JP2012126736A5 - - Google Patents
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- Publication number
- JP2012126736A5 JP2012126736A5 JP2012062968A JP2012062968A JP2012126736A5 JP 2012126736 A5 JP2012126736 A5 JP 2012126736A5 JP 2012062968 A JP2012062968 A JP 2012062968A JP 2012062968 A JP2012062968 A JP 2012062968A JP 2012126736 A5 JP2012126736 A5 JP 2012126736A5
- Authority
- JP
- Japan
- Prior art keywords
- mycobacterial
- product
- extract
- acid compound
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 13
- -1 5-aminosalicylic acid compound Chemical class 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 10
- ZWBTYMGEBZUQTK-PVLSIAFMSA-N [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,32-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-1'-(2-methylpropyl)-6,23-dioxospiro[8,33-dioxa-24,27,29-triazapentacyclo[23.6.1.14,7.05,31.026,30]tritriaconta-1(32),2,4,9,19,21,24,26,30-nonaene-28,4'-piperidine]-13-yl] acetate Chemical compound CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C2=O)c2c4NC5(CCN(CC(C)C)CC5)N=c4c(=NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C ZWBTYMGEBZUQTK-PVLSIAFMSA-N 0.000 claims 9
- 229960004909 aminosalicylic acid Drugs 0.000 claims 9
- 229960002626 clarithromycin Drugs 0.000 claims 9
- AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 claims 9
- 229960004963 mesalazine Drugs 0.000 claims 9
- 229960000885 rifabutin Drugs 0.000 claims 9
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 7
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims 6
- WDQPAMHFFCXSNU-BGABXYSRSA-N clofazimine Chemical compound C12=CC=CC=C2N=C2C=C(NC=3C=CC(Cl)=CC=3)C(=N/C(C)C)/C=C2N1C1=CC=C(Cl)C=C1 WDQPAMHFFCXSNU-BGABXYSRSA-N 0.000 claims 6
- 229960004287 clofazimine Drugs 0.000 claims 6
- AEUTYOVWOVBAKS-UWVGGRQHSA-N ethambutol Chemical compound CC[C@@H](CO)NCCN[C@@H](CC)CO AEUTYOVWOVBAKS-UWVGGRQHSA-N 0.000 claims 6
- 230000003053 immunization Effects 0.000 claims 4
- RXZBMPWDPOLZGW-XMRMVWPWSA-N (E)-roxithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N/OCOCCOC)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 RXZBMPWDPOLZGW-XMRMVWPWSA-N 0.000 claims 3
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 claims 3
- WUBBRNOQWQTFEX-UHFFFAOYSA-N 4-aminosalicylic acid Chemical compound NC1=CC=C(C(O)=O)C(O)=C1 WUBBRNOQWQTFEX-UHFFFAOYSA-N 0.000 claims 3
- GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 claims 3
- 229960004821 amikacin Drugs 0.000 claims 3
- LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 claims 3
- 229960004099 azithromycin Drugs 0.000 claims 3
- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 claims 3
- 229960003405 ciprofloxacin Drugs 0.000 claims 3
- 229960000285 ethambutol Drugs 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 claims 3
- 229960001699 ofloxacin Drugs 0.000 claims 3
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 claims 3
- 229960001225 rifampicin Drugs 0.000 claims 3
- 229960005224 roxithromycin Drugs 0.000 claims 3
- 244000052616 bacterial pathogen Species 0.000 claims 2
- 230000001717 pathogenic effect Effects 0.000 claims 2
- 241000187481 Mycobacterium phlei Species 0.000 claims 1
- 241000187644 Mycobacterium vaccae Species 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPO5940A AUPO594097A0 (en) | 1997-04-01 | 1997-04-01 | Novel methods of treating inflammatory bowel disease |
