JP2011529477A - １，６−ジヒドロ−２ｈ−３−オキサ−６−アザ−ａｓ−インダセン化合物 - Google Patents
１，６−ジヒドロ−２ｈ−３−オキサ−６−アザ−ａｓ−インダセン化合物 Download PDFInfo
- Publication number
- JP2011529477A JP2011529477A JP2011520509A JP2011520509A JP2011529477A JP 2011529477 A JP2011529477 A JP 2011529477A JP 2011520509 A JP2011520509 A JP 2011520509A JP 2011520509 A JP2011520509 A JP 2011520509A JP 2011529477 A JP2011529477 A JP 2011529477A
- Authority
- JP
- Japan
- Prior art keywords
- fluoro
- dihydro
- oxa
- aza
- indacene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 125000000217 alkyl group Chemical group 0.000 claims description 28
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- 229960003987 melatonin Drugs 0.000 claims description 19
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 18
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- 206010022437 insomnia Diseases 0.000 claims description 15
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 13
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- DMNDNXXVYMRGSK-UHFFFAOYSA-N 2,2,2-trifluoro-n-[2-(4-fluoro-2-methyl-2,6-dihydro-1h-furo[3,2-e]indol-8-yl)ethyl]acetamide Chemical compound O1C(C)CC2=C1C(F)=CC1=C2C(CCNC(=O)C(F)(F)F)=CN1 DMNDNXXVYMRGSK-UHFFFAOYSA-N 0.000 claims description 2
- VWXOZJSJOFFAPK-UHFFFAOYSA-N 2,2,2-trifluoro-n-[2-(4-fluoro-2-methyl-2,6-dihydro-1h-furo[3,2-e]indol-8-yl)propyl]acetamide Chemical compound FC1=C2OC(C)CC2=C2C(C(CNC(=O)C(F)(F)F)C)=CNC2=C1 VWXOZJSJOFFAPK-UHFFFAOYSA-N 0.000 claims description 2
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- VGRRAWQCYWLJHU-UHFFFAOYSA-N n-[2-(4-fluoro-2,6-dihydro-1h-furo[3,2-e]indol-8-yl)ethyl]butanamide Chemical compound FC1=C2OCCC2=C2C(CCNC(=O)CCC)=CNC2=C1 VGRRAWQCYWLJHU-UHFFFAOYSA-N 0.000 claims description 2
- BWVDPRLISOGKNL-UHFFFAOYSA-N n-[2-(4-fluoro-2,6-dihydro-1h-furo[3,2-e]indol-8-yl)ethyl]cyclopropanecarboxamide Chemical compound C1=2C=3CCOC=3C(F)=CC=2NC=C1CCNC(=O)C1CC1 BWVDPRLISOGKNL-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| EP08161485 | 2008-07-30 | ||
| EP08161485.1 | 2008-07-30 | ||
| PCT/EP2009/059829 WO2010012789A1 (en) | 2008-07-30 | 2009-07-29 | 1,6-dihydro-2h-3-oxa-6-aza-as-indacene compounds |
Publications (2)
| Publication Number | Publication Date |
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| JP2011529477A true JP2011529477A (ja) | 2011-12-08 |
| JP2011529477A5 JP2011529477A5 (OSRAM) | 2012-08-30 |
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| Country | Link |
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| US (1) | US8227501B2 (OSRAM) |
| EP (1) | EP2350088A1 (OSRAM) |
| JP (1) | JP2011529477A (OSRAM) |
| KR (1) | KR20110041495A (OSRAM) |
| CN (1) | CN102112480A (OSRAM) |
| AR (1) | AR075262A1 (OSRAM) |
| AU (1) | AU2009275918A1 (OSRAM) |
| BR (1) | BRPI0916395A2 (OSRAM) |
| CA (1) | CA2731405A1 (OSRAM) |
| CL (1) | CL2011000184A1 (OSRAM) |
| MX (1) | MX2011001062A (OSRAM) |
| PE (1) | PE20110208A1 (OSRAM) |
| RU (1) | RU2011107443A (OSRAM) |
| TW (1) | TW201018695A (OSRAM) |
| UY (1) | UY32016A (OSRAM) |
