JP2012504608A5 - - Google Patents
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- JP2012504608A5 JP2012504608A5 JP2011530057A JP2011530057A JP2012504608A5 JP 2012504608 A5 JP2012504608 A5 JP 2012504608A5 JP 2011530057 A JP2011530057 A JP 2011530057A JP 2011530057 A JP2011530057 A JP 2011530057A JP 2012504608 A5 JP2012504608 A5 JP 2012504608A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- pharmaceutical composition
- halogen
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 150000001875 compounds Chemical class 0.000 claims 20
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 229910052736 halogen Inorganic materials 0.000 claims 13
- 150000002367 halogens Chemical class 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 11
- 125000001424 substituent group Chemical group 0.000 claims 10
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 9
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 9
- -1 cyano, hydroxy Chemical group 0.000 claims 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 6
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 6
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims 6
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 6
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 4
- 125000001931 aliphatic group Chemical group 0.000 claims 4
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 4
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000003282 alkyl amino group Chemical group 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 208000030761 polycystic kidney disease Diseases 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10254108P | 2008-10-03 | 2008-10-03 | |
| US61/102,541 | 2008-10-03 | ||
| PCT/US2009/005435 WO2010039256A1 (en) | 2008-10-03 | 2009-10-02 | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015075248A Division JP6175465B2 (ja) | 2008-10-03 | 2015-04-01 | ２−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012504608A JP2012504608A (ja) | 2012-02-23 |
| JP2012504608A5 true JP2012504608A5 (show.php) | 2012-10-25 |
Family
ID=41402426
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011530057A Withdrawn JP2012504608A (ja) | 2008-10-03 | 2009-10-02 | ２−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
| JP2015075248A Expired - Fee Related JP6175465B2 (ja) | 2008-10-03 | 2015-04-01 | ２−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
| JP2017095022A Expired - Fee Related JP6297194B2 (ja) | 2008-10-03 | 2017-05-11 | ２−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
| JP2018028160A Pending JP2018087232A (ja) | 2008-10-03 | 2018-02-20 | ２−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015075248A Expired - Fee Related JP6175465B2 (ja) | 2008-10-03 | 2015-04-01 | ２−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
| JP2017095022A Expired - Fee Related JP6297194B2 (ja) | 2008-10-03 | 2017-05-11 | ２−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
| JP2018028160A Pending JP2018087232A (ja) | 2008-10-03 | 2018-02-20 | ２−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8309593B2 (show.php) |
| EP (2) | EP3078373A1 (show.php) |
| JP (4) | JP2012504608A (show.php) |
| KR (1) | KR101687039B1 (show.php) |
| CN (2) | CN102271678B (show.php) |
| CA (1) | CA2738768C (show.php) |
| IL (2) | IL211946A (show.php) |
| MX (1) | MX2011003517A (show.php) |
| RU (1) | RU2578947C2 (show.php) |
| WO (1) | WO2010039256A1 (show.php) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006053043A2 (en) | 2004-11-10 | 2006-05-18 | Genzyme Corporation | Methods of treating diabetes mellitus |
| HUE026057T2 (en) | 2006-05-09 | 2016-05-30 | Genzyme Corp | Procedures for the Treatment of Fatty Liver Disease, which comprises inhibition of glycosphingolipid synthesis |
| EP2167485B1 (en) | 2007-05-31 | 2015-09-30 | Genzyme Corporation | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
| EP2209473B1 (en) * | 2007-10-05 | 2017-11-22 | Genzyme Corporation | Method of treating polycystic kidney diseases with ceramide derivatives |
