JP2012501334A - 置換アミノチアゾール誘導体、医薬組成物、および使用の方法 - Google Patents
置換アミノチアゾール誘導体、医薬組成物、および使用の方法 Download PDFInfo
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- JP2012501334A JP2012501334A JP2011525147A JP2011525147A JP2012501334A JP 2012501334 A JP2012501334 A JP 2012501334A JP 2011525147 A JP2011525147 A JP 2011525147A JP 2011525147 A JP2011525147 A JP 2011525147A JP 2012501334 A JP2012501334 A JP 2012501334A
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- FRFAQMKDIVZURC-UHFFFAOYSA-N 3-[[4-[4-(4-fluorophenyl)cyclohexyl]-1,3-thiazol-2-yl]-[(5-methylthiophen-2-yl)methyl]amino]propanoic acid Chemical compound S1C(C)=CC=C1CN(CCC(O)=O)C1=NC(C2CCC(CC2)C=2C=CC(F)=CC=2)=CS1 FRFAQMKDIVZURC-UHFFFAOYSA-N 0.000 claims description 2
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- ZRZZQCNAIDQHNS-UHFFFAOYSA-N 3-[[4-(4,4-dimethylcyclohexyl)-1,3-thiazol-2-yl]-[(5-methylthiophen-2-yl)methyl]amino]propanoic acid Chemical compound S1C(C)=CC=C1CN(CCC(O)=O)C1=NC(C2CCC(C)(C)CC2)=CS1 ZRZZQCNAIDQHNS-UHFFFAOYSA-N 0.000 claims 1
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9284408P | 2008-08-29 | 2008-08-29 | |
| US61/092,844 | 2008-08-29 | ||
| PCT/US2009/054920 WO2010025142A1 (en) | 2008-08-29 | 2009-08-25 | Substituted aminothiazole derivatives, pharmaceutical compositions, and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012501334A true JP2012501334A (ja) | 2012-01-19 |
| JP2012501334A5 JP2012501334A5 (enExample) | 2012-05-17 |
Family
ID=41721863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011525147A Pending JP2012501334A (ja) | 2008-08-29 | 2009-08-25 | 置換アミノチアゾール誘導体、医薬組成物、および使用の方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8563742B2 (enExample) |
| EP (1) | EP2320738A4 (enExample) |
| JP (1) | JP2012501334A (enExample) |
| CA (1) | CA2731442A1 (enExample) |
| WO (1) | WO2010025142A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2797615T (pt) | 2011-12-29 | 2019-07-11 | Rhythm Pharmaceuticals Inc | Método de tratamento de distúrbios associados ao recetor de melanocortina-4 em portadores heterozigóticos |
| DK3356386T3 (da) | 2015-09-30 | 2024-05-21 | Rhythm Pharmaceuticals Inc | Fremgangsmåde til behandling af melanocortin-4 receptorbane-associerede lidelser |
| CA3096055A1 (en) | 2018-04-06 | 2019-10-10 | Rhythm Pharmaceuticals, Inc. | Compositions for treating kidney disease |
| WO2020051424A1 (en) | 2018-09-07 | 2020-03-12 | Pic Therapeutics | Eif4e inhibitors and uses thereof |
| EP4114529A1 (en) | 2020-03-03 | 2023-01-11 | PIC Therapeutics, Inc. | Eif4e inhibitors and uses thereof |
| EP4392421A1 (en) | 2021-08-25 | 2024-07-03 | PIC Therapeutics, Inc. | Eif4e inhibitors and uses thereof |
| JP2024534127A (ja) | 2021-08-25 | 2024-09-18 | ピク セラピューティクス， インコーポレイテッド | ｅＩＦ４Ｅ阻害剤及びその使用 |
| WO2023131667A1 (en) | 2022-01-07 | 2023-07-13 | V. Mane Fils | Cooling compounds and compositions |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2607369B2 (ja) | 1987-02-20 | 1997-05-07 | 興和株式会社 | 新規な複素環化合物 |
