JP2010521525A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010521525A5 JP2010521525A5 JP2009554528A JP2009554528A JP2010521525A5 JP 2010521525 A5 JP2010521525 A5 JP 2010521525A5 JP 2009554528 A JP2009554528 A JP 2009554528A JP 2009554528 A JP2009554528 A JP 2009554528A JP 2010521525 A5 JP2010521525 A5 JP 2010521525A5
- Authority
- JP
- Japan
- Prior art keywords
- adhesive matrix
- delivery device
- transdermal delivery
- layer
- active substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000853 adhesive Substances 0.000 claims 47
- 230000001070 adhesive effect Effects 0.000 claims 47
- 239000011159 matrix material Substances 0.000 claims 38
- 239000013543 active substance Substances 0.000 claims 31
- 230000037317 transdermal delivery Effects 0.000 claims 28
- 238000000034 method Methods 0.000 claims 20
- 239000000654 additive Substances 0.000 claims 8
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 6
- 229920000728 polyester Polymers 0.000 claims 6
- 229920001296 polysiloxane Polymers 0.000 claims 6
- 239000002904 solvent Substances 0.000 claims 6
- 239000002245 particle Substances 0.000 claims 5
- 229920002635 polyurethane Polymers 0.000 claims 5
- 239000004814 polyurethane Substances 0.000 claims 5
- 150000003431 steroids Chemical class 0.000 claims 5
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 claims 4
- XIQVNETUBQGFHX-UHFFFAOYSA-N Ditropan Chemical group C=1C=CC=CC=1C(O)(C(=O)OCC#CCN(CC)CC)C1CCCCC1 XIQVNETUBQGFHX-UHFFFAOYSA-N 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 claims 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 4
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 4
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 claims 4
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims 4
- 229960002428 fentanyl Drugs 0.000 claims 4
- 239000012943 hotmelt Substances 0.000 claims 4
- 238000002844 melting Methods 0.000 claims 4
- 230000008018 melting Effects 0.000 claims 4
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 claims 4
- 229960003086 naltrexone Drugs 0.000 claims 4
- 229960005434 oxybutynin Drugs 0.000 claims 4
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 claims 4
- 229960002702 piroxicam Drugs 0.000 claims 4
- -1 polyethylene Polymers 0.000 claims 4
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 claims 4
- 229960002646 scopolamine Drugs 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 239000011149 active material Substances 0.000 claims 3
- 238000005280 amorphization Methods 0.000 claims 3
- 239000003963 antioxidant agent Substances 0.000 claims 3
- 230000003078 antioxidant effect Effects 0.000 claims 3
- 239000013078 crystal Substances 0.000 claims 3
- 238000002425 crystallisation Methods 0.000 claims 3
- 230000008025 crystallization Effects 0.000 claims 3
- 239000012297 crystallization seed Substances 0.000 claims 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims 3
- 239000003623 enhancer Substances 0.000 claims 3
- 239000003966 growth inhibitor Substances 0.000 claims 3
- 238000010438 heat treatment Methods 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 239000003961 penetration enhancing agent Substances 0.000 claims 3
- 239000004014 plasticizer Substances 0.000 claims 3
- 229920006267 polyester film Polymers 0.000 claims 3
- 239000004447 silicone coating Substances 0.000 claims 3
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 claims 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 claims 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims 2
- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 claims 2
