JP2012050446A5 - - Google Patents
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- JP2012050446A5 JP2012050446A5 JP2011214349A JP2011214349A JP2012050446A5 JP 2012050446 A5 JP2012050446 A5 JP 2012050446A5 JP 2011214349 A JP2011214349 A JP 2011214349A JP 2011214349 A JP2011214349 A JP 2011214349A JP 2012050446 A5 JP2012050446 A5 JP 2012050446A5
- Authority
- JP
- Japan
- Prior art keywords
- monoclonal antibody
- protein
- autoimmune
- group
- isoform
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 9
- 238000000034 method Methods 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 229940000406 drug candidate Drugs 0.000 claims 3
- 230000006433 tumor necrosis factor production Effects 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 2
- 230000001363 autoimmune Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000000265 leukocyte Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 208000003343 Antiphospholipid Syndrome Diseases 0.000 claims 1
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims 1
- 206010050245 Autoimmune thrombocytopenia Diseases 0.000 claims 1
- 208000023328 Basedow disease Diseases 0.000 claims 1
- 208000009137 Behcet syndrome Diseases 0.000 claims 1
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims 1
- 208000033222 Biliary cirrhosis primary Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 208000007465 Giant cell arteritis Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 206010018910 Haemolysis Diseases 0.000 claims 1
- 208000001204 Hashimoto Disease Diseases 0.000 claims 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011152 Pemphigus Diseases 0.000 claims 1
- 208000031845 Pernicious anaemia Diseases 0.000 claims 1
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 208000006045 Spondylarthropathies Diseases 0.000 claims 1
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 206010047642 Vitiligo Diseases 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 208000007502 anemia Diseases 0.000 claims 1
- 201000004339 autoimmune neuropathy Diseases 0.000 claims 1
- 201000004982 autoimmune uveitis Diseases 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 201000001981 dermatomyositis Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 230000008588 hemolysis Effects 0.000 claims 1
- 238000011577 humanized mouse model Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 229940126619 mouse monoclonal antibody Drugs 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 claims 1
- 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 claims 1
- 201000001976 pemphigus vulgaris Diseases 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 208000005987 polymyositis Diseases 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 201000005671 spondyloarthropathy Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 206010043207 temporal arteritis Diseases 0.000 claims 1
- 230000003827 upregulation Effects 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51981803P | 2003-11-12 | 2003-11-12 | |
| US60/519,818 | 2003-11-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006539833A Division JP4979385B2 (ja) | 2003-11-12 | 2004-11-12 | 腫瘍壊死因子αの調節のための組成物及び方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012050446A JP2012050446A (ja) | 2012-03-15 |
| JP2012050446A5 true JP2012050446A5 (enExample) | 2012-12-13 |
Family
ID=34590450
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006539833A Expired - Fee Related JP4979385B2 (ja) | 2003-11-12 | 2004-11-12 | 腫瘍壊死因子αの調節のための組成物及び方法 |
