JP2012504609A5 - - Google Patents
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- Publication number
- JP2012504609A5 JP2012504609A5 JP2011530059A JP2011530059A JP2012504609A5 JP 2012504609 A5 JP2012504609 A5 JP 2012504609A5 JP 2011530059 A JP2011530059 A JP 2011530059A JP 2011530059 A JP2011530059 A JP 2011530059A JP 2012504609 A5 JP2012504609 A5 JP 2012504609A5
- Authority
- JP
- Japan
- Prior art keywords
- delivery device
- transdermal delivery
- layer
- adhesive matrix
- backing layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000037317 transdermal delivery Effects 0.000 claims description 99
- 239000000853 adhesive Substances 0.000 claims description 95
- 230000001070 adhesive effect Effects 0.000 claims description 95
- 239000011159 matrix material Substances 0.000 claims description 79
- KFQYTPMOWPVWEJ-INIZCTEOSA-N rotigotine Chemical compound CCCN([C@@H]1CC2=CC=CC(O)=C2CC1)CCC1=CC=CS1 KFQYTPMOWPVWEJ-INIZCTEOSA-N 0.000 claims description 25
- 229920006267 polyester film Polymers 0.000 claims description 22
- 229960003179 rotigotine Drugs 0.000 claims description 18
- 238000002425 crystallisation Methods 0.000 claims description 15
- 230000008025 crystallization Effects 0.000 claims description 15
- 239000000463 material Substances 0.000 claims description 15
- 229920001296 polysiloxane Polymers 0.000 claims description 14
- 229920006264 polyurethane film Polymers 0.000 claims description 12
- -1 polysiloxane Polymers 0.000 claims description 9
- 239000011248 coating agent Substances 0.000 claims description 8
- 238000000576 coating method Methods 0.000 claims description 8
- 230000001939 inductive effect Effects 0.000 claims description 8
- 239000004447 silicone coating Substances 0.000 claims description 7
- 229940079593 drug Drugs 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 239000004446 fluoropolymer coating Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000002184 metal Substances 0.000 claims description 5
- 229920002367 Polyisobutene Polymers 0.000 claims description 4
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 4
- 230000008018 melting Effects 0.000 claims description 4
- 238000002844 melting Methods 0.000 claims description 4
- 229920003052 natural elastomer Polymers 0.000 claims description 4
- 229920001194 natural rubber Polymers 0.000 claims description 4
- 230000001681 protective effect Effects 0.000 claims description 4
- 229910052710 silicon Inorganic materials 0.000 claims description 4
- 239000010703 silicon Substances 0.000 claims description 4
- 229920003051 synthetic elastomer Polymers 0.000 claims description 4
- 239000005061 synthetic rubber Substances 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 2
- 230000002776 aggregation Effects 0.000 claims description 2
- 238000004220 aggregation Methods 0.000 claims description 2
- 239000011888 foil Substances 0.000 claims description 2
- 238000004806 packaging method and process Methods 0.000 claims description 2
- 229920006254 polymer film Polymers 0.000 claims description 2
- 239000003522 acrylic cement Substances 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 239000003623 enhancer Substances 0.000 claims 1
- 239000010410 layer Substances 0.000 description 100
- 229920000728 polyester Polymers 0.000 description 8
- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 description 6
- 239000005038 ethylene vinyl acetate Substances 0.000 description 6
- 239000011140 metalized polyester Substances 0.000 description 6
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 6
- 239000002033 PVDF binder Substances 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 3
- BFMKFCLXZSUVPI-UHFFFAOYSA-N ethyl but-3-enoate Chemical compound CCOC(=O)CC=C BFMKFCLXZSUVPI-UHFFFAOYSA-N 0.000 description 3
- 229920006284 nylon film Polymers 0.000 description 3
- 229920000573 polyethylene Polymers 0.000 description 3
- 229920000098 polyolefin Polymers 0.000 description 3