| US5502025A (en) | 1987-08-13 | 1996-03-26 | Monsanto Company | Safening herbicidal pyrazolylsulfonylureas |
| US5201933A (en) | 1988-08-01 | 1993-04-13 | Monsanto Company | Safening herbicidal benzoic acid derivatives |
| YU48319B (sh) | 1988-08-01 | 1998-05-15 | Monsanto Company | Bezbednosni herbicidni derivati benzoeve kiseline |
| FR2656610B1 (fr) | 1989-12-29 | 1992-05-07 | Sanofi Sa | Derives d'amino-2 phenyl-4 thiazole, leur procede de preparation et leur application therapeutique. |
| JPH0532662A (ja) | 1990-11-09 | 1993-02-09 | Nissan Chem Ind Ltd | 置換ピラゾール誘導体および農園芸用殺菌剤 |
| CA2074933C (en) | 1990-11-30 | 2002-12-03 | Masatoshi Chihiro | Thiazole derivatives as active superoxide radical inhibitors |
| DE4124942A1 (de) | 1991-07-27 | 1993-01-28 | Thomae Gmbh Dr K | 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| WO1993015060A1 (fr) | 1992-01-22 | 1993-08-05 | Nissan Chemical Industries, Ltd. | Derive de pyrazole substitue et bactericide agrohorticole |
| US5326776A (en) | 1992-03-02 | 1994-07-05 | Abbott Laboratories | Angiotensin II receptor antagonists |
| US6310034B1 (en) | 1993-05-21 | 2001-10-30 | Ut-Battelle, Llc | Agouti polypeptide compositions |
| JPH07149745A (ja) | 1993-11-30 | 1995-06-13 | Hisamitsu Pharmaceut Co Inc | 新規な２−アミノチアゾール誘導体 |
| US5627131A (en) | 1995-01-09 | 1997-05-06 | Zeneca Limited | Herbicidal compositions of 4-benzoylisoxazole and antidotes therefor |
| US5766877A (en) | 1996-05-10 | 1998-06-16 | Amgen Inc. | Genes encoding art, an agouti-related transcript |
| WO1997047299A1 (en) | 1996-06-12 | 1997-12-18 | 3-Dimensional Pharmaceuticals, Inc. | Amidino and guanidino heterocyclic protease inhibitors |
| FR2754258B1 (fr) | 1996-10-08 | 1998-12-31 | Sanofi Sa | Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant |
| US6011048A (en) | 1997-01-28 | 2000-01-04 | Merck & Co., Inc. | Thiazole benzenesulfonamides as β3 agonists for treatment of diabetes and obesity |
| AU3964499A (en) | 1998-03-30 | 1999-10-18 | Gryphon Sciences | Agouti-related protein analogs and methods of use |
| US6689873B1 (en) | 1998-04-29 | 2004-02-10 | Merck & Co., Inc. | Nucleic acid encoding rat agouti related protein |
| US6699896B1 (en) | 1998-05-12 | 2004-03-02 | Wyeth | Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia |
| EP1077960A1 (en) | 1998-05-12 | 2001-02-28 | American Home Products Corporation | (2-acylaminothiazole-4-yl)acetic acid derivatives |
| CN1308618A (zh) | 1998-05-12 | 2001-08-15 | 美国家用产品公司 | 用于治疗胰岛素抗性和高血糖的噁唑芳基－羧酸 |
| GB9818666D0 (en) | 1998-08-27 | 1998-10-21 | Rhone Poulenc Agriculture | New herbicidal method |
| US6303749B1 (en) | 1999-01-29 | 2001-10-16 | Amgen Inc. | Agouti and agouti-related peptide analogs |
| MXPA01010292A (es) | 1999-04-15 | 2002-10-23 | Squibb Bristol Myers Co | Inhibidores ciclicos de la proteina tirosina cinasa. |
| US20040132788A1 (en) | 1999-10-11 | 2004-07-08 | Chabrier De Lassauniere Pierre-Etienne | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
| US7291641B2 (en) | 1999-10-11 | 2007-11-06 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
