CA2736353A1 - Mesenchymal stromal cell populations and methods of isolating and using same - Google Patents

Mesenchymal stromal cell populations and methods of isolating and using same Download PDF

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Publication number
CA2736353A1
CA2736353A1 CA2736353A CA2736353A CA2736353A1 CA 2736353 A1 CA2736353 A1 CA 2736353A1 CA 2736353 A CA2736353 A CA 2736353A CA 2736353 A CA2736353 A CA 2736353A CA 2736353 A1 CA2736353 A1 CA 2736353A1
Authority
CA
Canada
Prior art keywords
population
cells
mesenchymal stromal
mscs
stromal cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2736353A
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English (en)
French (fr)
Inventor
Claudia Lange
Christopher Westenfelder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALLOCURE Inc
Original Assignee
ALLOCURE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ALLOCURE filed Critical ALLOCURE
Publication of CA2736353A1 publication Critical patent/CA2736353A1/en
Abandoned legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0663Bone marrow mesenchymal stem cells (BM-MSC)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/70Undefined extracts
    • C12N2500/80Undefined extracts from animals
    • C12N2500/84Undefined extracts from animals from mammals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/90Serum-free medium, which may still contain naturally-sourced components

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2736353A 2008-08-04 2009-08-04 Mesenchymal stromal cell populations and methods of isolating and using same Abandoned CA2736353A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8603308P 2008-08-04 2008-08-04
US61/086,033 2008-08-04
PCT/US2009/052733 WO2010017216A2 (en) 2008-08-04 2009-08-04 Mesenchymal stromal cell populations and methods of isolating and using same

Publications (1)

Publication Number Publication Date
CA2736353A1 true CA2736353A1 (en) 2010-02-11

Family

ID=41664170

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2736353A Abandoned CA2736353A1 (en) 2008-08-04 2009-08-04 Mesenchymal stromal cell populations and methods of isolating and using same

Country Status (6)

Country Link
US (1) US20110293576A1 (enExample)
EP (1) EP2321408A4 (enExample)
JP (1) JP2011529706A (enExample)
AU (1) AU2009279736A1 (enExample)
CA (1) CA2736353A1 (enExample)
WO (1) WO2010017216A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12410405B2 (en) 2010-10-08 2025-09-09 Mesoblast International Sàrl Enhanced MSC preparations
US12473547B2 (en) 2017-11-22 2025-11-18 Mesoblast International Sàrl Use of mesenchymal lineage precursor cells or stem cells (MLPSCs) for delivery of oligonucleotides in the treatment of cancer