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 3
- 239000004743 Polypropylene Substances 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 229920006378 biaxially oriented polypropylene Polymers 0.000 description 2
- 239000011127 biaxially oriented polypropylene Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000010899 nucleation Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 239000012790 adhesive layer Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19531908P | 2008-10-06 | 2008-10-06 | |
| US61/195,319 | 2008-10-06 | ||
| PCT/US2009/005445 WO2010042152A2 (en) | 2008-10-06 | 2009-10-01 | Amorphous rotigotine transdermal system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012504609A JP2012504609A (ja) | 2012-02-23 |
| JP2012504609A5 true JP2012504609A5 (enExample) | 2012-11-08 |
Family
ID=41479237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011530059A Pending JP2012504609A (ja) | 2008-10-06 | 2009-10-01 | アモルファスロチゴチン経皮システム |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20100086582A1 (enExample) |
| EP (2) | EP2742934A1 (enExample) |
| JP (1) | JP2012504609A (enExample) |
| KR (1) | KR20110082142A (enExample) |
| CN (1) | CN102281873A (enExample) |
| AU (1) | AU2009302853B2 (enExample) |
| CA (1) | CA2739380C (enExample) |
| WO (1) | WO2010042152A2 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2515918C (en) | 2003-02-21 | 2010-11-16 | Schering Ag | Uv stable transdermal therapeutic plaster |
| US8668925B2 (en) | 2003-12-12 | 2014-03-11 | Bayer Intellectual Property Gmbh | Transdermal delivery of hormones without the need of penetration enhancers |
| US8962013B2 (en) | 2005-05-02 | 2015-02-24 | Bayer Intellectual Property Gmbh | Multi-layered transdermal system with triazine UV absorber |
| EP2490673A2 (en) | 2009-10-19 | 2012-08-29 | Actavis Group Ptc Ehf | Amorphous rotigotine co-precipitates |
| DE102009052972A1 (de) | 2009-11-12 | 2011-09-15 | Lts Lohmann Therapie-Systeme Ag | Verfahren zur Verhinderung der Kristallisation von Arzneistoffen in einem Polymerfilm |
| DE102010040299A1 (de) | 2010-09-06 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Transdermale therapeutische Systeme mit kristallisationsinhibierender Schutzfolie (Release Liner) |
| ES2617334T3 (es) | 2010-09-06 | 2017-06-16 | Bayer Intellectual Property Gmbh | Parches transdérmicos de dosificación baja con liberación elevada de fármaco |
| EP2457565A1 (de) * | 2010-11-29 | 2012-05-30 | Ratiopharm GmbH | Transdermales therapeutisches System enthaltend Rotigotin |
| EP2646009A1 (en) * | 2010-12-02 | 2013-10-09 | Ratiopharm GmbH | Rotigotine ionic liquid |
| WO2012084969A1 (en) | 2010-12-22 | 2012-06-28 | Hexal Ag | Adhesive composition containing rotigotine and transdermal therapeutic system comprising the adhesive composition |
| DE102010064358A1 (de) * | 2010-12-29 | 2012-07-05 | Acino Ag | Transdermales Applikationssystem mit überstehender Backingfolie |
| DE102011090178A1 (de) * | 2011-12-30 | 2013-07-04 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit geringer Neigung zur Spontankristallisation |
| DE102012205493A1 (de) * | 2012-04-03 | 2013-10-10 | Acino Ag | Einen Dopamin-Agonisten enthaltendes transdermales Applikationssystem |
| EP2682113B1 (de) * | 2012-07-02 | 2018-10-31 | Luye Pharma AG | Verschließen wirkstoffhaltiger Laminate |
| KR101558043B1 (ko) * | 2012-07-06 | 2015-10-07 | 에스케이케미칼주식회사 | 로티고틴 함유 경피흡수제제 |
| TW201431570A (zh) * | 2012-11-22 | 2014-08-16 | Ucb Pharma Gmbh | 用於經皮投服羅替戈汀（Ｒｏｔｉｇｏｔｉｎｅ）之多天式貼片 |
| CN103919755B (zh) * | 2013-01-15 | 2019-10-18 | 江苏康倍得药业股份有限公司 | 妥洛特罗透皮贴剂及其制备方法 |
| JP6726096B2 (ja) | 2013-07-03 | 2020-07-22 | エルテーエス ローマン テラピー−システメ アーゲー | 電子部品を有する経皮治療システム |
| CA2948219C (en) | 2014-05-20 | 2023-04-04 | Lts Lohmann Therapie-Systeme Ag | Method for adjusting the release of active agent in a transdermal delivery system |
| EP3145502B1 (en) * | 2014-05-20 | 2022-07-06 | LTS Lohmann Therapie-Systeme AG | Transdermal delivery system containing rotigotine |
