inc. | Nucleotide prodrug compounds |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5637688A (en) * | 1994-12-13 | 1997-06-10 | Eli Lilly And Company | Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride |
| KR100483256B1 (ko) | 1997-01-24 | 2005-04-15 | 콘파마 아에스 | 젬시타빈 유도체 |
| JP4979866B2 (ja) | 1999-09-08 | 2012-07-18 | リガンド・ファーマシューティカルズ・インコーポレイテッド | 肝臓に特異的なドラッグデリバリーのためのプロドラッグ |
| WO2004041203A2 (en) * | 2002-11-04 | 2004-05-21 | Xenoport, Inc. | Gemcitabine prodrugs, pharmaceutical compositions and uses thereof |
| GB0321613D0 (en) | 2003-09-15 | 2003-10-15 | Drug Discovery Lab As | Compounds |
| US20050137141A1 (en) * | 2003-10-24 | 2005-06-23 | John Hilfinger | Prodrug composition |
| EP1804838A2 (en) | 2004-09-15 | 2007-07-11 | Drug Discovery Laboratory AS | Drug conjugates of long chain fatty acid or ester moieties as protein binding prodrugs |
| ES2310860T3 (es) | 2004-12-17 | 2009-01-16 | Eli Lilly And Company | Profarmaco amida de gemcitabina, composiciones y uso del mismo. |
| NO322682B1 (no) * | 2005-03-18 | 2006-11-27 | Clavis Pharma Asa | Anvendelse av gemcitabinderivater for fremstilling av orale doseringsformer ved kreftbehandling, samt slike orale doseringsformer |
| US20070225248A1 (en) | 2006-03-21 | 2007-09-27 | Clavis Pharma As | Oral dosage forms of gemcitabine derivatives |
| ES2446092T3 (es) | 2006-06-21 | 2014-03-06 | Eli Lilly And Company | Formas cristalinas del profármaco amida gemcitabina, composiciones y uso de las mismas |
| US20090068286A1 (en) * | 2007-09-11 | 2009-03-12 | Resprotect, Gmbh | Method of treating cancer by administration of 5-substituted nucleosides |
| FR2922551B1 (fr) | 2007-10-17 | 2009-12-25 | Univ Claude Bernard Lyon | Prodrogues phosphoesters de la gemcitabine comme agents anticancereux |
| CN101525361B (zh) * | 2009-04-21 | 2010-11-17 | 济南圣鲁金药物技术开发有限公司 | 基于吉西他滨结构的前药及其合成方法及应用 |
-
2009
- 2009-04-21 CN CN2009100207167A patent/CN101525361B/zh not_active Expired - Fee Related
-
2010
- 2010-03-25 US US13/265,335 patent/US8653048B2/en not_active Expired - Fee Related
- 2010-03-25 JP JP2012506308A patent/JP2012524113A/ja active Pending
- 2010-03-25 EP EP10766577.0A patent/EP2423215A4/en not_active Withdrawn
- 2010-03-25 CA CA2759474A patent/CA2759474A1/en not_active Abandoned
- 2010-03-25 CN CN2010800179647A patent/CN102428093A/zh active Pending
- 2010-03-25 WO PCT/CN2010/000372 patent/WO2010121486A1/zh not_active Ceased
-
2011
- 2011-10-23 IL IL215792A patent/IL215792A0/en unknown