| EP1125579A3 (en) | 2000-01-18 | 2003-01-02 | Pfizer Products Inc. | Uses of agrp-melanocortin receptor binding modulating compounds |
| DE10006453A1 (de) | 2000-02-14 | 2001-08-16 | Bayer Ag | Piperidylcarbonsäuren als Integrinantagonisten |
| CN1705649A (zh) | 2000-06-29 | 2005-12-07 | 艾伯特公司 | 芳基苯基杂环基硫醚衍生物及其作为抑制细胞粘附的抗炎和免疫抑制剂的用途 |
| HUP0202719A3 (en) | 2001-08-21 | 2006-01-30 | Pfizer Prod Inc | Pharmaceutical compositions for the treatment of female sexual dysfunctions |
| JP2005507932A (ja) | 2001-10-12 | 2005-03-24 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | 肥満の処置のためのフェニル置換５−員窒素含有複素環 |
| RU2317292C2 (ru) | 2001-11-08 | 2008-02-20 | Орто-Макнейл Фармасьютикал, Инк. | Новые производные 1,2,4-тиадиазола в качестве модуляторов рецепторов меланокортина |
| CA2469228A1 (en) | 2001-12-03 | 2003-06-12 | Japan Tobacco Inc. | Azole compound and medicinal use thereof |
| US20030158199A1 (en) | 2002-01-25 | 2003-08-21 | Kylix, B.V. | Novel compounds for inhibition of Tie-2 |
| WO2003068738A1 (en) | 2002-02-11 | 2003-08-21 | Neurocrine Biosciences, Inc. | Pyrrole derivatives as ligands of melanocortin receptors |
| CA2488725A1 (en) | 2002-07-03 | 2004-01-15 | Su Qian | Agouti-related protein deficient cells, non-human transgenic animals and methods of selecting compounds which regulate energy metabolism |
| CA2493712A1 (en) * | 2002-08-07 | 2004-02-19 | F. Hoffmann-La Roche Ag | Aminothiazole derivatives as npy5 receptor inhibitors |
| RU2005134659A (ru) | 2003-04-09 | 2007-05-27 | Джапан Тобакко Инк. (Jp) | Гетероароматическое пентациклическое соединение и его применение в медицине |
| US20050009891A1 (en) | 2003-07-09 | 2005-01-13 | Lee Francis Y. | Combination of SRC Kinase inhibitors and chemotherapeutic agents for the treatment of proliferative diseases |
| MXPA06012130A (es) * | 2004-04-20 | 2007-01-31 | Transtech Pharma Inc | Derivados de tiazol y pirimidina substituidos como moduladores del receptor de melanocortina. |
| WO2006038594A1 (ja) | 2004-10-04 | 2006-04-13 | Ono Pharmaceutical Co., Ltd. | Ｎ型カルシウムチャネル阻害薬 |
| US7361672B2 (en) * | 2004-12-23 | 2008-04-22 | Hoffmann-La Roche Inc. | Heteroarylacetamide inhibitors of factor Xa |
| WO2007103550A2 (en) * | 2006-03-08 | 2007-09-13 | Achillion Pharmaceuticals, Inc. | Substituted aminothiazole derivatives with anti-hcv activity |
-
2009
- 2009-08-25 CA CA2731442A patent/CA2731442A1/en not_active Abandoned
- 2009-08-25 WO PCT/US2009/054920 patent/WO2010025142A1/en not_active Ceased
- 2009-08-25 US US12/547,018 patent/US8563742B2/en not_active Expired - Fee Related
- 2009-08-25 JP JP2011525147A patent/JP2012501334A/ja active Pending
- 2009-08-25 EP EP09810508A patent/EP2320738A4/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US20100056587A1 (en) | 2010-03-04 |
| CA2731442A1 (en) | 2010-03-04 |
| EP2320738A4 (en) | 2011-08-24 |
| EP2320738A1 (en) | 2011-05-18 |
| US8563742B2 (en) | 2013-10-22 |
| WO2010025142A1 (en) | 2010-03-04 |
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