| ES2954087T3 (es) | 2014-05-20 | 2023-11-20 | Lts Lohmann Therapie Systeme Ag | Sistema de administración transdérmica que incluye un mediador de interfase |
| KR102364378B1 (ko) | 2014-05-21 | 2022-02-16 | 에스케이케미칼 주식회사 | 안정성을 향상시킨 로티고틴 함유 경피흡수제제 |
| DE102018120506A1 (de) * | 2017-10-20 | 2019-04-25 | Amw Gmbh | Stabilisiertes transdermales Darreichungssystem |
| ES2988819T3 (es) | 2017-12-19 | 2024-11-21 | Hisamitsu Pharmaceutical Co | Parche que contiene rotigotina |
| WO2019234662A1 (en) * | 2018-06-07 | 2019-12-12 | Nal Pharmaceutical Group Limited | Transdermal drug delivery system containing rotigotine |
| CN113453676B (zh) | 2019-02-15 | 2025-08-05 | 久光制药株式会社 | 罗替戈汀稳定化方法 |
| KR102363479B1 (ko) * | 2021-03-12 | 2022-02-15 | 환인제약 주식회사 | 로티고틴 함유 경피 흡수 제제 |
| CN113368083A (zh) * | 2021-06-16 | 2021-09-10 | 华健医疗(深圳)有限公司 | 一种大麻二酚cbd透皮给药系统 |
| CN113384560A (zh) * | 2021-07-07 | 2021-09-14 | 华健医疗(深圳)有限公司 | 一种治疗或预防神经系统疾病的罗替戈汀与尼古丁的复方透皮贴片及制备方法 |
| WO2024040860A1 (zh) * | 2022-08-24 | 2024-02-29 | 新领医药技术(深圳)有限公司 | 抑制结晶的罗替高汀透皮给药系统及其制备方法和用途 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4022203A (en) * | 1976-01-22 | 1977-05-10 | Win Ackley | Treated patch for minor cuts |
| DE2920500A1 (de) * | 1979-05-21 | 1980-11-27 | Boehringer Sohn Ingelheim | Pharmazeutische zubereitung in form eines polyacrylatfilmes |
| DE3204551A1 (de) * | 1982-02-10 | 1983-08-18 | Boehringer Ingelheim KG, 6507 Ingelheim | Verfahren zur herstellung einer pharmazeutischen zubereitung in form eines polyacrylat-films |
| US4797284A (en) * | 1986-03-12 | 1989-01-10 | Merck & Co., Inc. | Transdermal drug delivery system |
| US4880633A (en) * | 1986-03-12 | 1989-11-14 | Merck & Co., Inc. | Transdermal drug delivery system |
| US4832953A (en) * | 1987-08-13 | 1989-05-23 | Alza Corporation | Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix |
| US4814168A (en) * | 1988-03-04 | 1989-03-21 | Noven Pharmaceuticals, Inc. | Transdermal multipolymer drug delivery system |
| GB9021674D0 (en) | 1990-10-05 | 1990-11-21 | Ethical Pharma Ltd | Transdermal device |
| US5164190A (en) * | 1990-12-11 | 1992-11-17 | Theratech, Inc. | Subsaturated transdermal drug delivery device exhibiting enhanced drug flux |
| US5676968A (en) * | 1991-10-31 | 1997-10-14 | Schering Aktiengesellschaft | Transdermal therapeutic systems with crystallization inhibitors |
| IT1253265B (it) | 1991-11-25 | 1995-07-14 | Rotta Research Lab | Preparato a matrice copolimerica adesiva a base acrilica per il rilascio transdermico dell'estradiolo. |
| US5229130A (en) * | 1991-12-20 | 1993-07-20 | Cygnus Therapeutics Systems | Vegetable oil-based skin permeation enhancer compositions, and associated methods and systems |
| US6162456A (en) * | 1992-09-24 | 2000-12-19 | Ortho-Mcneil Pharmaceutical, Inc. | Adhesive transdermal drug delivery matrix of a physical blend of hydrophilic and hydrophobic polymers |
| US5662928A (en) * | 1995-04-21 | 1997-09-02 | Ciba-Geigy Corporation | Method for the prevention or removal of crystalline scopolamine in a non-aqueous matrix of a transdermal system |
| US5906830A (en) | 1995-09-08 | 1999-05-25 | Cygnus, Inc. | Supersaturated transdermal drug delivery systems, and methods for manufacturing the same |
| US6238700B1 (en) * | 1995-12-01 | 2001-05-29 | Alza Corporation | Method for preventing crystal formation in a dispersion of a liquid in a matrix |
| ATE207348T1 (de) * | 1995-12-01 | 2001-11-15 | Alza Corp | Verbessertes verfahren zur verhinderung der kristallbildung in einer dispersion eines flüssigen stoffes in einer matrix |
| DE19548332A1 (de) * | 1995-12-22 | 1997-07-10 | Rotta Res Bv | Hormonpflaster |
| US6623763B2 (en) | 1996-01-08 | 2003-09-23 | Lts Lohmann Therape-System Ag | Pharmaceutical preparation adhering to the skin, in particular a transdermal therapeutic system for the release of 17-β-estradiol to the human organism |
| US5869089A (en) | 1996-03-21 | 1999-02-09 | China-America Technology Corp. (Ctc) | Manufacturing method of programmable transdermal therapeutic system |
