JP2012504161A5 - - Google Patents
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- Publication number
- JP2012504161A5 JP2012504161A5 JP2011530016A JP2011530016A JP2012504161A5 JP 2012504161 A5 JP2012504161 A5 JP 2012504161A5 JP 2011530016 A JP2011530016 A JP 2011530016A JP 2011530016 A JP2011530016 A JP 2011530016A JP 2012504161 A5 JP2012504161 A5 JP 2012504161A5
- Authority
- JP
- Japan
- Prior art keywords
- mdp
- microparticles
- composition
- microparticle
- radiation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011859 microparticle Substances 0.000 claims 116
- 239000000203 mixture Substances 0.000 claims 54
- 230000005855 radiation Effects 0.000 claims 20
- 231100000572 poisoning Toxicity 0.000 claims 12
- 230000000607 poisoning effect Effects 0.000 claims 12
- 206010073306 Exposure to radiation Diseases 0.000 claims 10
- 238000001959 radiotherapy Methods 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 102000004127 Cytokines Human genes 0.000 claims 4
- 108090000695 Cytokines Proteins 0.000 claims 4
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 4
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 4
- 230000037396 body weight Effects 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 102000000589 Interleukin-1 Human genes 0.000 claims 3
- 108010002352 Interleukin-1 Proteins 0.000 claims 3
- 102000000646 Interleukin-3 Human genes 0.000 claims 3
- 108010002386 Interleukin-3 Proteins 0.000 claims 3
- 102000004889 Interleukin-6 Human genes 0.000 claims 3
- 108090001005 Interleukin-6 Proteins 0.000 claims 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 3
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 3
- 229940076264 interleukin-3 Drugs 0.000 claims 3
- 229940100601 interleukin-6 Drugs 0.000 claims 3
- 210000003743 erythrocyte Anatomy 0.000 claims 2
- 230000003308 immunostimulating effect Effects 0.000 claims 2
- 230000005865 ionizing radiation Effects 0.000 claims 2
- 238000011084 recovery Methods 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 108010029961 Filgrastim Proteins 0.000 claims 1
- 101000839034 Giardia intestinalis (strain P15) Flavohemoprotein-1 Proteins 0.000 claims 1
- 101000839032 Giardia intestinalis (strain P15) Flavohemoprotein-2 Proteins 0.000 claims 1
- 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 claims 1
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims 1
- 208000005485 Thrombocytosis Diseases 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000001772 blood platelet Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 238000010322 bone marrow transplantation Methods 0.000 claims 1
- JJWKPURADFRFRB-UHFFFAOYSA-N carbonyl sulfide Chemical compound O=C=S JJWKPURADFRFRB-UHFFFAOYSA-N 0.000 claims 1
- 238000011262 co‐therapy Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000010894 electron beam technology Methods 0.000 claims 1
- 229960004177 filgrastim Drugs 0.000 claims 1
- 230000037406 food intake Effects 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- DCYOBGZUOMKFPA-UHFFFAOYSA-N iron(2+);iron(3+);octadecacyanide Chemical compound [Fe+2].[Fe+2].[Fe+2].[Fe+3].[Fe+3].[Fe+3].[Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] DCYOBGZUOMKFPA-UHFFFAOYSA-N 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 210000002850 nasal mucosa Anatomy 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 102000007863 pattern recognition receptors Human genes 0.000 claims 1
- 108010089193 pattern recognition receptors Proteins 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 210000000278 spinal cord Anatomy 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- UVJDUBUJJFBKLD-UHFFFAOYSA-L zinc;2-[bis[2-[bis(carboxylatomethyl)amino]ethyl]amino]acetate;hydron Chemical compound [H+].[H+].[H+].[Zn+2].[O-]C(=O)CN(CC([O-])=O)CCN(CC(=O)[O-])CCN(CC([O-])=O)CC([O-])=O UVJDUBUJJFBKLD-UHFFFAOYSA-L 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ571665A NZ571665A (en) | 2008-09-30 | 2008-09-30 | Compositions and methods for treatment of radiation exposure utilising cross-linked muramyl dipeptide microparticles |