- 238000005266 casting Methods 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000005038 ethylene vinyl acetate Substances 0.000 claims 2
- 239000004446 fluoropolymer coating Substances 0.000 claims 2
- 238000010030 laminating Methods 0.000 claims 2
- 229960004400 levonorgestrel Drugs 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 229910052751 metal Inorganic materials 0.000 claims 2
- 239000011140 metalized polyester Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims 2
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims 2
- BEKZXQKGTDVSKX-UHFFFAOYSA-N propyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCC BEKZXQKGTDVSKX-UHFFFAOYSA-N 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000008096 xylene Substances 0.000 claims 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 claims 1
- 239000002033 PVDF binder Substances 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920002367 Polyisobutene Polymers 0.000 claims 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 235000012216 bentonite Nutrition 0.000 claims 1
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 229960000913 crospovidone Drugs 0.000 claims 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 229940011871 estrogen Drugs 0.000 claims 1
- 239000000262 estrogen Substances 0.000 claims 1
- BFMKFCLXZSUVPI-UHFFFAOYSA-N ethyl but-3-enoate Chemical compound CCOC(=O)CC=C BFMKFCLXZSUVPI-UHFFFAOYSA-N 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 230000004907 flux Effects 0.000 claims 1
- 239000011888 foil Substances 0.000 claims 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims 1
- 229960002985 medroxyprogesterone acetate Drugs 0.000 claims 1
- PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 claims 1
- 239000002480 mineral oil Substances 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 229920003052 natural elastomer Polymers 0.000 claims 1
- 229920001194 natural rubber Polymers 0.000 claims 1
- 229960001652 norethindrone acetate Drugs 0.000 claims 1
- 229920006284 nylon film Polymers 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 229920001083 polybutene Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920006254 polymer film Polymers 0.000 claims 1
- 229920000098 polyolefin Polymers 0.000 claims 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000000583 progesterone congener Substances 0.000 claims 1
- 229940095055 progestogen systemic hormonal contraceptives Drugs 0.000 claims 1
- DPBVJRXPSXTHOL-UHFFFAOYSA-N propyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCCC DPBVJRXPSXTHOL-UHFFFAOYSA-N 0.000 claims 1
- 229920003051 synthetic elastomer Polymers 0.000 claims 1
- 239000005061 synthetic rubber Substances 0.000 claims 1
- 229960003604 testosterone Drugs 0.000 claims 1
- 238000013271 transdermal drug delivery Methods 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
- 239000011787 zinc oxide Substances 0.000 claims 1
- 235000014692 zinc oxide Nutrition 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/725,159 US20080226698A1 (en) | 2007-03-16 | 2007-03-16 | Amorphous drug transdermal systems, manufacturing methods, and stabilization |
| PCT/US2008/003221 WO2008115371A2 (en) | 2007-03-16 | 2008-03-11 | Amorphous drug transdermal systems, manufacturing methods, and stabilization |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013254188A Division JP6068324B2 (ja) | 2007-03-16 | 2013-12-09 | 非晶質薬物の経皮系、製造方法、および安定化 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010521525A JP2010521525A (ja) | 2010-06-24 |
| JP2010521525A5 true JP2010521525A5 (enExample) | 2011-03-17 |
Family
ID=39530666
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009554528A Pending JP2010521525A (ja) | 2007-03-16 | 2008-03-11 | 非晶質薬物の経皮系、製造方法、および安定化 |