| JP2011214349A Pending JP2012050446A (ja) | 2003-11-12 | 2011-09-29 | 腫瘍壊死因子αの調節のための組成物及び方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006539833A Expired - Fee Related JP4979385B2 (ja) | 2003-11-12 | 2004-11-12 | 腫瘍壊死因子αの調節のための組成物及び方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US7560265B2 (enExample) |
| EP (2) | EP2357238A3 (enExample) |
| JP (2) | JP4979385B2 (enExample) |
| CN (1) | CN101018808B (enExample) |
| AU (1) | AU2004290049B2 (enExample) |
| BR (1) | BRPI0416467A (enExample) |
| CA (1) | CA2545359C (enExample) |
| EA (1) | EA012567B1 (enExample) |
| IL (1) | IL175503A0 (enExample) |
| MX (1) | MXPA06005219A (enExample) |
| WO (1) | WO2005047478A2 (enExample) |
| ZA (1) | ZA200603780B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4979385B2 (ja) * | 2003-11-12 | 2012-07-18 | ザ・リージエンツ・オブ・ザ・ユニバーシテイ・オブ・コロラド、ア・ボデイー・コーポレイト | 腫瘍壊死因子αの調節のための組成物及び方法 |
| IL169622A0 (en) * | 2005-07-11 | 2007-07-04 | Yeda Res & Dev | Methods of screening modulators of interleukin-32 (il-32)modulators of il-32 identified by said methods and their use |
| KR100855299B1 (ko) * | 2007-02-16 | 2008-08-29 | 건국대학교 산학협력단 | 인간 ｉｌ-32 특이 항원결정기를 갖는 단일클론항체,특이항체분비 융합 세포주 및 항체들을 이용한 ｉｌ-32측정법 |
| US20090263377A1 (en) * | 2008-04-10 | 2009-10-22 | Charles Lin | Il-32b-targeted diagnosis and therapy |
| JP5395725B2 (ja) * | 2010-04-05 | 2014-01-22 | 富士フイルム株式会社 | 電子内視鏡システム |
| WO2012142597A1 (en) * | 2011-04-15 | 2012-10-18 | The Regents Of The University Of California | A method for generating potent dendritic cells |
| US9273284B2 (en) | 2011-04-19 | 2016-03-01 | The Regents Of The University Of California | Method for generating potent dendritic cells |
| CN102392043A (zh) * | 2011-12-13 | 2012-03-28 | 江南大学 | 毕赤酵母制备人白细胞介素32β的方法 |
| CN102660552B (zh) * | 2011-12-30 | 2014-03-19 | 西北农林科技大学 | 一种牛白细胞介素32γ亚型的分子克隆/稳转细胞系的建立及其方法 |
| WO2015001010A1 (en) | 2013-07-03 | 2015-01-08 | Immunoqure Ag | Human anti-il-32 antibodies |
| CN104975041B (zh) * | 2014-12-19 | 2018-01-23 | 中山大学 | 一种促进单核细胞向巨噬细胞分化的方法 |
| KR101693275B1 (ko) | 2015-03-03 | 2017-01-05 | 충북대학교 산학협력단 | IFN-γ 및 IL-32γ를 유효성분으로 포함하는 항암용 조성물 |
| GB201701404D0 (en) * | 2017-01-27 | 2017-03-15 | Micropharm Ltd | Therapies for treating inflammatory disorders |
| US20200264192A1 (en) * | 2017-09-28 | 2020-08-20 | Turun Yliopisto | Interleukin 32 as a biomarker of type 1 diabetes |
| WO2025137261A1 (en) * | 2023-12-20 | 2025-06-26 | Verily Life Sciences Llc | Methods of diagnosing and treating rheumatoid arthritis by identifying inflammatory initiators |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US6448380B2 (en) | 1989-08-07 | 2002-09-10 | Peptech Limited | Tumor necrosis factor antibodies |
| NZ235148A (en) | 1989-09-05 | 1991-12-23 | Immunex Corp | Tumour necrosis factor receptor protein and dna sequences |
| US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| GB9214857D0 (en) * | 1992-07-13 | 1992-08-26 | Medical Res Council | Human nucleic acid fragments and their use |
| IL121860A0 (en) | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
| US6706491B1 (en) | 1999-04-09 | 2004-03-16 | The Board Of Trustees Of The University Of Illinois | Reagents and methods for identifying and modulating expression of genes regulated by p21 |
| AU4347701A (en) | 2000-03-01 | 2001-09-12 | Corixa Corp | Compositions and methods for the detection, diagnosis and therapy of hematological malignancies |
