JP2012502064A - 酸化還元活性治療剤を用いての広汎性発達障害の処置 - Google Patents
酸化還元活性治療剤を用いての広汎性発達障害の処置 Download PDFInfo
- Publication number
- JP2012502064A JP2012502064A JP2011526277A JP2011526277A JP2012502064A JP 2012502064 A JP2012502064 A JP 2012502064A JP 2011526277 A JP2011526277 A JP 2011526277A JP 2011526277 A JP2011526277 A JP 2011526277A JP 2012502064 A JP2012502064 A JP 2012502064A
- Authority
- JP
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- Prior art keywords
- formula
- iiic
- disorder
- diene
- dione
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- IJWAQTHZBDBIID-UHFFFAOYSA-N CCCCCCCCCC(C(C(C)=C1C)=O)=C(C)C1=O Chemical compound CCCCCCCCCC(C(C(C)=C1C)=O)=C(C)C1=O IJWAQTHZBDBIID-UHFFFAOYSA-N 0.000 description 2
- 0 CC(C)(C(C)(C)N)C(C(C(S)=C1C)=O)=C(*)C1=O Chemical compound CC(C)(C(C)(C)N)C(C(C(S)=C1C)=O)=C(*)C1=O 0.000 description 1
- JDCJUYOHXVCXBG-UHFFFAOYSA-N CCCCCCCCCc1c(C)c(O)c(C)c(C)c1O Chemical compound CCCCCCCCCc1c(C)c(O)c(C)c(C)c1O JDCJUYOHXVCXBG-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
- C07C39/08—Dihydroxy benzenes; Alkylated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/02—Quinones with monocyclic quinoid structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/02—Quinones with monocyclic quinoid structure
- C07C50/06—Quinones with monocyclic quinoid structure with unsaturation outside the quinoid structure
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Psychiatry (AREA)
- Pediatric Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19169608P | 2008-09-10 | 2008-09-10 | |
| US61/191,696 | 2008-09-10 | ||
| PCT/US2009/056254 WO2010030607A1 (en) | 2008-09-10 | 2009-09-08 | Treatment of pervasive developmental disorders with redox-active therapeutics |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015055908A Division JP6259410B2 (ja) | 2008-09-10 | 2015-03-19 | 酸化還元活性治療剤を用いての広汎性発達障害の処置 |
| JP2015055909A Division JP2015120748A (ja) | 2008-09-10 | 2015-03-19 | 酸化還元活性治療剤を用いての広汎性発達障害の処置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012502064A true JP2012502064A (ja) | 2012-01-26 |
| JP2012502064A5 JP2012502064A5 (enExample) | 2012-10-25 |
Family
ID=41226405
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011526277A Withdrawn JP2012502064A (ja) | 2008-09-10 | 2009-09-08 | 酸化還元活性治療剤を用いての広汎性発達障害の処置 |
| JP2015055909A Withdrawn JP2015120748A (ja) | 2008-09-10 | 2015-03-19 | 酸化還元活性治療剤を用いての広汎性発達障害の処置 |
| JP2015055908A Active JP6259410B2 (ja) | 2008-09-10 | 2015-03-19 | 酸化還元活性治療剤を用いての広汎性発達障害の処置 |
| JP2015215902A Pending JP2016020399A (ja) | 2008-09-10 | 2015-11-02 | 酸化還元活性治療剤を用いての広汎性発達障害の処置 |
| JP2017076681A Withdrawn JP2017122125A (ja) | 2008-09-10 | 2017-04-07 | 酸化還元活性治療剤を用いての広汎性発達障害の処置 |
| JP2018116995A Pending JP2018162281A (ja) | 2008-09-10 | 2018-06-20 | 酸化還元活性治療剤を用いての広汎性発達障害の処置 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015055909A Withdrawn JP2015120748A (ja) | 2008-09-10 | 2015-03-19 | 酸化還元活性治療剤を用いての広汎性発達障害の処置 |
| JP2015055908A Active JP6259410B2 (ja) | 2008-09-10 | 2015-03-19 | 酸化還元活性治療剤を用いての広汎性発達障害の処置 |
| JP2015215902A Pending JP2016020399A (ja) | 2008-09-10 | 2015-11-02 | 酸化還元活性治療剤を用いての広汎性発達障害の処置 |
| JP2017076681A Withdrawn JP2017122125A (ja) | 2008-09-10 | 2017-04-07 | 酸化還元活性治療剤を用いての広汎性発達障害の処置 |
| JP2018116995A Pending JP2018162281A (ja) | 2008-09-10 | 2018-06-20 | 酸化還元活性治療剤を用いての広汎性発達障害の処置 |
Country Status (8)
| Country | Link |
|---|---|
| US (7) | US8314153B2 (enExample) |