| JP2013254188A Expired - Fee Related JP6068324B2 (ja) | 2007-03-16 | 2013-12-09 | 非晶質薬物の経皮系、製造方法、および安定化 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013254188A Expired - Fee Related JP6068324B2 (ja) | 2007-03-16 | 2013-12-09 | 非晶質薬物の経皮系、製造方法、および安定化 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20080226698A1 (enExample) |
| EP (3) | EP2522339A3 (enExample) |
| JP (2) | JP2010521525A (enExample) |
| KR (2) | KR101488457B1 (enExample) |
| CN (2) | CN106074455A (enExample) |
| AU (1) | AU2008227090B2 (enExample) |
| BR (1) | BRPI0808864A2 (enExample) |
| CA (3) | CA2947796A1 (enExample) |
| ES (1) | ES2436290T3 (enExample) |
| MX (1) | MX2009009856A (enExample) |
| NZ (1) | NZ580443A (enExample) |
| PL (1) | PL2136795T3 (enExample) |
| PT (1) | PT2136795E (enExample) |
| WO (1) | WO2008115371A2 (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9017301B2 (en) | 2007-09-04 | 2015-04-28 | Mylan Technologies, Inc. | Transdermal drug delivery systems comprising a coated release liner |
| WO2009106831A2 (en) | 2008-02-28 | 2009-09-03 | Syntropharma Limited | Pharmaceutical composition |
| EP2285924B1 (en) * | 2008-04-22 | 2014-06-11 | 3M Innovative Properties Company | Adhesive article |
| DE102008021842A1 (de) | 2008-04-30 | 2009-11-05 | Tesa Se | Polyolefinfolie und Verwendung derselben |
| WO2009158120A2 (en) * | 2008-05-30 | 2009-12-30 | Mylan Laboratories Inc. | Stabilized transdermal drug delivery system |
| AU2009302853B2 (en) * | 2008-10-06 | 2014-09-11 | Mylan Technologies, Inc. | Amorphous rotigotine transdermal system |
| JP2010163367A (ja) * | 2009-01-13 | 2010-07-29 | Nitto Denko Corp | 貼付剤および貼付製剤 |
| US8920392B2 (en) * | 2009-05-05 | 2014-12-30 | Watson Laboratories, Inc. | Method for treating overactive bladders and a device for storage and administration of topical oxybutynin compositions |
| DE102009052972A1 (de) * | 2009-11-12 | 2011-09-15 | Lts Lohmann Therapie-Systeme Ag | Verfahren zur Verhinderung der Kristallisation von Arzneistoffen in einem Polymerfilm |
| CN102665699A (zh) | 2009-12-22 | 2012-09-12 | 优时比制药有限公司 | 用于使非结晶形式的罗替戈汀的固体分散体稳定化的聚乙烯吡咯烷酮 |
| JP5766475B2 (ja) * | 2010-03-30 | 2015-08-19 | 日東電工株式会社 | 貼付製剤およびその製造方法 |
| US8563031B2 (en) * | 2010-05-27 | 2013-10-22 | Absize, Inc. | Piroxicam-containing matrix patches and methods for the topical treatment of acute and chronic pain and inflammation therewith |
| CN102038664A (zh) * | 2010-12-20 | 2011-05-04 | 蚌埠丰原涂山制药有限公司 | 一种东莨菪碱透皮贴片及其制备方法 |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| HRP20211377T1 (hr) | 2011-11-23 | 2022-01-07 | Therapeuticsmd, Inc. | Prirodne kombinirane hormonske supstitucijske formulacije i terapije |
| DE102011090178A1 (de) * | 2011-12-30 | 2013-07-04 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit geringer Neigung zur Spontankristallisation |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| KR101558043B1 (ko) * | 2012-07-06 | 2015-10-07 | 에스케이케미칼주식회사 | 로티고틴 함유 경피흡수제제 |
| JP5270035B1 (ja) * | 2012-12-06 | 2013-08-21 | 久光製薬株式会社 | 貼付剤及びその製造方法 |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| JP5307931B1 (ja) * | 2012-12-27 | 2013-10-02 | 久光製薬株式会社 | 貼付剤及びその製造方法 |
| CN103919755B (zh) * | 2013-01-15 | 2019-10-18 | 江苏康倍得药业股份有限公司 | 妥洛特罗透皮贴剂及其制备方法 |
| JP5415645B1 (ja) | 2013-06-28 | 2014-02-12 | 久光製薬株式会社 | 貼付剤の製造方法、貼付剤及び包装体 |
| KR20170005819A (ko) | 2014-05-22 | 2017-01-16 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 천연 복합 호르몬 대체 제형 및 요법 |
| CN104208041B (zh) * | 2014-08-28 | 2018-12-21 | 上海赛琅医药科技有限公司 | 一种用于预防、干预疤痕以及疤痕增生的可塑性硅凝胶和其制作方法 |
| US10010543B1 (en) | 2014-12-23 | 2018-07-03 | Barr Laboratories, Inc. | Transdermal dosage form |