| EP1341804A4 (en) * | 2000-11-17 | 2005-08-24 | Nuvelo Inc | NEW NUCLEIC ACIDS AND POLYPEPTIDES |
| WO2002048310A2 (en) | 2000-12-15 | 2002-06-20 | Genetics Institute, Llc | Methods and compositions for diagnosing and treating rheumatoid arthritis |
| IL158397A0 (en) | 2001-04-18 | 2004-05-12 | Genset Sa | Polypeptides, their preparation and their use |
| US20030092616A1 (en) | 2001-05-25 | 2003-05-15 | Akio Matsuda | STAT6 activation gene |
| AU2001286171B2 (en) | 2001-05-25 | 2008-01-10 | Serono Genetics Institute S.A. | Human CDNAs and proteins and uses thereof |
| WO2002096943A1 (en) | 2001-05-25 | 2002-12-05 | Asahi Kasei Kabushiki Kaisha | Stat6-activating genes |
| WO2002101075A2 (en) | 2001-06-13 | 2002-12-19 | Millennium Pharmaceuticals, Inc. | Novel genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer |
| US20030073623A1 (en) * | 2001-07-30 | 2003-04-17 | Drmanac Radoje T. | Novel nucleic acid sequences obtained from various cDNA libraries |
| WO2003012061A2 (en) | 2001-08-01 | 2003-02-13 | Coley Pharmaceutical Gmbh | Methods and compositions relating to plasmacytoid dendritic cells |
| JP2005514917A (ja) | 2001-10-03 | 2005-05-26 | インサイト・ゲノミックス・インコーポレイテッド | 分泌タンパク質 |
| WO2003080640A1 (en) | 2002-03-07 | 2003-10-02 | Ludwig Institute For Cancer Research | Lymphatic and blood endothelial cell genes |
| JP2004121218A (ja) | 2002-08-06 | 2004-04-22 | Jenokkusu Soyaku Kenkyusho:Kk | 気管支喘息または慢性閉塞性肺疾患の検査方法 |
| US20050048490A1 (en) | 2002-09-26 | 2005-03-03 | Incyte Corp. | Proteins associated with cell growth, differentiation, and death |
| WO2005019258A2 (en) | 2003-08-11 | 2005-03-03 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| JP4979385B2 (ja) * | 2003-11-12 | 2012-07-18 | ザ・リージエンツ・オブ・ザ・ユニバーシテイ・オブ・コロラド、ア・ボデイー・コーポレイト | 腫瘍壊死因子αの調節のための組成物及び方法 |
| KR100565698B1 (ko) | 2004-12-29 | 2006-03-28 | 디지탈 지노믹스(주) | 급성골수성백혈병(aml), b-세포형 급성임파구성백혈병(b-all), t 세포형 급성임파구성백혈병(t-all) 진단용 마커 |
| KR100855299B1 (ko) * | 2007-02-16 | 2008-08-29 | 건국대학교 산학협력단 | 인간 ｉｌ-32 특이 항원결정기를 갖는 단일클론항체,특이항체분비 융합 세포주 및 항체들을 이용한 ｉｌ-32측정법 |
-
2004
- 2004-11-12 JP JP2006539833A patent/JP4979385B2/ja not_active Expired - Fee Related
- 2004-11-12 MX MXPA06005219A patent/MXPA06005219A/es active IP Right Grant
- 2004-11-12 CA CA2545359A patent/CA2545359C/en not_active Expired - Fee Related
- 2004-11-12 US US10/578,943 patent/US7560265B2/en not_active Expired - Fee Related
- 2004-11-12 AU AU2004290049A patent/AU2004290049B2/en not_active Ceased
- 2004-11-12 EP EP11154031A patent/EP2357238A3/en not_active Withdrawn
- 2004-11-12 WO PCT/US2004/037578 patent/WO2005047478A2/en not_active Ceased
- 2004-11-12 EA EA200600936A patent/EA012567B1/ru not_active IP Right Cessation
- 2004-11-12 CN CN200480040092.0A patent/CN101018808B/zh not_active Expired - Fee Related
- 2004-11-12 BR BRPI0416467-9A patent/BRPI0416467A/pt not_active IP Right Cessation
- 2004-11-12 EP EP04810713A patent/EP1692175A4/en not_active Withdrawn
-
2006
- 2006-05-09 IL IL175503A patent/IL175503A0/en unknown
- 2006-05-11 ZA ZA200603780A patent/ZA200603780B/en unknown
-
2009
- 2009-06-11 US US12/482,987 patent/US8138312B2/en not_active Expired - Fee Related
-
2011
- 2011-09-29 JP JP2011214349A patent/JP2012050446A/ja active Pending
-
2012
- 2012-01-19 US US13/353,840 patent/US8735358B2/en not_active Expired - Fee Related
-
2014
- 2014-03-17 US US14/216,117 patent/US20140235829A1/en not_active Abandoned
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