| EP (2) | EP3827815B1 (enExample) |
| JP (6) | JP2012502064A (enExample) |
| BR (1) | BRPI0918139B1 (enExample) |
| CA (1) | CA2736250C (enExample) |
| LT (1) | LT3827815T (enExample) |
| MX (2) | MX2011002318A (enExample) |
| WO (1) | WO2010030607A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2024161510A (ja) * | 2018-10-17 | 2024-11-19 | ピーティーシー セラピューティクス, インコーポレイテッド | α-シヌクレイノパチー、タウオパチー、および他の障害を抑制および処置するための2,3,5-トリメチル-6-ノニルシクロヘキサ-2,5-ジエン-1,4-ジオン |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2583087C (en) | 2003-09-19 | 2012-07-10 | Galileo Pharmaceuticals, Inc. | Chroman derivatives |
| WO2006130775A2 (en) * | 2005-06-01 | 2006-12-07 | Edison Pharmaceuticals, Inc. | Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomakers |
| JP5374162B2 (ja) | 2006-02-22 | 2013-12-25 | エジソン ファーマシューティカルズ, インコーポレイテッド | ミトコンドリア病および他の症状の処置のためのレドックス活性化治療の側鎖変異体およびエネルギーバイオマーカーの調節 |
| EP3456707B1 (en) | 2007-11-06 | 2020-04-15 | PTC Therapeutics, Inc. | 4- (p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases |
| EA023618B1 (ru) | 2008-01-08 | 2016-06-30 | Эдисон Фармасьютикалз, Инк. | Производные (гет)арил-п-хинона для лечения митохондриальных болезней |
| CA2717734A1 (en) | 2008-03-05 | 2009-09-11 | Edison Pharmaceuticals, Inc | 2-substituted-p-quinone derivatives for treatment of oxidative stress diseases |
| WO2009158348A1 (en) * | 2008-06-25 | 2009-12-30 | Edison Pharmaceuticals, Inc. | 2-heterocyclylaminoalkyl-(p-quinone) derivatives for treatment of oxidative stress diseases |
| EP3827815B1 (en) * | 2008-09-10 | 2023-09-06 | PTC Therapeutics, Inc. | Treatment of pervasive developmental disorders with redox-active therapeutics |
| WO2010045220A1 (en) | 2008-10-14 | 2010-04-22 | Edison Pharmaceuticals, Inc. | Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells |
| TR201819154T4 (tr) | 2008-10-28 | 2019-01-21 | Bioelectron Tech Corp | Alfa-tokotrienol kuinone ve ara ürünlerini içeren bileşim. |
| WO2010126911A1 (en) | 2009-04-28 | 2010-11-04 | Edison Pharmaceuticals, Inc. | Treatment of leber's hereditary optic neuropathy and dominant optic atrophy with tocotrienol quinones |
| CA2772294C (en) * | 2009-08-26 | 2018-08-21 | Guy M. Miller | Methods for the prevention and treatment of cerebral ischemia |
| JP2013523816A (ja) * | 2010-04-06 | 2013-06-17 | エジソン ファーマシューティカルズ, インコーポレイテッド | 毛細血管拡張性運動失調症の治療 |
| AU2011245384C1 (en) * | 2010-04-27 | 2016-09-01 | Bioelectron Technology Corporation | Formulations of quinones for the treatment of ophthalmic diseases |
| US8828453B2 (en) * | 2010-04-29 | 2014-09-09 | Betul Hatipoglu | Herbal-based compositions for alleviating symptoms associated with autism |
| MX2013001469A (es) * | 2010-08-06 | 2013-05-14 | Edison Pharmaceuticals Inc | Tratamiento de enfermedades mitocondriales con naftoquinonas |
| US9464016B2 (en) | 2011-06-14 | 2016-10-11 | Edison Pharmaceuticals, Inc. | Catechol derivatives for treatment of oxidative stress diseases |
| JP2014520894A (ja) | 2011-07-19 | 2014-08-25 | エジソン ファーマシューティカルズ, インコーポレイテッド | 非アルファトコトリエノールの存在下でのアルファトコトリエノールの選択的酸化のための方法 |
| AU2012332574B2 (en) * | 2011-10-31 | 2015-11-05 | The Johns Hopkins University | Methods and compositions for treatment of autism |
| CA2883882A1 (en) | 2012-09-07 | 2014-03-13 | Edison Pharmaceuticals, Inc. | Benzoquinone derivatives for treating oxidative stress disorders |