| CN107406554B (zh) * | 2015-02-09 | 2023-04-14 | 美国陶氏有机硅公司 | 多相有机硅丙烯酸类混杂粘弹性组合物及其制备方法 |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| RU2737464C2 (ru) | 2015-12-30 | 2020-11-30 | Кориум Интернэшнл, Инк. | Системы и способы длительного трансдермального введения |
| WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
| KR20180126582A (ko) | 2016-04-01 | 2018-11-27 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 스테로이드 호르몬 약제학적 조성물 |
| US20190225746A1 (en) * | 2016-08-12 | 2019-07-25 | North Carolina State University | Surface-modified polymers |
| US20190216746A1 (en) * | 2016-10-11 | 2019-07-18 | Hisamitsu Pharmaceutical Co., Inc. | Oxybutynin-containing transdermal absorption preparation |
| AU2017384526B2 (en) | 2016-12-20 | 2023-11-02 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
| AU2017384392B2 (en) | 2016-12-20 | 2023-05-25 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene |
| JP6757351B2 (ja) | 2017-04-28 | 2020-09-16 | 日東電工株式会社 | 経皮吸収型製剤 |
| JP2020525545A (ja) | 2017-06-26 | 2020-08-27 | エルテーエス ローマン テラピー−ジステーメ アーゲー | アセナピンおよびシリコーンアクリルハイブリッドポリマーを含有する経皮治療システム |
| CN107320463A (zh) * | 2017-07-10 | 2017-11-07 | 徐静 | 一种含有单硝酸异山梨酯的缓释透皮贴剂及其应用 |
| CA3074636C (en) * | 2017-09-04 | 2024-04-30 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system including an emulsifier |
| DE102017127433A1 (de) * | 2017-11-21 | 2019-05-23 | Lts Lohmann Therapie-Systeme Ag | TTS auf Basis von klebenden Weichmacher-Polymer-Matrices |
| US11583484B2 (en) | 2018-01-03 | 2023-02-21 | Coloplast A/S | Skin care composition for the peristomal region |
| WO2019234662A1 (en) * | 2018-06-07 | 2019-12-12 | Nal Pharmaceutical Group Limited | Transdermal drug delivery system containing rotigotine |
| AU2019291060B2 (en) | 2018-06-20 | 2024-09-05 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
| US12329862B2 (en) | 2018-06-20 | 2025-06-17 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
| US11873149B2 (en) | 2018-11-09 | 2024-01-16 | Sofresh, Inc. | Blown film materials and processes for manufacturing thereof and uses thereof |
| GB2588612A (en) * | 2019-10-28 | 2021-05-05 | Univ Of Sunderland | Transdermal patch |
| CN112891324A (zh) * | 2021-01-19 | 2021-06-04 | 北京亚宝生物药业有限公司 | 一种透皮贴剂 |
| KR102763965B1 (ko) * | 2023-10-04 | 2025-02-05 | 신경연 | 피부 부착용 패치 및 이의 제조 방법 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US516419A (en) * | 1894-03-13 | Means for the propulsion of vessels | ||
| US4022203A (en) * | 1976-01-22 | 1977-05-10 | Win Ackley | Treated patch for minor cuts |
| DE2920500A1 (de) * | 1979-05-21 | 1980-11-27 | Boehringer Sohn Ingelheim | Pharmazeutische zubereitung in form eines polyacrylatfilmes |
| DE3204551A1 (de) * | 1982-02-10 | 1983-08-18 | Boehringer Ingelheim KG, 6507 Ingelheim | Verfahren zur herstellung einer pharmazeutischen zubereitung in form eines polyacrylat-films |
| US4655767A (en) * | 1984-10-29 | 1987-04-07 | Dow Corning Corporation | Transdermal drug delivery devices with amine-resistant silicone adhesives |
| US4880633A (en) * | 1986-03-12 | 1989-11-14 | Merck & Co., Inc. | Transdermal drug delivery system |
| US4797284A (en) * | 1986-03-12 | 1989-01-10 | Merck & Co., Inc. | Transdermal drug delivery system |
| JPH066534B2 (ja) * | 1986-10-09 | 1994-01-26 | 積水化学工業株式会社 | 経皮吸収貼付剤 |
| US4832953A (en) * | 1987-08-13 | 1989-05-23 | Alza Corporation | Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix |
| US4814168A (en) * | 1988-03-04 | 1989-03-21 | Noven Pharmaceuticals, Inc. | Transdermal multipolymer drug delivery system |
| JP2820306B2 (ja) * | 1990-02-27 | 1998-11-05 | 積水化学工業株式会社 | 経皮吸収製剤 |
| GB9021674D0 (en) * | 1990-10-05 | 1990-11-21 | Ethical Pharma Ltd | Transdermal device |