| WO (1) | WO2010012789A1 (OSRAM) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2014010602A1 (ja) * | 2012-07-10 | 2016-06-23 | アステラス製薬株式会社 | インドールカルボキサミド誘導体 |
| KR20170142904A (ko) * | 2016-06-17 | 2017-12-28 | 주식회사 대웅제약 | 다이페닐메탄 유도체의 제조방법 |
| JP2025531537A (ja) * | 2022-09-28 | 2025-09-19 | デーウン ファーマシューティカル カンパニー リミテッド | イナボグリフロジンの新規な結晶型及びその製造方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103601683B (zh) * | 2010-04-16 | 2016-03-30 | 中国科学院上海药物研究所 | 苯并杂环类化合物及其制备方法和用途 |
| CN104109143B (zh) * | 2013-04-22 | 2018-04-27 | 上海阳帆医药科技有限公司 | 一类褪黑激素(mt1-mt2)受体激动剂及其制备方法与用途 |
| CN104326916B (zh) * | 2014-10-10 | 2017-09-22 | 青岛农业大学 | 2‑氟‑4‑烯丙基‑6‑硝基苯酚与2‑氟‑4‑硝基‑6‑烯丙基苯酚的联合制备及用途 |
| EP4452937A4 (en) * | 2021-12-24 | 2025-12-03 | Psylo Pty Ltd | CONNECTIONS |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4600723A (en) | 1983-05-18 | 1986-07-15 | Monash University | Method for minimizing disturbances in circadian rhythms of bodily performance and function |
| DE3466215D1 (en) | 1983-05-18 | 1987-10-22 | Univ Monash | The use of melatonin for the manufacture of a medicament |
| EP0375726A4 (en) | 1987-08-17 | 1991-01-30 | Whitby Research Incorporated | Melatonin analogues |
| FR2680366B1 (fr) | 1991-08-13 | 1995-01-20 | Adir | Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| GB9326192D0 (en) * | 1993-12-22 | 1994-02-23 | Glaxo Group Ltd | Chemical compounds |
| WO1997001539A1 (en) | 1995-06-27 | 1997-01-16 | Takeda Chemical Industries, Ltd. | 4-acylamino(halogeno) alkyl-quinoline derivatives, their preparation and their use as melatonin agonists |
| US5732360A (en) | 1995-09-08 | 1998-03-24 | At & T Wireless Services And Atmel Corp | Mobile telecommunication device and method used for changing wireless communication between base stations of different kinds |
| EP0885210B2 (en) | 1996-03-08 | 2008-06-18 | Takeda Pharmaceutical Company Limited | Tricylic compounds having binding affinity for melatonin receptors, their production and use |
| US6034239A (en) | 1996-03-08 | 2000-03-07 | Takeda Chemical Industries, Ltd. | Tricyclic compounds, their production and use |
| FR2771739B1 (fr) | 1997-11-28 | 2001-04-20 | Adir | Nouveaux composes naphtaleniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2784375B1 (fr) | 1998-10-12 | 2000-11-24 | Adir | Nouveaux derives cycliques a chaine cycloalkylenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2793793B1 (fr) | 1999-05-19 | 2004-02-27 | Adir | Nouveaux derives dimeriques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CA2381468C (en) * | 1999-08-20 | 2013-05-28 | Yasuyuki Suzuki | Percutaneous absorption preparations containing melatonin receptor agonist for percutaneous treatment of sleep disorders |
| FR2799757B1 (fr) | 1999-10-15 | 2001-12-14 | Adir | Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6737431B2 (en) | 2002-03-12 | 2004-05-18 | Bristol-Myers Squibb Company | Benzoxazole derivatives as novel melatonergic agents |
| ATE444965T1 (de) | 2002-06-21 | 2009-10-15 | Suven Life Sciences Ltd | Sich als therapeutische mittel eignende arylalkylindole mit affinität für den serotoninrezeptor, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die diese enthalten |
