JP2011529946A5 - - Google Patents

Info

Publication number

JP2011529946A5

JP2011529946A5 JP2011521575A JP2011521575A JP2011529946A5 JP 2011529946 A5 JP2011529946 A5 JP 2011529946A5 JP 2011521575 A JP2011521575 A JP 2011521575A JP 2011521575 A JP2011521575 A JP 2011521575A JP 2011529946 A5 JP2011529946 A5 JP 2011529946A5

Authority

JP

Japan

Prior art keywords

particles

active ingredient

diameter

growth factor

pharmaceutical preparation

Prior art date

2009-08-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000002245 particle Substances 0.000 claims 19
• 239000004480 active ingredient Substances 0.000 claims 11
• 239000000825 pharmaceutical preparation Substances 0.000 claims 9
• 239000008194 pharmaceutical composition Substances 0.000 claims 8
• 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 7
• 102000003745 Hepatocyte Growth Factor Human genes 0.000 claims 6
• 108090000100 Hepatocyte Growth Factor Proteins 0.000 claims 6
• 210000001519 tissue Anatomy 0.000 claims 6
• 239000000546 pharmaceutical excipient Substances 0.000 claims 5
• 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 4
• 210000005003 heart tissue Anatomy 0.000 claims 4
• 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 3
• 102000014429 Insulin-like growth factor Human genes 0.000 claims 3
• 108010025020 Nerve Growth Factor Proteins 0.000 claims 3
• 239000002253 acid Substances 0.000 claims 3
• 238000009472 formulation Methods 0.000 claims 3
• 239000000203 mixture Substances 0.000 claims 3
• 208000010125 myocardial infarction Diseases 0.000 claims 3
• 230000008929 regeneration Effects 0.000 claims 3
• 238000011069 regeneration method Methods 0.000 claims 3
• 102100037597 Brain-derived neurotrophic factor Human genes 0.000 claims 2
• 108090000715 Brain-derived neurotrophic factor Proteins 0.000 claims 2
• 108010008951 Chemokine CXCL12 Proteins 0.000 claims 2
• 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 2
• 102000009024 Epidermal Growth Factor Human genes 0.000 claims 2
• 101800003838 Epidermal growth factor Proteins 0.000 claims 2
• 102000003951 Erythropoietin Human genes 0.000 claims 2
• 108090000394 Erythropoietin Proteins 0.000 claims 2
• 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 2
• 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 2
• 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 2
• 102000004858 Growth differentiation factor-9 Human genes 0.000 claims 2
• 108090001086 Growth differentiation factor-9 Proteins 0.000 claims 2
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• 108010056852 Myostatin Proteins 0.000 claims 2
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• 108090000099 Neurotrophin-4 Proteins 0.000 claims 2
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• 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 2
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• 229940077737 brain-derived neurotrophic factor Drugs 0.000 claims 2
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• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
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• 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims 1
• 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims 1
• 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 1
• 229920001661 Chitosan Polymers 0.000 claims 1
• 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 claims 1
• 102100031706 Fibroblast growth factor 1 Human genes 0.000 claims 1
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• 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 1
• AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 1
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
• 108090001005 Interleukin-6 Proteins 0.000 claims 1
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• 229920000954 Polyglycolide Polymers 0.000 claims 1
• 108010023082 activin A Proteins 0.000 claims 1
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• 229920000747 poly(lactic acid) Polymers 0.000 claims 1
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