CA2736353A1 - Mesenchymal stromal cell populations and methods of isolating and using same - Google Patents

Mesenchymal stromal cell populations and methods of isolating and using same Download PDF

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Publication number
CA2736353A1
CA2736353A1 CA2736353A CA2736353A CA2736353A1 CA 2736353 A1 CA2736353 A1 CA 2736353A1 CA 2736353 A CA2736353 A CA 2736353A CA 2736353 A CA2736353 A CA 2736353A CA 2736353 A1 CA2736353 A1 CA 2736353A1
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CA
Canada
Prior art keywords
population
cells
mesenchymal stromal
mscs
stromal cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2736353A
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English (en)
French (fr)
Inventor
Claudia Lange
Christopher Westenfelder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALLOCURE Inc
Original Assignee
ALLOCURE
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Filing date
Publication date
Application filed by ALLOCURE filed Critical ALLOCURE
Publication of CA2736353A1 publication Critical patent/CA2736353A1/en
Abandoned legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0663Bone marrow mesenchymal stem cells (BM-MSC)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/70Undefined extracts
    • C12N2500/80Undefined extracts from animals
    • C12N2500/84Undefined extracts from animals from mammals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/90Serum-free medium, which may still contain naturally-sourced components

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2736353A 2008-08-04 2009-08-04 Mesenchymal stromal cell populations and methods of isolating and using same Abandoned CA2736353A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8603308P 2008-08-04 2008-08-04
US61/086,033 2008-08-04
PCT/US2009/052733 WO2010017216A2 (en) 2008-08-04 2009-08-04 Mesenchymal stromal cell populations and methods of isolating and using same

Publications (1)

Publication Number Publication Date
CA2736353A1 true CA2736353A1 (en) 2010-02-11

Family

ID=41664170

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2736353A Abandoned CA2736353A1 (en) 2008-08-04 2009-08-04 Mesenchymal stromal cell populations and methods of isolating and using same

Country Status (6)

Country Link
US (1) US20110293576A1 (enExample)
EP (1) EP2321408A4 (enExample)
JP (1) JP2011529706A (enExample)
AU (1) AU2009279736A1 (enExample)
CA (1) CA2736353A1 (enExample)
WO (1) WO2010017216A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12410405B2 (en) 2010-10-08 2025-09-09 Mesoblast International Sàrl Enhanced MSC preparations
US12473547B2 (en) 2017-11-22 2025-11-18 Mesoblast International Sàrl Use of mesenchymal lineage precursor cells or stem cells (MLPSCs) for delivery of oligonucleotides in the treatment of cancer

Families Citing this family (36)

