JP2012505171A5 - - Google Patents
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- Publication number
- JP2012505171A5 JP2012505171A5 JP2011530445A JP2011530445A JP2012505171A5 JP 2012505171 A5 JP2012505171 A5 JP 2012505171A5 JP 2011530445 A JP2011530445 A JP 2011530445A JP 2011530445 A JP2011530445 A JP 2011530445A JP 2012505171 A5 JP2012505171 A5 JP 2012505171A5
- Authority
- JP
- Japan
- Prior art keywords
- emulsion according
- weight
- amount
- water
- emulsion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000839 emulsion Substances 0.000 claims 19
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 6
- 239000008385 outer phase Substances 0.000 claims 5
- 239000004480 active ingredient Substances 0.000 claims 4
- 230000002209 hydrophobic effect Effects 0.000 claims 3
- 239000012071 phase Substances 0.000 claims 3
- 239000004094 surface-active agent Substances 0.000 claims 3
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 claims 2
- 206010046914 Vaginal infection Diseases 0.000 claims 2
- 235000019445 benzyl alcohol Nutrition 0.000 claims 2
- 229920003086 cellulose ether Polymers 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- 208000032159 Vaginal inflammation Diseases 0.000 claims 1
- 201000008100 Vaginitis Diseases 0.000 claims 1
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims 1
- 229960004150 aciclovir Drugs 0.000 claims 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 claims 1
- 125000005250 alkyl acrylate group Chemical group 0.000 claims 1
- 229920013820 alkyl cellulose Polymers 0.000 claims 1
- 230000000843 anti-fungal effect Effects 0.000 claims 1
- 229940124599 anti-inflammatory drug Drugs 0.000 claims 1
- 230000000842 anti-protozoal effect Effects 0.000 claims 1
- 229940124350 antibacterial drug Drugs 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 239000003904 antiprotozoal agent Substances 0.000 claims 1
- 229960001631 carbomer Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- SCKYRAXSEDYPSA-UHFFFAOYSA-N ciclopirox Chemical group ON1C(=O)C=C(C)C=C1C1CCCCC1 SCKYRAXSEDYPSA-UHFFFAOYSA-N 0.000 claims 1
- 229960003749 ciclopirox Drugs 0.000 claims 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 claims 1
- 229960004022 clotrimazole Drugs 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 229920006037 cross link polymer Polymers 0.000 claims 1
- 229960005309 estradiol Drugs 0.000 claims 1
- 229930182833 estradiol Natural products 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 claims 1
- 229960002751 imiquimod Drugs 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims 1
- 229960000282 metronidazole Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000003232 mucoadhesive effect Effects 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 239000007764 o/w emulsion Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920001451 polypropylene glycol Polymers 0.000 claims 1
- 150000005846 sugar alcohols Polymers 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08166058.1 | 2008-10-08 | ||
| EP08166058A EP2174650A1 (en) | 2008-10-08 | 2008-10-08 | Modified release emulsions for application to skin or vaginal mucosa |
| PCT/EP2009/062190 WO2010040632A1 (en) | 2008-10-08 | 2009-09-21 | Modified release emulsions for application to skin or vaginal mucosa |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012505171A JP2012505171A (ja) | 2012-03-01 |
| JP2012505171A5 true JP2012505171A5 (https=) | 2012-05-17 |
Family
ID=40340663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011530445A Withdrawn JP2012505171A (ja) | 2008-10-08 | 2009-09-21 | 皮膚または膣粘膜へ適用するための徐放性エマルジョン |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20110195944A1 (https=) |
| EP (2) | EP2174650A1 (https=) |
| JP (1) | JP2012505171A (https=) |
| KR (1) | KR20110067115A (https=) |
| CN (1) | CN102170862A (https=) |
| AR (1) | AR073801A1 (https=) |
| AU (1) | AU2009301275A1 (https=) |
| BR (1) | BRPI0920565A2 (https=) |
| CA (1) | CA2737255A1 (https=) |
| CL (1) | CL2011000767A1 (https=) |
| CO (1) | CO6361898A2 (https=) |
| EA (1) | EA201170555A1 (https=) |
| IL (1) | IL211681A0 (https=) |
| MA (1) | MA32687B1 (https=) |
| MX (1) | MX2011003696A (https=) |
| NZ (1) | NZ591919A (https=) |
| PE (1) | PE20110449A1 (https=) |
| WO (1) | WO2010040632A1 (https=) |
| ZA (1) | ZA201101818B (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10286056B2 (en) * | 2011-01-27 | 2019-05-14 | Glaxosmithkline Biologicals S.A. | Adjuvant nanoemulsions with crystallisation inhibitors |
