JP2011529854A5 - - Google Patents
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- Publication number
- JP2011529854A5 JP2011529854A5 JP2011509498A JP2011509498A JP2011529854A5 JP 2011529854 A5 JP2011529854 A5 JP 2011529854A5 JP 2011509498 A JP2011509498 A JP 2011509498A JP 2011509498 A JP2011509498 A JP 2011509498A JP 2011529854 A5 JP2011529854 A5 JP 2011529854A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- methylprednisolone
- prednisolone
- dexamethasone
- days
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 13
- FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 claims 6
- 229960003957 dexamethasone Drugs 0.000 claims 6
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 6
- 229960004584 methylprednisolone Drugs 0.000 claims 6
- 229960005205 prednisolone Drugs 0.000 claims 6
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims 6
- 230000003110 anti-inflammatory effect Effects 0.000 claims 5
- 239000003246 corticosteroid Substances 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 238000013268 sustained release Methods 0.000 claims 5
- 239000012730 sustained-release form Substances 0.000 claims 5
- 239000004231 Riboflavin-5-Sodium Phosphate Substances 0.000 claims 4
- 239000012528 membrane Substances 0.000 claims 4
- 210000004049 perilymph Anatomy 0.000 claims 4
- 210000003477 cochlea Anatomy 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrug Drugs 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000001332 colony forming effect Effects 0.000 claims 2
- 230000000813 microbial effect Effects 0.000 claims 2
- 230000003204 osmotic effect Effects 0.000 claims 2
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims 2
- -1 polyoxypropylene Polymers 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000008223 sterile water Substances 0.000 claims 2
- 229920000428 triblock copolymer Polymers 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 206010011891 Deafness neurosensory Diseases 0.000 claims 1
- 208000027530 Meniere disease Diseases 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 208000009966 Sensorineural Hearing Loss Diseases 0.000 claims 1
- 208000032625 disorder of ear Diseases 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 125000002467 phosphate group Chemical class [H]OP(=O)(O[H])O[*] 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920001451 polypropylene glycol Polymers 0.000 claims 1
- 208000023573 sensorineural hearing loss disease Diseases 0.000 claims 1
Applications Claiming Priority (21)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12771308P | 2008-05-14 | 2008-05-14 | |
| US61/127,713 | 2008-05-14 | ||
| US6042508P | 2008-06-10 | 2008-06-10 | |
| US61/060,425 | 2008-06-10 | ||
| US7458308P | 2008-06-20 | 2008-06-20 | |
| US61/074,583 | 2008-06-20 | ||
| US8245008P | 2008-07-21 | 2008-07-21 | |
| US61/082,450 | 2008-07-21 | ||
| US8794008P | 2008-08-11 | 2008-08-11 | |
| US61/087,940 | 2008-08-11 | ||
| US9438408P | 2008-09-04 | 2008-09-04 | |
| US61/094,384 | 2008-09-04 | ||
| US9524808P | 2008-09-08 | 2008-09-08 | |
| US61/095,248 | 2008-09-08 | ||
| US10111208P | 2008-09-29 | 2008-09-29 | |
| US61/101,112 | 2008-09-29 | ||
| US14003308P | 2008-12-22 | 2008-12-22 | |
| GB0823378.5 | 2008-12-22 | ||
| GB0823378A GB2459910B (en) | 2008-04-21 | 2008-12-22 | Controlled Release Corticosteroid Compositions and Methods for the Treatment of Otic Disorders |
| US61/140,033 | 2008-12-22 | ||
| PCT/US2009/003066 WO2009139924A2 (en) | 2008-05-14 | 2009-05-14 | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014049354A Division JP6014069B2 (ja) | 2008-05-14 | 2014-03-12 | 制御放出型コルチコステロイド組成物、および耳の疾患を処置する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011529854A JP2011529854A (ja) | 2011-12-15 |
| JP2011529854A5 true JP2011529854A5 (https=) | 2012-02-02 |
| JP5551685B2 JP5551685B2 (ja) | 2014-07-16 |
Family
ID=41319223
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011509498A Expired - Fee Related JP5551685B2 (ja) | 2008-05-14 | 2009-05-14 | 制御放出型コルチコステロイド組成物、および耳の疾患を処置する方法 |
| JP2014049354A Expired - Fee Related JP6014069B2 (ja) | 2008-05-14 | 2014-03-12 | 制御放出型コルチコステロイド組成物、および耳の疾患を処置する方法 |
| JP2016094870A Pending JP2016153423A (ja) | 2008-05-14 | 2016-05-10 | 制御放出型コルチコステロイド組成物、および耳の疾患を処置する方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014049354A Expired - Fee Related JP6014069B2 (ja) | 2008-05-14 | 2014-03-12 | 制御放出型コルチコステロイド組成物、および耳の疾患を処置する方法 |
| JP2016094870A Pending JP2016153423A (ja) | 2008-05-14 | 2016-05-10 | 制御放出型コルチコステロイド組成物、および耳の疾患を処置する方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (9) | US8030297B2 (https=) |
| EP (1) | EP2303227B1 (https=) |
| JP (3) | JP5551685B2 (https=) |
| KR (2) | KR101534422B1 (https=) |
| CN (2) | CN103417472B (https=) |
| AU (1) | AU2009246870B2 (https=) |
| BR (1) | BRPI0912482A2 (https=) |
| CA (1) | CA2723458C (https=) |
| IL (2) | IL208806A (https=) |
| MX (1) | MX2010012397A (https=) |
| MY (1) | MY161021A (https=) |
| RU (2) | RU2469726C2 (https=) |
| WO (1) | WO2009139924A2 (https=) |
| ZA (1) | ZA201007482B (https=) |
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2009
- 2009-05-14 KR KR1020137021389A patent/KR101534422B1/ko not_active Expired - Fee Related
- 2009-05-14 US US12/466,310 patent/US8030297B2/en not_active Expired - Fee Related
- 2009-05-14 CN CN201310289183.9A patent/CN103417472B/zh not_active Expired - Fee Related
- 2009-05-14 CN CN200980116869XA patent/CN102026623B/zh not_active Expired - Fee Related
- 2009-05-14 BR BRPI0912482-9A patent/BRPI0912482A2/pt not_active Application Discontinuation
- 2009-05-14 KR KR1020107026567A patent/KR101477329B1/ko not_active Expired - Fee Related
- 2009-05-14 JP JP2011509498A patent/JP5551685B2/ja not_active Expired - Fee Related
- 2009-05-14 MX MX2010012397A patent/MX2010012397A/es active IP Right Grant
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- 2009-05-14 WO PCT/US2009/003066 patent/WO2009139924A2/en not_active Ceased
- 2009-05-14 AU AU2009246870A patent/AU2009246870B2/en not_active Ceased
- 2009-05-14 RU RU2010150863/15A patent/RU2469726C2/ru active
- 2009-05-14 EP EP09747010.8A patent/EP2303227B1/en active Active
- 2009-05-14 MY MYPI2010005337A patent/MY161021A/en unknown
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