| NZ571665 | 2008-09-30 | ||
| PCT/NZ2009/000207 WO2010039048A1 (en) | 2008-09-30 | 2009-09-30 | Compositions and methods for treatment of radiation exposure |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015160135A Division JP2016026157A (ja) | 2008-09-30 | 2015-08-14 | 放射線被曝の処置のための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012504161A JP2012504161A (ja) | 2012-02-16 |
| JP2012504161A5 true JP2012504161A5 (enExample) | 2012-11-15 |
| JP6053283B2 JP6053283B2 (ja) | 2016-12-27 |
Family
ID=42073685
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011530016A Expired - Fee Related JP6053283B2 (ja) | 2008-09-30 | 2009-09-30 | 放射線被曝の処置のための組成物および方法 |
| JP2015160135A Pending JP2016026157A (ja) | 2008-09-30 | 2015-08-14 | 放射線被曝の処置のための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015160135A Pending JP2016026157A (ja) | 2008-09-30 | 2015-08-14 | 放射線被曝の処置のための組成物および方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10232010B2 (enExample) |
| EP (1) | EP2349311B1 (enExample) |
| JP (2) | JP6053283B2 (enExample) |
| CN (1) | CN102170898A (enExample) |
| AU (1) | AU2009300442B2 (enExample) |
| BR (1) | BRPI0913783A2 (enExample) |
| CA (1) | CA2738622C (enExample) |
| ES (1) | ES2435438T3 (enExample) |
| NZ (1) | NZ571665A (enExample) |
| WO (1) | WO2010039048A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2926507A1 (en) * | 2015-10-06 | 2017-04-06 | Innate Immunotherapeutics Limited | Compositions and methods for protection and/or repair of the nervous system |
| WO2017059486A1 (en) * | 2015-10-06 | 2017-04-13 | Innate Immunotherapeutics Limited | Compositions and methods for the treatment of epilepsy |
| WO2017070731A1 (en) * | 2015-10-28 | 2017-05-04 | Innate Immunotherapeutics Limited | Compositions and methods for the treatment of alzheimer's disease |
| CN108273038B (zh) * | 2018-03-16 | 2019-03-19 | 中国人民解放军军事科学院军事医学研究院 | 防治肠型放射病的药物组合物 |
| CN111060697A (zh) * | 2019-02-24 | 2020-04-24 | 中国疾病预防控制中心辐射防护与核安全医学所 | 一种利用hmgb1的小肠放射性损伤标记方法 |
| WO2022150763A1 (en) * | 2021-01-11 | 2022-07-14 | The George Washington University | Nanoparticle-mediated immune cell manufacture and uses thereof |
| TWI843989B (zh) | 2021-02-19 | 2024-06-01 | 美商美威高能離子醫療系統公司 | 用於粒子治療系統之支架 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4815446A (en) * | 1985-05-09 | 1989-03-28 | Alpha Therapeutic Corporation | Process for treating metastasis of cancerous tumors |
| AU686660B2 (en) * | 1993-08-11 | 1998-02-12 | Jenner Technologies | Prostatic cancer vaccine |
| GB9320820D0 (en) * | 1993-10-08 | 1993-12-01 | Biokine Tech Ltd | Compounds for medicinal use |
| CA2268372C (en) * | 1996-10-10 | 2012-11-27 | Probe International | Compositions and methods for treating viral infections |
| CA2315115C (en) | 1998-10-23 | 2007-03-20 | Polyheal Ltd. | Compositions of microspheres for wound healing |
| JP5662309B2 (ja) * | 2008-04-01 | 2015-01-28 | イネイト・イムノセラピューティクス・リミテッド | 腫瘍性疾患を治療するための組成物および方法 |
-
2008
- 2008-09-30 NZ NZ571665A patent/NZ571665A/en not_active IP Right Cessation
-
2009
- 2009-09-30 EP EP09818038.3A patent/EP2349311B1/en not_active Not-in-force
- 2009-09-30 JP JP2011530016A patent/JP6053283B2/ja not_active Expired - Fee Related
- 2009-09-30 CA CA2738622A patent/CA2738622C/en not_active Expired - Fee Related
- 2009-09-30 US US13/121,796 patent/US10232010B2/en not_active Expired - Fee Related
- 2009-09-30 CN CN2009801387748A patent/CN102170898A/zh active Pending
- 2009-09-30 ES ES09818038T patent/ES2435438T3/es active Active
- 2009-09-30 AU AU2009300442A patent/AU2009300442B2/en not_active Ceased
- 2009-09-30 BR BRPI0913783A patent/BRPI0913783A2/pt not_active Application Discontinuation
- 2009-09-30 WO PCT/NZ2009/000207 patent/WO2010039048A1/en not_active Ceased
-
2015
- 2015-08-14 JP JP2015160135A patent/JP2016026157A/ja active Pending
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