| GB9720470D0 (en) | 1997-09-25 | 1997-11-26 | Ethical Pharmaceuticals South | Inhibition of crystallization in transdermal devices |
| SE9801704D0 (sv) | 1998-05-14 | 1998-05-14 | Bioglan Ab | Biologically active composition |
| DE19827732A1 (de) * | 1998-06-22 | 1999-12-23 | Rottapharm Bv | Transdermales System vom Matrix-Typ zur Abgabe von Wirkstoffen mit einer hohen Abgaberate von Steroid-Hormonen und die Verwendung eines derartigen Systems zur Hormonersatztherapie |
| JP2003520191A (ja) * | 1998-09-08 | 2003-07-02 | ワトソン ファーマシューティカルズ， インコーポレイテッド | 薬物の親水性塩類を含有する感圧接着剤マトリックスパッチの製造方法 |
| DE19906152B4 (de) | 1999-02-10 | 2005-02-10 | Jenapharm Gmbh & Co. Kg | Wirkstoffhaltige Laminate für Transdermalsysteme |
| US6383511B1 (en) * | 1999-10-25 | 2002-05-07 | Epicept Corporation | Local prevention or amelioration of pain from surgically closed wounds |
| US6562368B2 (en) * | 1999-12-16 | 2003-05-13 | Dermatrends, Inc. | Transdermal administration of oxybutynin using hydroxide-releasing agents as permeation enhancers |
| US6645520B2 (en) | 1999-12-16 | 2003-11-11 | Dermatrends, Inc. | Transdermal administration of nonsteroidal anti-inflammatory drugs using hydroxide-releasing agents as permeation enhancers |
| US6455066B1 (en) | 2000-03-10 | 2002-09-24 | Epicept Corporation | Intradermal-penetration agents for topical local anesthetic administration |
| AU2002235155A1 (en) * | 2000-12-05 | 2002-06-18 | Noven Pharmaceuticals, Inc. | Crystallization inhibition of drugs in transdermal drug delivery systems |
| DE10060550C1 (de) * | 2000-12-06 | 2002-04-18 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Oxybutynin und Verfahren zur Herstellung Oxybutynin enthaltender Wirkstoffschichten |
| WO2003034961A1 (en) | 2001-10-23 | 2003-05-01 | Euro-Celtique, S.A. | Terazosin transdermal device and methods |
| DE10212864B4 (de) * | 2002-03-22 | 2005-12-22 | Beiersdorf Ag | Polymermatrizes umfassend ein Mischsystem zur Löslichkeitsvermittlung von pharmazeutischen Wirkstoffen, Verfahren zu deren Herstellung und deren Verwendung |
| EP1386605A1 (en) * | 2002-07-30 | 2004-02-04 | Schwarz Pharma Ag | Improved transdermal delivery system for the administration of rotigotine |
| US8246979B2 (en) * | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system for the administration of rotigotine |
| DE10234673B4 (de) * | 2002-07-30 | 2007-08-16 | Schwarz Pharma Ag | Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren |
| DE10261696A1 (de) * | 2002-12-30 | 2004-07-15 | Schwarz Pharma Ag | Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base |
| US20050202073A1 (en) * | 2004-03-09 | 2005-09-15 | Mylan Technologies, Inc. | Transdermal systems containing multilayer adhesive matrices to modify drug delivery |
| ATE478659T1 (de) * | 2005-05-13 | 2010-09-15 | Alza Corp | Mehrlagiges arzneimittelausbringsystem mit sperre gegen reservoirmaterialfluss |
| GB2440350B (en) * | 2006-07-25 | 2009-10-14 | Siemens Magnet Technology Ltd | A cryostat comprising a cryogen vessel suspended within an outer vacuum container |
| US20080226698A1 (en) * | 2007-03-16 | 2008-09-18 | Mylan Technologies, Inc. | Amorphous drug transdermal systems, manufacturing methods, and stabilization |
-
2009
- 2009-10-01 AU AU2009302853A patent/AU2009302853B2/en not_active Ceased
- 2009-10-01 EP EP14158985.3A patent/EP2742934A1/en not_active Ceased
- 2009-10-01 EP EP09749216A patent/EP2349230A2/en not_active Withdrawn
- 2009-10-01 WO PCT/US2009/005445 patent/WO2010042152A2/en not_active Ceased
- 2009-10-01 CA CA2739380A patent/CA2739380C/en not_active Expired - Fee Related
- 2009-10-01 CN CN2009801489046A patent/CN102281873A/zh active Pending
- 2009-10-01 US US12/571,509 patent/US20100086582A1/en not_active Abandoned
- 2009-10-01 KR KR1020117008990A patent/KR20110082142A/ko not_active Ceased
- 2009-10-01 JP JP2011530059A patent/JP2012504609A/ja active Pending
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