| US8389517B2 (en) * | 2008-07-28 | 2013-03-05 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
| RU2578947C2 (ru) | 2008-10-03 | 2016-03-27 | Джензайм Корпорейшн | Ингибиторы глюкозилцерамидсинтазы 2-ациламинопропанольного типа |
| US8961959B2 (en) | 2011-10-17 | 2015-02-24 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
| CN102702010B (zh) * | 2012-05-23 | 2014-09-17 | 北京大学 | 光敏感的功能化固载相及其制备方法和应用 |
| EP2968268B1 (en) | 2013-03-15 | 2020-07-29 | Concert Pharmaceuticals Inc. | Inhibitors of the enzyme udp-glucose: n-acyl-sphingosine glucosyltransferase |
| MX374452B (es) * | 2013-09-20 | 2025-03-06 | Biomarin Pharm Inc | Inhibidores de glucosilceramida sintasa para el tratamiento de enfermedades. |
| WO2016001885A2 (en) * | 2014-07-03 | 2016-01-07 | Dr. Reddy’S Laboratories Limited | Amorphous form of eliglustat hemitartarate |
| ES2856898T3 (es) | 2015-02-02 | 2021-09-28 | Univ Michigan Regents | Inhibidores de glucosilceramida sintasa y métodos terapéuticos que usan los mismos |
| CN107635980A (zh) | 2015-03-11 | 2018-01-26 | 生物马林药物股份有限公司 | 用于治疗疾病的葡糖神经酰胺合酶抑制剂 |
| JP6895963B2 (ja) | 2015-11-18 | 2021-06-30 | ジェンザイム・コーポレーション | 多発性嚢胞腎のバイオマーカーおよびその使用 |
| CA3018745A1 (en) | 2016-03-25 | 2017-09-28 | Genzyme Corporation | Biomarkers of proteopathies and uses thereof |
| WO2017204319A1 (ja) * | 2016-05-27 | 2017-11-30 | 公益財団法人野口研究所 | グルコシルセラミド合成酵素阻害剤 |
| US20200339587A1 (en) | 2017-12-21 | 2020-10-29 | Lysosomal Therapeutics Inc. | Crystalline substituted cyclohexyl pyrazolo[1,5-a]pyrimidinyl carboxamide compound and therapeutic uses thereof |
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| US5041441A (en) | 1988-04-04 | 1991-08-20 | The Regents Of The University Of Michigan | Method of chemotherapy using 1-phenyl-2-decanoylamino-3-morpholino-1-propanol |
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| EP2167485B1 (en) * | 2007-05-31 | 2015-09-30 | Genzyme Corporation | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
| EP2209473B1 (en) | 2007-10-05 | 2017-11-22 | Genzyme Corporation | Method of treating polycystic kidney diseases with ceramide derivatives |
| WO2009117150A2 (en) | 2008-03-20 | 2009-09-24 | Genzyme Corporation | Method of treating lupus with ceramide derivatives |
| US8389517B2 (en) | 2008-07-28 | 2013-03-05 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
| RU2578947C2 (ru) | 2008-10-03 | 2016-03-27 | Джензайм Корпорейшн | Ингибиторы глюкозилцерамидсинтазы 2-ациламинопропанольного типа |
-
2009
- 2009-10-02 RU RU2011117028/15A patent/RU2578947C2/ru not_active IP Right Cessation
- 2009-10-02 EP EP16162074.5A patent/EP3078373A1/en not_active Withdrawn
- 2009-10-02 CN CN200980147488.8A patent/CN102271678B/zh not_active Expired - Fee Related
- 2009-10-02 KR KR1020117010056A patent/KR101687039B1/ko not_active Expired - Fee Related
- 2009-10-02 CA CA2738768A patent/CA2738768C/en not_active Expired - Fee Related
- 2009-10-02 US US13/122,135 patent/US8309593B2/en not_active Expired - Fee Related
- 2009-10-02 WO PCT/US2009/005435 patent/WO2010039256A1/en not_active Ceased
- 2009-10-02 CN CN201710483611.XA patent/CN107935983A/zh active Pending
- 2009-10-02 JP JP2011530057A patent/JP2012504608A/ja not_active Withdrawn
- 2009-10-02 MX MX2011003517A patent/MX2011003517A/es active IP Right Grant
- 2009-10-02 EP EP09741487.4A patent/EP2349255B1/en not_active Not-in-force
-
2011
- 2011-03-27 IL IL211946A patent/IL211946A/en not_active IP Right Cessation
-
2012
- 2012-08-27 US US13/595,251 patent/US9272996B2/en not_active Expired - Fee Related
-
2015
- 2015-04-01 JP JP2015075248A patent/JP6175465B2/ja not_active Expired - Fee Related
- 2015-05-03 IL IL238583A patent/IL238583B/en not_active IP Right Cessation
-
2016
- 2016-01-21 US US15/003,207 patent/US9744153B2/en not_active Expired - Fee Related
-
2017
- 2017-05-11 JP JP2017095022A patent/JP6297194B2/ja not_active Expired - Fee Related
-
2018
- 2018-02-20 JP JP2018028160A patent/JP2018087232A/ja active Pending
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