JP2011529706A - 間充織間質細胞集団、ならびにそれを単離および使用する方法 - Google Patents
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| EP2334785B2 (en) | 2008-09-16 | 2019-08-14 | Mayo Foundation For Medical Education And Research | Compositions containing platelet contents |
| WO2011053860A2 (en) * | 2009-10-30 | 2011-05-05 | Allocure, Inc. | Mesenchymal stromal cell populations and methods of using same |
| AU2010325546B2 (en) * | 2009-11-27 | 2014-10-16 | Stempeutics Research Pvt. Ltd. | Methods of preparing mesenchymal stem cells, compositions and kit thereof |
| ES2634545T3 (es) | 2010-06-01 | 2017-09-28 | Auxocell Laboratories, Inc. | Células madre nativas de la gelatina de Wharton y su purificación |
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| HUE048876T2 (hu) | 2011-05-09 | 2020-08-28 | Mayo Found Medical Education & Res | Rákos megbetegedések kezelése |
| CN104508124B (zh) | 2011-07-06 | 2017-11-17 | 细胞治疗有限公司 | 中胚层谱系祖细胞 |
| US20130129688A1 (en) | 2011-11-09 | 2013-05-23 | Allocure, Inc. | Assay for the Prediction of Therapeutic Effectiveness or Potency of Mesenchymal Stem Cells, and Methods of Using Same |
| US8961956B2 (en) | 2011-11-30 | 2015-02-24 | Ocata Therapeutics, Inc. | Mesenchymal stromal cells and uses related thereto |
| PL2785359T3 (pl) | 2011-11-30 | 2018-12-31 | Astellas Institute For Regenerative Medicine | Mezenchymalne komórki zrębowe i związane z nimi zastosowania |
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| US20190060365A1 (en) * | 2017-08-25 | 2019-02-28 | Meridigen Biotech Co., Ltd. | Pharmaceutical composition for treating chronic obstructive pulmonary disease and method thereof |
| WO2019102268A1 (en) | 2017-11-22 | 2019-05-31 | Mesoblast International Sarl | Cellular compositions and methods of treatment i |
| KR20220031555A (ko) | 2019-06-11 | 2022-03-11 | 옥소젠 코포레이션 | 조직의 습식 보존 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008034803A1 (en) * | 2006-09-18 | 2008-03-27 | Medizinische Universität Graz | Plasma-free platelet lysate for use as a supplement in cell cultures and for the preparation of cell therapeutics |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE528214C2 (sv) * | 2005-06-23 | 2006-09-26 | Proliff Ab | Förfarande för framställning av blodplättslysat |
-
2009
- 2009-08-04 WO PCT/US2009/052733 patent/WO2010017216A2/en not_active Ceased
- 2009-08-04 US US13/057,698 patent/US20110293576A1/en not_active Abandoned
- 2009-08-04 AU AU2009279736A patent/AU2009279736A1/en not_active Abandoned
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- 2009-08-04 EP EP09805454.7A patent/EP2321408A4/en not_active Withdrawn
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008034803A1 (en) * | 2006-09-18 | 2008-03-27 | Medizinische Universität Graz | Plasma-free platelet lysate for use as a supplement in cell cultures and for the preparation of cell therapeutics |
Non-Patent Citations (7)
| Title |
|---|
| JPN6014004918; 'Ｊｏｕｒｎａｌ ｏｆ Ｃｅｌｌｕｌａｒ Ｐｈｙｓｉｏｌｏｇｙ' ２００７， Ｖｏｌ．２１１， ｐｐ．１２１-１３０ * |
| JPN6014004921; 'Ｊｏｕｒｎａｌ ｏｆ Ｃｅｌｌｕｌａｒ Ｐｈｙｓｉｏｌｏｇｙ' ２００５， Ｖｏｌ．２０５， ｐｐ．２２８-２３６ * |
| JPN6014004922; 'Ｔｒａｎｓｐｌａｎｔａｔｉｏｎ ａｎｄ Ｃｅｌｌｕｌａｒ Ｅｎｇｉｎｅｅｒｉｎｇ' ２００７， Ｖｏｌ．４７， ｐｐ．１４３６-１４４６ * |
| JPN6014004925; 'Ｊｏｕｒｎａｌ ｏｆ Ｃｅｌｌｕｌａｒ Ｐｈｙｓｉｏｌｏｇｙ' ２００７， Ｖｏｌ．２１３， ｐｐ．１８-２６ * |
| JPN6014004928; 'Ｅｘｐｅｒｉｍｅｎｔａｌ Ｈｅｍａｔｏｌｏｇｙ' ０１．０８．２００８， Ｖｏｌ．３６， ｐｐ．１０１４-１０２１ * |
| JPN6014004930; 'Ｂｏｎｅ Ｍａｒｒｏｗ Ｔｒａｎｓｐｌａｎｔａｔｉｏｎ' ２００７， Ｖｏｌ．４０， ｐｐ．７８５-７９１ * |
| JPN6014004934; 'Ｔｉｓｓｕｅ Ｅｎｇｉｎｅｅｒｉｎｇ： Ｐａｒｔ Ｃ' １１．０７．２００８， Ｖｏｌ．１４， ｐｐ．１８５-１９６ * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021065971A1 (ja) * | 2019-09-30 | 2021-04-08 | テルモ株式会社 | 凍結保存細胞の希釈用緩衝液 |
| JPWO2021065971A1 (enExample) * | 2019-09-30 | 2021-04-08 | ||
| JP7582958B2 (ja) | 2019-09-30 | 2024-11-13 | テルモ株式会社 | 凍結保存細胞の希釈用緩衝液 |
| JPWO2022025238A1 (enExample) * | 2020-07-31 | 2022-02-03 | ||
| WO2022025238A1 (ja) * | 2020-07-31 | 2022-02-03 | 株式会社Rainbow | 自家血小板由来の血小板溶解物 |
| JP2022120063A (ja) * | 2020-07-31 | 2022-08-17 | 株式会社Rainbow | 自家血小板由来の血小板溶解物 |
| JP7137883B2 (ja) | 2020-07-31 | 2022-09-15 | 株式会社Rainbow | 自家血小板由来の血小板溶解物 |
| WO2022210514A1 (ja) | 2021-03-30 | 2022-10-06 | 株式会社カネカ | トリプシン阻害方法、それを用いた細胞製剤の製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20110293576A1 (en) | 2011-12-01 |
| WO2010017216A8 (en) | 2010-09-30 |
| WO2010017216A3 (en) | 2010-06-17 |
| WO2010017216A2 (en) | 2010-02-11 |
| EP2321408A2 (en) | 2011-05-18 |
| AU2009279736A1 (en) | 2010-02-11 |
| EP2321408A4 (en) | 2013-04-17 |
| CA2736353A1 (en) | 2010-02-11 |
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