| US9056137B2 (en) | 2011-04-01 | 2015-06-16 | University Of Florida Research Foundation, Incorporated | Thermo-sensitive, mucoadhesive or dermoadhesive, and penetration-enhancing formulations for topical delivery of therapeutics |
| DE102011076869A1 (de) * | 2011-06-01 | 2012-12-06 | Beiersdorf Ag | Emulsionszubereitungen mit verbesserten rheologischen Eigenschaften |
| BR112014012444B1 (pt) | 2011-11-23 | 2021-12-14 | Therapeuticsmd, Inc | Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| CN110075310A (zh) | 2011-12-20 | 2019-08-02 | 维奥姆治疗有限公司 | 用于治疗真菌感染的局部油组合物 |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| WO2014167554A2 (en) * | 2013-04-12 | 2014-10-16 | Vyome Biosciences Pvt. Ltd. | Composition and formulation of antimicrobial agents, processes thereof and methods for treating microbial infections |
| CA2942345C (en) * | 2014-03-12 | 2020-12-01 | Warner Chilcott Company, Llc | Low-dose estradiol cream |
| RU2016143081A (ru) | 2014-05-22 | 2018-06-26 | Терапьютиксмд, Инк. | Натуральные комбинированные гормонозаместительные составы и терапии |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| CA3040422A1 (en) * | 2016-10-13 | 2018-04-19 | Catalent U.K. Swindon Zydis Limited | Lyophilized pharmaceutical compositions for vaginal delivery |
| KR20200019735A (ko) * | 2017-06-22 | 2020-02-24 | 비라말 리미티드 | 약물 전달을 위한 조성물 및 그의 사용 방법 |
| WO2019213473A1 (en) | 2018-05-04 | 2019-11-07 | The Procter & Gamble Company | Compositions and methods for treating vaginal dryness |
| BR112021007877A2 (pt) | 2018-10-26 | 2021-08-03 | Viramal Limited | composição em gel mucoadesiva |
| EP3659583B1 (en) | 2018-11-30 | 2023-06-07 | Viramal Limited | A method of preparing a gelling agent, the gelling agent obtained thereby, and the use of said gelling agent |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE414511T1 (de) * | 2000-12-05 | 2008-12-15 | Los Angeles Childrens Hospital | Pharmazeutische zusammensetzungen von fenretinid mit erhöhter bioverfügbarkeit und verfahren zu deren verwendung |
| US20030228340A1 (en) * | 2002-04-04 | 2003-12-11 | Gans Eugene H. | Methods for treating rosacea with pyridones |
| US20060018937A1 (en) * | 2002-10-25 | 2006-01-26 | Foamix Ltd. | Steroid kit and foamable composition and uses thereof |
| US20060233721A1 (en) * | 2002-10-25 | 2006-10-19 | Foamix Ltd. | Foam containing unique oil globules |
| US20040087564A1 (en) * | 2002-10-31 | 2004-05-06 | Wright D. Craig | Delivery composition and method |
| CA2611577A1 (en) * | 2005-06-07 | 2007-09-07 | Foamix Ltd. | Antibiotic kit and composition and uses thereof |
| US20070071705A1 (en) * | 2005-09-29 | 2007-03-29 | De Oliveira Monica A M | Topical anti-microbial compositions |
| US20080075745A1 (en) * | 2006-09-21 | 2008-03-27 | Glenmark Pharmaceuticals Limited | Topical pharmaceutical compositions containing ciclopirox or a pharmaceutically acceptable salt thereof |
-
2008
- 2008-10-08 EP EP08166058A patent/EP2174650A1/en not_active Withdrawn
-
2009
- 2009-09-21 US US12/998,331 patent/US20110195944A1/en not_active Abandoned
- 2009-09-21 AU AU2009301275A patent/AU2009301275A1/en not_active Abandoned
- 2009-09-21 JP JP2011530445A patent/JP2012505171A/ja not_active Withdrawn
- 2009-09-21 BR BRPI0920565A patent/BRPI0920565A2/pt not_active IP Right Cessation
- 2009-09-21 KR KR1020117007601A patent/KR20110067115A/ko not_active Withdrawn
- 2009-09-21 NZ NZ591919A patent/NZ591919A/xx not_active IP Right Cessation
- 2009-09-21 EP EP09818802A patent/EP2331065A1/en not_active Withdrawn
- 2009-09-21 PE PE2011000670A patent/PE20110449A1/es not_active Application Discontinuation
- 2009-09-21 CN CN2009801391796A patent/CN102170862A/zh active Pending
- 2009-09-21 MX MX2011003696A patent/MX2011003696A/es unknown
- 2009-09-21 EA EA201170555A patent/EA201170555A1/ru unknown
- 2009-09-21 CA CA2737255A patent/CA2737255A1/en not_active Abandoned
- 2009-09-21 WO PCT/EP2009/062190 patent/WO2010040632A1/en not_active Ceased
- 2009-10-08 AR ARP090103886A patent/AR073801A1/es unknown
-
2011
- 2011-03-09 ZA ZA2011/01818A patent/ZA201101818B/en unknown
- 2011-03-10 IL IL211681A patent/IL211681A0/en unknown
- 2011-04-01 MA MA33736A patent/MA32687B1/fr unknown
- 2011-04-06 CL CL2011000767A patent/CL2011000767A1/es unknown
- 2011-04-07 CO CO11043013A patent/CO6361898A2/es not_active Application Discontinuation
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