| US9670170B2 (en) | 2013-03-15 | 2017-06-06 | Bioelectron Technology Corporation | Resorufin derivatives for treatment of oxidative stress disorders |
| EP2970158B1 (en) | 2013-03-15 | 2019-02-20 | BioElectron Technology Corporation | Alkyl-heteroaryl substituted quinone derivatives for treatment of oxidative stress disorders |
| US9296712B2 (en) | 2013-03-15 | 2016-03-29 | Edison Pharmaceuticals, Inc. | Resorufin derivatives for treatment of oxidative stress disorders |
| US9868711B2 (en) | 2013-03-15 | 2018-01-16 | Bioelectron Technology Corporation | Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders |
| EP3233786B1 (en) | 2014-12-16 | 2022-03-16 | PTC Therapeutics, Inc. | Polymorphic and amorphous forms of (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide |
| EP3390377A1 (en) | 2015-12-16 | 2018-10-24 | BioElectron Technology Corporation | Improved methods for enriching alpha-tocotrienol from mixed tocol compositions |
| US10703701B2 (en) | 2015-12-17 | 2020-07-07 | Ptc Therapeutics, Inc. | Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
| JP2018083799A (ja) | 2016-11-15 | 2018-05-31 | バイオエレクトロン テクノロジー コーポレイション | 2−置換アミノ−ナフト[1,2−d]イミダゾール−5−オン化合物またはその製薬学上許容される塩 |
| US11471497B1 (en) | 2019-03-13 | 2022-10-18 | David Gordon Bermudes | Copper chelation therapeutics |
| KR20220078644A (ko) | 2019-10-04 | 2022-06-10 | 스텔스 바이오테라퓨틱스 인코포레이티드 | 미토콘드리아 질환 치료를 위한 바티퀴논의 퀴논-, 히드로퀴논- 및 나프토퀴논-유사체 |
| WO2021077034A1 (en) | 2019-10-18 | 2021-04-22 | Ptc Therapeutics, Inc. | 2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1,4-dione for suppressing and treating hemoglobinopathy, thalassemia, sickle cell disease and other disorders |
| JP2023520462A (ja) | 2020-04-03 | 2023-05-17 | ステルス バイオセラピューティクス インコーポレイテッド | フリードライヒ運動失調症を含むミトコンドリア病の予防および/または治療のための組成物および方法 |
| CA3222132A1 (en) | 2021-06-10 | 2022-12-15 | Stealth Biotherapeutics Inc. | Compounds, compositions and methods for the prevention and/or treatment of various mitochondrial diseases or disorders, including friedreich's ataxia |
| KR20240032997A (ko) | 2021-07-08 | 2024-03-12 | 피티씨 테라퓨틱스, 인크. | 2,3,5-트리메틸-6-노닐사이클로헥사-2,5-디엔-1,4-디온을 포함하는 약제학적 조성물 |
| WO2024050725A1 (en) | 2022-09-07 | 2024-03-14 | Ptc Therapeutics, Inc. | Methods of producing 2, 3, 5, 6-alkyl-1, 4-benzoquinones |
Citations (3)
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|---|---|---|---|---|
| WO2005115478A2 (en) * | 2004-05-11 | 2005-12-08 | The Regents Of The University Of California | Methods and compositions for autism spectrum disorders |
| WO2006130775A2 (en) * | 2005-06-01 | 2006-12-07 | Edison Pharmaceuticals, Inc. | Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomakers |
| WO2007035496A1 (en) * | 2005-09-15 | 2007-03-29 | Edison Pharmaceuticals, Inc. | Tail variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
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| JP2024161510A (ja) * | 2018-10-17 | 2024-11-19 | ピーティーシー セラピューティクス, インコーポレイテッド | α-シヌクレイノパチー、タウオパチー、および他の障害を抑制および処置するための2,3,5-トリメチル-6-ノニルシクロヘキサ-2,5-ジエン-1,4-ジオン |
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| US8969420B2 (en) | 2015-03-03 |
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| US10736857B2 (en) | 2020-08-11 |
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| US20130053450A1 (en) | 2013-02-28 |
| JP2015120748A (ja) | 2015-07-02 |
| JP2016020399A (ja) | 2016-02-04 |
| CA2736250C (en) | 2016-12-20 |
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