| AUPO5940 | 1997-04-01 | ||
| AUPO9785 | 1997-10-14 | ||
| AUPO9785A AUPO978597A0 (en) | 1997-10-14 | 1997-10-14 | Methods of treating inflammatory bowel disease |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007232402A Division JP2008024713A (ja) | 1997-04-01 | 2007-09-07 | 炎症性腸疾患を治療するための方法および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012126736A JP2012126736A (ja) | 2012-07-05 |
| JP2012126736A5 true JP2012126736A5 (OSRAM) | 2013-05-09 |
Family
ID=25645389
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54099898A Withdrawn JP2001524951A (ja) | 1997-04-01 | 1998-04-01 | 炎症性腸疾患を治療するための方法および組成物 |
| JP2007232402A Withdrawn JP2008024713A (ja) | 1997-04-01 | 2007-09-07 | 炎症性腸疾患を治療するための方法および組成物 |
| JP2012062968A Pending JP2012126736A (ja) | 1997-04-01 | 2012-03-21 | 炎症性腸疾患を治療するための方法および組成物 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54099898A Withdrawn JP2001524951A (ja) | 1997-04-01 | 1998-04-01 | 炎症性腸疾患を治療するための方法および組成物 |
| JP2007232402A Withdrawn JP2008024713A (ja) | 1997-04-01 | 2007-09-07 | 炎症性腸疾患を治療するための方法および組成物 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6277836B1 (OSRAM) |
| EP (1) | EP0971735B1 (OSRAM) |
| JP (3) | JP2001524951A (OSRAM) |
| AR (1) | AR012304A1 (OSRAM) |
| AT (1) | ATE389417T1 (OSRAM) |
| CA (1) | CA2285923C (OSRAM) |
| CY (1) | CY1109783T1 (OSRAM) |
| DE (1) | DE69839261T2 (OSRAM) |
| DK (1) | DK0971735T3 (OSRAM) |
| ES (1) | ES2303351T3 (OSRAM) |
| IL (1) | IL132145A (OSRAM) |
| NO (1) | NO325947B1 (OSRAM) |
| NZ (1) | NZ500696A (OSRAM) |
| PT (1) | PT971735E (OSRAM) |
| SI (1) | SI0971735T1 (OSRAM) |
| WO (1) | WO1998043667A1 (OSRAM) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6551632B2 (en) * | 1997-04-01 | 2003-04-22 | Thomas Julius Borody | Methods and compositions for treating inflammatory bowel disease |
| AUPP325398A0 (en) * | 1998-04-30 | 1998-05-21 | Borody, Thomas J. | Improved method for eradicating h. pylori |
| EP1150666B1 (en) * | 1999-02-12 | 2009-10-28 | Washington University | Gm-csf for the treatment of crohn's disease |
| ATE285821T1 (de) * | 1999-10-08 | 2005-01-15 | Affinium Pharm Inc | Fab i inhibitoren |
| JP3369535B2 (ja) | 1999-11-09 | 2003-01-20 | 松下電器産業株式会社 | プラズマディスプレイ装置 |
| US7638496B2 (en) | 2000-02-15 | 2009-12-29 | Valeant Pharmaceuticals North America | Nucleoside analogs with carboxamidine modified monocyclic base |
| BR0109544A (pt) * | 2000-03-28 | 2003-06-10 | Biochemie Gmbh | Partìculas granuladas com sabor ocultado |
| CA2420576C (en) | 2000-08-29 | 2005-06-14 | Nobex Corporation | Immunoregulatory compounds, derivatives thereof and their use |
| US7049310B2 (en) * | 2001-04-06 | 2006-05-23 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
| US8048924B2 (en) | 2001-08-29 | 2011-11-01 | Biocon Limited | Methods and compositions employing 4-aminophenylacetic acid compounds |
| US20030118329A1 (en) * | 2001-12-21 | 2003-06-26 | Pere Obrador | Video indexing using high resolution still images |
| AUPS088702A0 (en) | 2002-03-04 | 2002-03-28 | Borody, Thomas Julius | Electrolyte purgative |
| JP4859460B2 (ja) | 2002-12-06 | 2012-01-25 | アフィニウム ファーマシューティカルズ， インク． | ヘテロ環化合物、その製造方法および治療におけるその使用 |