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WO2010003057A2 (en) 2008-07-03 2010-01-07 Mayo Foundation For Medical Education And Research Treating cancer
ES2982461T3 (es) 2008-09-16 2024-10-16 Mayo Found Medical Education & Res Composiciones que contienen contenido plaquetario
WO2011053860A2 (en) * 2009-10-30 2011-05-05 Allocure, Inc. Mesenchymal stromal cell populations and methods of using same
CN102639694B (zh) * 2009-11-27 2015-05-27 斯蒂姆普优提克斯个人研究有限公司 制备间充质干细胞、组合物和其试剂盒的方法
WO2011153205A1 (en) 2010-06-01 2011-12-08 Auxocell Laboratories, Inc. Native wharton's jelly stem cells and their purification
HRP20200793T1 (hr) 2011-05-09 2020-10-16 Mayo Foundation For Medical Education And Research Liječenje raka
CA2840307C (en) 2011-07-06 2021-10-19 Cell Therapy Limited Progenitor cells of mesodermal lineage
WO2013070765A1 (en) 2011-11-09 2013-05-16 Allocure, Inc. Assay for the prediction of therapeutic effectiveness or potency of mesenchymal stem cells, and methods of using same
RS57886B1 (sr) * 2011-11-30 2019-01-31 Astellas Inst For Regenerative Medicine Mezenhimalne stromalne ćelije i primene vezane za njih
US8961956B2 (en) 2011-11-30 2015-02-24 Ocata Therapeutics, Inc. Mesenchymal stromal cells and uses related thereto
WO2013166026A1 (en) 2012-04-30 2013-11-07 Allocure, Inc. Methods of treating acute kidney injury using mesenchymal stem cells
CA2876499C (en) 2012-07-12 2021-10-26 Imstem Biotechnology, Inc. Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
CA2917407C (en) 2012-10-01 2023-03-14 Mayo Foundation For Medical Education And Research Complexes containing albumin-containing nanoparticles and antibodies to treat cancer
WO2014193895A1 (en) 2013-05-29 2014-12-04 Allocure, Inc. Ex vivo perfusion of donor organs prior to transplantation using mesenchymal stem cells
ES2663482T3 (es) * 2013-08-01 2018-04-12 Fundación Pública Andaluza Progreso Y Salud Método para predecir la respuesta al tratamiento y prueba para el uso seguro de células madre mesenquimatosas en enfermedades inflamatorias
US11891620B2 (en) 2014-05-16 2024-02-06 Mayo Foundation For Medical Education And Research Cell culture media compositions for primary cells
CA2950926A1 (en) 2014-06-13 2015-12-17 Mayo Foundation For Medical Education And Research Albumin-bound paclitaxel nanoparticle/rituximab complexes for treatment of cd20-expressing lymphomas
JP6600651B2 (ja) 2014-06-16 2019-10-30 マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ 骨髄腫の治療
US9446148B2 (en) 2014-10-06 2016-09-20 Mayo Foundation For Medical Education And Research Carrier-antibody compositions and methods of making and using the same
TW201707725A (zh) 2015-08-18 2017-03-01 美國馬友醫藥教育研究基金會 載體-抗體組合物及其製造及使用方法
TW201713360A (en) 2015-10-06 2017-04-16 Mayo Foundation Methods of treating cancer using compositions of antibodies and carrier proteins
EP3399861A4 (en) 2016-01-07 2019-08-07 Mayo Foundation for Medical Education and Research METHOD FOR THE TREATMENT OF CANCER WITH INTERFERON
US11351254B2 (en) 2016-02-12 2022-06-07 Mayo Foundation For Medical Education And Research Hematologic cancer treatments
CA3018340A1 (en) 2016-03-21 2017-09-28 Mayo Foundation For Medical Education And Research Methods for improving the therapeutic index for a chemotherapeutic drug
EP3432926A4 (en) 2016-03-21 2019-11-20 Mayo Foundation for Medical Education and Research METHOD FOR REDUCING THE TOXICITY OF CHEMOTHERAPEUTICS
US10618969B2 (en) 2016-04-06 2020-04-14 Mayo Foundation For Medical Education And Research Carrier-binding agent compositions and methods of making and using the same
JP7525999B2 (ja) 2016-09-01 2024-07-31 マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ キャリアー-pd-l1結合剤組成物及び癌を処置する為にそれを使用する方法
EP3506950A1 (en) 2016-09-01 2019-07-10 Mayo Foundation for Medical Education and Research Methods and compositions for targeting t-cell cancers
EP3509635A1 (en) 2016-09-06 2019-07-17 Vavotar Life Sciences LLC Methods of treating triple-negative breast cancer using compositions of antibodies and carrier proteins
RU2756892C2 (ru) 2016-09-06 2021-10-06 Мэйо Фаундейшн Фор Медикал Эдьюкейшн Энд Рисерч Композиции с паклитакселом, альбумином и связывающим средством и способы их применения и получения
CN109843924A (zh) 2016-09-06 2019-06-04 梅约医学教育与研究基金会 治疗表达pd-l1的癌症的方法
US20190060365A1 (en) * 2017-08-25 2019-02-28 Meridigen Biotech Co., Ltd. Pharmaceutical composition for treating chronic obstructive pulmonary disease and method thereof
EP3982724A1 (en) 2019-06-11 2022-04-20 Axogen Corporation Wet preservation of tissue
JP7582958B2 (ja) * 2019-09-30 2024-11-13 テルモ株式会社 凍結保存細胞の希釈用緩衝液
EP4190892A4 (en) * 2020-07-31 2024-10-30 Rainbow Inc. Platelet lysate derived from autologous platelets
US20250075184A1 (en) 2021-03-30 2025-03-06 Kaneka Corporation Method for inhibiting trypsin, and method for producing a cell preparation using the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE528214C2 (sv) * 2005-06-23 2006-09-26 Proliff Ab Förfarande för framställning av blodplättslysat
EP2069479A1 (en) * 2006-09-18 2009-06-17 Medizinische Universität Graz Plasma-free platelet lysate for use as a supplement in cell cultures and for the preparation of cell therapeutics

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12410405B2 (en) 2010-10-08 2025-09-09 Mesoblast International Sàrl Enhanced MSC preparations
US12473547B2 (en) 2017-11-22 2025-11-18 Mesoblast International Sàrl Use of mesenchymal lineage precursor cells or stem cells (MLPSCs) for delivery of oligonucleotides in the treatment of cancer

Also Published As

Publication number Publication date
EP2321408A2 (en) 2011-05-18
WO2010017216A2 (en) 2010-02-11
WO2010017216A3 (en) 2010-06-17
EP2321408A4 (en) 2013-04-17
US20110293576A1 (en) 2011-12-01
AU2009279736A1 (en) 2010-02-11
WO2010017216A8 (en) 2010-09-30
JP2011529706A (ja) 2011-12-15

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Effective date: 20150804