| US5164190A (en) | 1990-12-11 | 1992-11-17 | Theratech, Inc. | Subsaturated transdermal drug delivery device exhibiting enhanced drug flux |
| US5676968A (en) * | 1991-10-31 | 1997-10-14 | Schering Aktiengesellschaft | Transdermal therapeutic systems with crystallization inhibitors |
| IT1253265B (it) * | 1991-11-25 | 1995-07-14 | Rotta Research Lab | Preparato a matrice copolimerica adesiva a base acrilica per il rilascio transdermico dell'estradiolo. |
| US5229130A (en) * | 1991-12-20 | 1993-07-20 | Cygnus Therapeutics Systems | Vegetable oil-based skin permeation enhancer compositions, and associated methods and systems |
| US6162456A (en) * | 1992-09-24 | 2000-12-19 | Ortho-Mcneil Pharmaceutical, Inc. | Adhesive transdermal drug delivery matrix of a physical blend of hydrophilic and hydrophobic polymers |
| US5662928A (en) * | 1995-04-21 | 1997-09-02 | Ciba-Geigy Corporation | Method for the prevention or removal of crystalline scopolamine in a non-aqueous matrix of a transdermal system |
| US5601839A (en) | 1995-04-26 | 1997-02-11 | Theratech, Inc. | Triacetin as a penetration enhancer for transdermal delivery of a basic drug |
| US5906830A (en) * | 1995-09-08 | 1999-05-25 | Cygnus, Inc. | Supersaturated transdermal drug delivery systems, and methods for manufacturing the same |
| ATE207348T1 (de) * | 1995-12-01 | 2001-11-15 | Alza Corp | Verbessertes verfahren zur verhinderung der kristallbildung in einer dispersion eines flüssigen stoffes in einer matrix |
| US6238700B1 (en) * | 1995-12-01 | 2001-05-29 | Alza Corporation | Method for preventing crystal formation in a dispersion of a liquid in a matrix |
| DE19548332A1 (de) * | 1995-12-22 | 1997-07-10 | Rotta Res Bv | Hormonpflaster |
| US6623763B2 (en) * | 1996-01-08 | 2003-09-23 | Lts Lohmann Therape-System Ag | Pharmaceutical preparation adhering to the skin, in particular a transdermal therapeutic system for the release of 17-β-estradiol to the human organism |
| US5869089A (en) * | 1996-03-21 | 1999-02-09 | China-America Technology Corp. (Ctc) | Manufacturing method of programmable transdermal therapeutic system |
| FR2749514B1 (fr) * | 1996-06-11 | 1998-08-07 | Hoechst Marion Roussel | Systemes transdermiques renfermant 2 principes actifs dans des compartiments separes, leur procede de preparation et leur application comme medicament |
| GB9720470D0 (en) * | 1997-09-25 | 1997-11-26 | Ethical Pharmaceuticals South | Inhibition of crystallization in transdermal devices |
| WO1999032153A1 (en) | 1997-12-22 | 1999-07-01 | Alza Corporation | Monoglyceride and ethyl palmitate permeation enhancer compositions |
| SE9801704D0 (sv) * | 1998-05-14 | 1998-05-14 | Bioglan Ab | Biologically active composition |
| DE19827732A1 (de) * | 1998-06-22 | 1999-12-23 | Rottapharm Bv | Transdermales System vom Matrix-Typ zur Abgabe von Wirkstoffen mit einer hohen Abgaberate von Steroid-Hormonen und die Verwendung eines derartigen Systems zur Hormonersatztherapie |
| DE19828273B4 (de) * | 1998-06-25 | 2005-02-24 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System, enthaltend Hormone und Kristallisationsinhibitoren |
| US6337086B1 (en) * | 1999-02-06 | 2002-01-08 | Dow Corning Corporation | Pressure sensitive adhesive compositions for transdermal drug delivery devices |
| DE19906152B4 (de) * | 1999-02-10 | 2005-02-10 | Jenapharm Gmbh & Co. Kg | Wirkstoffhaltige Laminate für Transdermalsysteme |
| US6562368B2 (en) * | 1999-12-16 | 2003-05-13 | Dermatrends, Inc. | Transdermal administration of oxybutynin using hydroxide-releasing agents as permeation enhancers |