| WO2004082586A2 (en) | 2003-03-17 | 2004-09-30 | Affinium Pharmaceuticals, Inc. | Phamaceutical compositions comprising inhibitors of fab i and further antibiotics |
| US6930093B2 (en) * | 2003-07-10 | 2005-08-16 | Valeant Research & Development | Use of ribofuranose derivatives against inflammatory bowel diseases |
| WO2005046567A2 (en) * | 2003-09-10 | 2005-05-26 | Meena Shelgaonkar | Synergistic formulation of antioxidants and antimycobacterial agents: a method of making the same |
| US7417037B2 (en) * | 2004-01-20 | 2008-08-26 | The Board Of Regents Of The University Of Oklahoma | Compositions and methods of treatment for inflammatory diseases |
| AU2005209948B2 (en) | 2004-02-06 | 2009-09-10 | Pharmatel (R&D) Pty Limited | Use of aminosalicylates in diarrhoea-predominent Irritable Bowel Syndrome |
| KR20130028807A (ko) * | 2004-05-28 | 2013-03-19 | 샐릭스 파마슈티컬스 인코포레이티드 | 방사선 유발성 장염의 예방, 치료 및 개선 방법 |
| CA2568914C (en) | 2004-06-04 | 2013-09-24 | Affinium Pharmaceuticals, Inc. | Therapeutic agents, and methods of making and using the same |
| PL1773767T3 (pl) | 2004-07-07 | 2016-07-29 | Biocon Ltd | Synteza azowo związanych związków immunoregulacyjnych |
| US8921344B2 (en) * | 2006-11-03 | 2014-12-30 | Salix Pharmaceuticals, Inc. | Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives |
| US7452872B2 (en) * | 2005-08-24 | 2008-11-18 | Salix Pharmaceuticals, Inc. | Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives |
| MX2008002283A (es) * | 2005-08-24 | 2008-09-08 | Salix Pharmaceuticals Inc | Formulaciones de balsalazida y elaboracion y uso de las mismas. |
| EP1973902A2 (en) * | 2005-12-05 | 2008-10-01 | Affinium Pharmaceuticals, Inc. | 3-heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents |
| CA2531261A1 (en) * | 2005-12-21 | 2007-06-21 | Institut Pasteur | Control of intestinal inflammatory syndromes with a preparation of killed or non infectious bacteria |
| US8318720B2 (en) | 2006-07-20 | 2012-11-27 | Affinium Pharmaceuticals, Inc. | Acrylamide derivatives as Fab I inhibitors |
| EP2125802A4 (en) | 2007-02-16 | 2014-08-20 | Debiopharm Int Sa | SALTS, PRODRUGS AND POLYMORPHES OF FAB I INHIBITORS |
| US8217083B2 (en) * | 2007-06-08 | 2012-07-10 | Aptalis Pharma Canada Inc. | Mesalamine suppository |
| US7541384B2 (en) | 2007-06-08 | 2009-06-02 | Axcan Pharma Inc. | Mesalamine suppository |
| US8436051B2 (en) | 2007-06-08 | 2013-05-07 | Aptalis Pharma Canada Inc. | Mesalamine suppository |
| JP2011500552A (ja) * | 2007-10-10 | 2011-01-06 | ルピン・リミテッド | 胃腸障害を処置するための医薬用組み合わせおよび組成物 |
| US20090098088A1 (en) * | 2007-10-10 | 2009-04-16 | The Procter & Gamble Company | Methods And Kits For The Treatment Of Diverticular Conditions |
| WO2009064953A1 (en) * | 2007-11-15 | 2009-05-22 | Enanta Pharmaceuticals, Inc. | Use of bridged macrolides or tylosin derivatives in treating inflammatory bowel diseases |
| DK2247291T3 (en) | 2008-02-08 | 2019-01-21 | Red Hill Biopharma Ltd | Methods and compositions for treating inflammatory bowel disease |
| EP2280713A1 (en) * | 2008-05-01 | 2011-02-09 | The Procter & Gamble Company | Methods and kits for the treatment of inflammatory bowel disorder conditions |
| WO2011044140A1 (en) * | 2009-10-05 | 2011-04-14 | Catabasis Pharmaceuticals, Inc. | Substituted thioacetic acid salicylate derivatives and their uses |
