MX2012007326A - Polivinilpirrolidona para la estabilizacion de una dispersion solida de forma no cristalina de rotigotina. - Google Patents

Polivinilpirrolidona para la estabilizacion de una dispersion solida de forma no cristalina de rotigotina.

Info

Publication number
MX2012007326A
MX2012007326A MX2012007326A MX2012007326A MX2012007326A MX 2012007326 A MX2012007326 A MX 2012007326A MX 2012007326 A MX2012007326 A MX 2012007326A MX 2012007326 A MX2012007326 A MX 2012007326A MX 2012007326 A MX2012007326 A MX 2012007326A
Authority
MX
Mexico
Prior art keywords
rotigotine
polyvinylpyrrolidone
solid dispersion
crystalline form
stabilization
Prior art date
Application number
MX2012007326A
Other languages
English (en)
Inventor
Christoph Arth
Hans-Michael Wolff
Luc Quere
Walter Mueller
Original Assignee
Lohmann Therapie Syst Lts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43568293&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2012007326(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lohmann Therapie Syst Lts filed Critical Lohmann Therapie Syst Lts
Publication of MX2012007326A publication Critical patent/MX2012007326A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La presente invención se refiere a un método para estabilizar rotigotina, comprendiendo el método proporcionar una dispersión sólida comprendiendo polivinilpirrolidona y una forma no cristalina de rotigotina, en donde la proporción en peso de rotigotina a polivinilpirrolidona está en un rango desde aproximadamente 9:3.5 hasta aproximadamente 9:6. La presente invención también se refiere a una dispersión sólida comprendiendo un agente dispersante y una fase dispersa, comprendiendo dicha fase dispersa rotigotina y polivinilpirrolidona, en donde la proporción en peso de rotigotina a polivinilpirrolidona está en un rango desde aproximadamente 9:3.5 hasta aproximadamente 9:6, una composición farmacéutica comprendiendo tal dispersión sólida, en particular un sistema terapéutico transdérmico, así como un método para la preparación del mismo.
MX2012007326A 2009-12-22 2010-12-22 Polivinilpirrolidona para la estabilizacion de una dispersion solida de forma no cristalina de rotigotina. MX2012007326A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28930209P 2009-12-22 2009-12-22
PCT/EP2010/070563 WO2011076879A1 (en) 2009-12-22 2010-12-22 Polyvinylpyrrolidone for the stabilization of a solid dispersion of the non-crystalline form of rotigotine

Publications (1)

Publication Number Publication Date
MX2012007326A true MX2012007326A (es) 2012-08-01

Family

ID=43568293

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012007326A MX2012007326A (es) 2009-12-22 2010-12-22 Polivinilpirrolidona para la estabilizacion de una dispersion solida de forma no cristalina de rotigotina.

Country Status (25)

Country Link
US (4) US9925150B2 (es)
EP (2) EP2515887B1 (es)
JP (1) JP5815556B2 (es)
KR (3) KR20160055971A (es)
CN (3) CN102665699A (es)
AU (1) AU2010334805B2 (es)
BR (1) BR112012017737A8 (es)
CA (1) CA2767068C (es)
CY (1) CY1120621T1 (es)
DK (1) DK2515887T3 (es)
EA (1) EA025584B1 (es)
ES (1) ES2679800T3 (es)
HK (1) HK1200335A1 (es)
HR (1) HRP20181173T1 (es)
HU (1) HUE039447T2 (es)
IL (1) IL219091A (es)
LT (1) LT2515887T (es)
ME (1) ME03053B (es)
MX (1) MX2012007326A (es)
PL (1) PL2515887T3 (es)
PT (1) PT2515887T (es)
RS (1) RS57457B1 (es)
SI (1) SI2515887T1 (es)
TR (1) TR201810322T4 (es)
WO (1) WO2011076879A1 (es)

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Also Published As

Publication number Publication date
DK2515887T3 (en) 2018-09-17
PL2515887T3 (pl) 2018-11-30
BR112012017737A8 (pt) 2018-04-17
SI2515887T1 (sl) 2018-10-30
KR101807721B1 (ko) 2018-01-18
IL219091A0 (en) 2012-06-28
US20120322845A1 (en) 2012-12-20
JP2013515041A (ja) 2013-05-02
HRP20181173T1 (hr) 2018-09-21
ES2679800T3 (es) 2018-08-31
AU2010334805B2 (en) 2015-01-22
WO2011076879A1 (en) 2011-06-30
CN102665699A (zh) 2012-09-12
US20190314294A1 (en) 2019-10-17
KR20170023772A (ko) 2017-03-06
EA201270657A1 (ru) 2012-12-28
LT2515887T (lt) 2018-08-10
IL219091A (en) 2017-08-31
RS57457B1 (sr) 2018-09-28
US9925150B2 (en) 2018-03-27
KR20160055971A (ko) 2016-05-18
KR20120107971A (ko) 2012-10-04
HK1200335A1 (en) 2015-08-07
EA025584B1 (ru) 2017-01-30
CA2767068A1 (en) 2011-06-30
CA2767068C (en) 2016-09-27
ME03053B (me) 2018-10-20
EP3257504A1 (en) 2017-12-20
TR201810322T4 (tr) 2018-08-27
AU2010334805A1 (en) 2012-05-03
CN105997952A (zh) 2016-10-12
US20180263921A1 (en) 2018-09-20
EP2515887A1 (en) 2012-10-31
JP5815556B2 (ja) 2015-11-17
HUE039447T2 (hu) 2018-12-28
US20180147154A1 (en) 2018-05-31
CN104189912A (zh) 2014-12-10
US10130589B2 (en) 2018-11-20
US10350174B2 (en) 2019-07-16
PT2515887T (pt) 2018-10-15
BR112012017737A2 (pt) 2016-09-13
CY1120621T1 (el) 2019-12-11
EP2515887B1 (en) 2018-06-06

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