| AU2002235155A1 (en) * | 2000-12-05 | 2002-06-18 | Noven Pharmaceuticals, Inc. | Crystallization inhibition of drugs in transdermal drug delivery systems |
| DE10060550C1 (de) * | 2000-12-06 | 2002-04-18 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Oxybutynin und Verfahren zur Herstellung Oxybutynin enthaltender Wirkstoffschichten |
| WO2003034961A1 (en) * | 2001-10-23 | 2003-05-01 | Euro-Celtique, S.A. | Terazosin transdermal device and methods |
| DE10212864B4 (de) * | 2002-03-22 | 2005-12-22 | Beiersdorf Ag | Polymermatrizes umfassend ein Mischsystem zur Löslichkeitsvermittlung von pharmazeutischen Wirkstoffen, Verfahren zu deren Herstellung und deren Verwendung |
| US8246979B2 (en) * | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system for the administration of rotigotine |
| DE10234673B4 (de) * | 2002-07-30 | 2007-08-16 | Schwarz Pharma Ag | Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren |
| JP4792193B2 (ja) * | 2002-08-28 | 2011-10-12 | 久光製薬株式会社 | 貼付剤 |
| DE10261696A1 (de) * | 2002-12-30 | 2004-07-15 | Schwarz Pharma Ag | Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base |
| ATE478659T1 (de) * | 2005-05-13 | 2010-09-15 | Alza Corp | Mehrlagiges arzneimittelausbringsystem mit sperre gegen reservoirmaterialfluss |
-
2007
- 2007-03-16 US US11/725,159 patent/US20080226698A1/en not_active Abandoned
-
2008
- 2008-03-11 EP EP12179591.8A patent/EP2522339A3/en not_active Ceased
- 2008-03-11 BR BRPI0808864-0A patent/BRPI0808864A2/pt not_active Application Discontinuation
- 2008-03-11 KR KR1020097020349A patent/KR101488457B1/ko not_active Expired - Fee Related
- 2008-03-11 WO PCT/US2008/003221 patent/WO2008115371A2/en not_active Ceased
- 2008-03-11 EP EP08726714.2A patent/EP2136795B1/en not_active Revoked
- 2008-03-11 CN CN201610517116.1A patent/CN106074455A/zh active Pending
- 2008-03-11 KR KR1020137006300A patent/KR101488458B1/ko not_active Expired - Fee Related
- 2008-03-11 CA CA2947796A patent/CA2947796A1/en not_active Abandoned
- 2008-03-11 EP EP14192914.1A patent/EP2848248A3/en not_active Withdrawn
- 2008-03-11 PL PL08726714T patent/PL2136795T3/pl unknown
- 2008-03-11 AU AU2008227090A patent/AU2008227090B2/en not_active Ceased
- 2008-03-11 CA CA2762981A patent/CA2762981C/en not_active Expired - Fee Related
- 2008-03-11 CN CN200880014519.8A patent/CN101674816B/zh not_active Expired - Fee Related
- 2008-03-11 ES ES08726714T patent/ES2436290T3/es active Active
- 2008-03-11 MX MX2009009856A patent/MX2009009856A/es active IP Right Grant
- 2008-03-11 CA CA2679535A patent/CA2679535C/en not_active Expired - Fee Related
- 2008-03-11 NZ NZ580443A patent/NZ580443A/en not_active IP Right Cessation
- 2008-03-11 PT PT87267142T patent/PT2136795E/pt unknown
- 2008-03-11 JP JP2009554528A patent/JP2010521525A/ja active Pending
-
2013
- 2013-12-09 JP JP2013254188A patent/JP6068324B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010521525A5 (enExample) | ||
| JP6068324B2 (ja) | 非晶質薬物の経皮系、製造方法、および安定化 | |
| CA2739380C (en) | Amorphous rotigotine transdermal system | |
| AU2008297001B2 (en) | Transdermal drug delivery systems comprising a coated release liner | |
| WO2013128562A1 (ja) | 貼付剤 | |
| CA2861782A1 (en) | Transdermal therapeutic system with a low tendency to spontaneously crystallize | |
| CN101087596A (zh) | 具有可激活的过饱和和可控的渗透促进的经皮治疗系统 | |
| JP6148861B2 (ja) | 貼付剤 | |
| AU2017279775A1 (en) | Amorphous drug transdermal systems, manufacturing methods, and stabilization | |
| HK1197883A (en) | Amorphous rotigotine transdermal system | |
| AU2014202107A1 (en) | Amorphous drug transdermal systems, manufacturing methods, and stabilization | |
| HK1177149A (en) | Amorphous drug transdermal systems, manufacturing methods, and stabilization |