| EP2493471B1 (en) | 2009-10-26 | 2019-11-27 | Thomas Julius Borody | Novel enteric combination therapy |
| WO2011137103A1 (en) | 2010-04-26 | 2011-11-03 | Salix Pharmaceuticals, Ltd. | Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives for the treatment of males |
| EP2651415B1 (en) | 2010-12-13 | 2020-10-07 | Rite-Prep Pty Ltd. | Gastric and colonic formulations and methods for making and using them |
| TWI573590B (zh) * | 2011-09-20 | 2017-03-11 | 雷希爾生藥有限公司 | 治療自體免疫疾病之組成物及方法 |
| WO2013190384A1 (en) | 2012-06-19 | 2013-12-27 | Affinium Pharmaceuticals, Inc. | Prodrug derivatives of (e)-n-methyl-n-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide |
| CN108175773A (zh) | 2012-07-27 | 2018-06-19 | 红山生物医药有限公司 | 用于结肠排空的制剂和制备制剂方法 |
| CN106535941A (zh) | 2014-05-22 | 2017-03-22 | 约翰·托德·金斯特纳 | 使用紫外线血液辐照和抗生素的组合治疗疾病 |
| RS61312B1 (sr) | 2016-02-26 | 2021-02-26 | Debiopharm Int Sa | Lek za lečenje infekcija dijabetskog stopala |
| CN116327781A (zh) | 2019-02-14 | 2023-06-27 | 德彪药业国际股份公司 | 阿法比星制剂及其制备方法 |
| MA56184A (fr) | 2019-06-14 | 2022-04-20 | Debiopharm Int Sa | Afabicine pour utilisation dans le traitement d'infections bactériennes impliquant un biofilm |
| US11590154B2 (en) | 2020-06-30 | 2023-02-28 | Redhill Biopharma Ltd. | Triple antibiotic fixed-dose combination products, dosing regimen, methods, and kits for treating pulmonary non-tuberculosis mycobacterial infections |
| WO2025026423A1 (en) * | 2023-08-02 | 2025-02-06 | Shenzhen Pharmacin Co., Ltd. | Compositions, their use and manufacture for treatment of gastrointestinal conditions |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4440763A (en) * | 1981-03-18 | 1984-04-03 | Block Drug Company, Inc. | Use of 4-aminosalicyclic acid as an anti-inflammatory agent |
| GB8919321D0 (en) * | 1989-08-25 | 1989-10-11 | Univ London | Treatment of chronic inflammatory conditions |
-
1998
- 1998-04-01 EP EP98912149A patent/EP0971735B1/en not_active Expired - Lifetime
- 1998-04-01 DE DE69839261T patent/DE69839261T2/de not_active Expired - Lifetime
- 1998-04-01 US US09/381,960 patent/US6277836B1/en not_active Expired - Lifetime
- 1998-04-01 AT AT98912149T patent/ATE389417T1/de active
- 1998-04-01 IL IL13214598A patent/IL132145A/xx not_active IP Right Cessation
- 1998-04-01 PT PT98912149T patent/PT971735E/pt unknown
- 1998-04-01 SI SI9830905T patent/SI0971735T1/sl unknown
- 1998-04-01 DK DK98912149T patent/DK0971735T3/da active
- 1998-04-01 AR ARP980101486A patent/AR012304A1/es unknown
- 1998-04-01 JP JP54099898A patent/JP2001524951A/ja not_active Withdrawn
- 1998-04-01 ES ES98912149T patent/ES2303351T3/es not_active Expired - Lifetime
- 1998-04-01 NZ NZ500696A patent/NZ500696A/en not_active IP Right Cessation
- 1998-04-01 CA CA2285923A patent/CA2285923C/en not_active Expired - Lifetime
- 1998-04-01 WO PCT/AU1998/000222 patent/WO1998043667A1/en not_active Ceased
-
1999
- 1999-09-30 NO NO19994778A patent/NO325947B1/no not_active IP Right Cessation
-
2007
- 2007-09-07 JP JP2007232402A patent/JP2008024713A/ja not_active Withdrawn
-
2008
- 2008-06-05 CY CY20081100591T patent/CY1109783T1/el unknown
-
2012
- 2012-03-21 JP JP2012062968A patent/JP2012126736A/ja active Pending
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