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2310006A4 (en) 2008-07-03 2012-04-25 Mayo Foundation CANCER TREATMENT
US20110171731A1 (en) 2008-09-16 2011-07-14 Dietz Allan B Compositions containing platelet contents
US20120269779A1 (en) * 2009-10-30 2012-10-25 Allocure, Inc. Mesenchymal stromal cell populations and methods of using same
WO2011064733A1 (en) * 2009-11-27 2011-06-03 Stempeutics Research Pvt. Ltd. Methods of preparing mesenchymal stem cells, compositions and kit thereof
EP2576768B1 (en) 2010-06-01 2017-05-10 Auxocell Laboratories, Inc. Native wharton's jelly stem cells and their purification
US9427477B2 (en) 2011-05-09 2016-08-30 Mayo Foundation For Medical Education And Research Cancer treatments
CN104508124B (zh) 2011-07-06 2017-11-17 细胞治疗有限公司 中胚层谱系祖细胞
EP2776578A1 (en) 2011-11-09 2014-09-17 Allocure, Inc. Assay for the prediction of therapeutic effectiveness or potency of mesenchymal stem cells, and methods of using same
PL2785359T3 (pl) 2011-11-30 2018-12-31 Astellas Institute For Regenerative Medicine Mezenchymalne komórki zrębowe i związane z nimi zastosowania
US8961956B2 (en) 2011-11-30 2015-02-24 Ocata Therapeutics, Inc. Mesenchymal stromal cells and uses related thereto
WO2013166026A1 (en) 2012-04-30 2013-11-07 Allocure, Inc. Methods of treating acute kidney injury using mesenchymal stem cells
WO2014011407A2 (en) 2012-07-12 2014-01-16 Imstem Biotechnology, Inc. Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
AU2013327638B2 (en) 2012-10-01 2018-06-14 Mayo Foundation For Medical Education And Research Cancer treatments
WO2014193895A1 (en) 2013-05-29 2014-12-04 Allocure, Inc. Ex vivo perfusion of donor organs prior to transplantation using mesenchymal stem cells
WO2015014988A1 (en) * 2013-08-01 2015-02-05 Fundacion Pública Andaluza Progreso Y Salud Method for predicting treatment response and test for safe use of mesenchymal stem cells on inflammatory diseases.
EP3143130B1 (en) 2014-05-16 2024-03-06 Mayo Foundation for Medical Education and Research Cell culture media compositions for primary cells
MX380597B (es) 2014-06-13 2025-03-12 Mayo Found Medical Education & Res Composición con complejos de nanopartículas/anticuerpos de paclitaxel unidos a albúmina para usarse al tratar linfoma.
US10213513B2 (en) 2014-06-16 2019-02-26 Mayo Foundation For Medical Education And Research Treating myelomas
US9446148B2 (en) 2014-10-06 2016-09-20 Mayo Foundation For Medical Education And Research Carrier-antibody compositions and methods of making and using the same
TW201707725A (zh) 2015-08-18 2017-03-01 美國馬友醫藥教育研究基金會 載體-抗體組合物及其製造及使用方法
TW201713360A (en) 2015-10-06 2017-04-16 Mayo Foundation Methods of treating cancer using compositions of antibodies and carrier proteins
WO2017120501A1 (en) 2016-01-07 2017-07-13 Mayo Foundation For Medical Education And Research Methods of treating cancer with interferon
US11351254B2 (en) 2016-02-12 2022-06-07 Mayo Foundation For Medical Education And Research Hematologic cancer treatments
WO2017165440A1 (en) 2016-03-21 2017-09-28 Mayo Foundation For Medical Education And Research Methods for reducing toxicity of a chemotherapeutic drug
US11878061B2 (en) 2016-03-21 2024-01-23 Mayo Foundation For Medical Education And Research Methods for improving the therapeutic index for a chemotherapeutic drug
US10618969B2 (en) 2016-04-06 2020-04-14 Mayo Foundation For Medical Education And Research Carrier-binding agent compositions and methods of making and using the same
EP3506950A1 (en) 2016-09-01 2019-07-10 Mayo Foundation for Medical Education and Research Methods and compositions for targeting t-cell cancers
US11548946B2 (en) 2016-09-01 2023-01-10 Mayo Foundation For Medical Education And Research Carrier-PD-L1 binding agent compositions for treating cancers
EP3509643A1 (en) 2016-09-06 2019-07-17 Mayo Foundation for Medical Education and Research Paclitaxel-albumin-binding agent compositions and methods for using and making the same
US11590098B2 (en) 2016-09-06 2023-02-28 Mayo Foundation For Medical Education And Research Methods of treating triple-negative breast cancer using compositions of antibodies and carrier proteins
US11427637B2 (en) 2016-09-06 2022-08-30 Mayo Foundation For Medical Education And Research Methods of treating PD-L1 expressing cancer
US20190060365A1 (en) * 2017-08-25 2019-02-28 Meridigen Biotech Co., Ltd. Pharmaceutical composition for treating chronic obstructive pulmonary disease and method thereof
KR20220031555A (ko) 2019-06-11 2022-03-11 옥소젠 코포레이션 조직의 습식 보존
JP7582958B2 (ja) * 2019-09-30 2024-11-13 テルモ株式会社 凍結保存細胞の希釈用緩衝液
WO2022025238A1 (ja) * 2020-07-31 2022-02-03 株式会社Rainbow 自家血小板由来の血小板溶解物
JPWO2022210514A1 (enExample) 2021-03-30 2022-10-06

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0501462L (sv) * 2005-06-23 2006-09-26 Proliff Ab Förfarande för framställning av blodplättslysat
WO2008034803A1 (en) * 2006-09-18 2008-03-27 Medizinische Universität Graz Plasma-free platelet lysate for use as a supplement in cell cultures and for the preparation of cell therapeutics

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12410405B2 (en) 2010-10-08 2025-09-09 Mesoblast International Sàrl Enhanced MSC preparations
US12473547B2 (en) 2017-11-22 2025-11-18 Mesoblast International Sàrl Use of mesenchymal lineage precursor cells or stem cells (MLPSCs) for delivery of oligonucleotides in the treatment of cancer

Also Published As

Publication number Publication date
EP2321408A4 (en) 2013-04-17
EP2321408A2 (en) 2011-05-18
WO2010017216A8 (en) 2010-09-30
AU2009279736A1 (en) 2010-02-11
JP2011529706A (ja) 2011-12-15
WO2010017216A2 (en) 2010-02-11
US20110293576A1 (en) 2011-12-01
WO2010017216A3 (en) 2010-06-17

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Effective date: 20150804