| US6908931B2 (en) | 2003-04-10 | 2005-06-21 | Bristol-Myers Squibb Company | Tetrahydroisoquinoline derivatives as melatonin MT2 antagonists |
| CA2551117A1 (en) | 2003-12-23 | 2005-07-14 | Abraxis Bioscience, Inc. | Substituted melatonin derivatives, process for their preparation, and methods of use |
-
2009
- 2009-07-29 JP JP2011520509A patent/JP2011529477A/ja not_active Abandoned
- 2009-07-29 PE PE2011000041A patent/PE20110208A1/es not_active Application Discontinuation
- 2009-07-29 MX MX2011001062A patent/MX2011001062A/es active IP Right Grant
- 2009-07-29 US US13/056,492 patent/US8227501B2/en not_active Expired - Fee Related
- 2009-07-29 WO PCT/EP2009/059829 patent/WO2010012789A1/en not_active Ceased
- 2009-07-29 EP EP09781255A patent/EP2350088A1/en not_active Withdrawn
- 2009-07-29 UY UY0001032016A patent/UY32016A/es unknown
- 2009-07-29 AU AU2009275918A patent/AU2009275918A1/en not_active Abandoned
- 2009-07-29 AR ARP090102880A patent/AR075262A1/es unknown
- 2009-07-29 KR KR1020117002324A patent/KR20110041495A/ko not_active Withdrawn
- 2009-07-29 BR BRPI0916395A patent/BRPI0916395A2/pt not_active IP Right Cessation
- 2009-07-29 CA CA2731405A patent/CA2731405A1/en not_active Abandoned
- 2009-07-29 CN CN2009801300227A patent/CN102112480A/zh active Pending
- 2009-07-29 RU RU2011107443/04A patent/RU2011107443A/ru not_active Application Discontinuation
- 2009-07-29 TW TW098125512A patent/TW201018695A/zh unknown
-
2011
- 2011-01-28 CL CL2011000184A patent/CL2011000184A1/es unknown
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2014010602A1 (ja) * | 2012-07-10 | 2016-06-23 | アステラス製薬株式会社 | インドールカルボキサミド誘導体 |
| KR20170142904A (ko) * | 2016-06-17 | 2017-12-28 | 주식회사 대웅제약 | 다이페닐메탄 유도체의 제조방법 |
| JP2019521985A (ja) * | 2016-06-17 | 2019-08-08 | デウン ファーマシューティカル カンパニー リミテッド | ジフェニルメタン誘導体の製造方法 |
| US10889574B2 (en) | 2016-06-17 | 2021-01-12 | Daewoong Pharmaceutical Co., Ltd. | Method for producing diphenylmethane derivative |
| KR102233229B1 (ko) | 2016-06-17 | 2021-03-29 | 주식회사 대웅제약 | 다이페닐메탄 유도체의 제조방법 |
| KR20210036892A (ko) * | 2016-06-17 | 2021-04-05 | 주식회사 녹십자 | 다이페닐메탄 유도체의 제조방법 |
| KR102379584B1 (ko) | 2016-06-17 | 2022-03-29 | 주식회사 녹십자 | 다이페닐메탄 유도체의 제조방법 |
| JP2025531537A (ja) * | 2022-09-28 | 2025-09-19 | デーウン ファーマシューティカル カンパニー リミテッド | イナボグリフロジンの新規な結晶型及びその製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20110144178A1 (en) | 2011-06-16 |
| US8227501B2 (en) | 2012-07-24 |
| AR075262A1 (es) | 2011-03-23 |
| MX2011001062A (es) | 2011-03-24 |
| CA2731405A1 (en) | 2010-02-04 |
| CL2011000184A1 (es) | 2011-09-16 |
| TW201018695A (en) | 2010-05-16 |
| UY32016A (es) | 2010-01-29 |
| EP2350088A1 (en) | 2011-08-03 |
| RU2011107443A (ru) | 2012-09-10 |
| AU2009275918A1 (en) | 2010-02-04 |
| KR20110041495A (ko) | 2011-04-21 |
| CN102112480A (zh) | 2011-06-29 |
| WO2010012789A1 (en) | 2010-02-04 |
| BRPI0916395A2 (pt) | 2016-02-16 |
| PE20110208A1 (es) | 2011-03-28 |
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